جستجوی مقالات مرتبط با کلیدواژه « اسید اوریک » در نشریات گروه « پزشکی »

Use of medicinal plants is considered as a safe and effective alternative treatment for hyperglycemia. In addition to the positive effects of exercise on diabetic patients. This study aimed to investigate the effects of Urtica Dioica (UD) and Swimming activity on the kidney Properties in diabetic rats

Materials: 

Adult male rats were randomly distributed in nine groups: intact control, diabetic control,diabetic + 625 mg/kg, 1.25 g/kg UD, diabetic + 100 mg/kg Metformin, diabetic + swimming, diabetic + swimming 625 mg/kg, 1.25 g/kg UD, and diabetic +100 mg/kg Metformin + swimming. Aqueous extract of  Urtica Dioica was given to rats by gavage for 4 weeks. Swim training protocol was performed for 4 weeks, 5 days per week. Blood bilirubin, albumin, creatinine and uric acid were determined. Renal tissue changes were examined in different experimental groups.

Bilirubin levels in metformin group, diabetes with swim training group, swim training with metformin group, UD extract at a dose of 1.25 g/kg group, UD extract at a dose of 625 mg/kg  group, UD extract at a dose of 1.25 g/kg with swim training group, UD extract at a dose of 625 mg/kg with swim training with diabetic control group showed a significant increase (p<0.05). Albumin, creatinine and uric acid levels compared to diabetic control group were not significantly different.

The present results show that swimming training with Urtica Dioica extract has beneficial effects on renal tissue changes in diabetic rats and these effects are dose dependent.

The present study aimed to assess the association between stone chemical compositions and Percutaneous Nephrolithotomy (PCNL) outcomes (stone-free result, operative time).

In this analytical cross-sectional study, the data of 113 patients who underwent PCNL, including stone chemical composition, stone-free result, and operative time, were recorded and analyzed.

In univariate analysis, no significant differences were observed between the group with the stone-free result and the group without stone-free result in mean percentages of calcium phosphate, calcium oxalate, uric acid, and the frequency of infectious stones time (P>0.05). Moreover, operative time was not significantly correlated with the percentages of calcium phosphate, calcium oxalate, and uric acid components (P>0.05). In addition, no significant difference was detected between the two groups (with and without infectious stones) in terms of mean operative time (47.00±17.38 vs. 45.99±20.98; P=0.817). In multivariate regression analysis, none of calcium phosphate, calcium oxalate, uric acid, and infectious stone were the predictive factors affecting stone-free result and operative time.

As evidenced by the obtained results, the compositions of upper urinary tract stones had no effect on the stone-free result and operative time in PCNL.

 Glucagon-like peptide 1 (GLP-1) has anti-diabetic, antioxidant and anti-inflammatory properties that change under different conditions. This peptide is known as a therapeutic target in diabetes and obesity. The aim of this study was to investigate the relationship between GLP-1 and oxidative stress in preterm infants.

In this case-control study, 40 term and preterm infants (gestational age less than 37 weeks) were used. GLP-1 concentration was measured by ELISA. Total antioxidant capacity (TAC), total oxidant status (TOS) and uric acid concentration were measured.

Serum GLP-1 level in preterm infants was significantly higher than term infants (p=0.003). Serum TAC level in preterm infants (973.16±235.53) was significantly lower than term infants (837.00±218.97) (p=0.006). Serum TOS level in preterm infants (65.46±33.52) was significantly higher than term infants (31.50±14.62) (p<0.001). Uric acid levels in preterm infants (5.83±1.73) were statistically higher than term infants (5.13±0.90) (p=0.02). Serum GLP-1 level in preterm infants was negatively and significantly correlated with TAC (p<0.001, r=-0.674) and positively and significantly correlated with TOS (p<0.001, r=0.754) and uric acid (p<0.001, r=0.633).

The results showed that the levels of GLP-1, TOS and uric acid in preterm infants were higher than term infants and GLP-1 had a negative correlation with TAC capacity and a positive correlation with TOS and uric acid in these infants.

 Obesity is one of the greatest health challenges in the world and can lead to kidney disease. The aim of this study was to investigate the effect of aerobic exercise with and without Bunium persicum (Boiss.) consumption on kidney function and the number of trace elements in the blood sample in obese menopausal women.

In this experimental study, 29 obese menopausal women were randomly divided into 3 groups: exercise, supplement, and exercise+supplement with the mean body mass index of 28.3±3.2, 30.4±4.14, and 31.67±4.93 kg/m2, respectively. Eight weeks of exercise was performed in three 45-min sessions per week at 65-75% of the maximum heart rate. The supplement group received two meals of B. persicum for 8 weeks. Before and after the intervention, creatinine, urea, uric acid, iron, zinc, sodium, and magnesium were measured. Data were analyzed by SPSS at the significance level of P≤0.05.

 The results showed that none of the renal function factors in the groups changed significantly. Intra-group changes in zinc significantly increased in the exercise and exercise + supplementation groups (P=0.041 and P=0.010, respectively). Intra-group changes in iron showed a significant decrease and increase in the exercise and supplement groups, respectively (P=0.001 and P=0.001, respectively). The inter-group variation of the iron was also significant (P=0.001).

 Eight weeks of aerobic exercises in water alone and in combination with B. persicum consumption did not affect renal function in obese and menopausal women, while aerobic exercise in water and B. persicum consumption alone led to some changes in trace elements.

The purpose of this study was to compare the serum levels of vitamin D and uric acid and insulin resistance in obese subject with and whithout metabolic syndrom in Ahvaz.

In this study 86 obese (BMI>30) who were referred to Diabetes clinic evaluated. They divided in two case (obese subjects with metabolic syndrome) and control groups (obese without any signs of metabolic syndrome). Data were analyzed by SPSS software version 22.

Thirty one (54.3%) in obese subject had metabolic syndrome and 14 (48.2%) had vitamin D deficiency. There was no significant difference in serum levels of vitamin D among obese and non-metabolic syndromes (P>0.05). The insulin resistance in obese people with metabolic syndrome was significantly higher than obese people without metabolic syndrome (P <0.05). There is no significant difference between diabetes status in obese and non-obese subjects with metabolic syndrome (P>0.05). The serum level of insulin in obese people with metabolic syndrome was significantly higher than obese people without metabolic syndrome (P<0.05). There was no significant difference in serum vitamin D and uric acid in obese and non-metabolic syndrome with insulin resistance (P>0.05). There was no significant difference between serum vitamin D levels and uric acid in obese and non-insulin dependent metabolic syndrome (P <0.05). There was no significant correlation between serum uric acid and insulin resistance in obese and non-diabetic obese subjects (P>0.05).

Insulin resistance in obese subjects with metabolic syndrome appears to be more common in obese than non-obese subjects.

Exercise intervention is associated with improvement of renal function indices. This effect is not exclusive to renal patients as it also improves the functioning of the kidneys in healthy people, especially athletes. The purpose of this study was to investigate the effect of 12-week pleomometric training program on creatinine and uric acid in young male bodybuilders who consumed whey protein. This quasi-experimental study was carried out using a pre-test and post-test design. The research population consisted of young male bodybuilders living in Tehran, who regularly consumed protein in their exercises. The research sample included 22 bodybuilders who were randomly selected and divided into two experimental and control groups each with eleven members. The collected data were analyzed using the independent and paired samples t-test at the significance level of p≤0.05. In the experimental group, the plyometric intervention led to a significant decrease in creatinine. The post-test results showed that creatinine level in the experimental group was significantly lower compared to the control group (p<0.001). A comparison of the pre- and post-test results did not show a significant difference in uric acid due to the plyometric intervention in the experimental group. Besides, the post-test results showed no significant difference between experimental and control groups in terms of uric acid (p= 0.976). The plyometric exercises decreased creatinine and improved the kidney function in bodybuilders who used abnormal levels of protein supplements. According to the findings, it can be suggested that athletes who take high doses of protein supplements during plyometric exercises are less exposed to kidney damage.

Obesity in patients is followed by decreased kidney function and leads to renal damage in healthy people. The aim of this study was to investigate the effect of aerobic exercise with and without green tea consumption on kidney function in sedentary postmenopausal women. Out of 60 volunteers, 29 sedentary postmenopausal women with a body mass index higher than 25 kg/m2 were randomly divided into three groups, exercise, supplement and exercise+supplement. Aerobic exercise program was performed for 8 weeks, 3 sessions per week and each session for 45 minutes at 65-75 % of maximum heart rate. Supplement groups consumed 6 g of green tea powder in 600 ml of almost boiling water (80 °) daily and one hour before their meals for 8 weeks. Combined group performed exercise and consumed supplement, simultaneously. In supplement group, creatinine levels (p=0. 048) decreased significantly; While none of the variables in exercise group (uric acid (p=0. 432), urea (p=0. 681) and creatinine (p=1) ) and exercise+supplement group (uric acid (p=0. 597), urea (p=0. 270) and creatinine (p=0. 235) ) had no significant change. Between groups changes in any of the variables was not significant too. Eight weeks of aerobic exercises in water alone and in combination with green tea consumption did not improve renal function in obese and overweight postmenopausal women, while green tea consumption alone decreased serum creatinine and improved renal function.

Aloe Vera gel, with strong antioxidant properties, is used in the treatment of many renal disorders. This study aimed to evaluate the effect of Aloe Vera gel (JA) on urea, uric acid and creatinine levels of serum, and tissue structure of kidneys of rats diagnosed with MS through Ethidium Bromide (EB). This experimental study was performed on 48 female rats, which were divided into 6 groups of 8 samples, including control, sham (intraventricular treatment with saline), experimental treated with 14 μl of EB solution to the lateral ventricles with normal saline as a Gavage and receivers of 300, 600 and 1200 mg/ kg alcoholic extracts )JA(, as gavage with EB intraventricular meditation. In this study, prescriptions were taken for 35 days. In the end, after blood sampling from animal’s heart, some amount of urea, uric acid, and creatinine are extracted, and with providing different cross- sections, the tissue structure of their kidneys was studied based on histologic measurements. Finally, the data were analyzed using SPSS software (Version 20) using ANOVA and Duncan tests at the level of P <0.05. The results showed that EB increased serum urea, uric acid, and creatinine levels, decreased the diameter of the medulla, glomerulus, renal corpuscle sections, and increased the diameter of the near and further curved tubes at the level of P≤0.05. Furthermore, the treatment with high-dose JA significantly reduced the serum urea, uric acid and creatinine levels, increased the diameter of medulla sections, glomerulus, renal corpuscle, and reduced the near and further curved tubes alone in comparison with the EB group at P≤0.05. Aloe Vera gel, in dose-dependent forms, can reduce urea, uric acid, creatinine, and tissue modification of kidneys in animals with MS

There are low and conflicting data about the relationships between homocysteine, adiponectin/ homocysteine ratio and uric acid with insulin resistance indexes in gestational diabetes mellitus (GDM). Therefore, this study was performed with aim to evaluate serum values of homocysteine, adiponectin, adiponectin/ homocysteine ratio and uric acid and their relationships with insulin resistance index in GDM compared with normal pregnancy.
This cross-sectional study was performed on 30 women with GDM and 30 normal pregnant women referred to Asalian hospital of Khorramabad during 2013-2014. Serum levels of glucose and uric acid were measured by photometric method and serum levels of homocysteine, adiponectin and insulin were measured by ELISA method. Data was analyzed by independent t-test and Pearson’s correlation analysis. P
Serum levels of homocysteine were significantly increased in GDM compared with normal pregnant women (P Increased serum values of homocysteine and decreased values of adiponectin/ homocysteine ratio and lightly increased levels of uric acid could be considered as risk factors for insulin resistance in GDM.

Smoking is a harmful habit and saliva is the first fluid that is exposed to cigarette smoke as a source of oxidant and peroxidant agent. Salivary antioxidant system plays an important role in its anti-cancer potential. Uric acid has a role as antioxidant in the body and could increase plasma antioxidant capacity and has a specific role as inhibitor on radicals and peroxidant agent. Therefore, the aim of this study was to evaluate indicators of oxidative stress or malondialdehyde (MDA) as an important parameter of lipid peroxidation and total antioxidants capacity in smokers and non-smoking persons.
In this case-control study which was conducted in clinical biochemistry labratory, Mazandaran University of Medical Sciences on Spring 2016. The sample on salivary fluids was collected by spitting method in tubs from 50 smokers (cases group) and nonsmokers (controls group) after all night fasting. As soon as saliva was collected, at the first step total whole salivary fluids were centrifuged and the superior parts were transferred in a tub and stored at -80 ℃ until analyzed. Total antioxidant capacity (TCA) of their saliva was evaluated by Ferric reducing ability of plasma (FRAP) method, lipid peroxidation parameter (MDA) with thiobarbituric acid (TBARS) and uric acid by calorimetry (uricase) methods. The data were analyzed via SPSS software and independent t-test was used to compare the two groups.
Indicators of oxidative stress, in the case group was 1.17±0.29 nmol/ml significantly higher than compared to control group with 0.91±0.16 nmol/ml. TCA in the case group was 220.66±39.68 μmol/l compared to control group 272.26±40.64 μmol/l was significantly lower (P The result of this study indicates that smoking can reduce total antioxidant capacity and increase lipid peroxidation parameters. In addition, duration of cigarette using has destructive effects on body that it can lead to several diseases. The important thing is to keep trying to quit smoking. For smokers who are willing to quit, it would be recommend that smokers be managed with a combination of behavioral support and pharmacologic therapy.

Recently the neuroprotective role of uric acid (UA), as a natural biochemical substance, in neurodegenerative diseases has been proposed. Due to the critical role of apoptosis in many diseases of the nervous system, the present study was designed to investigate the anti-apoptotic effect of UA on motor neurons of the ventral spinal horn in neonate rats.
Two-day-old rat neonates (n=10) were subdivided into experimental and control groups. In both groups, right sciatic nerve was transected. Experimental neonates were immediately treated with 10mg/kg UA intraperitoneally, while the control’s wound was closed without treatment. Five days after axotomy, transverse sections of spinal cord at L5 level were prepared for morphometric cell count and TUNNEL assay.
The motor neuron loss in axotomized side compared to intact side was 30.48%, which illustrates the effectiveness of axotomy in inducing motoneuron cell death. The TUNNEL assay confirmed the apoptotic characteristics of cell death. Comparing the mean motoneurons loss in the axotomized side of the control and UA-treated neonates, revealed a significant difference between the two groups (p Neuroprotective effect of UA is possibly through inhibiting the apoptotic cell death, which occurred with the axotomized motoneurons in ventral spinal horn.

Background & Ma-al-Shaeerisanon-alcoholicbeer which usually consumed in the younger generation in Islamic countries. It is regarded as having antioxidant compounds and in additiontohavingthe desirable organoleptic properties. Therefore, thisstudy designed to determine the effect of non- alcoholic beer (Ma-al-Shaeer) intake on the total antioxidant capacity (TAC) levelsinyoung people.
Material & In an interventional study,50 students including; 25 girls and 25 boys were selectedas simple random. Then,4ml ofblood was takenfroman individual before and after consumption of 240 millitr Ma-al-Shaeer respectively .After separating the serum, total antioxidant levels was measured by Ferric Reducing Antioxidant Power (FRAP) method. Thespectrophotometric method was used for measuring the level sof uric acid and total thiols (Hu's method). Statistical analysis was done by software SPSS, version 17. It was used for determination mean, standard deviation, number and percent and also one-way ANOVA test for comparison of variables. P The mean age of samples 20±1.2 year. It was observed significant differenceinmean of total antioxidant level in subjectsbefore and after intervention (1312.3±301 μ mol /lvs.1374.4±345 μ mol/l) (P= 0.0001). But, there was no significant differenceinserumuricacidlevels of subjects. It was observed significant difference between mean serum levels of totalthiols of subjects in before and after intervention (0.42 ± 0.22 mg/ dl vs. 0.59 ± 0.18 mg/dl) (P= 0.0001). There was a significantpositive correlation between consumption of total antioxidant level and totalthiol of subjects in before(r=1, P Results showed thatnon-alcoholic drink Ma-al-Shaeer dramatically increased serum TAC and protein thiols in subjects. According to effect of antioxidant in health, it seems increase of antioxidant power in Ma-al-Shaeer can be analyzed which requires to more extensive investigation.

It has been proposed that uric acid (UA) and FetuinA (FA) are independent risk factor for the development of cardiovascular disease (CAD). UA is the end-product of purine metabolism and is considered an endogenous antioxidant. FA is a protein secreted by the liver; acting as an inhibitor of coronary artery calcification. The aim of the present investigation was to survey the association between severity of CAD and sera UA or FA. Subjects (n=83) undergoing coronary angiography were enrolled. According to angiographic results, the subjects were divided into: Control (CTL; n=21; age 55±8.9 years), one vessel obstruction (1VD; n=20; 57±10.1 years) and multi-vessel obstruction (Multi VD; n=42; 65.4±9.7 years). FA level were determined by ELISA. Clinical biochemical parameters were assayed by routine laboratory methods. Statistical analyses were performed using SPSS package (version 22). Serum UA levels in multi VD and 1VD were higher than that of CTL group (P=0.05). FA levels slightly declined with the severity of CAD (P=0.23). Multi-regression analysis revealed that age, BMI, HDL-C, glucose and Hb were associated with the severity of CAD. It was also found that UA is independent for the prevalence of CAD. Considering the small sampling size, this study demonstrates that increasing UA levels is associated with the severity of CAD and is an independent risk factor for the occurrence of CAD. Regarding the impact of FA on the severity of CAD, further studies with larger sample size and the implementation of a scoring system for degree of artery calcification are deemed necessary.

Metabolic syndromes are known as a set of risk factors for the development of cardio-vascular disease and diabetes in the individual. The association between concentration of uric acid and metabolic syndrome in adolescents has yet to be established thoroughly. The aim of this study was to investigate the relationship between uric acid and metabolic syndrome in a sample of adolescents. This cross-sectional study was conducted from September 23, 2009 to September 22, 2010 in Jundishapur University of Medical Sciences, Ahvaz, Iran. In this study, 240 individuals aged 10-19 years were randomly selected among participants of the Ahvaz MetS study (120 subjects normal and 120 subjects MetS). The serum levels of UA were measured by a colorimetric method. In the normal group, anyone with abdominal obesity, high systolic or diastolic blood pressure, High-density lipoprotein (HDL)≤40 mg/dl, TG≤110 mg/dl, fasting blood sugar (FBS)≤100 mg/dl or diabetes was excluded from the study. History of Anticonvulsive drugs or steroids use was the criteria for exclusion for both groups. Of the 240 subjects aged a mean of 14.95±2.64 years, mean of uric acid in metabolic syndrome group was 4.8±1.4 mg/dl and in the control group was 4.18±1.01 mg/d (P=0.001). Participants were divided into three groups based on uric acid levels: ≤4.9 mg/dl, 4.9-5.7 mg/dl and >5.7 mg/dl. The risk of metabolic syndrome was significantly higher in third group of uric acid than the second and first group (odds ratio [OR], 3.7; 95% confidence interval [CI], 1.70 - 8.04) and (OR, 5.9; 95% CI, 2.42-14.35, P<0.001). In addition, uric acid level was inversely associated with hyperglycemia. The ORs of hypertriglyceridemia for the second and third group of uric acid were 4.36 (95% CI, 2.01- 9.47) 5.75 (95% CI, 2.43-13.61) respectively, compared with lowest group of UA. The results showed that hyperuricemia was significantly linked with increased risk for hypertriglyceridemia, low high-density lipoprotein cholesterol level, high blood pressure and waist circumference. Among Ahvaz adolescents, serum concentrations of uric acid strongly associated with the prevalence of metabolic syndrome and several of its components.

The neuroprotective effect of uric acid as a natural antioxidant on neurodegenerative diseases has been proposed repeatedly, but its antiapoptotic effect on spinal neurons has not been examined yet. Due to the critical role of sensory neurons in the improvement of functional outcome in neuroprotective strategies, the antiapoptotic effect of uric acid on dorsal root ganglions was investigated. In this study, 10 two-day-old neonate rats were subdivided into experimental and control groups. In both groups right sciatic nerve was transected. In the experimental group immediately following surgery 10mg/kg uric acid and in control group the same volume of normal saline was injected intraperitoneally. Five days following axotomy, bilateral L5 dorsal root ganglia in both groups were prepared for morphometric cell counting and TUNEL assay. In the control group, in axotomized side compared to intact side, 37.41% of the sensory neurons were lost, indicating the efficiency of axotomy model in the induction of cell death in sensory neurons. The results of TUNEL assay approved the apoptotic type of neural cell death. Comparison of the control and experimental groups indicated that intraperitoneal injection of uric acid could not inhibit apoptosis of dorsal root ganglion sensory neurons. This study illustrated that uric acid has not any significant neuroprotective effect on axotomized sensory neurons of dorsal root ganglia.

The role of physical activities in control and improvement of type II diabetes has always been considered. However, the effect of physical activity on diabetic patients’ renal function has been less taken into account. Therefore, the present research aimed to evaluate the effect of a ten-week resistance training program on some selected biochemical factors of renal function in patients with type II diabetes.
In this study, 21 patients between 40 and 60 years old who suffered from type II diabetes were randomly assigned to an intervention (N=11) and a control (N=10) group. The intervention included a progressive resistance training program which involved 6 exercises using weight machines performed twice or thrice a week for 10 weeks. The participants completed 3 sets of 12 repetitions of each exercise and discontinued exercising in case they got tired. The intervention was performed in a special stadium. The control group continued their usual activities. For measuring Glomerular Filtration Rate (GFR) and Urea (BUN), Creatinin (Cr), and Uric Acid (UAc) serum levels, blood samples were obtained from the subjects at the beginning and end of the 10 weeks. Then, the data were analyzed using the SPSS statistical software.
Exercise program resulted in a significant decrease in the intervention group’s GFR (P=0.003) and BUN (P=0.05) and Cr (P=0.001) serum levels. However, no significant changes were found in UAc concentration. The above-mentioned factors showed no significant changes in the control group.
The findings of this research suggested that the 10-week progressive resistance training led to a significant improvement in GFR and BUN and Cr serum levels. Therefore, this method can be effective in improvement of the subjects’ renal function.

Background and The traditioal Phlebotomy is one of the therapies method of traditional medicine to bring back and regenerative balance in the organism. however our resources in the field of traditional Phlebotomy are rich but, our knowledge about the involved Mechanisms in this field, despite of the science progress in different areas are very low and in previous conducted studies, different opinions about the effectiveness of this method on the treatment of Diseases were expressed that with determining the mechanism of traditional medicine,Can be presented with more stronger motivation to the medical community. The aim of the present study was to compare the amount of hemoglobin, Hematocrit and uric acid in the venous blood and obtained bloodfrom the traditional Phlebotomy and evaluation existing differences. The present study is interventional and type of one factorial intra-case which the Research Center of Phlebotomy was conducted on 111 reffered patients. sampling method in this study is, simple random that after obtaining written consent and the general examination, in case of no exclusion criteria attempt to get the venous blood and Phlebotomy and the experiments have been done by one person with one type of kit. After collecting the information, data were analyzed, by using of statistical T-test and spss software. The mean of hemoglobin, hematocrit and uric acid in venous blood were respectively (15.74 ± 1.6 mg/dl), (47.40 ± 3.74) percent (6.35 ± 1.65 mg/dl) and in the blood of phlebotomy (18.76 ± 1.7 mg/dl) (56.6 ± 6.68) percent (6.90 ± 1.34 mg/dl) which these differencies were statistically significant (p< 0.001). Due to higher amounts of hemoglobin, hematocrit and uric acid in the obtained blood From phlebotomy is recommended the use of phlebotomy be more considered in Polycythemia and hyperuricemia therapy.

Several studies have indicated that serum uric acid increases in patients with pre-diabetes and the early of type 2 diabetes mellitus. As diabetes continues and blood sugar goes uncontrolled، the level of serum uric acid drops again. This study aimed to determine the relationship between serum uric acid and blood sugar levels in the elderly، diabetic patients of Amirkola city. This cross-sectional study was a part of Amirkola Health and Ageing Project (AHAP). Blood samples were obtained from all the patients in order to measure the Fasting Blood Sugar (FBS) and blood uric acid levels. Afterwards، the relationship between the serum uric acid and Blood Glucose was evaluated. Of the 1525 older people aged 60 and over، 351 (23%) were known to have type 2 diabetes and 116 people was diagnosed as diabetes mellitus based on the measurements of FBS. Data analysis revealed an inverse relationship between FBS and serum uric acid level (p=0. 012، r=-0. 054) and age (p=0. 001، r=-0. 090) whereas there was a direct relationship between FBS and Body Mass Index (BMI) (p=0. 001، r=0. 115). According to the findings of this study، FBSis inversely correlated with the serum uric acid and age whereas there is a direct correlation between BMI and FBS.

Systemic lupus erythematosus is a common rheumatologic disease. Systemic Lupus Erythematosus disease activity index (SLEDAI) is a valuable and reliable scoring for lupus activity. Always clinical and paraclinical findings in SLEDAI don’t answer with disease progression, and also some factors including ESR, CRP, Anti-dsDNA and complements may be increased in non-active disease. Therefore, we decided to assess serum uric acid level as an index of disease activity. This cross- sectional study was carried out on lupus patients that referred to the rheumatology clinic of Imam Reza hospital in Mashhad. Serum uric acid level, Anti-dsDNA, ESR, C3 and C4 were measured with standard methods and SLEDAI determined for all patients. Pearson’s correlation coefficient ranking was used to evaluate the relation of serum uric acid level with SLEDAI and Anti-dsDNA. In this study, 82 patients (76 females and 6 males) with an average age of 32.02 ± 9.29years and mean disease duration of 4.49± 4.68 years were studied. Serum uric acid levels correlated directly and significantly with SLEDAI (P=0.001, r=0.35), Anti-dsDNA(P=0.0001, r=0.54), and Serum uric acid levels had indirect and significant correlation with C3 (P=0.04, r=-0.22), and C4 levels (P=0.02, r=-0.25). Our study demonstrated that high serum uric acid levels were correlated with lupus disease activity. Nevertheless, application of serum uric acid level, as an index of lupus disease activity, needed more studies.

There is accumulation evidence regarding the protective role of higher serum uric acid in bone loss and osteoprotic fractures. This effect may arise from its antioxidant properties. The main aim of this study was to investigate serum uric acid in relation to bone turnover markers in postmenopausal women. A total of 382 postmenopausal women who participated in a prospective study were selected randomly from Bushehr port. Serum uric acid levels and biochemical markers including serum alkaline phosphatase were measured. Circulating levels of CrossLaps, osteocalcin and hsCRP were also measured by ELISA. Uric acid levels had significant correlation with osteocalcin & alkaline phosphatase. However, no correlation could be found between uric acid and CrossLaps. The correlation between uric acid & osteocalcin (r= 0.25, P=0.0001) & alkaline phosphatase(r=0.12, P=0.019) remained after adjustment with age, BMI & hsCRP. Serum uric acid had a positive and significant correlation with osteoblastic born turnover markers. Hence, the role of uric acid in osteoblastic function should be investigated.