Antinociceptive Effect of the Endemic Species Nepeta depauperata Benth

Nepeta depauperata Benth is an endemic species and is extensively exploited as an anti-inflammatory agent in Iranian traditional medicine..
This study was designed to evaluate the antinociceptive activity of methanol extract of N. depauperata in male mice..
The anti-nociceptive activities of the extract were investigated by the formalin test and Hot plate test respectively. Comparisons between the groups were carried out using one-way analysis of variance (ANOVA), and post Hoc Tukey test..
N. depauperata extract showed anti-nociceptive effect. Doses of 50, 100 and 200 mg/kg reduced the paw flexing time in formalin test from the control (P This study revealed that the methanol extract of N.depauperata may minimize both the acute and chronic forms of nociception and may have potent role against inflammation..