جستجوی مقالات مرتبط با کلیدواژه "هورمون جنسی" در نشریات گروه "پزشکی"

Agricultural pesticides including organophosphates cause various adverse effects on body tissues. This study was performed to evaluate the effect of malathion on sex hormones and its carcinogenic effects through skin contact in male mice.

Thirty adult male mice were divided into control and treatment groups. In the treatment group, 1 ppm malathion in 1 ml was poured on the skin for 12 weeks. At the end of the period, serum levels of testosterone, LH, and FSH were measured. Tissue samples were also taken from the target organs. Cytotoxicity was also assessed in vitro using MTT and micronucleus tests and IC50 was determined.

LH hormone did not significantly change by malathion but FSH and testosterone significantly decreased compared to the control group. A mild hepatotoxicity was observed in malathion-treated group. The frequency of micronuclei at concentrations of 25, 50, and100 µg / ml, and the MTT test at concentrations of 10-100 µg / ml showed significant difference compared to control group (p < 0.05).

Skin contact with malathion can have destructive effects on sex hormones and body tissues. Given the excessive use of this insecticide in Iran, it is necessary to pay more attention to how it is used and the amount of human contact with it to prevent possible dangers on body tissues.

Lead is one of the toxic and heavy metals that had different effects and side effects on biological systems of living creatures suchas humon, also, it causes various risks such as infertility. This study investigate antioxidant effect of cinnamon on elimination of lead poisoning in reproductive system in order to find a solutim for the problem of people in facing with lead.
The animals in this into 7 groups of 6 rats that includes one control group which received no remedy, control group 1 (solvent), control group 2 (0.6 g/l lead acetate daily), control group 3 (1.5 g/kg cinnamon extract daily), experimental group 1,2,3 that daily received 0.6 g/l lead acetate in addition to respectively received 0.1, 0.2 , 0.5 g/kg cinnamon extract for 14 days. Then, statistical data determineal significantly by ANOVA (one – way analysis of variance) through SPSS software , version 18.
The results shows that The concentration of the hormone estrogen decreased in control group 2 and increased in control group 3 signiticantly compared to control group in 5% level. The concentrate of hormone progesterone decreased in control group 2 and increased in control group 3 significantly compared to control group.
The results of this study indicates that cinnamon extract in a dose dependent manner and with antioxidant properties reduces the side effects of lead on sex hormones.

there is a great concern for the possible adverse effects of cell phones and noise waves and it looks these weaves effects on the individuals’ health. Thus, the present study was conducted to examine the effect of cell phone waves, severity noise, and simultaneous effect of cell phone waves and severity noise on sperm motility and sexual hormones in adult male rats. this experimental study was performed on twenty eight Wistar adult male rats (200-250 gr). The animals were randomly assigned to four groups (n=7): control group, two-week exposure to cell phone simulated waves group, exposure to noise group, and simultaneous exposure to cell phone simulated waves and sound group. The means of sperm motility in all groups were determined with criterions of WHO and sexual hormones concentration of blood plasma in all groups were determined by RIA. The results were analyzed by one-way ANOVA statistical technique followed by Tukey test using SPSS (version 16) software. sperm motility in the exposure to cell phone simulated waves and simultaneous exposure to cell phone simulated waves and noise groups decreased significantly compared to control group (P<0.05). The testosterone hormone concentration of blood plasma in all exposure groups decreased significantly compared to control group (P<0.05). exposure to cell phone waves and simultaneous exposure to cell phone simulated waves and sharp noise can cause a significant decrease in sperm motility and also, can cause a significant decrease the testosterone hormone concentration in adult male rats resulting in abnormality fertility.