جستجوی مقالات مرتبط با کلیدواژه « هورمون آنتی مولرین » در نشریات گروه « پزشکی »

Assisted reproductive technologies (ART), including in vitro fertilization (IVF) and embryo transfer, have achieved considerable success, largely due to controlled ovarian hyperstimulation (COH). However, there remains a shortage of studies on the estimation of various ovarian response markers linked to the GnRH agonist-controlled ovarian stimulation (COS) regimen. The objective of the current study is to assess the productiveness of Follicle Stimulating Hormone (FSH) and Anti-Mullerian Hormone (AMH) in determining ovarian responses in infertile patients undergoing controlled ovarian stimulation.

This cohort study involved 90 females, aged 20 to 43 years, with primary and secondary infertility lasting between 3 and 13 years, attending the Al-Najef fertility center for ICSI cycles between June 2020 and January 2021. Patients with a history of ovarian surgery, polycystic ovary syndrome (PCOS), and premature ovarian failure (POF) were excluded. FSH and AMH levels were calculated on second 2 of the menstrual cycle, and the association between these indicators and outcome factors was evaluated.

AMH demonstrated a negative link with age and a positive link with the antral follicle count, total number of follicles after induction, and retrieved oocyte count (p<0.05). FSH exhibited a significant negative link by the total number of follicles after induction (p<0.05). AMH demonstrated the best sensitivity and specificity, positive predictive value (PPV) and negative predictive value (NPV) for predicting ovarian response. Specificity, sensitivity, PPV and NPV for AMH with cut-off values >2 ng/mL test providing 84%, 80%, 86%, 57% in comparison to FSH with cut-off values >4 IU/mL yielded 67%, 68%, 50% and 54%, respectively.

In conclusion, our findings suggest that AMH is a superior predictor of ovarian response compared to FSH.

Anti-Mullerian Hormone (AMH) is related to woman's age, the number of antral follicles, and the outcome of assisted reproductive techniques. The present study was performed with aim to evaluate the relationship between anti-mullerian hormone levels and ovarian response and pregnancy outcomes in infertile women undergoing assisted reproductive techniques (ART) and IUI.

This cross-sectional (descriptive-analytical) study was performed on 186 infertile women undergoing ART referred to Besat Hospital Infertility Center, Sanandaj, Iran during 2016-2020. Demographic information, FSH level, AMH level, number of gonadotropin injections, number of antral follicles and number of fetuses were evaluated and recorded in the questionnaire.. Also, pregnancy outcomes including abortion, fetal death, fetal malformation and birth were determined and recorded in the questionnaire. Data were analyzed by SPSS software (version 22) and chi-square, Fisher exact, one-way analysis of variance and Pearson correlation. P<0.05 was considered statistically significant.

The mean of anti-mullerian hormone level was 4.0±3.0 (range of 0.1 to 12 ng / ml) and the mean of FSH level was 6.1±2.5 (range of 0.6 to 12.7 IUI / L). There was a significant relationship between anti-mullerian hormone level with the number of ovarian follicles, number of injected HMG, number of eggs retrieved, total number of embryos (P <0.05). There was no significant relationship between anti-mullerian hormone levels with abortion, fetal death, live birth and neonatal malformations (P >0.05).

Determination of AMH levels can help for administration of gonadotropins, prediction of antral follicle numbers, number of eggs retrieved and number of embryos obtained, but Anti-mullerian hormone levels are not associated with pregnancy outcomes.

The serum level of Anti Müllerian hormone (AMH) is a powerful test for predicting ovarian response that reflects not only the size of the primary follicle but also the quality of the oocytes. This study was conducted aimed to determine the relationship between serum AMH levels and the quality of oocytes obtained from IVF cycles in patients using IVF in Zahedan infertility center.

This descriptive-analytical study was performed in 2017-2018 on 108 infertile women who were candidates for IVF in Zahedan. Patients were selected by census and entered the study. Patients' files were extracted and the necessary information such as age, oocytes quality and serum AMH levels were extracted and recorded in the patient's information form. Data were analyzed by SPSS software (version 19) and Chi-Square test and ANOVA. P< 0.05 was considered statistically significant.

The mean serum AMH level of patients was 3.81 ± 3.26 ng/ml. 87 patients (80.6%) had oocyte quality (A), 80 patients (74.1%) had B quality, 34 patients (31.5%) had C quality and one patient (0.9%) had D quality. The mean age was not significantly associated with serum AMH levels and oocytes quality (P> 0.05).

AMH levels are associated with oocyte quality in IVF cycles, while age was not associated with AMH levels and oocyte quality. Therefore, AMH levels are an indicator of the quality of oocyte in IVF cycles.

Follicular fluid (FF) plays a key role in preparing a microenvironment for the development and fertilization of oocytes. Moreover, biochemical and hormonal changes in the FF surrounding the oocyte can affect its quality and successful fertilization. The present study was conducted to investigate the relationship of beta human chorionic gonadotropin (beta-HCG) and anti-mullerian hormone (AMH) levels of FF with oocyte maturation in in-vitro fertilization (IVF) cycles.

FF was monitored in 30 women under a controlled ovarian stimulation cycle. Oocyte maturation was examined by an embryologist. Beta-HCG and AMH levels were then investigated in the FF containing metaphase I (MI), metaphase II (MII) and germinal vesicle (GV) oocytes using ELISA. To evaluate clinical pregnancy, serum levels of beta-HCG were measured 14 days after transfering the embryo. Identifying fetal heart rate (FHR) was considered clinical pregnancy.

No significant differences were observed in the mean betal-HCG levels between the mature (53.73±21.081 IU/ml) and immature oocytes (52.90±21.000 IU/ml) (P=0.8). Beta-HCG levels of the FF containing the MII oocytes (64.73±14.49 IU/ml) were significantly related to clinical pregnancy (P=0.04). Oocyte maturation and clinical pregnancy were also found not to be significantly related to AMH levels of FF.

The present study found oocyte maturation not to be significantly associated with the beta-HCG and AMH levels of FF. Beta-HCG levels of FF were also found to be associated with clinical pregnancy. The other constituents of FF along with AMH and beta-HCG might have therefore affected the oocyte quality and maturation.

Systemic lupus erythematosus (SLE) is a common autoimmune disease, and if not diagnosed and treated in a timely manner, can lead to irreversible complications such as lupus nephritis. Thus, the early detection of the disease is very important. On the other hand, some studies have shown that there is a relationship between the serum levels of anti-Mullerian hormone (AMH) and the activity of lupus disease. The aim of this study was to determine the relationship between antibody titer with severity and activity level of SLE.

In a cross-sectional study, 70 women in age range of 18-35 years old with SLE who referred to rheumatology clinic of Alzahra hospital, Isfahan, Iran, were selected. Lupus activity was determined using SLE Disease Activity Index-2000 (SLEDAI-2k) score, and serum level of AMH was measured; and the relationship between SLE activity and serum level of AMH was evaluated.

Mean serum level of AMH was 1.49 ± 1.58 ng/ml, ranging from 0.20 to 7.36; and thus, 11 patients (15.7%) had low levels of the hormone. Moreover, there was a statistically significant inverse correlation between disease activity scores and serum levels of AMH, as much as 0.46 (P < 0.001).

The results of our study showed a relation between lupus activity and serum AMH. Especially, among the patients under treatment with corticosteroids and cyclophosphamide pulse therapy, there were lower levels of AMH; and this might lead to ovarian reserve loss and fertility problems in women of childbearing age

Poor and low fertility in IVF cycles can be due to hormonal status and hormonal levels results from induced ovulation protocols. In cases of decreased ovarian reserve، follicular response to gonadotropin stimulation also decreases and the small number of oocytes will be resulted. This article measured the predictive effects of anti-mullerian hormone (AMH) and follicle-stimulating hormone (FSH) levels and antral follicle count (AFC) in infertile women prior to IVF and ICSI on ovarian response and the success rate of pregnancy.

This prospective observational study was conducted during 2011 to 2013 on 60 patients referred to Montaserie infertility center of Mashhad، Iran for IVF or ICSI. Serum levels of AMH، FSH، CBC، LFT، TFT، Ur، Cr and Prolactin were measured and vaginal ultrasound was performed to determine AFC. Required number of gonadotropin ampoules were determined and recorded. At days 20 and 21 of menstrual cycle patients underwent imitated transfer and GnRH was injected. At the 2nd day of menstruation، gonadotropin was injected. 6 days after injection، the ultrasound was performed every other day until at least two follicles up to 17-18mm were observed. Based on the number of follicles، 5000 to 10000 units of hCG was administered. After 36 to 40 hours، IVF or ICSI was performed. Finally bHCG was measured as an index of pregnancy. Data were analyzed by SPSS software version 11andt-test and chi-square tests. P value less than 0. 05 was considered significant.

The mean number of antral follicular and oocytes before and after treatment was 4. 43±4. 17 and 3. 09±3. 71، respectively. Mean of bHCG after treatment was 94. 79±265±86 Pmol/dl. Adequate ovarian response occurred in 52 cases (86. 7%) and the incidence of pregnancy was 30% (18 cases). In all patients، AMH was 1. 34±2. 66 Pmol/dl and FSH was 6. 81±4. 54 Pmol/dl. Comparison of hormone levels in women with positive and negative ovarian response showed no significant differences (p>0. 05)، but the differences of these hormones were significant in terms of pregnancy and pregnancy outcomes (p<0. 05). In pre-treatment، the level of AFC in these groups showed no significant difference (p>0. 05)، .

AMH and FSH hormones are predictive factor for positive pregnancy in infertile women after IVF and ICSI.