جستجوی مقالات مرتبط با کلیدواژه « پروگرانولین » در نشریات گروه « پزشکی »

Progranulin (PGRN) has been recently introduced as a new indicator of chronic inflammatory response in type 2 diabetes. The present study aimed to investigate the effect of combined training on serum levels of progranulin, glycosylated hemoglobin (HbA1c), and insulin resistance in overweight and obese women with type 2 diabetes.

A total of 36 women were divided into three groups: control, combined exercise 1 (combined aerobic-resistance training), and combined exercise 2 (combined resistance-aerobic exercise training, including aerobic exercises with an intensity of 80% to 95% of maximum heart rate and resistance training with an intensity of 60% to 85% of one-repetition maximum). Anthropometric indices, muscle strength, aerobic capacity, variations of PGRN, HbA1c, and insulin resistance were also measured before and after training. To analyze the data, repeated measures analysis of variance (ANOVA) was used, and the level of statistical significance was set at <0.05.

The main and interaction effects of training on PGRN, HbA1c, insulin resistance, muscle strength, and aerobic capacity were significant over time (P=0.001). Despite improvements in PGRN, HbA1c, insulin resistance, lower-body muscle strength, and aerobic capacity in the training groups, no significant difference was observed between the combined training groups and the control group (P<0.05). However, the upper-body muscle strength significantly increased in both combined training groups, compared to the control group (P=0.001).

The use of combined exercise training in different orders for 12 weeks did not have any significant effects on the PGRN, HbAc1, insulin resistance, and functional factors.

Poly Cystic Ovary Syndrome (PCOS) is the most commonly encountered endocrine gland disease affecting 5-10 present of women at their reproductive age. This syndrome is associated with type 2 diabetes، dyslipidemia، and obesity. Progranulin and relaxin are adipokins that are related with carbohydrate and lipid metabolism. Due to limited data about progranulin and relaxin plasma levels´ in women with PCOS and normal BMI، this study was conducted. This study is a cross-sectional. During the study 39 women with PCOS and BMI< 25 on the basis of Rotterdam criteria were chosen as the patient group and 38 healthy women were selected as the control group. The concentration of progranulin and relaxin were measured by ELISA technique. The difference in Plasma concentration of progranulin and relaxin، and also some of the biochemical parameters in the patient group versus to the control group was not significant، but there was significant difference in the concentrations of VLDL، triglyceride (p=0. 046)، insulin (p=0. 016)، HOMA-IR (p=0. 015)، testosterone (p=0. 01)، and DHEAS (p=0. 034) in the patients group compared to the control group. In this study، the difference in Plasma concentration of progranulin and relaxin in the patient group compared to the control group was not significant. It could be inferred that lack of change in plasma level of progranulin and relaxin in women with PCOS is related to BMI<25 and FBS<110. Moreoverestosterones، insulin، DHEAS and HOMA-IR changes could be better predictors of PCOS and its associated diabetes.