Comparison of aerobic and combined (resistance-aerobic) training on changes in angiogenesis, alkanin phosphatase and CRP as risk factors for cardiovascular disease in elderly men

Cardiovascular diseases are one of the most common deaths in the elderly, but the molecular mechanism of initiating the process of capillary network development and reducing the risk factors for cardiovascular disease in response to exercise is still not well understood. This study aimed to compare aerobic and combined training on changes in angiogenesis, alkaline phosphatase and CRP in elderly men.

30 elderly men with a mean age of 65-75 years were divided into three groups of aerobic, combined and control exercises. Exercises were performed for 8 weeks with a frequency of 3 sessions per week. Aerobic exercises with 60 to74% of maximum heart rate and resistance exercises with 60-75% of 1RM were performed. Blood samples were collected 24 hours before training and 48 hours after the last training session to assess changes in ALP, CRP and TGF-β factor levels. Analysis and comparison between groups were done by ANCOVA test and for in-group comparison of data by paired t-test at a significant level of P<0.05.

Results of significant decrease in serum concentrations of CRP (P=0.03), TGF-β (P=0.005) in the aerobic group and the combined group compared to the control group and Showed a significant decrease in pre-test compared to post-test in serum ALP concentration in the aerobic group (P=0.027).

decrease in CPP, ALP and an increase in TGF-β1 due to exercise appropriate to the age and condition of these individuals, caused adaptation to physical stresses such as exercise and improved health in the elderly.