Preparation,Characterization, Antimicrobial and Antitumor Activity of Chitosan Schiff base / PVA / PVP Au, Ag Nanocomposite in Treatment of Breast Cancer Cell Line

In this research, chitosan Schiff base was prepared from the reaction of chitosan with carbonyl group of 4-nitro benzaldehyde. The gold and silver nanoparticles were prepared by the onion peels extract as reducing agent. The prepared AgNPs and AuNPs were characterized by UV-visible spectroscopy, SEM microscopy and XRD analysis. Polymer blends of Chitosan Schiff base, PVA and PVP were synthesis by solution casting method, Chitosan Schiff base / PVA / PVP Au and Ag nanocomposites were manufacture. the polymer blends and nano composites were characterized by FT-IR, SEM, DSC, and TGA, the blends and nano composites showed good activity against different gram +ve and gram -ve bacterium kinds, The antimicrobial activities toward the tested microorganisms, which can be attributed to chemical structure of Chitosan Schiff base, the presence of the Schiff-base molecule's imine group (C=N) with its 𝜋 - electrons is thought to improve the molecule's lipophilicity, making it easier for it to enter the microbe's cell membrane, the nano composites showed good results in inhibition of breast cancer cell line MCF7.