Effect 8-Weeks Endurance Training on the Blood Coagulation and Fibrinolysis System Response to Exhaustive Training in Male Rats

The purpose of the present study was to determine the effect 8 weeks endurance training on the blood coagulation and fibrinolysis system response to exhaustive training inthe young male rats. Forty- eight rats were divided randomly into control and experimental groups and subgroups. The experimental training programs were carried out for five days a week at the progressive treadmill with a defined speed and duration for eight weeks. Exhaustive training group performed 5 mins running with speed 20 m/min, 10 min with speed 25 m/min, and then with speed 30 m/min into exhaustion phase. Blood samples were drawn following 12 hours overnight fasting. The fibrinogen, activated partial thromboplastin time (APTT) and plasminogen activator inhibitor (PAI-1) were measured by clotting and ELISA methods, respectively. Data was analyzed using two-way ANOVA with repeated measure and independent t-student tests. Statistical significance was accepted at P≤ 0/05. The results showed the exhaustive training has increased fibrinogen and APTT levels and decreased PAI-1 concentration. On the other hand, 8 week of endurance training lead to a decrease in fibrinogen (P≤0/000) and APTT (P≤0/049) levels in training group in comparison with control group. Furthermore, PAI-1 value was significant in training group in comparison with control group. Also, 8 weeks ofendurance training induced significant changes in the resting fibrinogen (P≤0/056), APTT(P≤0/013) levels in training group in respect to control. These findings suggest the exhaustive training causes coagulation system simulation and endurance training with moderate intensity can improved exhaustive training-induced impairment on haemostatic system and prevent thrombus events.