جستجوی مقالات مرتبط با کلیدواژه "cost reduction" در نشریات گروه "پزشکی"
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Background
Hospital strategies aimed at increasing quality of care and simultaneously reducing costs show potential to improve healthcare, but knowledge on real-world effectiveness is limited. In 2014, two Dutch hospitals introduced such quality-driven strategies. Our aim was to evaluate contexts, mechanisms, and outcomes of both strategies using multiple perspectives.
MethodsWe conducted a mixed methods evaluation. Four streams of data were collected and analysed: (1) semistructured interviewing of 62 stakeholders, such as medical doctors, nurses, managers, general practitioners (GPs), and consultants; (2) financial statements of both organisations and other hospitals in the Netherlands (counterfactual); (3) national database of quality indicators, and patient-reported experiences; and (4) existing material on strategy development and effects.
ResultsBoth strategies resulted in a relative decrease in volume of care within the hospital, while quality of care has not been affected negatively. One hospital failed to cut operating costs sufficiently, resulting in declining profit margins. We identified six main mechanisms that impacted these outcomes: (1) Quality-improvement projects spur change and commitment; (2) increased coordination between hospital and primary care leads to substitution of care; (3) insufficient use of data and support hinder quality improvement; (4) scaling down hospital facilities is required to convert volume reductions to cost savings; (5) shared savings through global budgets lead to shared efforts between payer and hospital; and (6) financial security for physicians facilitates shift towards quality-driven care.
ConclusionThis integrated analysis of mixed data sources demonstrated that the institution-wide nature of the strategies has induced a shift from a focus on production towards quality of care. Longer-term (financial) sustainability of hospital strategies aimed at decelerating production growth requires significant efforts in reducing fixed costs. This strategy poses financial risks for the hospital if operating costs are insufficiently reduced or if payer alignment is compromised. Keywords: Hospital Strategy, Quality Improvement, Cost Reduction, Implementation, The Netherlands Copyright: © 2023 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/ by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Hospital Strategy, Quality Improvement, Cost Reduction, Implementation, The Netherlands -
هدف
امروزه درمان با سلول های CAR-T، به عنوان درمانی موثر برای بدخیمی های خونی پذیرفته شده است. سلول های CAR-T، سلول های T اتولوگ هستند که با تکنیک های انتقال ژن به منظور بیان یک گیرنده آنتی ژن کایمری (CAR) مهندسی می شوند. علی رغم نتایج امیدوارکننده و تایید شش فرآورده سلولی CAR-T، هنوز این محصولات برای تومورهای جامد تایید نشده اند. علاوه بر این، هزینه بالای درمان با سلول های CAR-T، دسترسی بیماران به این داروهای نجات بخش را محدود کرده است. بنابراین، بایستی ملاحظات کلیدی در طراحی و توسعه سلول های CAR-T تعریف شده و روش های کاهش هزینه این روش درمانی مورد بررسی قرار گیرد.
مواد و روش هااین مطالعه بر اساس جست وجوی دقیق در پایگاه های مطالعاتی مثل Pubmed، Scopus،Web of Science و موتور جست وجوگر Google Scholar و نیز وب سایت شرکت های دارویی انجام شده است.
یافته هاگیرنده های سنتزی CAR حاوی قلمروی خارج سلولی شناسایی کننده آنتی ژن هستند که به نواحی فضاساز، تراغشایی و ناحیه پیام رسان داخل سلولی متصل می شود. هر قسمت از ساختار CAR روی بعضی عملکردهای CAR از جمله شناسایی هدف، فعال شدن و لیز سلولی اثر می گذارد. تاکنون پنج نسل سلول های CAR-T توسعه داده شده تا ظرفیت پیام رسانی این سلول ها بهبود یابد. علاوه بر این، سیستم های انتقال ژن مثل الکتروپوریشن، ترنسپوزون و سیستم های ویرایش ژنوم، به عنوان جایگزین ناقل های ویروسی جهت تولید سلول های CAR-T ایمن و مقرون به صرفه معرفی شده است. هم چنین توسعه ی محصولات به صورت آماده مصرف، تولید محصول در مکان هایی دورتر از محل مصرف، پلتفرم ها و روش های قیمت گذاری جدید و ابتکارات سیستم بیمه سلامت به عنوان راه کارهای کاهش قیمت پیشنهاد شده است.
نتیجه گیریدر این مقاله، به مرور چگونگی توسعه سلول های CAR-T، عوامل مهم در طراحی گیرنده کایمری، روش های مختلف انتقال ژن و راه حل هایی جهت کاهش هزینه این روش درمانی پرداخته شد. با به کارگیری این استراتژی ها می توان از پتانسیل سلول های CAR-T در ایمنی درمانی سرطان به صورت کامل بهره برد.
کلید واژگان: گیرنده کایمری آنتی ژن, ایمنی درمانی سرطان, طراحی CAR, تکنیک های انتقال ژن, کاهش هزینهKoomesh, Volume:25 Issue: 1, 2023, PP 1 -15IntroductionToday, treatment with CAR-T cells is accepted as an effective treatment for blood malignancies. CAR-T cells are autologous T cells that are engineered by gene transfer techniques to express a chimeric antigen receptor (CAR). Despite the promising results and the approval of six CAR-T cell products; these products have not yet been approved for solid tumors. In addition, the high cost of treatment with CAR-T cells has limited patients' access to these life-saving drugs. Therefore, key considerations in the design and development of CAR-T cells should be defined and methods of reducing the cost of this treatment method should be investigated.
Materials and MethodsThis study was performed based on an accurate bibliography through research databases such as PubMed, Scopus, Web of Science, and Google Scholar search engine, as well as the websites of pharmaceutical companies.
ResultsCAR synthetic receptors contain an antigen-recognizing extracellular region that connects to the space-forming, transmembrane and intracellular messenger regions. Each part of the CAR structure affects some functions of CAR, including target recognition, activation and cell lysis. So far, five generations of CAR-T cells have been developed to improve the messaging capacity of these cells. In addition, gene transfer systems such as electroporation, transposon and genome editing systems have been introduced as an alternative to viral vectors to produce safe and affordable CAR-T cells. Also, the development of ready-to-use products, product production in places far from the place of consumption, new pricing platforms and methods, and health insurance system initiatives have been suggested as ways to reduce prices.
ConclusionIn this article, an overview of how to develop CAR-T cells, important factors in the design of chimeric receptors, different methods of gene transfer and solutions to reduce the cost of this treatment were discussed. By using these strategies, the potential of CAR-T cells in cancer immunotherapy can be fully utilized.
Keywords: Chimeric antigen receptor, Cancer Immunotherapy, CAR design, Gene Transfer techniques, Cost reduction -
Background
A lack of knowledge exists on real world hospital strategies that seek to improve quality, while reducing or containing costs. The aim of this study is to identify hospitals that have implemented such strategies and determine factors influencing the implementation.
MethodsWe searched PubMed, EMBASE, Web of Science, Cochrane Library and EconLit for case studies on hospitalwide strategies aiming to increase quality and reduce costs. Additionally, grey literature databases, Google and selected websites were searched. We used inductive coding to identify factors relating to implementation of the strategies.
ResultsThe literature search identified 4198 papers, of which our included 17 papers describe 19 case studies from five countries, mostly from the United States. To accomplish their goals, hospitals use different management strategies, such as continuous quality improvement (CQI), clinical pathways, Lean, Six Sigma and value-based healthcare (VBHC). Reported effects on both quality and costs are predominantly positive. Factors identified to be relevant for implementation were categorized in eleven themes: (1) strategy, (2) leadership, (3) engagement, (4) reorganization, (5) finances, (6) data and information technology (IT), (7) projects, (8) support, (9) skill development, (10) culture, and (11) communication. Recurring barriers for implementation are a lack of physician engagement, insufficient financial support, and poor data collection.
ConclusionHospital strategies that explicitly aim to provide high quality care at low costs may be a promising option to bend the cost curve while improving quality. We found a limited amount of studies, and varying contexts across case studies. This underlines the importance of integrated evaluation research. When implementing a quality enhancing, cost reducing strategy, we recommend considering eleven conditions for successful implementation that we were able to derive from the literature.
Keywords: Scoping Review, Hospital Strategy, Quality Improvement, Cost Reduction, Implementation -
Journal of Pediatric Perspectives, Volume:8 Issue: 83, Nov 2020, PP 12503 -12515Background
Health transformation planwas implemented in 2014 in Iran with the aim of reducing healthcare expenditures. Transformation plans always have a financial impact on healthcare expenditures because of potential to increase the utilization. Drug utilization review is one of the effective solutions to explore consumption and improve rational use. This study aimed to evaluate the medicine utilization after health transformation with implementation of an evidence-based protocol in a tertiary hospital.
Materials and MethodsThis is a before-after study which was conducted in a tertiary children’s hospital with 400 beds in Iran. At first, costly medications were identified by ABC analysis in drug and therapeutic committee meetings of the hospital. Increased use of these medications was measured after the implementation of the health transformation plan. Then, the pattern of prescription, its appropriateness and impact of protocol implementation on the health expenditures reduction and rational use was evaluated.
ResultsInitial estimation of the usage showed that before protocol implementation, in six-month, albumin, pantoprazole, and Apotel® increased by 31.9%, 22.6%, and 21.9%, respectively following the health transformation plan. Medical records of 6,554 patients were evaluated for target medications. The frequency of inappropriate prescription reduced significantly from the first to the second phase for albumin (65.5%-35.8%, P=0.001), pantoprazole (58.9%-22%, p <0.001), and Apotel® (66%-17%, p <0.001), respectively. Health expenditures also reduced significantly for albumin (P=0.003), pantoprazole (P=0.001) and acetaminophen (p <0.001), respectively.
Conclusion:
Timely implementation of medication prescription protocols can provide health benefits to patients and cost savings to the health service provider that could lead the health transformation plan to reach the aim of reduction in health expenditures with rational use.
Keywords: Cost reduction, Drug Utilization Review, Health Care Reform, protocol implementation -
مقدمه
هدف مقاله حاضر، بررسی تعیین تاثیر مدیریت فرآیند شش سیگما بر بهبود کیفیت خدمات اطلاع درمانی و کاهش هزینه های درمانی است.
روش پژوهشروش شناسی پژوهش حاضر که به لحاظ هدف در زمره مطالعات کاربردی است، پیمایشی توصیفی از نوع همبستگی بوده است. جامعه آماری این پژوهش را کلیه مدیران، سرپرستان و کارشناسان بیمارستان فرهیختگان تشکیل می دهد که تعداد آن ها 125 نفر است. برای تعیین حجم نمونه از فرمول کوکران استفاده شده است که با توجه به جامعه آماری، 94 نفر می باشد. روش انتخاب نمونه های آماری هم با توجه به موضوع و ماهیت پژوهش، نمونه گیری تصادفی ساده است. جمع آوری داده های مورد نیاز نیز با استفاده از ابزار پرسشنامه استاندارد و تجزیه و تحلیل داده ها با استفاده تحلیل رگرسیون از طریق نرم افزار spss 23 صورت گرفته است.
یافته هامدیریت فرآیند شش سیگما از طریق متغیر میانجی کیفیت خدمات اطلاع درمانی بر کاهش هزینه ها تاثیر دارد. بنابراین نقش میانجی کیفیت خدمات اطلاع درمانی تایید می شود.
نتیجه گیریشش سیگما یک رویکرد سیستماتیک برای بهبود فرایندهای کاری بر پایه نیاز مشتری و تجزیه و تحلیل واقعی فرایندهای در حال انجام در هر موسسه ارایه می کند. این موضوع تفاوت شش سیگما با سایر روش ها و دلیل اصلی به کارگیری در موسسات مراقبت بهداشتی است. صرف نظر از این تفاوت ها، پیاده سازی هر رویکردی به بسترسازی و پذیرش فرهنگ کیفیت در آن سازمان نیاز دارد. همچنین، بهبود کیفیت فرایندی مستمر است که با همکاری و تعامل گروه های کاری و استفاده از ابزارها و متدولوژی مناسب برای حل مشکل خاص انجام می شود
کلید واژگان: فرآیند شش سیگما, کیفیت خدمات, اطلاع درمانی, بیمارستان, کاهش هزینه هایIntroductionThe aim of this paper is to investigate the effect of Six Sigma process management on improving the quality of health information services and reducing treatment costs. Research
MethodologyThe methodology of the present study, which is among the applied studies in terms of purpose, has been a descriptive survey of the type of correlation. The statistical population of this study consists of all managers, supervisors and experts of Farhikhtegan Hospital, which is 125 people. The Cochran's formula has been used to determine the sample size, which is 94 people according to the statistical population. The method of selecting statistical samples is also a simple random sampling according to the subject and nature of the research. The required data were collected using standard questionnaire tools and data analysis using regression analysis through SPSS 23 software.
ResultsThe management of the six Sigma process through the mediating variable of the quality of health information services has an impact on cost reduction. Therefore, the mediating role of quality of health information services is confirmed.
ConclusionSix Sigma provides a systematic approach to improving business processes based on customer needs and real-time analysis of ongoing processes in each institution. This is the difference between Six Sigma and other methods and the main reason for using it in health care institutions. Regardless of these differences, the implementation of any approach requires the establishment and acceptance of a culture of quality in that organization.
Keywords: Six Sigma process, Quality of Services, information therapy, Hospital, cost reduction -
Healthcare is expensive and often inaccessible to many. As a result, surgeons must consider simple, less expensiveinterventions when possible. For wound care, an older but quite effective cleaning agent is Dakin’s solution (0.5%sodium hypochlorite), an easily made mixture of 100 milliliters (ml) bleach with 8 teaspoons (tsp) baking soda into agallon of clean water or 25 ml bleach and 2 tsp baking soda into a liter of water. Gauze is then wet with this solution,placed on the wound, and replaced every 24 hours as needed. Our team of surgeons in Haiti and the United Statesis currently using Dakin’s solution for wound care following orthopedic surgery and finds it to be a low-cost, safe, andeffective treatment for post-surgical wound care for both resource-limited and non-resource strained environments.This report aims to update the current literature and encourage the consideration of Dakin’s solution for modernwound care.Level of evidence: IIIKeywords: Cost-reduction, Dakin’s Solution, Haiti, Low-resource Settings, Wound Care
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Background
This paper investigated the impact of hospitals´ horizontal integration in the Czech Republic on the cost behavior. The aim of the research was to examined the hospitals costs in specific environment of region hospitals at NUTS 3 level (Nomenclature of Units for Territorial Statistics) – Administrative Regions.
MethodsThe survey was conducted in the period from April to August 2016 in the Czech Republic. The research was divided into two parts. The first part was based on data obtained from the Institute of Health Information and Statistics of the Czech Republic. We used Statgraphics Centurion XVII for the descriptive statistics and data visualization. Second part of the results was obtained through a survey research focused on managers of the horizontal integrated hospitals and their experiences with the cost behavior.
ResultsThe results from statistical survey showed that up to 80 percent of the observed region hospitals at NUTS 3 level, the cost of treatment for a patient per day has decreased after integration into an association. Based on primary survey, 73% hospital managers confirm these results and see one of the advantages that it is possible to reduce costs through integration of hospitals. The largest savings, according to hospital managers, are due to central purchasing and investments, together and they have a better negotiation position with suppliers.
ConclusionWe can confirm that horizontal integration of hospitals can lead to reduction of costs and higher efficiency, in the specific environment of region hospitals at NUTS 3 level.
Keywords: Hospitals, Costs, Horizontal integration, Effectiveness, Cost reduction -
زمینه و هدفامروزه یکی از سازمان هایی که بسیار زیاد در جهت اجرای برنامه استاندارد مدیریت کیفیت ایزو 2008-9001 اقدام نموده اند، آزمایشگاه های تشخیص طبی هستند. یکی از اهداف اغلب آزمایشگاه ها در اجرای این استاندارد کاهش هزینه های جاری از جمله تکرار آزمایش است.روش بررسیتعداد آزمایش های تکراری در دو بخش بیوشیمی (گلوکز، اوره، کراتینین، کلسترول، تریگلیسیرید، AST و ALT) و هورمون (T3،T4،TSH) در سه مرحله (قبل از اجرای برنامه استاندارد سازی، سه و نه ماه پس از اجرای برنامه) مورد ارزیابی قرار گرفت. برای تجزیه و تحلیل داده ها از نرم افزار stat data نسخه 8 و آزمون Pearson chi square استفاده شد.یافته هادرصد موارد تکراری برای آزمایش های گلوکز، اوره، کراتینین، کلسترول، تریگلیسیرید، AST، ALT، T3، T4، TSH در نوبت اول به ترتیب 5/16، 57/2، 88/2، 7/12، 9/14، 38/10، 6/12، 55/3، 69/4، 85/1 در نوبت دوم 5/20، 56/5، 41/5، 25/7، 0/20، 2/27، 1/30، 3/0، 04/6، 08/3 و در نوبت سوم 8/19، 3/8، 2/9، 1/7، 8/12، 4/17، 5/19، 0/0، 81/5و 01/1 بدست آمد. بر اساس آزمون آماری تغییرات در آزمایش های اوره، کراتینین، کلسترول، AST،ALT و TSH معنی دار بود. روند درصد تکرار آزمایش های اوره و کراتینین افزایشی و TSH کاهشی بود.نتیجه گیریبا توجه به ماهیت آزمایش ها و اصول حاکم بر تکرار یک آزمایش، پذیرش و اجرای فرآیند ایزو 2008-9001 تنها به منظور کاهش هزینه از طریق کاهش درصد تکرار آزمایش ها توجیه پذیر نمی باشد. در اجرای این فرآیند باید تمام جوانب اثر بخشی بصورت یکجا مورد توجه قرار گیرد.
کلید واژگان: ایزو 2008, 9001, آزمایشگاه تشخیص طبی, اثر بخشی, کاهش هزینهBackground And ObjectiveOne of the organizations that have proceeded for very high standard quality management programs, ISO 9001-2008, is medical diagnostic laboratories. One of the important goals of most laboratories in the implementation of this standard is to reduce the current costs of repeated tests.Material And MethodsThe number of repeated tests was evaluated in biochemistry section (Glucose, Urea, Creatinine, Cholesterol, Triglycerides, AST and ALT) and hormones (T3, T4, and TSH) in three stages (pre-standard implementation, three and nine months after performing program). We analyze the data by Stat data software (version 8) using Pearson chi square test.ResultsThe percentages of repeated tests for glucose, urea, creatinine, cholesterol, triglycerides, AST, ALT, T3, T4, TSH were 16.5, 2.57, 2.88, 12.7, 14.9, 10.38, 12.6, 3.55, 4.69, 1.85 for the first time and 20.5, 5.56, 5.41, 7.25, 20.0, 27.2, 30.1, 0.3, 6.04, 3.08 for the second time and 8, 8.3, 9.2, 7.1, 12.8, 17.4, 19.5, 0.0, 5.81,1.01 for the third time, respectively. The changes in statistical analysis of urea, creatinine, cholesterol, AST, ALT, and TSH were significant. The percentage trend of repeated tests for urea and creatinine was increased while for TSH, it was decreased.ConclusionDue to the nature of the experiments and the principles governing repeated tests, the acceptance and implementation of the ISO 9001-2008 only to reduce costs by reducing the percentage of repeated tests cannot be justified. To implement this process, all aspects of the effectiveness should be considered together.Keywords: ISO 9001, 2008, Medical Diagnostic Laboratory, Effectiveness, Cost Reduction
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