Effect of oral tramadol on rat Spleen tissue in male Wistar rats

Tramadol the right drugs are synthetic opioid analgesics or Epoxied. The aim of this study was to evaluate the effect of oral tramadol on Spleen in rats Wistar male rats.

In this study, 60 male Wistar rats randomized into 3 groups (1 control group, and experimental groups of 1, 2). In control group adequate serum physiology and in experimental groups a dose of mercuric chloride infused into peritoneal cavity, for 30 days. The amount of gavage tramadol were, 50ml /kg group 2, 100 ml /kg , every other day for 30 days. After the end of the day appointed for Histological analysis Some blood parameters of Spleen samples, were tested.

And & two experimental groups a very high density and exposure area is full of blood and lymphoid cells. Particles of hemosiderin in both groups showed a significant increase..

This study showed that long-term oral administration of Tramadol causes histological changes in the Spleen.