جستجوی مقالات مرتبط با کلیدواژه « burn » در نشریات گروه « پزشکی »

 Burns are wounds caused by thermal, chemical, electrical, or radiation injuries. They are complex wounds that are difficult to heal and are associated with thousands of deaths each year. Cinnamic acid (CA) is a natural organic compound found in plants, fruits, vegetables, and honey. CA possesses antimicrobial, anti-inflammatory, antioxidant, and wound healing properties.

 The aim of this study was to compare the healing effects of CA with silver sulfadiazine (SSD), a standard topical agent for burn treatment, on deep second-degree burns.

 This experimental study compared the healing effects of CA and SSD on second-degree burns. Fifteen New Zealand white rabbits weighing 2 to 2.3 kg were divided into 5 equal groups. Deep second-degree burn wounds were created on the backs of the rabbits by contacting a heated circular metal plate. The first group was treated with SSD 1% cream, the second, third, and fourth groups were treated with prepared ointments containing 0.1%, 0.5%, and 1% w/w of CA in Eucerin, respectively. The fifth group was treated with Eucerin alone. Wound healing effects were assessed by measuring the rate of wound contraction and the amount of collagen in tissue specimens obtained from different groups. Additionally, histopathological studies were performed on tissue samples.

 The results showed that CA was significantly more effective than SSD in burn wound healing. Cinnamic acid ointments significantly increased the rate of wound contraction (P < 0.05) and tissue collagen content (P < 0.001) compared to SSD and Eucerin.

 Our findings suggest that topical CA possesses burn wound healing properties and could be used as an effective topical agent for the treatment of burns.

Nowadays, herbal medicine with antimicrobial and anti-inflammatory activities, such as Arnebia euchroma, has been considered in the treatment of burn wounds. Therefore, this study aimed to determine the healing effect of Arnebia euchroma L on burn wounds in rats by reviewing the results of published studies in this field.

The keywords "Arnebia euchroma", "burn", and "rat", and their synonyms were explored in PubMed, Scopus, and ScienceDirect for English articles, and SID, Magiran, and Irandoc for Persian articles without time limitation until May 4, 2021. Inclusion criteria for this study were laboratory research articles focused on the effect of Arnebia euchroma L on wound healing in rats. Finally, the included studies were reviewed and assessed according to the given criteria.

Amongst the seven articles included in this research, four articles studied the healing effect of the medicine on second-degree burn wounds, one article addressed third-degree burn wounds, and two articles generally studied burn wounds. Arnebia euchroma L has been found to be effective in healing burn wounds in approximately 57% of studies, while the rest of the studies have emphasized its ineffectiveness in accelerating burn wound healing.  

The literature review demonstrated that Arnebia euchroma is effective in both healing and accelerating the recovery of burn wounds. Since there is an insignificant difference between the number of studies that have found this medicine effective and the number of those that have found it ineffective, further studies are required to determine the effectiveness of this medicine.

This study investigated the demographic characteristics and factors influencing burn injuries,primarily in low socioeconomic societies where such incidents are prevalent due to factors such as illiteracyand poverty. This cross-sectional study included all burn patients admitted to Shahid Motahari Hospital inTehran, Iran. Demographic data such as age, sex, occupation, education level, and residence as well as detailedinformation about the burn incidents such as date, time, location, number of people present at the scene, andreferral place was collected. Additionally, comprehensive burn details such as cause, extent, severity, previoushistory, and need for hospitalization directly at the emergency department were documented. The study included 2213 patients (mean age 34.98±19.41 years; range 1-96), with a men predominance(60.6%). The majority of burns (64.4%) occurred at home, primarily due to accidents (99.6%), with boilingwater being the most common cause (39.2%). The most frequent burns were second-degree burns (91.8%),with an average injured body area of 6.31±6.67%. There were significant correlations between burn severityand demographic factors such as age, sex, occupation, cause of burn, hospital admission, outcome, and lengthof stay. Remarkably, the extent of burns was negatively correlated with the distance to the hospital, whilepositively correlated with the length of hospital stay. Burn injuries were significantly influenced by demographic factors. Enhancing treatment facilitiesand reducing the time and distance to medical care could be crucial in high-risk cases.

 According to recent statistics, the rate of burns in Iran is higher than the world’s average. Therefore, it is necessary to improve the treatment protocols as much as possible.

 This study investigated the level of mineral intake (iron, zinc, selenium) and thyroid hormones (TSH, T3, T4) serum levels among burn patients.

 This cross-sectional study was conducted on 24 patients admitted to the intensive care unit (ICU) of Taleghani Hospital, Ahvaz, Iran. The Kolmogorov-Smirnov test was used to check the normality of the distribution of quantitative variables. Blood samples were taken on the first, third, and fifth days of hospitalization. Serum levels of zinc, selenium, iron, T3, T4, and TSH were measured. The correlation of qualitative variables was examined using the chi-square test, and the correlation of quantitative variables was examined using Spearman's correlation analysis. The t-test was used to compare the means in two different groups with the standard value. The generalized estimating equation (GEE) test was used to investigate the effect of time and compare the two groups. Statistical analysis of the data was performed in SPSS v. 22.

 The levels of iron, zinc, selenium, and thyroid hormones changed during the examined days, but these changes were not statistically significant. The amount of the analyzed elements in some cases was lower than their standard serum average, but this difference was significant only for selenium. Besides, there was no significant relationship between iron, zinc, T3, TSH, and the length of stay at the ICU; this relationship was positive and significant only for T4.

 Burn patients in the ICU have insufficient intake of minerals. Changes occur in the serum levels of micronutrients in these patients, affecting their physiological conditions and reducing the speed of recovery.

  The hypermetabolic response has undoubtedly evolved to help survive burns, but this physiological response has inconsistent consequences and increases the clinical consequences, such as increased heart work and ultimately its decline, decreased immune system function, risk of  sepsis, increased long-term  hospitalization, which increases the mortality of patients. This study aims to examine the effect of propranolol on post-traumatic stress disorder and clinical outcomes in burn patients. 

  This was an open-labeled randomized clinical trial in a single center with two parallel groups without placebo control. Propranolol was given 48 hours after starting of resuscitation. 

  In this study, the burn wound of the patients who used propranolol healed faster. In addition, the administration of propranolol reduced the size of the burning surface, the size of the tissue required skin graft, the rejection rate of skin grafts, and also the length of stay in the hospital. 

  Using propranolol in treating burns can play an influential role in the recovery of burn patients,  and reduce the post-traumatic stress disorder.

Treating burn scar contractures remains challenging for reconstructive surgeons; no clear guidelines declare the optimal and most effective technique. We evaluated the efficacy of local flaps in treating patients with post-burn contractures.

This retrospective study included 243 patients with post-burn contractures referred to Taleghani Hospital (Khuzestan, southwest Iran) for local flap reconstruction from 2011 to 2020. Patients' demographic data, detailed descriptions of scars, surgical procedures, and flap outcomes were assessed. A plastic surgeon conducted all surgical procedures, the goals of which were to release the scar and cover the defect. Joint range of motion (ROM) (according to goniometric measurements), complications, need for second-stage surgery, and patient satisfaction were assessed.

After scar release, 70.4% of joints were covered with a Z-plasty and similar local flaps, 26.1% with a Z-plasty plus skin grafts, and 3.5% with only skin grafts. The outcome after one year revealed a significant improvement in mean ROM (by 45.80% of the normal ROM; P< 0.001). The mean functional and aesthetic satisfaction scores were 9.45 and 7.61 out of 10, respectively. The complication rate was 10.82%: re-contracture occurred in 3.82%, flap tip necrosis in 1.27%, and partial flap necrosis in 0.31%.

Simple local flaps such as the Z-plasty are safe and effective in covering the joint following post-burn contracture release. Due to the feasibility, minimal need for facilities, steep learning curve, acceptable functional and aesthetic outcomes, and low complication rate, we strongly recommend the Z-plasty for reconstructing burn contractures, particularly in LMICs.

Pain is a common and challenging problem in burn patients. The severity of pain in these patients often requires multi drug therapy. On the other hand, with increasing the number and dosage of drugs, the complications increase, so finding an instruction that provides acceptable analgesia with minimal complications is necessary.

Based on the dose and half-life, the initial dose for paracetamol was 15 mg/kg every 6 hours, this dose was reduced to 30% after three days of initiation of the treatment to prevent liver toxicity and was discontinued after one week. Morphine started with an initial dose of 0.01 mg/kg/h and for opioid-tolerant patients, the initial dose was 0.02 mg/kg/h. Morphine infusion dose raised by 30 percent every week. The continuous intravenous infusion of ketamine (0.15 mg/kg/hr) with continuous intravenous infusion of morphine was administered by a silicone pump.

The mean NRS was significantly reduced in the first visit after the intervention (three hours later) (8.5 ± 1.04 vs.3.9 ± 1.74; p <0.001) and this decrease was observed in NRS in continuous observations (P> 0.001). Pain reduction was independent of history of opioids use.

Continuous infusion of ketamine, morphine and paracetamol showed an effective pain management program for burn patients.

According to the reports of the World Health Organization approximately 300,000 deaths occuryearly worldwide due to burns or burn-associated injuries. This study aims to review the epidemiology of burnsin pediatrics and adolescents in Fars province between 2017 and 2018.

This is a cross-sectional study that investigated all people ≤18 years old who suffered from burninjuries in Fars province between 2017 and 2018. We use data from the file of burn patients which was providedby pre-hospital emergency services of Fars province. This data comprises demographic information (age andgender), burn-related information (type, degree, and severity of burns), mode of transfer (outpatient surgery ortransfer to hospital) and the outcome of the disease (death before arrival to the hospital or alive).

The average age of the subjects of this study was 5.8±8.9. We also categorized the subjects into fourage groups, 1-4, 5-8, 9-13 and 15-18 years. The number of boys who suffered from burn injuries is significantlymore than the girls (p=0.011). Also, there is a remarkable correlation between burn with age (p<0.001) andburn with disease outcome (p=0.01). The Most common cause of burns in boys was nonchemical hot objectsand liquids (28.5%). Likewise, the possibility of mortality in burn patients who faced an electric shock was22.66%. ([95%CI=2.32-220.63], p<0.001 OR=22.66).

This study shows that pediatrics and adolescents ≤ 4 have the most burn injuries, and boys havetwice as many burn events as girls. More importantly, the most common cause of burns in both genders wasburning with non-chemical hot objects and liquids, in particular, in the age group of 1-4 years, in which eventhappens at home.

To study the anti-inflammatory and antioxidant effects of flaxseed oil and olive oil on inflammatorymarkers for facilitating wound healing. One hundred and twelve patients were randomly selected to four groups with a total burn surfacearea (TBSA) of 20-50%. The four groups includes olive oil (OO), flaxseed oil (FO), mixture of olive oil andflaxseed oil (OF), and control group and received 30g of oils for three weeks. Serum high-sensitivity C-reactiveprotein (hs-CRP), ferritin and albumin level as inflammatory markers, as well as cholesterol, triglyceride,high-density lipoprotein (HDL) and low-density lipoprotein (LDL) as the lipid profile were explored. Woundhealing was assessed by photographing on days 2, 8, 15, and 22 (during three weeks of intervention) and wereanalyzed in imageJ software. The greatest reduction in the level of hs-CRP and ferritin was observed in the OF (-21.38±44.41)(-132.79±165.36), while the lowest reduction was reported in the control group (-36.36±79.03) (141.08±262.36).Compared to control group, OO significantly increased albumin (0.88±0.65). Reduction of wound healing at theend of the first week of intervention was not significant in the study groups. However, the stereology examinationshowed significant improvement in wound healing at the end of the second and third weeks in the OF. Based on the findings, combination of herbal oils reduce inflammation and improve wound healingand showed positive effects on the size of wounds in burn patients.

The incidence and mortality rates of burns have decreased dramatically with the advancement of medical technology; however, it is still challenging.

This study aimed to investigate the status of preoperative anxiety and postoperative pain in pediatric burn patients and analyze the correlation between preoperative anxiety and postoperative pain.

This cross-sectional study was conducted on pediatric burn patients who underwent burn surgery under general anesthesia in Qinghai Provincial People's Hospital, Xining, China, from October 2020 to August 2021. For the evaluation of postoperative pain, the patients were tested at the post-anesthesia care unit, 2 h, 24 h, 48 h, and 72 h after surgery, and burn time before operation, burn location, burn area, and burn depth were assessed. Face, Legs, Activity, Cry, Consolability Behavioral Tool, and Facial Expression Pain Scale were used to evaluate the pain of the children, and State-Trait Anxiety Inventory and Yale Preoperative Anxiety Scale were used to evaluate the anxiety of the children. The correlation was used to analyze the effect of preoperative anxiety on postoperative pain in burned children.

In total, 108 pediatric patients were included in this study. Preoperative anxiety and severe anxiety accounted for more than 50% of burned children. Moreover, there was a statistically significant difference between 1-3-year-old and 4-12-year-old children in terms of preoperative anxiety and postoperative pain. Parental trait anxiety, showed that each influencing factor has a significant influence on postoperative pain in children (P<0.05). Based on the analysis of the correlation between preoperative anxiety and postoperative pain in children with burns, preoperative anxiety in children aged 1-3 years had a significant impact on postoperative pain in children. Moreover, the correlation analysis showed that there was a positive correlation between anxiety score and postoperative pain in children with burns (r=0.479, P=0.001).

Incidence rate of preoperative anxiety in pediatric burn patients is high. Besides, the postoperative pain scores are different in various age groups. In addition, there is a positive correlation between preoperative anxiety and postoperative pain in pediatric burn patients; accordingly, the higher the anxiety score of the patient, the more intense their postoperative pain.

Curcumin (diferuloylmethane) is one of the mostactive components of turmeric. This herbal compound has antiinflammatoryand positive wound-healing impacts. The principalobjective of this study was to evaluate the impacts of curcuminnanoliposomes on cell viability and motility of mouse fibroblastNIH 3T3 cells and its wound healing effects on second-degreeskin burns in BALB/c mice. Mature male BALB/c mice (n = 48) were dividedinto 4 groups (n = 12 per group). Group one received curcuminnanoliposome ointment; the positive and negative control groups(groups 2&3) were treated with silver sulfadiazine and placebo,respectively, and group four (sham) received no treatment. Theburn wound was created by a metal device with a diameter of 1cm. Animals received treatment twice daily. On days 4, 7, 10, and14, deep anesthesia and a biopsy of the wound were performed,and a microscopic study and MTT assay were carried out. Cellular studies on mouse fibroblast NIH-3T3 cellsshowed that low-dose curcumin nanoliposomes increased cellproliferation and motility at 8, 12, and 24 hours in comparisonwith the control group. In tissue samples of mice treated withcurcumin nanoliposome (day 14), less inflammation was observed,while granulation tissue formation, fibroblast proliferation,epithelialization, and collagen fiber synthesis increased significantlycompared with the control groups. Our study indicates the positive effects of curcuminnanoliposomes on the motility process of mouse fibroblast NIH-3T3 cells (in vitro) and on the inflammatory and proliferativephases (in vivo) of burn wound healing in mice.

Studies have shown that burn wounds are one of the most severe forms of trauma which may cause disability, morbidity and mortality, stupendous hospital costs, and emotional disturbance. In spite of the therapeutic effects of synthetic drugs, due to their unwanted side effects, the tendency of people to use these drugs has been decreasing, contrary to the use of natural origin drugs. Medicinal plants that can be formulated to treat and repair the wound should be identified. Therefore, in this article a number of native Iranian medicinal plants that have been studied and their healing effects on burn wounds have been reported are discussed. In this review article, the keywords medicinal plants, burn, burn wound repair, burn wound and Iran were used to search for relevant articles indexed in databases such as IranMedex, Scientific Information Database, Google Scholar, Scopus, Institute for Scientific Information,  Web of Science and PubMed. Based on the results, the medicinal plants Aloe vera (L.) Burm.f., Matricaria chamomilla L, Quercus brantii Lindl., Cydonia oblonga Mill., Scrophularia striata, Camellia sinensis (L.) Kuntze, Portulaca oleracea L, Cinnamomum zeylanicum Blume, Achillea talagonica Boiss., Olea europaea L., Hypericum perforatum L., Cucurbita pepo L., Teucrium polium L., Myrtus communis, Brassica oleracea L., Plantago major L., Malva sylvestris L., Arnebia euchroma (Royle) I.M.Johnst., Cucurbita moschata Duchesne, Achillea millefolium L., Lythrum salicaria L., Crocus sativus L. and Allium sativum L.  are some of the most important herbal remedies to repair burn wounds. According to the various researches on the medicinal plants, the anti-inflammatory, antimicrobial and antimicrobial effects of these plants have been scientifically demonstrated, which has led to information that can be used to produce antimicrobial drugs for infectious and burn wounds.

This study was aimed to evaluate the prognosis of patients with severe burns by measuring the plasma base excess and serum lactate levels and comparing it with the ABSI scoring system as an important indicator in the resuscitation of burn patients. This prospective cohort study was performed on all patients hospitalized in the burn ward of the hospital. The demographic data and ABSI scoring of all patients were recorded. Patients' clinical information and routine tests, gasometry (for measuring plasma base excess) and serum lactate levels were measured at the time of admission, 12 hours, and 24 hours after admission. A total of 311 burning patients were evaluated in this study. Mann-Whitney test showed a significant difference in the mean plasma BE1 (at the time of admission) and BE2 (24 hours after admission) between the patients who were discharged and the patients who died (P <0.001). The results indicated a difference in the process of lactate changes between two groups of patients in terms of intensity of ABSI(P <0.001). The multivariate logistic regression with the entry of BE and lactate at the time of admission and ABSI as predictive variables indicated a significant BE and ABSI. The results of this study confirmed that the plasma base excess can be used as a valuable tool in the monitoring of burn patients' resuscitation along with clinical criteria. On the other hand, the ABSI scoring system is still a valuable tool to predict the deaths of burn patients.

Burns are among the major health challenges of all societies and more than any other trauma incur physical, mental, social, and economic burdens on the patient and society. This study was conducted to assess whether Recove® burn ointment is capable of alleviating the pain, preventing the formation of new blisters and controlling the microbial contamination of the wound.

We, therefore, compared its efficacy to ​​nitrofurazone 0.2% cream. This randomized clinical trial was conducted on individuals who had two burn injuries in their body at the same time in the Motahari Burn Hospital, Tehran Province, from June to October 2016. Sampling was carried out with a non-random method using available samples. The intervention in experimental and control groups was Recove® and nitrofurazone, respectively. The effect of interventions on pain relief, the formation of new blisters and prevention of infection at the burn wound were evaluated. In our double-blind study, blindness was applied to the patients and the person evaluating the outcomes.

Both Recove® and nitrofurazone interventions significantly alleviated pain (P < 0.01), but Recove ®showed more effectiveness (P=0.01). Similarly, in terms of new blister formation, the experimental group receiving Recove® showed less new blister formation over 24 hours after treatment compared to nitrofurazone group (P=0.03) and with respect to antimicrobial activity, there was no significant difference between Recove® and nitrofurazone (P=0.12).  

Recove® was effective on pain reduction, prevention of new blisters formation as well as infection. Therefore, it seems that Recove® could be considered as a new and efficient treatment for burn.