Effects of oral isotertinoin on serum lipids and gamma glutamyl transpeptidase activity in acne vulgaris patients

Isotretinoin is a common drug in treatment of acne vulgaris. In the present study، the effect of isotretinoin on serum lipids and index hepatic enzymes in patients with acne vulgaris was examined. In this clinical trial study، 44 patients with moderate to severe acne vulgaris with mean age of 23. 6 ± 6. 0 years referred to dermatologist and resistant to conventional treatment were enrolled according to availability method. The patients were administered with oral isotretinoin in 0. 5 mg/kg/day dose for 120 days. Fasting blood glucose، cholesterol، triglyceride، and the activity of ALT، AST، and gamma glutamyl transpeptidase (GGT) were measured by commercially available kits prior to and after treatment. The obtained data were analyzed by software using paired t-test in SPSS software. This study indicated that serum level of cholesterol، triglyceride، and GGT increased by 12. 02% (P=0. 001)، 57. 9% (P=0. 001) and 33. 55% (P=0. 001)، respectively. The results of the present study indicated that isotretinoin has negative effects on lipid and antioxidant status in patients with acne vulgaris consuming this drug. Therefore، it is recommended to examine the administration of some antioxidants like vitamin E alongside isotretinoin in patients in the future studies.