جستجوی مقالات مرتبط با کلیدواژه "high intensity interval training" در نشریات گروه "پزشکی"

Adipokines dysregulation plays important role in the type 2 diabetes (T2D) pathogenesis. However, exercise training can be effective in improving the glycemic control in T2D patients by modulating the adipokines levels. In the present research, the effects of 12 weeks of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on the serum levels of progranulin and MCP-1 in type2 diabetic women have been investigated.

36 qualified and volunteer women with T2D were randomly assigned in the three groups including control, MICT and HIIT groups. Both HIIT (90 percent of maximum heart rate) and MICT (60 to 70 percent of maximum heart rate) protocols were conducted on treadmill for 12 weeks. Blood samples were collected in pre and post-test stages. Between groups difference were determined by analysis of covariance test and significant level was P<0.05.

The present study findings indicated that both HIIT (p<0.001) and MICT (p=0.014) protocols cause significant decrease in the MCP-1 levels. However, the progranulin reduction compared to the control group was significant only in the HIIT group (p<0.001) and MICT does not have significant effect on the progranulin levels (p=0.077). Decrease in body fat percentage and insulin resistance was also significant for both HIIT and MICT protocols compared to the control group (p<0.001).

Both HIIT and MICT exercise trainings are effective for modulating the adipokines levels in the T2D patients. However, the effectiveness of HIIT was greater for reduction of progranulin levels compared to the MICT group, which indicates the importance of paying more attention to HIIT in the management of T2D.

Fatty liver disease is the most common cause of chronic liver diseases in the world, which can cause cardiovascular diseases, so this research aims to scrutiny a period of intense intermittent sports activity and growth hormone perfuse on cardiac mitochondrial PGC1α and some indicators of oxidative stress in mice with liver damage.

The present research was conducted from September 2022 to March 2023 in the specialized physical training laboratory of Ferdowsi University of Mashhad. The statistical population was twenty one adult male Syrian mice with an average weight of twenty three grams. The sports activity protocol was adopted for fifty-six days using the special video recorder for rodents. The intense interval training program was carried out in the form of ten one-minute repetitions and two-minute active rest, so that the total daily training time for each person was thirty minutes.The vaccination protocol includes the daily vaccination of somatropin injected intraperitoneally.

The PGC1α levels were significantly higher in both the HIIT (P=0.02) and H- GH (P=0.03) groups collationed to the witness team. Moreover, the levels of SOD were considerably increased, in both the HIIT (P=0.05) and H-GH (P=0.005) team s compared to the witness team. Moreover, the levels of MDA were considerably decreased, in both the HIIT (P=0.007) and H-GH (P=0.04) teams compared to the witness team. The decrease in insulin resistance was significant only in the HIIT (P=0.05) team compared to the witness team and slightly increased in the H-GH (P=0.36) team but was not considered. The difference between HIIT and H-GH team (P=0.03) was also significant.The proportion of ALT/AST in both HIIT (P=0.02) and H-GH (P=0.03) teams had a significant decrease compared to the witness team. LDL/HDL proportion evidenced considered decrement at just in the HIIT team (P=0.01).

Intense intermittent sports activity was able to produce a more optimal response compared to GH peptide in improving NAFLD-related indices. Injection of this hormone single may have adverse outcomes on some indexes of this abnormality.

Exercise training is employed as a practical method to combat muscle atrophy. The purpose of this study was to investigate the effects of high-intensity interval training (HIIT) conducted before and after hindlimb suspension (HLS) on the gene expression of MSTN and ActRIIB in the skeletal muscle of male Wistar rats.

Thirty-two male rats, aged four to six months, were randomly divided into four groups (N=8 each): (1) control, (2) training-suspension-retraining, (3) non-training-suspension-retraining, and (4) training-suspension-non-training. The HIIT duration was five weeks, while the HLS lasted for two weeks. Gene expression levels were assessed using RT-PCR.

A significant decrease in the expression of MSTN and ActRIIB was observed in the soleus muscle of the group (2) compared to the other groups (p<0.05). There was also a notable reduction in MSTN expression in the extensor digitorum longus (EDL) muscle among the experimental groups relative to the control group (p<0.05), with the group (2) showing a greater effect than the others. Additionally, a significant decline in ActRIIB expression in the EDL muscle of the group (2) was noted compared to the other groups (p<0.05). The group (3) also exhibited a significant decrease in ActRIIB expression in the EDL muscle compared to the control group (p<0.05).

The findings of this study suggest that the training-retraining approach (with HIIT) is particularly effective in mitigating muscle atrophy induced by HLS. These results highlight the HIIT training model as a highly efficient treatment method for preventing and reducing atrophy in rodent skeletal muscle.

Adipose tissue fibrosis is involved in glucose metabolism disorder and insulin resistance in obesity, but the effect of exercise on the progression of adipose tissue fibrosis is still unknown.This study aimed to investigate the effect of high intensity interval training (HIIT) simultaneously with high-fat diet on TGF-β1, MMP-9 and MMP-2 in the subcutaneous adipose tissue of male rats.

24 male rats were randomly divided into 4 groups: normal diet (ND), high fat diet (HFD), Normal diet + high intensity interval training (ND+HIIT), high fat diet+ high intensity interval training (HFD+HIIT). The HIIT protocol includes 8 bouts of intense activity at 90% of maximum running capacity (MRC) for 2.5 minutes, with active rest periods at 50% of maximum running capacity for 2.5 minutes for 12 weeks (5 sessions per week). 48 hours after the last training session, blood was taken, and subcutaneous fat was removed. Western blot method was used evaluate the TGF-β1 and ELISA method was used to measure levels of MMP-9, MMP-2, insulin.

Induction of obesity was associated with a significant increase in TGF-β1, MMP-9 and MMP-2 and insulin resistance (P˂ 0.0001). In contrast, high-intensity interval with high fat diet compared to the high fat diet group causes a significant decrease in the amount of TGF-β1, MMP-9, MMP-2, and insulin resistance (P˂ 0.0001).

In conclusion, our data indicate that High-intensity interval training may weaken the progression of adipose tissue fibrosis and have a preventive effect on the increase in glucose metabolism disorders caused by a high-fat diet.

Physical activity is examined in various aspects, such as the structure of the muscular system. This study investigated the impact of a high-intensity interval training (HIIT) program combined with a high-fat diet on the expression of M1 and M2 macrophages in the gastrocnemius muscle of male Wistar rats.

24 healthy adult male Wistar rats with an average weight of 195±15 grams and age of 6 weeks were randomly divided into 4 groups: control, HIIT, high-fat diet, and HIIT with a high-fat diet. Interventions included 10 weeks of HIIT and a high-fat diet. Subsequently, samples were collected from the gastrocnemius muscle. The levels of M1 and M2 macrophages were measured using Real-Time-PCR. Data analysis was performed using one-way analysis of variance at a significance level of P<0.05.

Significant differences were observed between groups in the expression of M1 (P=0.0004) and M2 (P=0.0023) macrophages. M1 macrophage expression was significantly higher in the high-fat diet group compared to the HIIT group (P=0.0001). M1 macrophage expression was significantly lower in the HIIT with a high-fat diet group compared to the high-fat diet group (P=0.0001), but M2 macrophage expression was significantly higher in the HIIT with a high-fat diet group compared to the high-fat diet group (P=0.0003).

These findings suggest that HIIT can reduce M1 macrophage expression and increase M2 macrophage expression, mitigating the negative effects of a high-fat diet.

Inflammasome complex causes maturation and expansion of caspase-1activity and pro-inflammatory  cytokines including IL-1β. It is also critical for inducing pyroptotic cell death in response to pathogens and endogenous danger signals. Therefore, the present study was conducted to investigate the effect of high-intensity interval training with high-fat food on the regulation of the inflammasome complex in the adipose tissue of male Wistar rats.

In the present experimental study; 24 male Wistar rats (age: six weeks); were divided into four groups: control (C), exercise (HIIT), high-fat diet (HFD), high-fat diet+exercise (HFD+HIIT). Diet and exercise interventions started at the same time and continued for 10 weeks. Weight, BMI, serum lipid profile, and also the expression of NLRP3 and IL-1β in visceral adipose tissue were measured. To determine changes between groups, one-way ANOVA and Tukey's post hoc test were used, and an independent t-test was used to determine the intensity of the effect size using SPSS27 software (P<0.05).

Significant weight reduction (P=0.009), NLRP3 expression (P=0.001), IL-1β (P=0.001), and LDL and cholesterol levels (P=0.001) in the HFD+HIIT group compared to HFD were seen. Also, a significant increase in HDL and HDL/LDL was observed in the HFD+HIIT group compared to the HFD group (P=0.001).

The exercise training protocol is used in the current study as an effective therapeutic strategy for improving metabolic disorders and inflammatory conditions, which leads to the reduction of inflammation. However, more research is needed to determine other cellular mechanisms of inflammation.

Type 2 diabetes is associated with increased inflammation in various tissues, including the heart. Examining the factors related to the increase in inflammation caused by diabetes , and its consequences , can be controlled to some extent through the application of non-invasive therapeutic interventions. The aim of this study was to investigate the effect of high - intensity interval training and L-cysteine consumption on the levels of COX2 and IL-1B in the heart tissue of rats with type 2 diabetes.

In this experimental study, 30 male Wistar rats were divided into five control and experimental groups by simple random sampling. After the induction of diabetes in the experimental and diabetic control groups, the intervention groups of exercise and L-cysteine supplement consumption performed intense intermittent exercise and supplement consumption for eight weeks. To determine the difference between groups, one-way analysis of variance and LSD post hoc test were used.

The results of this study showed that the implementation of intense interval training resulted in a significant decrease in IL-1B level (p=0.001) and the use of L-cysteine supplement led to a non-significant decrease (p=0.087). In contrast, intense interval training caused a non-significant increase (p=0.14) in Cox2 levels compared to the diabetic control group in the heart tissue of rats. It seems that the decreasing changes in Cox2 levels in the L-cysteine supplement group worsened the diabetic inflammation conditions.

Performing HIIT for eight weeks led to significant changes in the levels of IL-1B in the heart tissue of rats. Also, single and combined L-cysteine supplementation with this type of exercise did not cause obvious changes in IL-1B and COX-2 levels. One of the main limitations of this study was the lack of simultaneous sampling in all samples.

Exercise programs can lead to different physiological adaptations, but the effects of low-volume, low-frequency HIIT protocols with varying interval structures have not been thoroughly investigated. This study aimed to explore the impact of HIIT with high compression (HC) and low compression (LC), with or without berberine (BBR) supplementation, on hematological parameters in pre-diabetic men.

This semi-experimental study was conducted between October and December 2021 at Mazandaran University. Fifty-four overweight/obese men with a mean age of 48.6±6.6 years, a body mass index of 30.7±7.3 kg/m², and a body fat percentage of 34.4±4.3% were randomly and equally divided into one of six groups: HC, LC, HC+BBR, LC+BBR, BBR, and control. The HC group (2:1 work-to-rest ratio) and LC group (1:1 work-to-rest ratio) underwent training programs comprising 2-4 sets of 8 exercises at an intensity of 80-95% of their maximum heart rate twice a week for 8 weeks. Hematological responses to Bruce's incremental exercise test were measured before and after the intervention. Data were analyzed using a two-way ANOVA with Bonferroni's post hoc test, with a significance level set at P<0.05.

Baseline hematological indices showed no significant differences between pre-diabetic and non-diabetic groups (all, P>0.05). Following the 8-week intervention, there were significant decreases in white blood cells (WBCs) in the LC and LC+BBR groups, and in lymphocytes across all intervention groups except BBR (all, P<0.05). Additionally, hemoglobin and hematocrit levels showed significant reductions in the HC and HC+BBR groups (both, P<0.05). However, in response to Bruce's incremental exercise test, a significant decrease in WBCs was observed in the LC and LC+BBR groups, with reductions of 18% and 25%, respectively (both, P<0.05).

The LC protocol, even without berberine supplementation, seems to provide better immunological benefits and result in less hemolysis compared to the HC protocol, as evidenced by reductions in white blood cell counts.

Obesity is an obstacle to health and the cause of many diseases; physical activity can improve these conditions to some extent. The present study aimed to investigate the effect of obesity and subsequent training on the factors involved in the browning of adipose tissue in male rats.

30 healthy male Wistar rats were fed high-fat diet and six (ND) were fed normal diet for eight weeks. After eight weeks, six mice fed high fat diet (HFD) and six mice fed normal diet (ND) were sacrificed . 24 obese mice were divided into four groups of six including obese control group (OC), resistance training group (RT), endurance training group (ET), and high intensity interval training (HIIT) group.  They practiced five sessions per week for eight weeks. Real Time-PCR method was used to measure irisin, UCP-1 and BAIBA gene expression. The statistical method of one-way analysis of variance (ANOVA) and Tukey's post hoc test was used to determine the difference between groups at a significance level of p≤0.05.

The results showed that obesity caused a significant decrease in the expression of irisin, UCP-1 and BAIBA genes in the adipose tissue of male rats (p<0.05) and subsequently resistance, endurance and intense interval training caused a significant increase in the expression of the mentioned genes compared to the control group became obese (p<0.05). Also, a significant increase in the expression of irisin and UCP-1 genes was observed in the intense interval training group compared to the resistance training and endurance training groups (p<0.05).

According to the results of the present study, it can be stated that obesity prevents the development of brown adipose tissue and its use in the treatment of metabolic diseases by reducing non-vibrational heat generation in adipose tissue. While various resistance, endurance and intense periodic exercises. as an effective method in increasing brown fat tissue and with a positive effect on the intracellular factors that increase lipolysis, can be considered as useful exercises in the field of fat reduction and as a result, health promotion

Inactivity and sedentary are of the most important health problems that can affect serum proteins. The present research was conducted with aim to investigate the effect of eight weeks of high-intensity interval training (HIIT) along with the consumption of thyme suplementation on the serum levels of adropin and Tumour Necrosis Factor alpha (TNF-α) in sedentary young girls.

In this quasi-experimental study conducted in 2023, 48 sedentary young girls with mean age of 20.00±1.61 years were randomly divided into four groups: HIIT, thyme, HIIT+thyme and control. Venous blood was taken in the pre-test and post-test stages. Serum levels of adropin and TNF-α were analyzed using specific ELISA kits. The data was analyzed by SPSS statistical software (version 22) using ANOVA and paired t tests. P<0.05 was considered statistically significant.

There was no significant difference between the studied groups in the serum level of adropin before the test (P=0.501) and after the test (P=0.732), and the changes in adropin were not significant in the studied groups (P>0.05). A significant decrease in TNF-α values was observed in the thyme (P=0.001) and HIIT + thyme groups (P=0.014) after the interventions, while a significant increase in TNF-α values was observed in the HIIT group (P=0.007).

Performing HIIT exercises increases TNF-α levels and consuming thyme supplements decreases it and in cases where they are used at the same time, the effect of thyme is still stronger. Adropin levels were not affected by exercise or thyme supplementation.

In the last decade, vitamin D has attracted more attention as a non-enzymatic antioxidant compound. The aim of this study was to survey of changes in BDNF and malondialdehyde (MDA) levels after a period of high intensity interval resistance training (HIIRT) and vitamin D intake in inactive overweight women women.

The subjects were first selected by the available sampling method, then they were randomly divided into four groups: control, interval exercise, vitamin D, and combined. HIIRT was performed in three sets at intensity with 80% one maximum repetition and 2.5 minutes rest between sets. Vitamin D and combined groups consumed vitamin D (50000 units) once a week. BDNF and MDA levels were measured before and after the interventions.

The findings showed that the MDA levels in the interval exercise, vitamin D and combined groups decreased after 8 weeks and BDNF levels increased significantly. But the combined intervention had a stronger effect on the change of MDA and BDNF levels compared to the other two interventions (p<0.05). In addition, no significant difference was observed between the changes in the levels of interval exercise and vitamin D (P<0.05).

It seems that HIIRT and vitamin D consumption can exert their protective effects in overweight people with abnormal levels of vitamin D, by reducing MDA levels and up-regulation of BDNF protein. But these effects were further developed with combined intervention.

The prevalence of obesity and overweight in adults is increasing, so high-intensity interval training (HIIT) and carbohydrate-restricted diet (CRD) may be an effective intervention to improve body composition and maximal oxygen consumption. Therefore, the aim of this study is to investigate the combined effect of high-intensity interval training and carbohydrate-restricted diet on body composition and aerobic fitness in normal weight, overweight, and obese adults.

A comprehensive search was conducted in the information databases of PubMed, Web of Science, SID, Magiran, and Google Scholar for articles published up to January 2023. A meta-analysis was conducted to investigate the combined effect of HIIT and CRD on body composition in adults. Standardized mean difference (SMD) or weighted mean difference (WMD) and 95% confidence interval were calculated using random effect model.

The results of 13 studies with 173 subjects showed that HIIT and low-carbohydrate diet caused a significant decrease in body weight [-4.23, P=0.001], BMI [-1.14, P=0.001], body fat percentage [-3.18, P=0.001], fat mass [-2.94, P=0.001] becomes obese in normal weight, overweight, and obese adults. But these two interventions do not change the muscle mass [-0.1, P=0.8].

Using a low-carbohydrate diet along with HIIT can lead to weight loss and body composition improvement in normal weight, overweight and obese adults. Also, these two interventions simultaneously can exert optimal effects on aerobic performance.