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عضویت

جستجوی مقالات مرتبط با کلیدواژه "disease" در نشریات گروه "پزشکی"

  • Ciamak Ghazaei *

    The spectrum of diseases caused by intracellular bacterial pathogens (IBPs) is broad, ranging from life-threatening conditions such as tuberculosis to other infectious-transmitted diseases. Conventional antibiotic treatment faces challenges due to antibiotic resistance, host cell toxicity, and limited drug penetration. Despite the excellent ability of these perilous pathogens to modulate host cell biology, localize in, and multiply through targeting the key virulence factors, cell brings about auspicious maneuvers to combat pathogenic diseases and alleviate their significant global burden. Modulation and identification of molecules, pathways, and responses are the initial steps of targeted therapy, varying from disease to disease. This article explores the cutting-edge advancements in targeted therapy approaches. Innovations such as nanoparticlebased drug delivery systems, phage therapy, immunomodulation, and gene editing, which hold a promising future for overcoming the limitations of traditional treatment, are also discussed. Efficient delivery systems, drug optimizations, and inch-perfect distribution and retention of therapeutic agents are some of the determining factors in the success of targeted therapy for bacterial pathogens. The article also presents a novel application wherein filamentous phages are loaded as targets in nanocarriers for therapeutic purposes. The present challenges faced by the researchers, along with future directions for this field of medical science, are also outlined. Overall, the scope of this article involves the various strategies involved in targeted therapy, drug modulations, and limitations faced in our current approaches.

    Keywords: Disease, Intracellular Bacterial Pathogen, Targeted Therapy, Drug Optimization, Drug Modulation
  • Shima Bordbar, Marziye Hadian, Elaheh Mazaheri, Zahra Shoara, Abdosaleh Jafari
    Background

    Viral hepatitis is the most prevalent liver disease in the world. This disease imposes a great economic burden on families and the health system. This study was conducted to investigate the economic burden of hepatitis B at different ages of the disease using a systematic review method.

    Methods

    Using the systematic review method, the researcher extracted articles related to the economic burden of hepatitis B at different stages of the disease using domestic and international databases including SID, MEDLINE/PubMed, Embase, Web of Science, NHS Economic Evaluation Database (EED), EconLit, and Google Scholar before April 2020 and used the PICOTS framework to select the inclusion criteria. Quality assessment of methodology of the studies was evaluated using Drummond’s checklist.

    Results

    After searching for articles based on inclusion and exclusion criteria, 18 articles were included in the final analysis. The findings showed that the highest mean direct medical costs were $ 2748 for chronic hepatitis B, $ 18903 for compensated cirrhosis, $35668 for decompensated cirrhosis, and $93228 for liver cancer. In all of the studies, the highest mean direct medical costs were those of liver transplantation ($ 355000).

    Conclusions

    The treatment costs of diseases related to chronic hepatitis B increase significantly at different stages the disease progression. Although vaccination actions can reduce the disease, we require more investment in the health system infrastructure to provide patients’ access to hepatitis drugs and reduce their direct payments.

    Keywords: Cost Of Illness, Disease, Economic Burden, Hepatitis B, Systematic Review
  • Hieu Huynh, Maxime Lacroix, Pierre Guigui, Emmanuelle Ferrero, Tchao Meatchi, Marc Khalifé
    Background

    Pseudomyxoma peritonei(PMP) is a rare condition, with no previously described location in the spine. Here is presented a case of PMP extension to the thorax and then the spine, treated with two-level vertebrectomy, laminectomy, and posterior fusion.

    Case Report:

    We report here the case of a 64-year-old man presenting pathological fractures of T6 and T7 due to PMP extension to the pleural cavity and thoracic spine. He presented interscapular pain with mild spinal cord compression symptoms. He was treatedby achieving T5-T8 laminectomy, T2-T10 pedicle fixation, and T6-T7 vertebrectomy. The postoperative course was uneventful apart from a pulmonary embolism (PE) with favorable evolution under anticoagulants.

    Conclusion

    To achieve spinal cord decompression, kyphosis correction, and spine stabilization, a two-level vertebrectomy, laminectomy, and posterior fusion would be beneficial for a PMP lesion of the thoracic spine

    Keywords: Pseudomyxoma Peritonei, Disease, Spine
  • فرشید عابدی، مریم خیام زاده، محمد رضایی پور*
    زمینه و هدف

    امروزه از استعاره های مفهومی، برای تبدیل موضوعات انتزاعی و پیچیدهبه مطالبی با مفاهیم عینی و ملموس که انسان به طور روزمره با آن سروکار دارد، استفاده شود.در علوم پزشکی استفاده از استعاره های مفهومی می تواند به ارتباط بین پزشک، بیمار و خانواده های ایشان و یا در حوزه سیاست گذاری های مربوط به این علوم کمک کند.

    روش

    این مطالعه مروری، یک مطالعه کتابخانه ای است که برای گردآوری مطالب از پایگاه های اطلاعاتی داخلی و بین المللی با استفاده از کلیدواژه های مربوطه استفاده شد.

    یافته ها

    استعاره مفهومی در تمام زندگی روزمره انسان جاری است چراکه حوزه های زبان و عمل انسان، استعاری هستند. طرحواره های تصوری به صورت پل ارتباطی امکان برقراری ارتباط میان تجربه های فیزیکی انسان با حوزه شناختی پیچیده تر مثل زبان را فراهم می آورند.پیکره، مجموعه ای از متون نوشتارییا گفتاری آوانویسی شده است که بتوان آن را برای تحلیل ها و توصیف های زبانی به کار برد. استفاده از پیکره ها در مطالعه این مفاهیم، جنبه های سازوکار ذهنی انسان را به خوبی نشان می دهند. از استعاره های مفهومی در بیان بیماری های کرونا و سرطان استفاده شده و پژوهش های متعددی صورت گرفته است.

    نتیجه گیری

    در این پژوهش به مطالعه و تحلیل اطلاعات ارائه شدهدرمقاله هایی با کلید واژه های «استعاره» و «بیماری» پرداخته شد و بررسی پیکره بنیاد اخبار و مقاله های مربوط به بیماری هایی چون سرطان و کووید-19 تحلیل استعاره های موجود در آن ها صورت گرفت.

    کلید واژگان: استعاره, بیماری, سلامتی, زبان شناسی
    Background

    Nowadays, conceptual metaphors should be used to transform abstract and complex topics into material with objective and concrete concepts that people deal with on a daily basis. In medical sciences, the use of conceptual metaphors can help the communication between physicians, patients and their families, or in the field of policy making related to these sciences.

    Methods

    This review study is a library study that was used to collect material from domestic and international databases using relevant keywords.

    Results

    Conceptual metaphor is present in all human daily life because the areas of human language and action are metaphorical. Imaginary schemas as a bridge provide the possibility of communicating between human physical experiences and more complex cognitive domains such as language. Corpus is a collection of transcribed written or spoken texts that can be used for linguistic analysis and description. The use of figures in the study of these concepts show well the aspects of human mental mechanism. Conceptual metaphors have been used in the expression of corona diseases and cancer and many researches have been done.

    Conclusion

    In this research, the study and analysis of the information presented in articles with the keywords "metaphor" and "disease" was done, and the corpus of news and articles related to diseases such as cancer and covid-19 and the existing metaphors were analyzed.

    Keywords: Disease, Health, Metaphor, Linguistics
  • مهدی احمدی*
    زمینه و هدف

     مهاجرت نیروی کار ایرانی به جنوب قفقاز طی سال های پایانی قرن نوزدهم و اوایل قرن بیستم میلادی روند رو به رشدی به خود گرفته بود، به نحوی که هر ساله چند صد هزار نفر برای جستجوی کار به این مناطق می رفتند. عده زیادی از این مهاجران در باکو، گنجه، تفلیس، ایروان و باطوم در کارخانه ها، معادن، صنایع نفت، اسکله ها و زمین های کشاورزی به خدمت گرفته می شدند و برخی هم به دست فروشی، بنایی و... اشتغال و در محل کار یا حاشیه شهرها سکونت داشتند، لذا بهداشت و سلامت نقش مهمی در زیست این کارگران داشت.

    روش

     مقاله پیش رو با رویکرد «تاریخ از پایین» و با تکیه بر منابع کتابخانه ای و آرشیوی درصدد پاسخ به این پرسش است که کارگران مهاجر ایرانی به لحاظ وضعیت بهداشتی در چه شرایطی زندگی می کردند و این وضعیت چه تاثیری در سلامت جسمانی آنان داشت؟

    ملاحظات اخلاقی: 

    در این پژوهش صداقت و امانتداری در استفاده از منابع تاریخی رعایت شده است.

    یافته ها

     نوع زیست اجتماعی کارگران ایرانی در قفقاز باعث شده بود تا بیشترین آسیب های جسمانی و حتی مرگ و میر به نسبت کارگران ملیت های دیگر متوجه ایرانیان باشد، به گونه ای که برخی جان خود را از دست می دادند و عده ای هم دچار بیماری هایی همچون وبا، طاعون، مالاریا، مشکلات تنفسی و یا معلولیت جسمانی می شدند.

    نتیجه گیری

     کارگران مهاجر ایرانی در قفقاز به علت فقدان سرمایه مادی و ابزار تولید و دانش و مهارت، سخت ترین کارها را انجام می دادند و در کلبه ها و آلونک ها یا محل کار سکونت داشتند. این مکان ها به لحاظ سلامت و بهداشت پرخطر و نامناسب بود و باعث می شد تا بیشترین آسیب های جسمانی و حتی مرگ متوجه آنان باشد.

    کلید واژگان: کارگران, سلامت, تلفات و بیماری, مهاجران, قفقاز, ایران, روسیه تزاری
    Mahdi Ahmadi
    Background and Aim

     The migration of Iranian labor to the South Caucasus experienced a growing trend during the last years of the 19th century and the beginning of the 20th century, with hundreds of thousands of Iranians travelling to these areas every year in search of work. Many of these immigrants were employed in factories, mines, oil industries, wharves and agricultural lands in Baku, Ganja, Tbilisi, Erevan and Batum. Some were engaged in peddling, construction, etc. and lived in the workplace or on the outskirts of cities. The aspects of health and safety in these two locations significantly influenced the lives of these workers.

    Methods

     This article employs an approach of "history from below" and relies on library and archival sources to investigate the conditions in which the Iranian immigrant workers lived in terms of their health status and the effects it had on their physical health.

    Ethical Considerations: 

    In this research, honesty and trustworthiness have been observed in the use of historical sources.

    Results

     The social life experienced by Iranian workers in the Caucasus was accompanied by a high rate of physical injuries and even deaths compared with workers of other nationalities. Consequently, some of them lost their lives and some suffered from diseases such as cholera, plague, malaria, shortness of breath, or physical disabilities.

    Conclusion

     Iranian emigrant workers in the Caucasus undertook the most difficult jobs due to lack of material capital, production tools, knowledge and skills as well as living in huts and sheds or workplaces. These two places were dangerous and inappropriate in terms of health and hygiene, leading to a high incidence of physical injuries and even fatalities among Iranian workers.

    Keywords: Workers, Health, Casualties, Disease, Immigrants, Caucasus, Iran, Tsarist Russia
  • آمنه جوانمرد*، علیرضا صالحان
    زمینه و هدف

    در سال 1960، ویروس های کرونا کشف شدند. موجودات زنده درشت پیکر از خانواده ویروس های پاکت دار که RNA تک رشته ای با منشاء جانوری دارند. ویروس های کرونا در انسان می تواند به بیماری تنفسی خفیف یا شدید تنفسی تبدیل شوند. در سال 2020، سازمان بهداشت جهانی ویروس کووید-19 را یک بیماری همه گیر جهانی اعلام کرد. هدف این مطالعه استفاده از ضریب همبستگی جاکارد جهت تعیین شباهت الگوی رفتار بیماری کووید-19 در فصول مختلف سال است.

    روش بررسی

    در این بررسی از سیستم های یادگیری ماشین و معیار تشابه در تعیین الگوی رفتار بیماری کووید-19 در فصل های سال استفاده شد. مکان انجام مطالعه، بیمارستان موسی بن جعفر (ع) مشهد و زمان دقیق انجام مطالعه از اردیبهشت 1399 لغایت شهریور 1401 می باشد. علایم بیماران مبتلا با مجموعه داده تدوین شده مقایسه و تشابه بیماران در ماتریس شباهت تهیه و ضریب همبستگی جاکارد روی داده ها انجام شد. نهایتا تحلیل سویه ها از ابتدای پیدایش تا آخرین سویه بررسی شد.

    یافته ها

    شاخص های عملکرد الگوریتم در روش تشابه جاکارد، معیار یادآوری با مقدار 94/0، معیار دقت با مقدار 1، معیار امتیاز F1 با مقدار 86/0 و معیار صحت با مقدار 76/0 را نشان داد. مهمترین فاکتورهای موثر در بررسی، گلبول های سفید خون، پلاکت، RT PCR، CT SCAN، تنگی تنفس، تب، SPO2 و تعداد تنفس می باشند.

    نتیجه گیری

    در این مطالعه رفتار ویروس کووید-19 با استفاده از الگوریتم های یادگیری ماشین با احتساب موقعیت جغرافیایی و فصلی در بیماران بررسی شد و یک الگوی واضح از ارتباط فصل ها در گسترش کووید-19 مشخص گردید، به طوری که در هر فصل علایم مشخصی مشاهده شده است که با سویه همان فصل مطابقت دارد.

    کلید واژگان: کووید-19, بیماری, بومی شناسی, یادگیری ماشین, سویه ها
    Ameneh Javanmard*, Alireza Salehan
    Background

    Coronaviruses were discovered in 1960. Large-sized living organisms from the Coronaviridae family, with single-stranded RNA of animal origin. Coronaviruses in humans can cause mild respiratory illness or severe respiratory illness. In 2020, the World Health Organization declared COVID-19 a global pandemic. The aim of this study is to use the Jaccard similarity coefficient to determine the similarity of COVID-19 behavior patterns in different seasons of the year.

    Methods

    This study used machine learning systems and similarity metrics to determine the behavior pattern of COVID-19 in different seasons of the year. The location of research was the Mousa ibn Ja'far Hospital in Mashhad, and the time was from May 2020 to August 2021. The symptoms of affected patients were compared with the compiled dataset, and the similarity of patients was prepared in a similarity matrix, and the Jaccard correlation coefficient was calculated on the data. Finally, the analysis of strains from the beginning of emergence to the latest strain was examined. The performance indicators of the algorithm in the Jaccard similarity method showed a recall metric with a value of 0.94, a precision metric with a value of 1, an F1 score with a value of 0.86, and remove accuracy metric with a value of 0.76. The most important factors in the investigation include white blood cells, platelets, RT-PCR, CT SCAN, shortness of breath, fever, SPO2, and respiratory rate.

    Results

    The transmission of the COVID-19 virus depends on several factors, including human interaction. The evidence of the collected data shows that people with COVID-19 have low lymphocyte count and it is very consistent with the results of recent studies. Due to the lack of a dataset, a comparative study was conducted and a dataset was collected.

    Conclusion

    This study, leveraging machine learning algorithms, identified a clear seasonal correlation in the spread of COVID-19. Considering geographical and seasonal variations among patients, distinct symptoms were observed in each season corresponding to the prevalent strain during that period.

    Keywords: Covid-19, Disease, Epidemiology, Machine Learning, Strains
  • محمدمصطفی اسعدی*

    قرآن کریم برای جهاد مومنان در جبهه حق، فرجامی دوگانه تعریف می کند که یا منتهی به پیروزی یا منتهی به شهادت است و این دو را با عنوان «یکی از دو نیکی» بیان می کند تا هیچ نگاه منفی به این شرایط سخت وجود نداشته باشد. پرسش مشخص در پژوهش حاضر این است که بر اساس دیدگاه اهل بیت، آیا می توان ایده قرآنی مذکور در تعریف فرجام شناور دوگانه نیک را (فارغ از مصداق دو نیکی در فرجام جهاد) به وضعیت بیماری برای بیمار تسری و انطباق داد؟ بر اساس یافته های پژوهش به روش تحلیلی- تطبیقی، اهل بیت دو نوع نیکی دوگانه در دو وضعیت بیماری منتهی به سلامت و بیماری منتهی به مرگ (به قید مومن بودن) تعریف کرده اند: در نوع اول، نیکی افزایش درجات مومن یا نیکی زدایش گناهان مومن تعریف می شود. در نوع دوم نیز دوگانه نیکی در مرگ با رهایی از درد و رنج دنیا یا نیکی در مرگ با پاک سازی از گناهان تصویر می شود. در نتیجه مشخص گردید معارف دینی، نگاه بیمار مومن را تحت هر شرایطی به آینده خود روشن می سازد و هرگونه منفی نگری را نسبت به آینده ، مرتفع می سازد. همچنین آثار معنوی بیماری در نگره مومنانه، شمول حداکثری در جامعه ایمانی می یابند؛ نه این که صرفا مومنانی که مقامی والا دارند، بدان دست یابند.

    کلید واژگان: دین و سلامت, احدی الحسنیین, بیماری و نگرش دینی, قرآن و بیماری, اهل بیت و بیماری
    Muhammadmustafa Asady *

    The Holy Qur'an defines a dual outcome for the believers' jihad in the front of truth, which either leads to victory or martyrdom, and it describes these two as "one of the two virtues" so that there is no negative view of these difficult conditions. be The specific question in the current research is that, based on the view of the Ahl al-Bayt, can the Qur'anic idea mentioned in the definition of the floating end of the good be extended and adapted to the condition of the patient? ? Based on the findings of the comparative analytical method, the Ahl al-Bayt have defined two types of double goodness in two situations: disease leading to health and disease leading to death (with the condition of being a believer). In the first type, the goodness of increasing the ranks of the believer or the goodness of removing the sins of the believer is defined. In the second type, the duality of goodness in death is depicted by freedom from the pain and suffering of the world, or goodness in death by cleansing from sins. As a result, it was found that religious education enlightens the believer patient's view of his future under any circumstances and eliminates any negativity towards the future. Also, the spiritual effects of the disease in the believer's view find maximum inclusion in the faith society; Not that only believers who have a high position can achieve it.

    Keywords: Religion, Health, One Of The Two Virtues, Disease, Religious Attitude, Quran, Ahl Al-Bayt
  • علی جهانشاهی افشار*، مینا احمدی نسب

    در گذشته جبر محیطی حاکم بر ذهن بشر بدوی به دید و شناخت تک ‏بعدی او منجر می ‏شد؛ به این صورت که هر چه را می ‏دید، واقعیت و جاندار می پنداشت و برای آنچه نمی‏ توانست بشناسد، افسانه‏ ای می آفرید و در خیالات خود پاسخ مجهولات را دنبال‏ می‏ کرد. این واکنش تک بعدی و دید افقی نسبت به پدیده ‏ها در راهکارهای درمانی او نیز نمایان می شد؛ یعنی بخشی از درمان را با استفاده از داروهایی که‏ در طبیعت شناخته بود یا ابزاری که ابداع کرده بود، انجام می داد و بخشی دیگر از بیماری ها را که‏ نمی ‏توانست بشناسد به ماوراءالطبیعه نسبت می داد و معمولا به شیوه هایی غیرعادی از قبیل‏ سحر، جادو و اعمال و ابزار غیرمرتبط با بیماری متوسل می‏ شد که این روش ها گاهی به دلیل تاثیر روانی بر بیمار می‏ توانست سبب مداوای او نیز شود. در ابتدا، درمان های غیرمتعارف بیشتر کاربرد داشت، اما رفته رفته با شکل ‏گیری علوم و گسترش دامنه شناخت آدمی، روش های درمان صورت علمی تری یافت و تنها بخش کوچکی از این درمان ها در فرهنگ عامه باقی ماند.‏ با توجه به این که این راهکار‏ها بخشی از فرهنگ عامه هستند و حفظ این میراث ضروری‏ است، همچنین به ‏دلیل این که کرمان از حوزه‏ های زیستی بسیار کهن فلات ایران به ‏شمار می آید که در زمینه علم طب نیز عمری دراز و قدمتی طولانی دارد، در این پژوهش سعی شده است که برخی از‏ باور‏ها و روش ‏های درمانی مربوط به کرمان بررسی شود. اطلاعات و داده ‏های پژوهش به شیوه کتابخانه ‏ای و میدانی جمع ‏آوری شد. روش تحقیق نیز توصیفی تحلیلی ‏است. یافته ‏های پژوهش نشان می ‏دهد که رویارویی مردم کرمان با بیماری‏ ها یا بر پایه دانش و آگاهی بوده، یا بر پایه باور و دریافت های روانی و درونی که در گونه اخیر با وجود نداشتن استناد علمی، گاه بر مبنای تلقین و تاثر روانی، شیوه درمانی باوربنیاد موثر واقع می شده است.

    کلید واژگان: فرهنگ عامه, بیماری, درمان شناسی, دانش
    Ali Jahanshahi Afshar*, Mina Ahmadi-Nasab

    The environmental determinism governing the primitive human mind caused his knowledge to become one-dimensional in such a way that he thought everything was real and alive, and so created a legend for the unknown and sought the answer to the unknown in his imagination. This one-dimensional reaction and horizontal view of phenomena was also seen in his treatment strategies. That is, he performed some treatments using the drugs he knew in nature or the tools he invented, and attributed some other diseases that he could not recognize to the supernatural and usually resorted to unusual methods such as magic, and actions and tools unrelated to the disease for treatment. These methods sometimes lead to treatment due to the psychological effect on the patient. In the beginning, more unusual treatments were used, but gradually, with the formation of science and the expansion of human knowledge, treatment methods became more scientific and only a small part of these treatments remained in folklore. These therapies are part of the folklore and it seems necessary to preserve this heritage. Kerman is one of the very ancient biological areas of the Iran plateau, which also has a long life and a long history in the field of medicine. Therefore, this research, has endeavored to investigate some beliefs and treatment methods used in Kerman. The data was collected in a library and field method. The research method is descriptive-analytical. The findings of the research show that the people of Kerman face diseases either on the basis of knowledge and awareness, or on the basis of belief and psychological and internal perceptions. Although the latter method of treatment is not scientific, it has sometimes been effective due to indoctrination and psychological influence.

    Keywords: Popular culture, Disease, Therapeutics, Knowledge
  • Malihe Sadeghi Sarhangi, Sohrab Yazdani Moghadam *, Hossein Mohammadi, Mirhadi Hosseini
    The transformation of the public and individual health system from 1925 to 1941 was known as one of the pillars of the development and acceleration of the modernization process in Iran. Despite this expansion, public health and collective health, especially in schools, found a close connection with the underdevelopment of the country. Trachoma disease was one of the most common and contagious diseases among elementary school students, and the government tried to take some measures to deal with it, such as spreading public awareness, creating a skilled workforce through the training of teachers and school staff, and applying comprehensive monitoring of students’ health in the family and school. Despite these measures, there were challenges, such as a lack of medicine, a lack of skilled workforce, and financial problems that negatively affected the quality of the government’s actions. This research raises the central question: How did trachoma disease in schools become a serious issue for the government? The hypothesis is that although the government succeeded in dealing with Trachoma in primary schools, this process was gradual, slow, and temporary due to the underdevelopment of the country’s infrastructure.
    Keywords: Reza Shah Government, Schools, Health, trachoma, Disease
  • Alireza Khammar, Mehdi Nouri, Elham Saber, Ali Miri, Javad Vatani, Mehran Maleki Roveshti*
    Background & Aims

    Dust storms, which are considered natural occurrences, have harmed the global population’s health as a result of the broad increase in climate change. The most serious consequences of these alterations are cardiovascular, pulmonary, and cerebrovascular diseases. This review study focused on the effect of dust storms and climatic factors on mortality and morbidity in worldwide and assessed the prediction of these diseases based on changes in each of the meteorological factors and dust storms.

    Materials and Methods

    For data collection, English literature was searched using keywords “dust storm” and “respiratory disorders” or “cardiovascular disease” or “cerebrovascular disease” in PubMed, Web of Science, and Scopus as databases, along with Google Scholar as engine search. The first step was to use statistics on the number of instances of cardiovascular, cerebrovascular, and respiratory diseases. The association between the occurrence of these diseases and variations in climatic factors underwent assessment.

    Results

    Adverse repercussions could be noticed when dust storms were paired with changes in metrological parameters. More local information about the link of these diseases with dust storms and changes in metrological variables in the nation, as well as their capacity to anticipate them, is needed to prevent and reduce the health risk of these diseases.

    Conclusion

    In areas prone to dust storms, the population will be prone to its effects and consequences. Thus, preventive measures are beneficial at the community level.

    Keywords: Climate change, Dust, Cyclonic storms, Risk factors, Environmental health, Disease
  • Jing Liu, Hongying Nie, Fan Rao
    Background

    We aimed to assess the effect of life-cycle management on the satisfaction and health outcomes of children with chronic diseases and their parents, as well as the career benefits of healthcare workers.

    Methods

    Participants were children with chronic diseases who received long-term treatment at the Three Gorges Hospital Affiliated to Chongqing University from January 2021 to November 2022. From the first admission, compare the children's disease onset, satisfaction and professional benefits of medical staff among "Medical and Nursing Integration" + "Internet plus"-based life cycle management group (n = 221, the experimental group), the routine management group (n = 53, the control group 1) and the "Medical and Nursing Integration" group (n = 67, control group 2).

    Results

    The overall satisfaction of children in the experimental group (100 %) was higher than that in the control group 1 (98.11%) and control group 2 (98.51%). The times of second admission and third admission of patients in the experimental group were significantly lower than those in control group 1 were (both P<0.001) and control group 2 (both P<0.01). Nurses' sense of professional benefit, professional identity, and doctor's satisfaction with nurses in the experimental group were significantly higher than those in control group 1 (P<0.05, P<0.01, P<0.001) and control group 2 (all P<0.05).

    Conclusion

    The application of "Medical and Nursing Integration" + "Internet plus"-based life cycle management in chronic disease nursing management can effectively improve the management on pediatric chronic diseases.

    Keywords: Disease, Public health, Children, Nursing
  • Abdulsamet Erden, Berkan Armağan, Serdar Can Güven, Özlem Karakaş *, Fatma Erden, Bahar Özdemir, Ahmet Omma, Orhan Küçükşahin
    Background

    We aimed to investigate the frequency of Demodex infestation and clinical implications in connective tissue disease patients with facial erythema.

    Methods

    Patients diagnosed with a connective tissue disease and had facial erythema were consecutively enrolled in the study from 2019-2020. An age and gender matched control group was formed from healthy volunteers. Presence of Demodex was investigated by standardized skin surface biopsy. Number of Demodex mites over 5 per centimeter square was considered meaningful for infestation. Topical or systemic metronidazole treatment was given to the connective tissue disease patients with Demodex infestation. Facial erythema visual analog scale was questioned in patients at treatment onset and one month after.

    Results

    A total of 31 connective tissue disease patients with facial erythema were enrolled. Control group included 31 healthy volunteers. Demographics and comorbidities were similar between groups. Demodex infestation was present in 58.1% of the disease group and in 25.8% of the control group (P=0.01). Pruritus was the most common symptom in patients with infestation. Median (IQR) facial erythema visual analog scale score was 6 (3) at treatment onset and was 2 (2.5) one month later (P<0.001).

    Conclusion

    When evaluating facial cutaneous lesions, Demodex infestation should not be overlooked in a patient group like connective tissue diseases with dysfunctional immune system.

    Keywords: Parasite, Connective tissue, Disease, Erythema, Demodex
  • علیرضا رحیمی، سمیه اعلایی، ماهرخ کشوری*، محمدجواد طراحی، مجتبی کرباسی
    مقدمه

    سالمندان، در معرض خطر ابتلا به بیماری و ناتوانی هستند. درک رفتار اطلاع یابی سلامت و عوامل مرتبط با آن، از جمله عوامل فردی،  به منظور ارایه مراقبت های سلامت به سالمندان بسیار مهم می باشد. هدف از پژوهش حاضر تعیین ارتباط عوامل فردی با رفتار اطلاع یابی سلامت سالمندان در مراکز خدمات جامع سلامت شهر اصفهان  بود.

    روش بررسی

    این پژوهش مقطعی، با  نمونه گیری  خوشه ای یک مرحله ای ، بر روی 580 سالمند تحت پوشش مراکز خدمات جامع سلامت شهر اصفهان، درسال 1396 انجام گردید. جهت جمع آوری داده ها از پرسشنامه محقق ساخته استفاده شد. روایی محتوایی و صوری پرسشنامه توسط متخصصان کتابداری و اطلاع رسانی پزشکی و طب سالمندان تایید و پایایی آن با استفاده از آلفای کرونباخ  میزان 87/0 محاسبه شد. داده ها با استفاده از آمار توصیفی و استنباطی(Pearson Correlation ، t-test Independentو ANOVA) تحلیل شد.

    یافته ها

    میانگین نمره مردان در مولفه موانع دستیابی به اطلاعات سلامت، بیشتر از زنان بود (.(p<0/05بین سن و موانع دستیابی به اطلاعات سلامت رابطه مستقیم و معنی دار بود (.(p<0/05درمولفه موانع دستیابی به اطلاعات سلامت، میانگین نمره زنان مطلقه و همسر فوت شده (p<0/05)؛ وافراد بازنشسته و کارگر (p<0/01)، بیشتر از سایر گروه ها بود .بعلاوه، افراد بازنشسته و دارای شغل آزاد، بیشترین نمره را در مولفه استفاده از منابع اطلاعاتی کسب نمودند ((p<0/01.

    نتیجه گیری

    ویژگیهای فردی مختلفی مثل جنس، سن، وضعیت تاهل و شغل برفرآیند جستجوی اطلاعات و نیز دسترسی به اطلاعات به طور کلی بارفتار اطلاع یابی سلامت سالمندان مرتبط هستند.

    کلید واژگان: رفتار اطلاع یابی سلامت, ویژگیهای فردی, سالمند, بیماری
    Alireza Rahimi, Somaye Alaei, Mahrokh Keshvari *, Mohammad Tarahi, Mojtaba Karbasi

    The elderly are at risk of disease and disability. Understanding health information seeking behavior and related factors, including individual factors, is very important in order to provide health care to the elderly. The aim of the present study was to determine the relationship between individual factors and the health information seeking behavior of the elderly in comprehensive health service centers in Isfahan city..

    Methods

    This descriptive-correlational study was performed on 580 elderly individuals covered by comprehensive health service centers in Isfahan, who were selected by one-stage cluster sampling and quota random sampling in the academic year 2017. A researcher-made questionnaire was employed to collect data for the variable behavior of elderly health information in disease control. The content and face validity of the questionnaire were confirmed by librarians and medical information and geriatrics specialists. The reliability of the questionnaire was calculated 0.87 using Cronbach's alpha. Data were analyzed using descriptive and inferential statistics.

    Results

    The results revealed that there was a significant difference between men and women in the component of barriers to accessing health information. There was a direct relationship between age and some components of information seeking behavior. Besides, there was a significant relationship between marital status and type of job with some components of information seeking behavior.

    Conclusion

    Due to the desire of the elderly to obtain health information, it seems necessary to transfer information related to the elderly through portals and taking into account different personal characteristics and contexts affecting the information search process to play an effective role. Various personal characteristics such as gender, age, marital status, occupation, and access to information affect the health information seeking behavior of the elderly.

    Results

    The results showed that there was a significant difference between men and women in the component of barriers to accessing health information. There was a direct relationship between age and some components of information seeking behavior. Also, a significant relationship was observed between marital status and type of job with some components of information seeking behavior.

    Conclusion

    Due to the desire of the elderly to obtain health information, it is necessary to transfer information related to the elderly through the portals used by them and taking into account different personal characteristics and contexts affecting the information search process in order to play an effective role. In increasing their awareness of disease control. Various personal characteristics such as gender, age, marital status, occupation in access to information and also affect the health information seeking behavior of the elderly.

    Keywords: Health Information Behavior, Individual characteristics, Elderly, Disease
  • مهدی بلالی مود*

    نظر به اینکه ژن ها تحت تاثیر عوامل محیطی و فردی تغییر می کنند، بنابراین نقش این عوامل در تامین سلامت انسان اهمیت بیشتری پیدا کرده اند. در کشورهایی که پایه های تامین سلامت مانند هوای پاک، آب و غذای سالم، امکانات ورزشی و رفاهی، عدالت و تامین اجتماعی و موازین پیشگیری از بیماری ها برای همه مردم فراهم می باشد، جامعه سالم و با نشاطند و لذا بیماری ها کمتر شده اند؛ ولی متاسفانه در بعضی کشورها مانند ایران که به این عوامل توجه کافی نشده بیماری زایی و مرگ ومیر در حال افزایش است.

    کلید واژگان: بیماری, ژن, سلامت, پیشگیری
    Mahdi Balalimood*

    Since the gens change due to the environmental and individual factors, the role of these factors is now more important for the human health. In countries that the facilities such as clean air, healthy water and food, sport and recreational sites, social security and disease prevention programs readily available for all, the society is healthy and happy. Thus, the overall morbidities and mortalities have been declined. But unfortunately, in some countries like Iran that has not paid attention to these factors, the overall morbidities and mortalities have been increased.

    Keywords: Disease, Gens, Health, Prevention
  • Hamideh Molaei, Mohsen Saberi Isfeedvajani, Esmat Davoudi-Monfared *, Masoud Nemati
    Background
    Investigating the frequency pattern and types of skin diseases is considered to be extremely important in order to improve the diagnosis process and patients' conditions.
    Objectives
    The aim of this study was to investigate the epidemiological pattern of skin diseases in patients referred to the skin clinic of Baqiyatallah Hospital.
    Methods
    This cross-sectional study was conducted on 400 patients who had referred to the skin clinic of Baqiyatallah Hospital during 2016 and 2017. These participants were selected using a convinced sampling model. The type of skin diseases were determined in patients and then collected data were analyzed using the SPSS(V-22) software.
    Results
    Out of the 400 patients who had referred to the abovementioned clinic, 281 (70.3%) were women and 119 (29.7%) were men. The most common reasons for visiting the skin clinic were acne, warts, wrinkles and acute eczema, respectively. The most affected area was the face. The skin disease diagnosed in patients had a significant relationship with patients' age (P = 0.001), gender (P = 0.001), and education (P = 0.011).
    Conclusion
    According to the findings of the present study, acne, warts, and wrinkles are the most common skin problems in patients who had referred to the skin clinic of Baqiyatallah Hospital, respectively. Demographic and background factors have a significant effect on the type of skin disease.
    Keywords: skin, Disease, Epidemiology, Acne, Warts
  • Arezoo Chouhdari, Omidvar Rezaei, Mohammad Samadian, Guive Sharifi, Kaveh Ebrahimzadeh, Zahra Davoudi*
    Introduction

    Cushing disease is a rare problem that usually has an important effect on the quality of life (QoL).

    Objective

    This survey aimed to evaluate patients’ QoL and determine predictors of improving QoL scores in patients.

    Materials and Methods

    In this before-after study, basic characteristics were collected from 56 patients with Cushing disease who underwent endoscopic transsphenoidal surgery, and their QoL score during one year was assessed. Finally, predictor factors of QoL score improvement were identified. To compare the QoL scores before, 6 months, and 12 months after surgery, repeated measures ANOVA and for determining predictors of QoL score improvement, multivariable logistic regression analysis was used. P<0.05 was considered significant in all tests.

    Results

    The Mean±SD age of the samples was 33.92±12.82 years, and 43 (76.8%) were female. In all 56 patients who underwent endoscopic transsphenoidal surgery, the QoL score significantly improved. In multivariable logistic regression analysis, weight loss (OR= 1.2, 95% CI; 1.01-6.5, P=0.01), no fatigue (OR= 2.1, 95%CI; 1.6-8.3, P=0.009), no decreased libido (OR= 1.5, 95% CI; 1.2-10.62, P=0.01), no gonadal axis disorder (OR=2.2, 95% CI; 1.07-4.06, P=0.01) and post-operation no thyroid axis disorder (OR=2.5, 95% CI; 1.8-5.7, P=0.01) were predictors for more QoL score improvement.

    Conclusion

    According to the results of this study, many factors can affect the quality of life in patients with Cushing disease. Therefore, support groups should include the cooperation of physicians and psychologists, provision of health services, and social support to improve the QoL of patients.

    Keywords: Quality of life (QoL), Cushing, Disease
  • مجتبی سپندی، یوسف علی محمدی*

    آبله میمون یک بیماری عفونی مشترک بین انسان و دام است که توسط ویروس های آبله میمون، نوعی از ارتوپاکس ویروس از خانواده Poxviridae، که در آفریقا بومی است، ایجاد می شود. آبله میمون که معمولا یک بیماری خود محدودکننده است، با علایمی شبیه آنفولانزا (تب، دردهای عضلانی، لرز و خستگی) شروع می شود. معمولا در عرض 1 تا 3 روز (گاهی اوقات بیشتر) پس از شروع تب، بیمار دچار بثوراتی می شود که اغلب از صورت شروع شده و سپس به سایر نقاط بدن سرایت می کند. ضایعات ممکن است در سراسر بدن ظاهر شوند. کاهش مصونیت جمعیت ها به دلیل قطع واکسیناسیون آبله در گذشته، راه را برای آبله میمون هموار کرده است. این را افزایش تعداد موارد و همچنین عود بیماری در برخی کشورها نشان می دهد. با توجه به اهمیت آبله میمون و تعداد محدود منابع فارسی زبان در این زمینه، مقاله حاضر با هدف معرفی این بیماری به عنوان یک بیماری عفونی مشترک بین انسان و دام که اخیرا در چندین کشور گزارش شده است، انجام شده است.

    کلید واژگان: آبله میمون, باز پدید, عفونی, بیماری
    Mojtaba Sepandi, Yousef Alimohamadi*

    Monkeypox is a rare zoonotic infectious disease caused by the Monkeypox viruses, a type of Orthopoxvirus of the family Poxviridae, which is endemic to Africa. Monkeypox, which is usually a self-limiting illness, starts with flu-like symptoms (fever, muscle aches, chills, and fatigue). Usually, within 1 to 3 days (sometimes longer) after the onset of fever, the patient develops a rash that often starts on the face and then spreads to other parts of the body. Lesions may appear all over the body. Decreased immunity of populations due to the cessation of smallpox vaccination in the past, has paved the way for Monkeypox. This is shown by the increase in the number of cases as well as the recurrence of the disease in some countries. Due to the importance of the Monkeypox and the limited number of Persian language sources in this regard, the present article aimed to introduce this disease as a zoonotic infectious disease that has recently, been reported in several countries.

    Keywords: Monkeypox, Re-emerging, Infectious, Disease
  • Mahnaz Akbari, Alireza Negahi, Najmeh Dabbagh, Amir Hossein Salimi Kordasiabi, SabaZarean Shahraki, Mohammad Esmaeil Akbari
    Background

    Idiopathic Granulomatous Mastitis (IGM) is a benign disease; it can clinically and radiologically mimic the symptoms of breast cancer.

    Objectives

    Due to the rare and limited number of studies in Iran, this study was designed and conducted to evaluate patients’ clinical characteristics and treatment management with IGM.

    Methods

    In this cross-sectional and retrospective descriptive-analytic study, we studied the medical records of 293 patients with IGM, such as demographic information, characteristics of breast lesions, type of treatment, complications, and their outcome, which were recorded in the Cancer Research Centers of Shahid Beheshti University of Medical Sciences (SBMU) from 2010 to 2019. The patients were contacted by telephone to visit clinically or collect additional information. Data were analyzed by SPSS software version 24.

    Results

    The mean age of patients was 39.21 (ST = 8.29) years. Breast involvement in 236 cases (80.5%) was unilateral, and in 50 cases (17.1%), the involvement was Pere pri-Areola. The most common type of treatment was conservative therapy (analgesia + drainage) (178 cases, 60.8%), which was the primary treatment in our study; 66 patients (22.5%) received antibiotic therapy + analgesia + drainage, and 41(14%) cases received corticosteroid in addition to this treatment. Totally, 132 cases (79.5%) were completely cured with the performed treatments, 17 cases (5.8%) had a recurrence of symptoms, and 14.7% of the patients were still receiving treatment. Recurrence after 1 year in patients who had a longer duration of disease (more than 12 months) was higher than in those who had a shorter period (less than 12 months) (15.3% vs. 5.1%, P = 0.004). Also, the highest recurrence rate was in the group receiving corticosteroids compared to the group receiving the usual treatment and usual treatment plus antibiotics. This relationship was statistically significant (22.0% vs. 9 % and 6.1%, respectively, P = 0.032). Complications (scar or breast skin color change) were significantly higher in patients without a pregnancy history than in patients who had pregnancy (50.0% vs. 22.8%, P = 0.030). Also, these complications were significantly higher in patients who had a longer duration of disease (more than 12 months) than in shorter periods of disease (less than 12 months) (31.4% vs. 17.3%, P = 0.005).

    Conclusions

    The results of our study and its comparison with the results of other studies still emphasize the uncertainty of the etiology of IGM disease and its treatment, but to some extent, our study has shown that conservative treatment (drainage with analgesic drugs) is one of the best treatment options. Also, corticosteroid therapy is associated with a higher recurrence rate, but in some cases is necessary and recommended in many studies.

    Keywords: Idiopathic Granulomatous Mastitis, Disease, Breast
  • محمد احمدی زاده*، حامد آرضایی، اعظم قاسمی

    پرسش از تکیه‏ دانش پزشکی و نظام سلامت به شناخت های بنیادین و واکاوی ریشه های فلسفی آن مدخل مهم فلسفه‏ پزشکی است که به اندازه کافی به آن توجه نشده است تا جایی که گاه پزشکی و نظام سلامت و بهداشت بی‏ نیاز از آن تلقی می شود. در این مقاله به این موضوع توجه شده که آیا در میان حکما و فلاسفه اسلامی و به ویژه فیلسوف - پزشکان می توان سابقه ای از مباحث فلسفی در ارتباط با موضوعات پزشکی یافت؟ مسایلی چون «سلامت چیست؟ آیا سلامت واقعیتی عینی یا امری اعتباری است؟ نسبت بیماری با سلامت چیست؟ منشا سلامت و بیماری چه اموری است؟ آیا امور غیرجسمانی می‏ توانند در سلامت جسم انسان موثر باشند؟ درد چیست؟ ملاک تقسیم‏ بندی بیماری‏ ها چیست؟ بیماری روانی چیست و چگونه است؟ رابطه پزشک با بیمار چگونه باید باشد؟ آیا به دلایلی مانند سختی درمان یا سلامت همراه با رنج می توان مرگ را تجویز کرد و... ؟» ازجمله پرسش های عینی و میدانی دانش پزشکی و نظام سلامت است که تلاش برای پاسخ گویی به آنها پژوهشگر را با مباحث بنیادین فلسفی، به ویژه انسان‏شناسی فلسفی مواجه می نماید. مواضع مختلف فلسفی در مسایلی اساسی چون شناخت انسان و مراتب حیات او و چیستی علم و روش علمی می تواند تاثیر شایان توجهی در شکل‏ گیری دانش پزشکی و به تبع آن در نظام سلامت داشته باشد، به گونه ‏ای که اصول علمی و روش ‏های تشخیص و درمان را در گستره‏ای از مکاتب طبی مختلف از طب مدرن تا طب‏ های سنتی و مکمل دست خوش بازبینی ها و تغییرات اساسی قرار دهد. این امر می تواند در طی زمان به شکل گیری نظام های طبی بی‏ انجامد که هریک در دستگاه ‏های معرفتی خود و برآمده از مبانی فلسفی خود شناخته شوند.

    کلید واژگان: سلامت, بیماری, فلسفه, انسان شناسی پزشکی
    Mohammad Ahamadizadeh*, Hamed Arezaei, Azam Ghasemi

    One of the important entries in philosophy of medicine is the discussion on the reliance of medical knowledge and the health system on fundamental knowledge and the analysis of its philosophical roots. It is noteworthy that, not enough attention has been paid to this issue, to the extent that sometimes it is not deemed necessary for medicine and the health system. This study endeavors to explore a history of philosophical discussions in relation to medical issues among Islamic and contemporary philosophers, physicians, and especially philosopher-physicians. This study also touches on issues such as: What is health? Is health an objective fact or a credit matter? What is the relationship between illness and health? What is the origin of health and illness? Can non-physical things be effective in the health of the human body? What is pain? What are the criteria for classification of diseases? What is a mental illness and what is it like? How should the physician’s relationship with the patient be? Is it possible to prescribe death for reasons such as incurability or suffering? These are among objective and field questions of medical knowledge and the health system. In the attempt to answer the mentioned questions, a researcher is confronted with fundamental philosophical issues, especially philosophical anthropology. Indeed, different philosophical views on basic issues such as anthropology and the stages of man's life, philosophy of science, and the scientific methods can have a significant effect on formation of medical knowledge, and thereby, the health system. As a result, scientific principles and methods of diagnosis and treatment in a range of different medical schools, from modern medicine to traditional and complementary medicines, have undergone fundamental revisions and changes. This can lead to formation of medical systems over time, each of which is recognized in its own epistemological system and arising from unique philosophical foundations.

    Keywords: Health, Disease, Philosophy, Medical Anthropology
  • حمیدرضا سهرابی*، سلیمان افروغی، فرزانه عسکری طیبی
    زمینه و هدف

    در تمام ادیان آسمانی و مکتب های بشری بر مسله امید تاکید شده است. از نظر اسلام اگر نا امیدی بر کسی غلبه کند به کفر و دوری از رحمت خداوند نزدیک می شود . امید نقطه شروع تکامل انسان در قرآن، به سوی خلیفه‏ الله و مظهر تجلی اسمای الهی است. پژوهش حاضر با هدف نقش امید درمانی در شفای بیمارهای جسمی و روحی  و کاربرد نقش امید در طب در حوزه سلامت معنوی انجام گرفته شده است.

    روش ها

    این تحقیق با روش توصیفی و تحلیلی  و به شیوه کتابخانه ای و با مراجعه به منابع  تفسیری  و روایی مرتبط با  آموزه های دینی انجام گرفته است.

    یافته ها

    بر اساس یافته ها این پژوهش داشتن امید به آینده ی برای پیشگیری و درمان بیماری ها جسمی و روانی نقش اساسی دارد. امید، می‏ تواند از افراد در برابر رویدادهای استرس ‏زای زندگی حمایت کند و از طرفی بیماران جسمی با داشتن امید می توانند بر نارسایی هایی سیستم ایمنی خود غلبه کرده و باعث تقویت سیتم ایمنی در مقابل بیماری ها شوند. همچنین  قرآن کریم و سیره اولیای الهی منبع و سرچشمه تولید امید و امیدواری  می باشند که بیماران می توانند از این چشمه های امید سیراب گردند و جسم و روح خود را شفا نمایند زیرا امید حقیقی در ارتباط با «الله» است. امید آنچنان در اسلام دارای اهمیت است که قرآن آن را مرز بین کفر و ایمان تعبیر  کرده است
     

    نتیجه گیری

     براساس نتایج این پژوهش توجه به آموزه های دینی می تواند باعث ارتقا سطح امیدواری افراد شود. ارتقا سطح امیدواری و  امید به آینده در هر مرحله ای از زندگی فرد عامل تحرک، نشاط و موفقیت بوده است  که در این زمینه افراد بیمار برای بازیابی سلامت جسمی و روانی خود می توانند از مقوله امید درمانی بهرمند گردند.

    کلید واژگان: امید درمانی, بیماری, سلامت, دین, درمان
    Hamidreza Sohrabi*, Suleiman Afroghi, Frzanh Askry
    Background and purpose

    In all heavenly religions and human schools, the issue of hope is emphasized. According to the religion of Mobin Islam, if despair overcomes someone, he is close to disbelief and distance from God's mercy. Hope is the starting point of human evolution in the Qur'an, towards the Caliph of God and the manifestation of the divine names. The current research has been conducted with the aim of the role of hope therapy in healing physical and mental diseases and the application of the role of hope in medicine in the field of spiritual health.

    Methods

    This research was carried out with a descriptive and analytical method and in a library manner and by referring to interpretive and narrative sources related to religious teachings.

    Findings

    Based on the findings of this research, having hope for the future plays an essential role in the prevention and treatment of physical and mental diseases. Hope can support people against stressful events in life, and on the other hand, physically sick people can overcome the deficiencies of their immune system and strengthen their immune system against diseases. Also, the Holy Qur'an and the lives of the divine saints are the source and source of producing hope and hope that patients can get water from these springs of hope and heal their body and soul because true hope is in connection with "Allah". Hope is so important in Islam that the Qur'an has interpreted it as the boundary between disbelief and faith.

    Conclusion

    Based on the results of this research, paying attention to religious teachings can improve people's level of hope. Improving the level of hope and hope for the future in every stage of a person's life has been the factor of mobility, vitality and success, and in this field, sick people can benefit from the category of hope therapy to restore their physical and mental health.
     .

    Keywords: Therapeutic Hope, Disease, Health, Religion, Treatment
نکته
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