جستجوی مقالات مرتبط با کلیدواژه « هیدروکورتیزون » در نشریات گروه « پزشکی »

Anal fissure can be associated with trauma caused by passing hard stools or prolonged diarrhea. The present study aimed to determine the effectiveness of topical hydrocortisone in the treatment of anal fissures in patients under medical treatment referred to Fatemi Hospital and Kausar Clinic of Ardabil Medical Sciences, Ardabil, Iran, in 2019.

In this clinical trial study, 200 patients with anal fissures were randomly divided into two groups. The intervention group was treated with diltiazem gel, psyllium powder, lactulose syrup, and hydrocortisone topical ointment. Hydrocortisone ointment was not used in the control group.

The mean scores of initial pain were 8.06±0.7 and 7.79±1.02 in the intervention and control groups, respectively. The mean pain at the end of the first week was 2.5±1.06 in the intervention group and 3.34±0.89 in the control group. Pain reduction was significantly higher in the intervention group than in the control group in the first week of treatment. Two weeks later, the pain was 1.46±0.7 in the intervention group and 1.86±0.74 in the control group. There was a significant difference between the two groups in the first and second weeks of treatment.

The therapeutic combination of a topical corticosteroid with a calcium channel blocker at the beginning of treatment for chronic fissures during the first week of treatment led to a faster response in the form of pain reduction

Inflammatory responses are one the factors influencing the prognosis of multiple trauma patients. Hydrocortisone, with an appropriate dose, diminishes the inflammatory responses without immunosuppression, improving the patients’ immune system. Administering vitamins specifically vitamin B and C to multiple trauma patients, by eliminating free radicals, could decrease the mortality of these patients. This study was done to evaluate the efficacy of treatment with a combination of Hydrocortisone+ Ascorbic acid+ Neurobion (vitB1+B6+B12) on the prognosis of multiple trauma patients hospitalized in Intensive Care Units.

In a three-blind clinical trial study, 60 multiple trauma patients randomly allocated to two groups of intervention and control. In the intervention group, the patients received 1.5g vitamin C every 6 hours for a period of 4 days, Hydrocortisone 50 mg every 6 hours for a period of 7 days, two Neurobion every 12 hours for 4 days. In the control group, the patients received placebo. The patients in both groups were followed for ninety days and eventually, length of ICU stay, the need for mechanical ventilation and duration of mechanical ventilation were determined and compared between the two groups.

The mean duration of mechanical ventilation in the intervention and control group were 8.96 ± 6.03 and 14.8 ± 8.11 respectively which was statistically significant. There were no significant differences between the two groups in other outcome measures.

Our study shows administration of combination of Hydrocortisone+ Ascorbic acid+ Neurobion (vitB1+B6+B12) could decrease the duration of mechanical ventilation in multiple trauma patients.

Atracurium, as one of the neuromuscular relaxants, is one of the most important irritants of the allergic reaction during anesthesia, which causes the release of histamine. This study was conducted with the aim of determining the effect of hydrocortisone on hemodynamic changes resulting from atracurium drug in patients with upper limb fractures under general anesthesia.

In this double-blind randomized clinical trial study, 50 patients with upper limb fractures under general anesthesia, 18 to 60 years old with ASA class 1 and 2, were randomly assigned to two groups of hydrocortisone and placebo (distilled water). In intervention group, 30 minutes before entering the operating room, vial oxycort (hydrocortisone) was administered intravenously and bolus with 300 ml of normal saline. Hemodynamic changes in patients before administration of hydrocortisone, 30 minute after administration, 5 minutes after the peak effect of atracurium (before intubation) and after extubation were recorded in the relevant checklist and comparisons were made between the two groups.

There was no significant difference between the two groups in terms of age, gender and duration of surgery. Systolic blood pressure 5 minutes after the peak effect of atracurium (before intubation) in the control group was lower than the intervention group and this difference was statistically significant (P=0.02). Thirteen minute after hydrocortisone administration, mean blood pressure systolic and diastolic patients decreased and this decrease continued after administration of histamine release atracurium (before intubation); but after extubation, the patients’ mean blood pressure has increased. Also, after administration of atracurium, the mean heart rate of patients decreased by 14.44 units as compared to before administration of hydrocortisone and this decrease was significant (P=0.001).

The results of this study show that hydrocortisone can be used as an effective factor in maintaining hemodynamic stability in patients under general anesthesia. However, its use as a factor in maintaining hemodynamics has not yet been widespread and needs further investigation.

Propofol is an intravenous anesthetic drug that has been widely used in outpatient and short-term surgery due to its rapid recovery. However, pain during propofol injection can cause discomfort in 28 to 91% of patients. Various sources have argued that the effects of hydrocortisone and lidocaine on pain during propofol injection are contradictory. The present study was investigated the comparison of effect of hydrocortisone and lidocaine on pain during propofol injection.

In a randomized double-blind clinical trial, 150 patients, aged 15-65 years with ASA I and II physical grade who were candidates for elective surgery under general anesthesia at Shahid Mohammadi Hospital in Bandar Abbas in 2019 were enrolled. They were, randomly divided into 3 groups of 50 subjects'. Group A received lidocaine 2%, 1 mg / kg; group B received 25 mg hydrocortisone; and group C received 5 ml saline. The severity and incidence of pain after propofol injection were evaluated. Data were analyzed by SPSS software, version 19 and analyzed by independent t-test and chi-square or fisher exact test. P-values ​​less than 0.05 were considered as significant.

There was a significant difference in incidence of pain during propofol injection between the three groups (lidocaine and hydrocortisone, lidocaine and hydrocortisone and with normal saline) (p <0.001). There was also a significant difference in pain severity between the lidocaine and hydrocortisone with normal saline groups, while there was no significant difference between the lidocaine and hydrocortisone groups (p= 0.615). The effect of hydrocortisone and lidocaine on pain was not significant according to sex, age and weight.

Hydrocortisone and lidocaine reduce pain during propofol injection and the effect of lidocaine was more than hydrocortisone. However, using of these medications may be able to reduce the pain resulted during propofol injection.

nowadays, gene therapy has been considered as a novel therapeutic approach. Particularly, following the introduction of immunotherapy and gene editing using CRISPR/Cas9 platform great attention has been directed to gene therapy. However, finding an efficient carrier with low toxicity is still one of the major challenges for researchers. Among non-viral gene carriers, polyethyleneimine (PEI) could be considered as the most studied polycationic compound for gene delivery. However, toxicity, lack of targeting and non-specific interactions with serum components limit its wide application. Therefore, PEI structure must be modified through chemical conjugations. In this study, conjugation of hydrocortisone on the polymer structure was carried out in order to direct the carriers into the cell nucleus.

hydrocortisone was conjugated onto polyethylenimine followed by the grafting of the targeted PEI domain onto another unmodified polymer via succinic acid linker. The conjugate w::as char::acterized in terms of buffering capacity, zeta potential, particle size, protection of DNA against enzymes and condensation ability.

The results demonstrated that the conjugates could condense plasmid DNA successfully and form nanoparticles with the size of around 300 nm. Meanwhile, the conjugates showed higher buffering capacity compared with the unmodified polymer. Also, the protection ability of the conjugates was significant rather than the parent polymer.

According to the results, design and synthesis of the PEI derivative with two separated domains responsible for targeting and plasmid condensation could be considered as an efficient strategy to create nano gene delivery systems.