The Comparison of the Effect a Single Acute Exercise on Plasma, CRP, TNFα and IL-6 Levels in Immature Obese and Normal-weight Boys

Background and

TNFα، ÇRP، and ÏL-6 are new cardiovascular inflammatory markers that an increase in their concentration results in an increase in cardiovascular diseases. This study is designed to compare the effect of a single acute exercise on plasma TNFα، ÇRP and ÏL-6 in immature obese and normal-weight boys.

 quasi-experimental study was designed and 21 healthy boy students of 11-14 years old were selected based on systematic randomization. Then، they were assigned into two groups of obese (77. 07 ± 17. 33 kg) and normal-weight boys (54. 7 ± 8. 28 kg). Âfter a five-minute warm-up، every participant started cycling on ergometer cycle with 65-70% of his maximum oxygen uptake (VÔ2 max) for 40 minutes، and then he ended his exercise with a five-minute cool-down. Blood samples were taken before، immediately and one hour after exercise to measure TNFα، HS-ÇRP، and ÏL-6 levels. Data were analyzed using the independent T-test، analysis of variance with repeated measures (R-ÂNÔVÂ) test، and the LSD post hoc test.

Ït was shown that the level of ÇRP، TNFα، and ÏL-6 in obese boys were significantly higher than that of the normal-weight group in all three times of measurement (P<0. 05). Çonclusion: The results of this study showed that exercise with 65-70% of VÔ2 max can increase inflammatory factors in immature obese and normal-weight boys. Thus، exercise can stimulate their inflammatory and immune responses and increase the level of some of the mentioned markers.