Design, fabrication, and characterization of sesamol loaded polymeric nanoparticles: In vivo hepatoprotective potential in Wistar rats

Liver diseases affect millions of people worldwide, which are difficult to treat with conventional drug delivery. Numerous drugs have been investigated for treatment of diseases associated with liver however correct drug delivery system need to be find for delivery of drugs. Sesamol is a well-recognized antioxidant phytoactive found in sesame oil has reported to scavenge hydroxyl radical. However unfavorable physicochemical properties limits its use as effective therapeutic agent. Thus present study was started with aim to fabricate sesamol loaded polymeric nanoparticles to minimize limitations associated with conventional delivery of sesamol. Drug encapsulated nanoparticles were formulated using solvent evaporation ultrasonication technique. The selected technique was found to be effective for preparation of nano sized particles with good physicochemical properties. The formulated nanoparticles were evaluated with respect to physicochemical properties and in vivo hepatoprotective potential. The drug loaded nanoparticles revealed significantly better hepatoprotective activity with reduction of serum liver injury markers and proinflammatory cytokines compared to standard Liv-52. Thus formulated nano sized particles based system could be promising alternative to deliver sesamol.