جستجوی مقالات مرتبط با کلیدواژه « دوکسوروبیسین » در نشریات گروه « دامپزشکی »

Doxorubicin is one of the most widely used anticancer chemotherapeutic agents in small animal practice. The use of doxorubicin can cause cardiotoxicity, hepatotoxicity, neurotoxicity, and nephrotoxicity.

This study was carried out to evaluate the effects of ascorbic acid on doxorubicin hepatotoxicity in mice.

Twenty-four Balb/c mice were randomly divided into four groups. Group one received normal saline, group two received 100 mg/kg ascorbic acid, group three received 8 mg/kg doxorubicin and group four received ascorbic acid and doxorubicin intraperitoneally, with the same doses of groups 2 and 3. Twenty-one days after injection, the mice were euthanized. The activities of ALP, ALT, AST enzymes and total bilirubin levels in the serum samples were measured. Liver samples were evaluated histopathologically.

The activities of ALP, ALT, AST, and total bilirubin levels and histopathologic scores of hepatotoxicity were significantly lower in the group that received ascorbic acid + doxorubicin in comparison to those of the doxorubicin group.

Ascorbic acid may be useful in the prevention of doxorubicin hepatotoxicity in mice. Further studies are recommended for evaluation of the use of ascorbic acid in small animals.

Doxorubicin (DOX) has a wide spread use in cancer chemotherapy and Zingiber officinale (ginger) has androgenic property and effects on fertility. The aim of the present study was to investigate the protective effects of Alcoholic extract of ginger on reproductive toxicity induced by DOX in male rats. In this experimental study, 56adult Wistar male rats were randomly divided into 7 groups of 8. The extract was orally administered an hour after intraperitoneal injection of DOX. DOX injection was carried out once a week for four weeks. On the day 29, testes were removed, fixed, sectioned, stained and examined histologically by light microscope. According to the findings, DOX caused an increase in interstitial space and deformation of cells in DOX group. Conversely, the number of spermatids, and leydig cells were significantly (p<0.05) decreased compared to the control group. Moreover, concomitant consumption of ginger alcoholic extract and DOX significantly (p<0.05) improved the induced toxicity. It was concluded that ginger alcoholic extract could prevent DOX toxic effect on testicular structure and therefore improve male reproductive activities

Breast cancer is the most commonly diagnosed cancer in women. One in eight women will be diagnosed with breast cancer in their lifetime. Chemotherapy works on active cells. Active cells are cells that are growing and dividing into more of the same type of cell. Cancer cells are active, but so are some healthy cells. Also, scientists work constantly to develop ways of providing treatment with fewer chemotherapy side effects.
The aim of this study was antitumor effect of simultaneous low-intensity, 150 kHz ultrasound, in combination with the reduced dose of anticancer drug Doxorubicin (DOX) on breast adenocarcinoma using murine model (BALB/c).
Twenty-five female BALB/c mice were used in this study. The tumor was implanted under the breast skin of mice. Mice were divided into five groups, namely control, sham, drug (IV injected of 2 mg/kg of DOX), drug (IV injected of 1 mg/kg of DOX) US (150 kHz for 15 minutes) and exposure to ultrasound (150 kHz for 15 minutes) alone. The data were analyzed employing ANOVA using SPSS software V.13 and complementary test of Tooki was done.
It was shown that, after injection of DOX, exposure to ultrasound at 150 kHz the necrotic spaces in adenocarcinoma tumors compared to control and sham groups have meaningful variance (p The co-administration of DOX and low-intensity ultrasound provided a more effective treatment than the drug alone in murine adenocarcinoma breast cancer. The combined treatment appeared to produce synergistic effects that could prove potentially useful in reducing the side effects of DOX by lowering the required effective dose of the drug while increasing the efficiency of the therapy as a whole.

One of the most well known anti-cancer drug is Doxorubicin. However, green tea has many antioxidant properties. In this study, the long-term effects of green tea on bone marrow lesions caused by Doxorubicin in rats were studied. 30 adult male Wistar rats were randomly divided into 6 groups. Control, LGT (long-term use of 3% green tea extract for 60 days), SHGT (shortterm use of 3% green tea extract for 10 days), LGT DXR (long-term use of 3% green tea extract for 60 days with injections IP doxorubicin for 3 days), SHGT DXR (short-term use of 3% green tea extract for 10 days in combination with doxorubicin (IP) injection for 3 days), DXR (doxorubicin injection for 3 days). 24 hours after the last injection of DXR, rats euthanized and tissue samples were taken for histopathology of the femur. The enzymes catalase and superoxide dismutase (SOD) were measured. The histopathology results show that the DXR induced severe bone marrow suppression that myeloid cells was more involved. SHGT DXR group was similar to DXR, but the cell density was similar to control group. The LGT DXR cell density was very similar to the control group. There was a small amount of myeloid cell destruction. Measurement of catalase and SOD indicates a significant difference between treatment and control groups. Results show that Doxorubicin may cause damage in rat bone marrow, but long-term use of green tea can reduce the damage caused by doxorubicin.