The effect of aerobic training with calorie restriction on some indicators of vascular inflammation and interleukin 1 in obese male rats
Increased inflammation caused by obesity is related to vascular health. The present study was conducted with the aim of investigating the effect of aerobic training and caloric restriction on some indicators of vascular inflammation and interleukin 1 in obese male rats.
Twenty-four male rats were randomly divided into four groups: control, exercise, calorie restriction, and exercise + calorie restriction. The aerobic training program was maintained for eight weeks, and the intensity was 24-33 meters per minute with a slope of 15%, and the duration of the training was from 10 minutes on the first day of training to 60 minutes per day, increasing in the fifth week of training and until the end of the program with the same conditions. Restricted groups received 50% of the amount of food consumed by other groups. The concentration of I-selectin, ICAM and interleukin-1 was measured by ELISA method. One-way analysis of variance and Tukey's post hoc test were used at a significance level of 0.05.
The findings showed that aerobic training, calorie restriction and aerobic training with calorie restriction led to a significant decrease in e-selectin (P=0.001), decrease in ICAM (P=0.002) and interleukin-1 (P=0.001).
Eight weeks of aerobic training without and with calorie restriction leads to improvement of some vascular inflammation factors.