جستجوی مقالات مرتبط با کلیدواژه "نوروپروتکتیو" در نشریات گروه "پزشکی"

Traumatic brain injury (TBI) is one of the most complex diseases of the central nervous system (CNS). Nesfatin is an 82-amino acid effective polypeptide in CNS. In this study, we investigated the role of nesfatin in neuron protection in the process of diffuse concussion in rats and also its effect on the level of matrix metalloproteinase-9.

In this experimental study, 56 Wistar rats were subjected to TBI by the Marmaru method. After 30 minutes, nesfatin was injected intraperitoneally at different doses, and repeated on second and third days. The results of Veterinary Coma Scale, beam walk and beam balance tests were recorded at Pre-TBI, immediately after TBI, 24, 48, and 72 hours after TBI. After 72 hours, CSF was collected from the cisterna magna and used for ELISA test to measure the matrix metalloproteinase-9.

Intraperitoneal administration of nesfatin at 50 µg/kg and 10 µg/kg can reduce cerebral edema, destruction of the blood-brain barrier, and neurological and balance-motor scores (P<0.0001) compared with the control group (Sham and Intact) (P<0.0001). Nesfatin was not found effective at 20µg/kg (P>0.05).

Nesfatin has been able to affect the consequences of trauma and reduce brain edema, accelerate the improvement of blood-brain barrier and neurological and balance scores. Probably part of these neuroprotective effects is through reduction of MMP-9.

Allicin has a wide range of pharmacological functions, all of which can be demonstrated in anti-inflammatory, antioxidant, antifungal and anti-tumor activities. In this research, we investigated the neuroprotective role of allicin in the process of diffuse traumatic brain injury and its effect on interleukin levels and histological changes in rats.

In this experimental study, Wistar rats (n=56) underwent diffuse controlled brain injury by Marmarou method, and 30 minutes later, the drug was injected intraperitoneally at different doses. Veterinary Coma Scale was used and Beam Walk and Beam Balance movement and balance tests were taken at pre-traumatic times, immediately after recovery from the trauma, and 24, 48, and 72 hours after the trauma.

Findings showed that allicin at 25 mg/kg and 50 mg/kg can reduce these differences compared to the control group (Sham and Intact) (P<0.001). Allicin was found to be more effective at 25 mg/kg (P<0.0001).

Allicin showed neuroprotective effects in the brain and can affect the consequences of trauma, reduce cerebral edema, accelerate improvement of blood-brain barrier, and improve neurological scores and the function of vestibular system.

The effects of injuries in peripheral nervous system returns to the cell body of neurons in central nervous system in a retrograde manner which leads to brain and spinal degeneration. It is probable that Achillea biebersteinii might prevent the injury progress. Hence, the present study aimed to investigate the neuroprotective effect of alcholic extract of Achillea biebersteinii leaves on spinal α motoneurons degenarion after sciatic nerve compression in rats.

30 male wistar rats were divided randomly into groups of control, compression, compression with treatment of 50, 75, 100 mg/kg doses. Sciatic nerve was exposed to compression for 60 s using locker pincers. Extract injection was done intraperitoneally in the first and second weeks after compression. Then 28 days after compression under perfusion method, the lumber spinal cord was sampled. After cutting and coloring, the density of motoneurons was measured using dissector methods.

The study results demonstrated a meaningful difference between compression and control groups in regard with neuronal density (P=0.000). Neuronal density showed also a significant meaningful increase (P<0.01) in alcoholic extract treatment groups of 50,75,100 mg/kg compared to the compression group.

The study findings revealed that Alcohlic extracts of Achillea biebersteinii leaves, containing growth and regeneration factors, has neuroprotective effect on spinal cord alpha motoneurons after injury. The extract with 75mg/kg dose was reported as the most effective one.

The assessment of the ability of combined treatment of bone marrow stromal cells graft (BMSCs) and oral administration of Coenzyme (CoQ10) in rat model of Parkinson disease as a good substitute for common current Parkinson treatments and the comparison of this combined treatment method with alone application of these treatments

In this experimental study of male Wistar rats were used. They were divided into six groups: control sham lesion treatment groups with oral administration of CoQ10 treatment with graft BMSC and combined treatment with graft BMSC and oral administration of CoQ10. Oral administration of CoQ10 with 200 mg/kg/daily dose started a week before the model creation procedure and continued throughout the whole treatment period. The laboratory model of Parkinson disease in rats was performed by injecting 2.5 microlitre saline solution 0.9 % containing 8 micrograms 6-hydroxy dopamine (6-OHDA) and 0.2 % ascorbic acid in substantia nigra pars compacta. Also in sham group the same volume solution saline-ascorbic was injected. BMS Cells were labeled by 5-Bromo-2´-deoxyuridine (Brdu) before transplantation. Behavioral assessment before creating the model two weeks after creating the model and eight weeks after cell transplantation was performed. At the end of second month of treatment Immunohistochemistry and histology Studies were performed.

Behavioral assessment of two groups of alone treatments indicated the equal recovery in comparison with lesion group (p

We investigated the role of sex hormones on changes in brain edema intracranial pressure (ICP), cerebral perfusion pressure (CCP) after trauma brain injury (TBI) in ovarectomized female (OVX) rats.

In this study female rats are divided into five groups. Control group (Intact) sham group and other groups include: vehicle, estrogen group (1mg/kg) and progesterone group (8 mg/kg) which on all groups TBI was induced by Marmarou method. 30 minutes after TBI, drugs were injected i.p. ICP was measured in spinal cord using a standard procedure. CPP was calculated by the mean arterial pressure (MAP) - ICP. Neurologic scores were measured by motor, eye and respiratory reflex

The results showed after TBI, water content was significantly lower in estrogen and progesterone groups (P<0.001) compared with vehicle group. Analysis showed a stable ICP up to 24 hours. The ICP in estrogen and progesterone groups was significantly decreased at 4 and 24 hours as compared to vehicle group (P<0.001in both cases). The CPP at 24 hours after TBI, significantly increased in estrogen and progesterone groups compared with vehicle (P<0.001). Also after TBI, neurologic scores was significantly higher in estrogen and progesterone groups as compared with vehicle (at 1hours P<0.05, and at 24hours P<0.001 for estrogen), (at 1hours P<0.01 for progesterone).

Our findings indicated an improvement of ICP, CPP and neurologic scores produced by pharmacologic doses of estrogen and progesterone after TBI in OVX rat. These effects may be contribute to neuroprotective effects of these hormones