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جستجوی مقالات مرتبط با کلیدواژه « oral » در نشریات گروه « پزشکی »

  • زهره کریمیان کاکلکی*
    مقدمه

    مطالعه حاضر به منظور بررسی ارتباط سواد سلامت دهان و دندان مادران با وضعیت بهداشت دهان و دندان کودکانشان انجام شد.

    روش کار

    این مطالعه به روش تحلیلی در سال 1402 انجام شد. حجم نمونه167 نفر از مادران دارای فرزند 12-6 سال مراجعه کننده به مراکز خدمات جامع سلامت شهرکرد بودند. نمونه گیری به صورت تصادفی ساده صورت گرفت. جمع اوری اطلاعات با استفاده از پرسشنامه استاندارد سواد سلامت دهان و دندان بزرگسالان و معاینه دهان و دندان کودکان صورت گرفت. داده های جمع آوری شده با آزمون های آنوا و همبستگی پیرسون آنالیز شد.

    نتایج

    میانگین سنی مادران شرکت کننده در این مطالعه99/4± 23/37 سال بود. میانگین نمره و انحراف معیار سواد سلامت دهان و دندان مادران 19/15± 65/66 و میانگین نمره و انحراف معیار تعداد دندانهای پوسیده، پر شده و از دست داده 58/1± 38/2 بود. بین نمره کل سواد سلامت دهان و دندان مادران و میانگین تعداد دندان پوسیده، پر شده و از دست داده رابطه معکوس و معنی داری وجود داشت (026/0p= 025/0-r=). همچنین بین سواد سلامت دهان و دندان مادران با تعداد دندان پوسیده (025/0p= 032/0-r=) و از دست رفته (045/0p= 043/0-r=)، رابطه معکوس و معنی داری وجود داشت ولی با دندان های پرشده رابطه معنی داری نشان نداد (229/0=p).

    نتیجه گیری

    با توجه به ارتباط بین نمره سواد سلامت دهان و دندان مادران با میانگین تعداد دندانهای پوسیده، پر شده و از دست داده کودکانشان، به منظور بهبود سواد سلامت مادران و مراقبت از دندانهای کودکانشان آموزش های متناسب با سطح تحصیلات افراد برنامه ریزی شود.

    کلید واژگان: سواد سلامت دهان و دندان, مادران, بهداشت دهان و دندان, کودکان}
    Zohreh Karimiankakolaki *
    Introduction

    The present study was conducted in order to investigate the relationship between oral and dental health literacy of mothers and the oral and dental health status of their children.

    Methodology

    This analytical study was conducted in 2023. The sample size was 167 mothers with 6-12-year-old children who referred to comprehensive health service centers of Shahrekord. Sampling was done in a simple random way. Data collection was done by using the standard oral and dental health literacy questionnaire of adults and oral and dental examination of children. The data collected after coding was analyzed with ANOVA and Pearson correlation tests.

    Results

    The mean age of mothers participating in this study was 37.23 ± 4.99 years. The distribution of the mean score and SD of oral and dental health literacy of mothers was 66.65±15.19 and the distribution of the mean score of the number of decayed, filled and missing teeth was 2.38±1.58. There was an inverse and significant relationship between the total oral and dental health literacy score of mothers and the average number of decayed, filled and missing teeth (p=0.026 r=-0.025).. Also, there was an inverse and significant relationship between oral and dental health literacy of mothers with the number of decayed teeth (p=0.025 r=-0.032) and missing teeth (p=0.045 r=-0.045), but it did not show a significant relationship with filled teeth (p=0.229).

    Conclusion

    It is necessary to improve the oral health literacy of mothers and take care of their children's teeth, training should be planned according to the education.

    Keywords: Oral, Dental Health Literacy, Mothers, Dental Health, Children}
  • Kamal Mirmohammadi*, Shirin Fattahi, Fatemeh Tavakoli, Ali Tashakor
    Background and Aim

    Lichen planus (LP) is a chronic inflammatory mucocutaneous disease usually diagnosed based on clinical and histopathological findings. Prognostic evaluation of malignant transformation in LP is clinically and histologically complex. Due to the inconsistent results of previous studies regarding the prevalence of dysplastic changes in LP, this study aimed to evaluate the prevalence of dysplasia in oral lichen planus (OLP) patients.

    Materials and Methods

    This cross-sectional study was conducted on biopsy samples of OLP patients referred to Tabriz Dental Faculty from 2012 to 2020. The diagnosis of OLP was based on the World Health Organization criteria, which was confirmed by reassessment of the microscopic slides by a pathologist. The clinical subtype of OLP samples was specified based on the information present in patient files. Data were analyzed by the Chi-square test using SPSS 17 (alpha=0.05). 

    Results

    The buccal mucosa was the most commonly involved area (27 out of 36 cases). The tongue ranked next (10 out of 36 cases). The most common clinical subtype was reticular form with 23 cases (63.9%). In 8 cases (21.9%), epithelial dysplasia was observed; of which, 7 cases were grade I and 1 was grade II. Among the observed dysplastic features, nuclear hyperchromatosis and enlarged nucleus had the highest incidence (11.1%).

    Conclusion

    The percentage of dysplasia in OLP specimens was not high in the study population. However, considering the risk of transformation to squamous cell carcinoma (SCC), accurate diagnosis of SCC based on history, and clinical and histopathological findings is critical. In case of histopathological detection of dysplasia, long-term follow-up of patients is necessary.

    Keywords: Lichen Planus, Oral, Prevalence, Squamous Cell Carcinoma}
  • Jannan Ghapanchi, Mohammadjavad Fattahi, Raziye Ghodsi, Abbas Ghaderi, Mahsa Sadre Arhami, Fatemeh Lavaee *
    Background

    Oral lichen planus is a chronic inflammatory disease that can develop into a malignancy. This study aimed to compare the IL-37 gene variant (rs4241122) in oral lichen planus patients and the healthy controls.

    Methods

    This cross-sectional study was conducted in the School of Dentistry, Shiraz University of Medical Sciences (Shiraz, Iran). 70 serum samples from patients with oral lichen planus (OLP) and 100 serum samples from healthy volunteers were collected from 2018 to 2019. The IL-37 polymorphism (rs4241122) in OLP patients and healthy controls was assessed using a PCR test, and its relationship with the location and type of OLP lesions, sex, and age was investigated. A Chi-square test was used to determine the relationship between OLP and genotype, genotype and location, and the lesion type. P < 0.05 was considered statistically significant.

    Results

    The OLP group included 46 women (66 %) and 24 men (34%) with a mean age of 45.71 ± 13.2 years old. The healthy control group consisted of 61 women (61%) and 39 men (39%), with a mean age of 43.9 ± 10.39 years. There were no significant differences between the two groups in terms of genotype and polymorphism of IL-37 rs4241122.

    Conclusion

    In this study, there was no difference between polymorphism of IL-37 (rs4241122) and OLP lesions. However, allele A was more prevalent in healthy controls than in OLP patients.

    Keywords: Interleukins, Lichen Planus, Oral, Polymorphism Genetic}
  • فرزاد فیروزی جهانتیغ*، هدی قائینی حصاروئیه، زهرا قربانی

    شناسایی عوامل تاثیرگذار بر رفتارهای بهداشت دهان در بیماران دیابتی گامی مهم در ارتقای سلامت دهان و دندان است. از این رو هدف از این مطالعه پیش بینی سلامت بهداشت دهان و دندان در افراد مبتلا به دیابت و مقایسه آن ها با افراد سالم است.

    مواد و روش ها

    این مطالعه در بازه زمانی سال های 1399-1400  به روش نمونه گیری در دسترس انجام شد. گروه مورد مطالعه شامل 261 (مرد و زن) که 131 نفر سالم و130 نفردیابتی بودند  و جمع آوری اطلاعات با استفاده از پرسشنامه، پرونده پزشکی و معاینه صورت گرفت. 6 متغیر سن، جنسیت، دندان های پوسیده، دندان های کشیده شده، دندان های ترمیم  شده و شاخص سلامت دهانی در این افراد بررسی شد. از دو الگوریتم درخت تصمیم گیری و ماشین بردار پشتیبان  با استفاده از نرم افزار Spss Modeler  استفاده شد.

    یافته ها

    مهمترین یافته های تحلیل درخت تصمیم گیری عبارت بود از: 1- اگر سن فرد کمتر و مساوی 37 سال باشد، آنگاه فرد 100 درصد سالم است. 2- اگر سن بالاتر از 37 سال باشد و تعداد دندان های پوسیده شده کمتر از میانگین 7 باشد و دندان کشیده شده هم نداشته باشیم، با احتمال 82 درصد فرد دیابتی است. اگر سن بالاتر از 37 سال باشد و تعداد دندان های پوسیده شده کمتر از میانگین 7 باشد و دندان کشیده شده بیشتر از 1 داشته باشیم آنگاه افراد کمتر از 49 سال، با شاخص بهداشت دهانی بیشتر از 0/9 ، 100 درصد دیابتی هستند. همچنین دقت کل ماشین بردار پشتیبان خطی 70/73درصد بوده  و نشان دهنده این است که دندان پوسیده شده با کمترین مقدار وزن تاثیر کمی در پیش بینی دیابتی و یا سالم بودن افراد دارد.

    نتیجه گیری

    به نظر می رسد استفاده از الگوریتم های درخت تصمیم گیری و ماشین بردار پشتیبان می تواند پیش بینی کننده ابتلا به دیابت بر اساس سلامت و بهداشت دهان و دندان در بیماران مبتلا به دیابت باشد.

    کلید واژگان: بهداشت, دهان و دندان, دیابت, درخت تصمیم گیری, ماشین بردار, هوش مصنوعی}
    Farzad Firouzi Jahantigh*, Hoda Ghaeini Hessarouieh, Zahra Ghorbani
    Background and Aim

      Diabetes may increase the incidence of tooth decay due to dry mouth and high blood sugar levels. Identifying the factors influencing oral health behaviours in diabetic patients is thus an essential step toward promoting oral and dental health. As a result, this study aimed to predict oral health in people with diabetes and compare them to healthy people.

    Material and Methods

    The available sampling method was used to conduct this study from  2021 to 2022. The study group consisted of 261 persons (men and women), 131 of whom were healthy and 130 of whom were unhealthy (diabetic), and information was gathered through a questionnaire, medical records, and an examination. These people looked at six variables: age, gender, decayed teeth, extracted teeth, filled teeth, and oral health index. Using the Spss Modeler program, two decision tree methods and a support vector machine and spss Modeler soft ware were used.

    Results

    The most important findings of decision tree analysis are 1- If the person's age is less than or equal to 37 years, then the person is 100% healthy. 2- If the age is over 37 years and the number of decayed teeth is less than the average of 7, and we do not have any extracted teeth, there is an 82% chance of diabetes. If the age is over 37 and the number of decayed teeth is less than the average of 7, and the number of extracted teeth is more than 1, then people under the age of 49 with an OHI index greater than 0.9 are 100% diabetic. Also, the total accuracy of the linear support vector machine is 70.73%, which indicates that decayed teeth with the least amount of weight have little effect on diabetes or health.

    Conclusion

     Decision tree algorithms and support vector machines could predict oral and dental health in diabetic patients.

    Keywords: Health, Oral, dental, Diabetes, Decision Tree, Vector Machine, Artificial Intelligence}
  • علی فیضی، بهار حافظی*، سعید باقری فرادنبه، شهرام توفیقی
    مقدمه

    افزایش استفاده از خدمات بهداشت دهان و دندان و معاینات معمول آن می تواند به سلامت بهتر منجر شود و شاخص های عدالت در سلامت را ارتقا بخشد. هدف مطالعه حاضر تحلیل عوامل موثر بر بهره مندی از خدمات بهداشت دهان و دندان در خانوارهای شهرستان اهواز در سال 1401 می باشد.

    روش ها

    مطالعه حاضر به صورت توصیفی-تحلیلی از نوع مقطعی می باشد که در آن با روش نمونه گیری طبقه ای-خوشه ای تعداد 715 خانوارها که شامل2680 نفر از افراد ساکن در شهرستان اهواز می باشند، مورد مطالعه قرار گرفت. جمع آوری اطلاعات مورد نیاز از طریق پرسشنامه انجام شد و برای تحلیل داده ها و برآورد کشش عوامل اثرگذار از مدل لاجستیک و نرم افزار Stata  بهره گیری شد.

    یافته ها

    بر اساس نتایج این مطالعه میزان بهره مندی 80/55 درصد می باشد و نسبت شانس بهره مندی از خدمات بهداشت دهان و دندان در خانم ها نسبت به آقایان کمتر می باشد. (P-value=00, Odd ratio=0/74)، افراد دارای تحصیلات دانشگاهی نسبت به سایر افراد شانس بیشتری برای دریافت خدمات دارند(Odd ratio=1/83, P-value=0/03)افراد دارای درآمد بدون کار(Odd ratio=0/79, P-value=0/59) نسبت به افراد بیکار شانس کمتری برای دریافت این خدمات دارند. افرادی که دارای بیمه های خصوصی هستند شانس بیشتری برای دریافت این خدمات دارند(Odd ratio=5/84, P-value=0/00) همچنین داشتن تمرینات ورزشی کمتر از 3 بار در طول هفته نیز شانس دریافت این خدمات را نسبت به افرادی که هیچ گونه تمرین ورزشی ندارند، افزایش می دهد(Odd ratio=1/25, P-value=0/02).

    نتیجه گیری

    بر اساس نتایج این مطالعه می توان گفت وضعیت اشتغال و درآمد خانوار، افزایش پوشش بیمه ای، افزایش سطح تحصیلات و داشتن سبک زندگی سالم از جمله داشتن تمرینات ورزشی، شانس بهره مندی از این خدمات را افزایش می دهد.

    کلید واژگان: بهره مندی, بهداشت, دهان و دندان, اهواز}
    Ali Feizi, Bahar Hafezi*, Saeed Bagheri Faradonbeh, Shahram Tofighi
    Introduction

    An increase in the use of oral and dental health services and routine examinations can lead to better health and improve health equity indicators. This study aimed to analyze the factors affecting the utilization of oral and dental health services in the households of Ahvaz in 2022.

    Methods

    The present study is a cross-sectional descriptive-analytical study in which 715 households including 2680 people living in the city of Ahvaz were studied by using the stratified-cluster sampling method. The collection of the required data was performed through a questionnaire, and the logistic model and Stata software were used to analyze the data and estimate the elasticity of the influencing factors.

    Results

    According to the results of this study, the utilization rate of oral and dental health services is 80.55%, and the odd ratio of the utilization of these services is 0.26% less for women compared to men, which is a statistically significant result. People with tertiary education also have a 1.83 times higher chance compared to other people to receive the services, which is statistically significant. People with income but without work have a 0.29 lower chance of receiving these services compared with unemployed people, although this result is not significant. Furthermore, people who have private insurance have 5.84 times more chances to receive these services, and this result is completely significant. Also, the individuals who exercise less than 3 times a week have the chance of receiving these services by 1.25 times compared to people who do not exercise at all, which is a significant result.

    Conclusion

    Based on the results of this study, it can be mentioned that employment and household income status, increased insurance coverage, higher education level, and a healthy lifestyle, including engaging in physical exercise, increase the chance of benefiting from dental services.

    Keywords: Oral, dental health, utilization, Ahvaz}
  • علی نورائی سفید دشتی، مهدی ابریشمی*، آذر اسلامی، حمید بشیری
    مقدمه

    امروزه درمان نواحی بی دندانی با استفاده از ایمپلنت ها، بسیار رواج پیدا کرده است، اما در بسیاری از بیماران که مدت بسیاری از بی دندان بودن ناحیه گذشته است، تغییر پوزیشن سینوس باعث کامپلیکیشن هایی در هنگام جایگذاری ایمپلنت می شود که برای حل آن می توان با تکنیک های مختلف، موقعیت سینوس را تا حد نیاز جابجا نمود. هدف از این مطالعه، ارزیابی فاصله ی مدیولترالی سینوس ماگزیلا با استفاده از این می باشد.

    مواد و روش ها

    این مطالعه ی مشاهده ای- مقطعی، از بین مراجعه کنندگان (160 بیمار) به بخش رادیولوژی دانشگاه آزاد اسلامی واحد اصفهان (خوراسگان) که نیاز به تصویربرداری CBCT داشتند انتخاب شدند. برش کرونال قسمت میانی هر دندان از دست رفته، برای اندازه گیری فاصله ی مدیولترالی سینوس (عرض سینوس) انتخاب شد. در برش کرونال انتخاب شده، ارتفاع ریج باقی مانده و عرض سینوس در ارتفاع 5، 10 و 15 میلی متری از کف سینوس اندازه گیری شد. داده ها با آزمون های t-test و Man-Whitney آنالیز شدند (0/05 = α).

    یافته ها

    میامیانگین عرض سینوس در زنان در فواصل 5 و 15 میلی متری بیشتر از آقایان بود و در فاصله ی 10 میلی متری عرض سینوس در خانم ها کمتر از آقایان بود. میانگین ریج باقی مانده برای زنان و مردان به ترتیب برابر با 9/69 و 8/27 بود که نشان دهنده ی بالاتر بودن میزان ریج باقی مانده در خانم ها بود اما این تفاوت معنی دار گزارش نگردید. بیشترین ریج باقی مانده در ناحیه ی پرمولر اول بود و کم ترین میزان ریج باقی مانده در مولر اول می باشد

    نتیجه گیری

    هر چه نواحی بی دندانی از پرمولرها به سمت مولرها می رود، شاهد عریض تر شدن سینوس هستیم و همچنین هرچه میزان ریج باقی مانده کمتر باشد، ممکن است در سطح پایین تری با سینوس مواجه شویم.

    کلید واژگان: سینوس ماگزیلاری, توموگرافی کامپیوتری با اشعه ی مخروطی, جراحی دهان}
    Ali Nooraei Sefid Dashti, Mahdi Abrishami, Azar Eslami, Hamid Bashiri
    Introduction

    Nowadays, implant-based treatment of edentulous areas has gained significant popularity. However, in many patients who have been edentulous for a long time, changing the position of the sinus causes complications during implant placement, which is necessary to solve Many of these cases can be moved to the required extent with different techniques. This study aims to evaluate the mediolateral distance of the maxillary sinus using Cone Beam Computed Tomography (CBCT).

    Materials and Methods

    This observational-cross-sectional study of 160 patients who needed CBCT imaging were selected from among those referred to the radiology department of Isfahan Islamic Azad University. A sagittal section of the middle part of each missing tooth was selected to measure the mediolateral sinus distance (sinus width). In the selected sagittal section, the residual ridge height and sinus width were measured at 5, 10- and 15-mm height from the alveolar crest. The data were analyzed using the paired t-test and Man-Whitney (p value < 0.05).

    Results

    The average sinus width in women was greater than that in men at the 5 and 15 mm intervals, and in the interval of 10 mm, the sinus width in women was less than that in men. The average residual ridge for women and men was equal to 9.69 and 8.27, respectively, which indicated that the amount of residual ridge was higher in women, but this difference was not significant. The premolar area exhibited the highest remaining ridge height, while the first molar area had the lowest.

    Conclusion

    As we move from premolars to molars in edentulous areas, the maxillary sinus tends to widen, and also, the less the remaining ridge is, we may encounter the sinus at a lower level.

    Keywords: Maxillary sinus, Cone-beam computed tomography, Surgery, Oral}
  • Somayeh Niakan, Nafise Asgari, Niyousha Rafeie, Solmaz Barati

    Conventional obturator prostheses might cause dissatisfaction in patients with hard or soft palate defects due to inadequate retention and function during speech, mastication, and swallowing. Thus, surgical reconstruction and implant-supported obturators are considered as alternative treatments for these patients. This case-report study describes the prosthetic reconstruction of an 88-year-old patient suffering from a hard palate defect after surgical resection of verrucous carcinoma in the left side of the hard palate. Fifteen months after radiotherapy, two implants were placed in the right side of the remaining ridge, in the second and third molar region. After the implant healing period, the implant-supported obturator prosthesis was fabricated. The patient was satisfied with the esthetics and function of the obturator at the 12-month recall visit and radiographs showed normal healing and no bone loss around the implants.

    Keywords: Dental Implants, Palatal Obturators, Surgery, Oral}
  • Ayla Bahramian, Mona Rahbaran, Maria Bahramian, Sepideh Bohlouli, Katayoun Katebi*
    Background

    Oral lichen planus (OLP) and one of its main presentations, desquamative gingivitis, are common diseases with no definite treatment. Zinc deficiency has a critical role in the pathogenesis of oral mucosal diseases. The current study systematically reviewed the effect of zinc in addition to topical corticosteroids in the treatment of OLP.

    Methods

    English articles in PubMed, Web of Sciences, Embase, and Scopus were searched until August 2022. The differences in symptoms were analyzed, including pain, burning sensation, and lesion sizes in patients with lichen planus receiving zinc supplementation as an adjuvant to corticosteroid treatment.

    Results

    A total of 148 articles related to the searched keywords were found. Eventually, two clinical trials were selected. The total population of studied individuals included 60 patients. Due to the high heterogeneity between the studies, meta-analysis was not possible. Administering zinc, in addition to corticosteroids, did not improve the symptoms compared to corticosteroid monotherapy.

    Conclusion

    Considering the limited number of studies and lack of sufficient evidence, it is not currently possible to reach a definite conclusion regarding the effects of zinc on OLP.

    Keywords: Adrenal cortex hormones, Gingivitis, Lichen planus, Oral, Systematic review, Zinc}
  • مهیار نصابی، شیرین فتاحی *، خونریزی، ریسک، جراحی دهان و دندان، متاآنالیز
    زمینه و هدف

    هدف بررسی حاضر پاسخ به سوال PICO زیر است: "خطر خونریزی در بیمارانی که داروهای ضد انعقاد خوراکی مصرف می کنند و تحت عمل جراحی دهان با یا بدون قطع درمان آنتی ترومبوتیک قرار می گیرند، چیست؟" بر این اساس، با انجام این مطالعه متاآنالیز، هدف ما تعیین خطر خونریزی در حین و بعد از جراحی دندان در بیماران تحت درمان ضد انعقاد، و همچنین ارایه راهنمایی هایی است که به متخصصان دندانپزشکی در تصمیم گیری آگاهانه بالینی کمک می کند، می باشد.

    مواد و روش ها

    در این مطالعه متاآنالیز، ما جستجوهایی را برای مطالعات کارآزمایی بالینی واجد شرایط در مرکز کتابخانه کاکرین (واحد مرکزی کارآزمایی های کنترل شده کاکرین) و Medline (Ovid وEMBASE) از پایگاه های داده ای ذکر شده با کلید واژه-های جراحی دهان، اگزودنتیا و نصب ایمپلنت دندان، خطر حوادث خونریزی دهنده و مترادف آنها و ضد انعقاد خوراکی (آنتاگونیست های ویتامینK) انجام دادیم. تجزیه و تحلیل برای هر ضد انعقاد و نتیجه مورد انتظار انجام شد. برای مطالعاتی که پیامدهای دوگانه را گزارش کردند، خطر نسبی (RR) همراه با فاصله اطمینان 95% محاسبه شد. اثرات تصادفی مرتبط با متاآنالیز با استفاده از نرم افزار STATA (نسخه 1/10) تعیین شد.

    یافته ها

    نتایج یک تا سه برابر بیشتر خطر خونریزی را در بیمارانی که وارفارین مصرف می کنند در مقایسه با بیمارانی که استفاده از داروهای ضد انعقاد را در حین عمل قطع کرده بودند (67/1=RR و 89/2-97/0:CI) و بعد از عمل (44/1=RR و 92/2-71/0:CI) نشان داده اند.

    نتیجه گیری

    خطر خونریزی حین و پس از جراحی در بیمارانی که داروی ضد انعقاد خود را قطع نکنند، نسبت به بیمارانی که داروی خود را قطع نمایند، در حین اعمال جراحی مینور دهان و دندان وجود دارد؛ با این حال، یافته ها باید با احتیاط تفسیر شوند و مطالعات جدید در مورد این موضوع باید آغاز شود.

    Nesabi M, Fattahi Sh *
    Introduction & Objective

    The purpose of this study is to answer the following PICO question: "What is the risk of bleeding in patients who take oral anticoagulants and undergo oral surgery with or without discontinuation of antithrombotic therapy?" Accordingly, by conducting this systematic review, we aim to determine the risk of bleeding during and after dental surgery in patients receiving anticoagulation therapy, as well as provide guidance that will assist dental professionals in making informed clinical decisions.

    Materials & Methods

    In this meta-analysis study, we performed searches for eligible clinical trial studies in the Cochrane Library (Cochrane Central Unit for Controlled Trials) and Medline (Ovid and EMBASE) from the databases listed with the keywords oral surgery, extradontia and implants. We performed dental implants, the risk of bleeding events and their synonyms, and oral anticoagulants (vitamin K antagonists). Analyzes were performed for each anticoagulant and expected outcome. For studies that reported dichotomous outcomes, relative risk (RR) with 95% confidence interval was calculated. Random effects associated with meta-analysis were determined using STATA software (version 10/1).

    Results

    One to three times higher risk of bleeding in patients taking warfarin compared to patients who stopped using anticoagulants during the operation (RR=1.67 and CI: 0.97-2-2.89) and after surgery (RR=1.44 and CI: 0.71-0.2-92) have shown.

    Conclusions

    There is a risk of bleeding during and after surgery in patients who do not discontinue their anticoagulant medication compared to patients who discontinue their medication during minor oral and dental surgery; however, the findings should be interpreted with caution and new studies on this topic should be initiated.

    Keywords: Bleeding, Risk, Oral, Dental Surgery, Meta-Analysis}
  • Reza Vaez, Monir Moradzadeh Khiavi *, Khadijeh Abdal, Hossein Borhani
    Introduction

    Odontogenic lesions related to impacted teeth are common findings in routine dental exams, with the potential to cause tooth pain, displacement, bone expansion, or even bone erosion. Thus, their early detection is important. This study aimed to evaluate the frequency of such lesions based on patient age, gender, and location at the Tehran University of Medical Sciences, School of Dentistry, over five years.

    Materials and Methods

    This retrospective study evaluated records from the oral pathology department, covering a five-year period. The association of odontogenic lesions with impacted teeth was assessed. Data on lesion type, patient age and gender, involved jaw, lesion location, and affected teeth were extracted from patient records. Statistical analysis was performed using SPSS 24.

    Results

    Out of 815 odontogenic lesions, 44.4% were associated with impacted teeth. The patient distribution was 52.48% male and 47.52% female. Lesions were most prevalent in the third decade of life (24.58%), and third molars (59.39%) were frequently involved. The posterior mandible (68.5%) and mandibular third molar (55%) were common sites. Dentigerous cysts had the highest frequency (35.4%), with odontogenic cysts (developmental) occurring more frequently (70.7%) than odontogenic tumors.

    Conclusion

    The study underscores a significant association between odontogenic lesions and impacted or unerupted teeth. Periodic follow-ups are crucial for retaining impacted teeth based on these findings.

    Keywords: Tooth, Impacted, Odontogenic cysts, Odontogenic tumors, Jaw, Pathology, Oral}
  • همایون یوسفی*، فرامرز زکوی، ماریا چراغی، هاشم محمدیان پستکان، علیرضا کریمی ملایر
    زمینه و هدف

    مطالعه حاضر با هدف تعیین وضعیت سلامت دهان مرتبط با کیفیت زندگی در بیماران تالاسمی ماژور در شهر اهواز انجام شد.

    روش کار

    این مطالعه مقطعی -تحلیلی که بر روی دو گروه افراد مبتلا به تالاسمی ماژور و افراد سالم انجام شده است. جامعه آماری در گروه مورد 120 نفر از بیماران مبتلا به بیماری تالاسمی ماژور بود که به بیمارستان شفای شهرستان اهواز در سال 1401 مراجعه کرده و گروه شاهد 120 نفر از افراد سالمی بود که همراه بیماران یا از اعضای خانواده آنها بودند. ابزار جمع اوری داده ها دو پرسشنامه استاندارد مربوط به خشکی دهان و پرسشنامه مربوط به کیفیت زندگی وابسته به سلامت دهان بود.

    نتایج

    بین میانگین نمره کلی کیفیت زندگی مرتبط به سلامت دهان و ابعاد آن (به غیر از ناتوانی فیزیکی) در بیماران مبتلا به بتاتالاسمی ماژور با افراد سالم تفاوت معنادار وجود داشت (P<0.05). بین میانگین نمره کلی ناتوانی فیزیکی در بیماران مبتلا به بتاتالاسمی ماژور با افراد سالم تفاوت معنادار وجود نداشت (P>0.05). بین میانگین نمره محدودیت عملکردی در بیماران مبتلا به بتاتالاسمی ماژور با افراد سالم برحسب سن تفاوت معنادار وجود داشت (P<0.05). بین میانگین نمره ناتوانی فیزیکی در بیماران مبتلا به بتاتالاسمی ماژور با افراد سالم برحسب سن و خشکی دهان تفاوت معنادار وجود داشت (P<0.05).

    نتیجه گیری

    با توجه به نتایج بدست آمده از مطالعه حاضر، بایستی اقدامات و راهکارهای روانشناختی مناسب جهت بهبود وضعیت کیفیت زندگی مرتبط با سلامت دهان در بیماران مبتلا به بیماری بتاتالاسمی ماژور انجام گردد.

    کلید واژگان: کیفیت زندگی, سلامت, دهان, بتاتالاسمی, ماژور}
    Homayon Yousefi *, Faramarz Zakavi, Maria Cheraghi, Hashem Mohamadian, Alireza Karimi Malayer

    The present study aimed to determine the oral health status related to the quality of life among patients with beta-thalassemia major in Ahvaz city.

    Methodology

    This was a cross-sectional analytical study conducted on two groups: individuals with beta-thalassemia major and healthy individuals. The case group consisted of 120 patients with beta-thalassemia major who had referred to Shafa Hospital in Ahvaz in 2022, and the control group included 120 healthy individuals who accompanied the patients. Data collection tools included two standard questionnaires on dry mouth and oral health-related quality of life. All analyses were performed using SPSS software version 22, with a significance level of less than 0.05.

    Results

    There was a significant difference in the mean score of overall oral health-related quality of life and its dimensions between patients with beta-thalassemia major and healthy individuals (P<0.05). There was a significant difference in the mean score of functional limitation between patients with beta-thalassemia major and healthy individuals based on age (P<0.05). There was a significant difference in the mean score of physical disability between patients with beta-thalassemia major and healthy individuals based on age and dry mouth (P<0.05). There was a significant difference in the mean score of disability between patients with beta-thalassemia major and healthy individuals based on gender, education level, tobacco use, and dry mouth (P<0.05).

    Conclusion

    Appropriate psychological interventions and strategies should be implemented to improve the oral health-related quality of life among patients with beta-thalassemia major.

    Keywords: Quality of Life, oral, Health, Beta-Tallahassee, Major}
  • Saeedeh Khalesi, Laleh Maleki, Shahnaz Eskandari, Foad Zare Dehabadi, Amirhossein Yousefi Kohpaee
    Background

    Oral squamous cell carcinoma (OSCC) is the most common malignant tumor among oral cancers. Cyclin D1 and Ki‑67 have associated with cell division. The aim of this study was to compare the expression of these markers in OSCC with and without cervical lymph node (LN) metastasis.

    Materials and Methods

    This cross‑sectional study was performed on 40 OSCCs with and without cervical LN metastasis (20 in each group) that was recorded in the pathology archive of Ayatollah Kashani Hospital in Isfahan. Clinical information including age, gender, and location was collected. Some histopathological parameters including depth of invasion, lymphovascular invasion (LVI), perineural invasion (PNI), number of LN metastases, histopathological grade, and stage of disease were evaluated. Immunohistochemical staining was performed for cyclin D1 and Ki‑67. All data were entered into SPSS24 software and were analyzed by Mann–Whitney, Kruskal–Wallis, Chi‑square, Fisher’s exact, and t‑tests. P < 0.05 was considered statistically significant.

    Results

    Based on LVI and stage of disease, a significant correlation was found between the two groups (P < 0.001).There was a significant difference between the two groups based on cyclin D1 expression (P = 0.05).The expression of the Ki‑67 showed a significant difference based on tumor location (P = 0.026) and PNI (P = 0.033).

    Conclusion

    The use of markers should be considered in determining the prognosis of OSCC, and the cyclin D1 marker is one of the useful markers for predictors of cervical LN metastasis.

    Keywords: Cancer, cyclin D1, immunohistochemistry, Ki‑67, oral}
  • Kamyar Tayyebi, Sepideh Arab, Farnoosh Razmara, Allahyar Geramy, MohammadJavad Kharazifard, Elaheh Kamali
    Background

    Facial asymmetry is one reason orthodontic patients seek treatment. This study assessed the effect of mandibular asymmetry on facial esthetics and treatment needs perceived by laypersons, orthodontists, and maxillofacial surgeons.

    Materials and Method

    In this descriptive cross‑sectional study, the frontal image of a model was captured and symmetrized from the facial midline using Adobe Photoshop software. The mandible was rotated 0°–8° with 1° intervals. Images were presented to 41 laypersons, 39 orthodontists, and 29 surgeons using an online questionnaire. The observers rated each image’s esthetics with a 0–100 Visual Analog Scale and determined their treatment need by choosing one of the following three choices: No need for treatment, needs treatment, acceptable, but better to be treated. Analysis of variance for repeated measurements model. The regression method, Kruskal–Wallis analysis, was used for statistical analysis and the level of significance was set as P < 0.05.

    Results

    The images with 0° and 1° rotation received the highest esthetic rates among all three groups, while the images with 8° rotation were the least attractive ones. Furthermore, the image esthetic ratings significantly affected their treatment need. Mandibular asymmetry diagnosis threshold was 1° for orthodontists, and 3° for both laypersons and surgeons. The treatment need threshold was 5°, 6°, and 7° for surgeons, orthodontists, and laypersons, respectively.

    Conclusion

    The esthetics of images decreased when mandibular asymmetry increased. Treatment need was also related to increased asymmetry. Orthodontists were the most sensitive group in diagnosis, while surgeons were the most sensitive ones when it came to treatment.

    Keywords: Esthetics, facial asymmetry, oral, maxillofacial surgeons, orthodontists}
  • علی فیضی، بهار حافظی*، سعید باقری فرادنبه، شهرام توفیقی
    زمینه و هدف

    درمان بیماری های دهان و دندان در تمام دنیا پرهزینه محسوب می شود و این بیماری ها چهارمین بیماری گران ازنظر هزینه های درمان محسوب می شوند. هدف مطالعه حاضر تحلیل مواجهه خانوارها با هزینه های کمرشکن مراقبت های بهداشت دهان و دندان در خانوارهای شهرستان اهواز در سال 1401 بود.

    روش پژوهش: 

    مطالعه حاضر از نوع مقطعی می باشد که در آن با روش نمونه گیری چندمرحله ای تعداد 715 خانوار ساکن شهرستان اهواز در سال  1401 موردمطالعه قرارگرفته است. جمع آوری اطلاعات موردنیاز از طریق پرسشنامه انجام شد و برای تحلیل داده ها و برآورد کشش عوامل اثرگذار از مدل لوجیت و نرم افزار Stata 17  بهره گیری شد.

    یافته ها

    براساس نتایج مطالعه نسبت مخارج بهداشت دهان و دندان از ظرفیت پرداخت های خانوار برابر 59/03درصد بوده و 52/16درصد خانوارها با هزینه های کمرشکن مواجه شده اند. همچنین بیمه های تکمیلی با نسبت شانس 1/39، زندگی در منطقه جنوب با نسبت شانس 1/08 و قرار گرفتن در پنجک درآمدی 2 با نسبت شانس 1/10، نقش تقویت کنندگی در مواجهه با هزینه های کمرشکن دارند.

    نتیجه گیری

    توجه به نتایج این مطالعه، به منظور کاهش اثرات منفی هزینه های بهداشت دهان و دندان، اصلاح سیاست های تامین مالی این خدمات و حرکت به سمت عدالت در تامین مالی از طریق افزایش پوشش های بیمه ای ضروری به نظر می رسد.

    کلید واژگان: مواجهه, هزینه, بهداشت دهان و دندان, کمرشکن}
    Ali Feizi, Bahar Hafezi*, Saeed Bagheri Faradonbeh, Shahram Tofighi
    Background

    The treatment of oral and dental diseases is expensive all over the world and these diseases are considered the fourth most expensive diseases. The aim of the present study is analysis of exposure of households to catastrophic expenditures of oral and dental health care in Ahvaz city.

    Methods

    The present cross-sectional descriptive-analytical study was conducted on 715 households living in Ahvaz city in 2022using multistage sampling. Collecting the data was done through a questionnaire, and logistic model and Stata 17  software were used to analyze the data and estimate the elasticity of influencing factors.

    Results

    According to the results of the study, the ratio of oral and dental health expenditures to household payment capacity was 59.03 %, and 52.16 % of households faced catastrophic expenditures. Also, supplementary insurances with Odd Ratio (OR) = 1.39, living in the southern region with OR = 1.08, and being in the 2nd income quintile with OR = 1.1 had a strengthening role in facing catastrophic expenditures.

    Conclusion

    According to the results of this study, in order to reduce the negative effects of oral and dental health expenditures, it seems necessary to modify the financing policies of these services and move towards equity in financing through increasing insurance coverage.

    Keywords: Exposure, Expenditure, Oral, dental health, Catastrophic}
  • مجید بنیادی منش، علی افخم*
    زمینه و هدف
    سلامت دهان و دندان یکی از شاخص های مهم  بهداشت در جامعه می باشد. مهمترین شاخص های مورد استفاده در ارزیابی سلامت دهان و دندان، شاخص های DMFT و CPITN است. این مطالعه به منظور بررسی وضعیت سلامت دهان و دندان در دانش آموزان  11 تا 13 ساله شهر مشهد و ارتباط آن با آب مصرفی آن ها و برخی عوامل مرتبط انجام شده است.
    مواد و روش ها
    این مطالعه ی مقطعی تحلیلی در سال 1400 بر روی 1232 دانش آموز انجام شد. نمونه برداری از تمام چاه های دستی، نیمه عمیق و عمیق و قنات های دشت مشهد  در سال 1400 انجام شد. تمامی پارامترهای آب آشامیدنی با توجه به استاندارد های کتاب Standard Methods for the Examination of Water and Wastewater اندازه-گیری شدند. داده ها، توسط نرم افزارSPSS  نسخه ی 20 مورد تجزیه و تحلیل آماری قرار گرفتند.
    یافته ها
    میانگین شاخص DMFT در دانش آموزان مشهد0/98 بدست آمد. میانگین فلویور آب آشامیدنی 0.38 میلی گرم بر لیتر بود. که کمتر از میزان مجاز فلوراید در آب اشامیدنی بود. مطابق با آزمون های آماری مربوطه بین شاخص DMFT و مقدار مصرف آب آشامیدنی در شبانه روز، مقدار فلویور آب آشامیدنی و استفاده از نخ دندان در شبانه روز رابطه ی معنی داری وجود داشت (p<0/05). همچنین بین شاخص CPITN با استفاده از مسواک رابطه ی معنی داری یافت شد(p<0/05).
    نتیجه گیری
    با توجه به اینکه فلویور آب آشامیدنی و استفاده از نخ دندان در شبانه روز، با شاخص DMFT ارتباط دارند، باید فلویور آب آشامیدنی در محدوده ی استاندارد حفظ شود و روش های مراقبت از سلامت دهان و دندان مثل استفاده از نخ دندان و مسواک به دانش آموزان آموزش داده شود.
    کلید واژگان: سلامت دهان و دندان, کیفیت آب, فلوراید آب آشامیدنی, شاخصDMFT, CPITN}
    Majid Bonyadi Manesh, Ali Afkham *
    Background and Objective
    Oral and dental health is crucial to public health. The primary indices used to assess oral and dental health are DMFT and CPITN indices. This study aimed to evaluate the oral and dental health status of 11 to 13-year-old students in Mashhad City and its relationship with their water consumption and other related factors. 
    Materials and Methods
    This cross-sectional analytical study was conducted in 2021 on 1,232 students. Sampling was done from all hand-dug wells, semi-deep wells, deep wells, and qanats (underground channels) in the Mashhad region in 2021. All drinking water parameters were measured according to the standards outlined in "Standard Methods for the Examination of Water and Wastewater." Data were analyzed using SPSS software version 20.
    Result
    The mean DMFT index among Mashhad students was 0.98. The average fluoride content in drinking water was 0.38 milligrams per liter(mg/L), lower than the permissible fluoride level in drinking water. According to the relevant statistical tests, there was a significant relationship (p<0.05) between the DMFT index and daily water consumption, fluoride content in drinking water, and daily flossing. Furthermore, a significant relationship (p<0.05) was found between the CPITN index and toothbrush usage.    
    Conclusion
    Given the significant association between fluoride content in drinking water and daily flossing with the DMFT index, it is essential to maintain fluoride levels in drinking water within the standard range. Moreover, oral health care practices, such as flossing and toothbrushing, should be taught to students.
    Keywords: CPITN, dmft index, drinking water fluoride, Water Quality, oral, dental health}
  • Leila Barati, Sajjad Khatami, Mitra Valizadeh, Homeira Khoddam*
    Background

    Available evidence on the efficacy of sweet solutions for reducing pain in infants is insufficient. This study aimed to assess the effects of 10% oral dextrose on the pain of infants during venipuncture.

    Methods

    This randomized controlled clinical trial was done on 60 infants undergoing venipuncture. Eligible infants were randomly assigned into an intervention and control group. Two minutes before venipuncture, 2 ml of 10% oral dextrose solution and 2 ml of water were given to the intervention and control groups, respectively. The infants' pain intensity during the procedure was measured by two independent experts based on the Face, Legs, Activity, Cry, and CONSOL ability Behavioral Pain Scale. Data were analyzed using independent t-test and ANOVA tests. A P-value of ≤0.05 was considered statistically significant.

    Results

    The mean (±standard deviation) age of infants in the intervention and control groups were 6.37 (2.96) and 9.03 (3.10) months, respectively (P0.05). In addition, the standardized mean difference in pain score between the two groups was -0.2 (95% confidence interval: -0.30 to 0.71). Despite a significant difference (P=0.003) in the pain score between females and males, the effect of intervention after gender effect correction was not statistically significant.

    Conclusion

    Using 2 ml of 10% oral dextrose 2 minutes before venipuncture has a weak and non-significant effect on the pain of infants. Based on the effect size and 95% confidence interval, conducting further trials with a larger study population is recommended.

    Keywords: Infant, Phlebotomy, Pain, Glucose, Oral, dextrose, solution}
  • Yavuzer Koza *, Oğuzhan Birdal, Rauf Macit, Hakan Taş, Ednan Bayram

    We report a case of a myocardial infarction (MI) due to multiple culprit vessels in a young woman. MI caused by more than 1 culprit vessel is very rare. Oral contraceptives (OCSs) are used for birth control. Despite a few case reports, the association between the new-generation OCS use and the MI risk remains controversial. A 53-year-old woman who had been consuming combined OCS-Yasmin (30 μg of ethinyl estradiol and 3 mg of drospirenone) for 2 years was admitted to our hospital with chest pain. Her past medical history revealed no coronary risk factors except for smoking. No hemodynamic instability was noted at admission. The admission electrocardiogram revealed slight ST elevations in D1 and aVL leads. An urgent coronary angiography showed distal occlusions in the right coronary, left anterior descending, first diagonal, and left circumflex coronary arteries. Unfractionated heparin and abciximab were administered during the procedure, with the latter continued for 12 hours after the procedure. During the hospital course, the patient complained of recurrent anginal attacks. A repeat coronary angiography demonstrated the persistence of thrombotic occlusions. After 24 hours, she experienced chest pain, and her electrocardiogram revealed diffuse ST elevations with a blood pressure of 60/40 mm Hg. She was urgently transferred to the catheterization laboratory. Multiple balloon inflations with intracoronary alteplase (10 mg over 5-10 min) injections failed to restore coronary flow, and she developed cardiovascular collapse. Despite maximal mechanic and mechanical support, she passed away.

    Keywords: Myocardial infarction, Contraceptives, oral, combined, Coronary thrombosis}
  • Maryam Tangarpoor, Bijan Khademi, Maryam Mardani, Mahyar Malekzadeh, Zohreh Jaafari-Ashkavandi *
    Background
    This study aimed to evaluate serum vitamin D levels in patients with oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC) in comparison to healthy controls in an Iranian population.
    Method
    A cross-sectional study was conducted, which included 69 patients with OLP, 40 patients with OSCC, and 60 healthy controls. Serum vitamin D levels were measured using the ELISA method. The data were analyzed using Mann-Whitney and T-tests, and statistical significance was set at P < 0.05.
    Results
    The study found that 17.9% of OLP patients, 27.25% of OSCC patients, and 25% of the control group had normal vitamin D levels. The mean vitamin D level in OLP patients (17.00 ± 14.16 ng/mL) was significantly lower than that in the control group (22.99 ± 14.46 ng/mL) (P = 0.003). However, in OSCC patients, the mean vitamin D level (24.63 ± 16.19 ng/mL) was not significantly different from that of the control group.
    Conclusion
    The study revealed a high rate of vitamin D deficiency and insufficiency in OLP, OSCC, and control group patients. Vitamin D deficiency was more common in patients with OLP. Vitamin D deficiency may potentially increase the risk of OLP and OSCC development and progression.
    Keywords: Neoplasms, Lichen planus, Oral, Vitamin D, serum}
  • رویا علاسوند جوادی، مهدی تولا، ملوک بیرم وند، سمیرا رزاقی، رضا ارجمند*

    زمینه و هدف:

     آکانتامبا م یتواند بیمار یهای انسانی وخیم ازجمله کراتیت آمیبی و انسفالیت آمیبی گرانولوماتوز را ایجاد کند که اکثرا در افراد با نقص سیستم ایمنی دیده م یشود. پژوهش حاضر به بررسی ژنوتایپ استری نهای آکانتامبا جداشده از حلق و بینی افراد با نقص سیستم ایمنی پرداخته است.

    روش بررسی :

    ترشحات حلق و بینی 179 بیمار سندرم نقص ایمنی با سوآپ نمونه گیری شد. پس از انتقال به آزمایشگاه گروه انگ لشناسی دانشگاه علوم پزشکی جندی شاپور اهواز در محیط آگار پایه کشت داده شد و نمون ه های مثبت جهت انجام آزمایش مولکولی استفاده شد.

    یافته ها:

     از مجموع 179 بیمار مورد مطالعه، 6 نمونه ازنظر وجود آمیب مثبت بودند و برای همه موارد مثبت تعیین توالی انجام شد و همه 6 سویه شناخت هشده ژنوتایپ T4 بودند. تفاوت آماری معناداری میان نمون ه های مثبت ترشحات حلق   4 درصد  با نمون ه های مثبت ترشحات بینی  5/ 1 درصد  وجود داشت.

    نتیجه گیری:

     نتایج به دست آمده از مطالعه حاضر نشان داد که میزان آلودگی افراد با نقص سیستم ایمنی به انگل آکانتامبا در جمعیت مورد مطالعه بیش از سایر افراد است.

    کلید واژگان: آکانتامبا, آمیب آزاد, حفره های دهان و بینی, نقص ایمنی}
    Roya Alasvand Javadi, Mehdi Tavalla, Molouk Beiromvand, Samira Razzaghi, Reza Arjmand *
    Introduction

    Acanthamoeba is a free-living amoeba that can be found in various environments. It is found in ear, nose and pharyngeal mucosa of patients with respiratory problems .This is the most common protozoan found in the environment. The antibodies against Acanthamoeba antigens have been found in the serum of more than 80% of people with complete immunity, which indicates high human contact with this amoeba. Acanthamoeba is the cause of human diseases such as amoebic keratitis and granulomatous amebic encephalitis, which is mostly seen in immunocompromised people.Skin wounds and nasopharyngeal infections caused by this amoeba have also been observed, mostly in people with AIDS. Based on rRNA gene sequence determination, Acanthamoeba genus is divided into 12 different genotypes (T1 to T12). Most human Acanthamoeba infections are related to the T4 genotype.Studies have shown that the number of amoebic keratitis is increasing worldwide due to use of contact lenses. Acanthamoeba genotyping is a useful tool for taxonomic and epidemiological studies. It explains the relationships between infectious isolates and the phenotype of the disease. Since different strains show different pathogenic power, determining the strains with high pathogenic power can have more therapeutic importance. More studies to identify pathogenic features and genetic markers are needed to clarify this matter. The present study aims to determine the genotype of Acanthamoeba strains isolated from the oral cavity of people with immunodeficiency.

    Methods

    This cross-sectional descriptive study was conducted for 18 months.
    The samples were collected with a sterile swab from pharyngeal or nasal secretions of 179 eligible patients in Golestan and Shafa hospitals in Ahvaz, Iran in 2019. The patients who had immunodeficiency with various underlying diseases including diabetes, AIDS, those who were under treatment with chemotherapy drugs and steroids, as well as dialysis patients were included in the study. In the university laboratory, the swab soaked in secretions was cultured on basic agar medium. Before closing the environment, it was autoclaved for 15 minutes at 121°C and divided into plates under the hood. The plates were fixed with parafilm and kept in refrigerator at 4°C. To detect Acanthamoeba, all samples were cultured separately in a non-nutrient medium (1.5% Bacto agar) along with an old medium of Escherichia coli. Then, bacteria were added to the medium to provide a good source of food for amoeba. The media were incubated at a room temperature and microscopic observation was done on days 2-14 to identify the samples positive for Acanthamoeba. All positive amoebae isolates can be cloned by subculturing method to produce pure culture for extracting pure DNA. Therefore, the existing parasites were transferred to new plates. To determine the genotype of the target sample, after cultivation using the primers presented in Table 1, polymerase chain reaction (PCR) was performed under the conditions shown in Table 2.The primers were diluted. For this purpose, 180 µL of distilled water and 20 µL of primer were added to two micro-tubes named as diluted G₁ and diluted G₂.To determine the genotype of Acanthamoeba isolated from patients, the PCR product was finally determined and the information related to sequencing of the fragment for each sample was compared with the information available in the gene bank, and the genotype of the amoeba was finally determined. Statistical analysis was done using SPSS software, version 22.

    Results

    In this study, 110 men and 69 women participated. Most of them (n=48, 26.8%) were at the age group of 60-69 years, and the mean age of participants was 48±1 years. As shown in Table 4, 99 samples were taken from the throat and 80 samples were taken from the nose of patients.Among the samples examined by PCR, 6(3.4%) were positive to Acanthamoeba, collected from the oral (n=4) and nasal (n=2) cavities of patients. Acanthamoeba was identified in the medium by observing star-shaped cysts. The PCR analysis was successfully performed on these samples and the nucleotide sequence was determined for them. All positive samples of T4 genotype were obtained. The PCR analysis was confirmed by observing the 500-bp band on agarose gel (Figure 1).

    Conclusion

    The prevalence of infection with Acanthamoeba parasite in patients with immunodeficiency is higher. The Acanthamoeba positive samples identified in these people belong to the T4 genotype.

    Keywords: Acanthamoeba, Free-living amoebae, Oral, nasal cavities, Immunodeficiency}
  • مقدمه

     نزدیک به دو سوم موارد مرگ و میر در سال اول زندگی ناشی از زایمان زودرس است.

    هدف

     هدف مطالعه حاضر، بررسی اثرات ترکیبات مبتنی بر پروژسترون در پیشگیری از زایمان زودرس بود.

    مواد و روش ها

     این مطالعه کارآزمایی بالینی تصادفی سازی شده روی 146 زن باردار بستری در گروه زنان و زایمان در کرمان، ایران در خرداد 1398 انجام شد. بیماران مبتلا به زایمان زودرس، توکولیتیک و 12 میلی گرم بتامتازون را در دو دوز طی 2 روز، به منظور بلوغ ریه های جنین دریافت کردند. توقف زایمان زودرس به عنوان یک دوره 12 ساعته بدون انقباض پس از اتمام توکولیتیک در نظر گرفته شد. پس از قطع زایمان زودرس، بیماران به مدت 48 ساعت تحت نظر قرار گرفتند. پس از قطع موفقیت آمیز درد زایمان، بیماران به دو گروه تقسیم شدند. در گروه A و B، بیماران به ترتیب 200 میلی گرم کپسول لوتوژل خوراکی در روز و دوز هفتگی 250 میلی گرم پرولوتون به صورت تزریق عضلانی دریافت کردند. درمان در هر دو گروه تا هفته 36 یا زایمان ادامه داشت. بیماران به صورت هفتگی و با تشخیص علایم زایمان زودرس پیگیری شدند. معاینه واژن توسط متخصص زنان و زایمان انجام شد.

    نتایج

     فراوانی زایمان زودرس در هر دو گروه یکسان بود. به همین ترتیب، در فاز نهفته (07/0 = p)، میانگین وزن هنگام تولد (17/0 = p) و فراوانی بستری شدن در بخش مراقبت های ویژه نوزادان (58/0 = p) در دو گروه تفاوت معنی داری وجود نداشت.

    نتیجه گیری

     در نتایج به دست آمده از عوارض ارزیابی  شده در هر دو گروه تفاوتی وجود نداشت و هر دو دارو به طور مشابه به بهبود بارداری و عوارض دوران نوزادی ناشی از زایمان زودرس منجر شدند. استفاده از فرم خوراکی با اثرات مفید مشابه در این مطالعه مورد اشاره قرار گرفت که می تواند راه حلی برای مشکلات ناشی از تزریق های متعدد باشد که در تجویز تزریقی این دارو اجتناب ناپذیر است.

    کلید واژگان: زایمان, زایمان زودرس, پروژسترون, خوراکی, تزریقی}
    Maryam Dalili, Moeeneh Barkhori-Mehni, Fatemeh Karami Robati
    Background

    Approximately two-thirds of infant mortality within the first year of life are caused by preterm labor (PL).

    Objective

    This study aimed to investigate the effects of progesterone-based compounds to prevent PL.

    Materials and Methods

    This randomized clinical trial study was conducted on 146 pregnant women admitted to Department of Obstetrics and Gynecology, Afzalipour hospital in Kerman University of Medical Sciences, Kerman, Iran in June 2019. The participants with PL received Tocolytic and 12 mg Betamethasone in 2 doses over 2 days to mature the fetus’s lungs. Stopping PL was considered a 12-hr period without any contractions after finishing the Tocolytic. Following the successful cessation of PL, the participants were monitored for 48 hr. Subsequently, the participants were divided into 2 groups. Participants received 200 mg Lutogel capsules orally per day in group A while group B received a weekly dose of 250 mg Proluton in the form of intramuscular injection, respectively. Treatment in groups continued until the 36th wk of delivery. The participants were followed-up weekly, and if any signs of PL were detected, an obstetrician carried out a vaginal examination.

    Results

    The incidence of PL was the same in both groups. There was no significant difference in the latent phase, average birth weight, and the neonatal intensive care unit admission frequency (p = 0.07, 0.17, 0.58, respectively) between groups.

    Conclusion

    No difference in the results obtained from the neonatal outcomes evaluated in groups. Both medications similarly led to recovering pregnancy and neonatal outcomes caused by PL. Applying the oral form with similar beneficial effects were pointed out in this study, which can be a solution to the issues caused by numerous injections that are inevitable in the injected administration of this medicine.

    Keywords: Obstetric labor, Premature, Progesterone, Oral, Injections}
نکته
  • نتایج بر اساس تاریخ انتشار مرتب شده‌اند.
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