Study of Oxidative stress, inflammatory factors and Some Cardiovascular risk factors in Polycystic Ovary Syndrome (Case control study)

Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders in women of infertility. Women with PCOS are at high risk for early cardiovascular disease. The aim of this study was to evaluate the oxidative stress, inflammatory factors and other cardiovascular risk factors in patients with PCOS.

In this case-control study, 50 women with PCOS and 50 healthy women referred to Zahedan Infertility Clinic who were matched for age and BMI were selected by convenient  sampling method. Anthropometric parameters, biochemical tests, C3 and C4 complements, TAC and MDA levels were measured in all subjects. Data were analyzed using independent t-test and analysis of variance at the significant level P

Results showed that mean waist circumference (P = 0.048), systolic blood pressure (P <0.01) and diastolic (P = 0.048), serum LDLC levels (P = 0.05) and MDA (P <0.0001) were significantly higher in women with PCOS and serum HDL-C levels (P = 0.03) and TAC (P = 0.05) were significantly lower than   control group. Mean serum levels of C3 and C4 were higher in the PCOS group than in the control group, but this difference was only significant for C3 (P = 0.03) .

The findings showed that levels of dyslipidemia, oxidative stress and inflammatory factors were higher in PCOS women with abdominal obesity. Thus, screening of these factors and weight management, especially in obese women with polycystic ovary syndrome, is recommended in treatment strategy.