فهرست مطالب ali reza farsinezhad

Cell therapy is applied in tendonitis to speed the healing process of tendon tissue and restore its functional properties. Almost all types of stem cells can differentiate from the recipient cells after transplantation.

The main goal of this study is to compare the effects of two sources of mesenchymal stem cells on tendon regeneration.

This study randomly divided 32 New Zealand rabbits into 4 groups. The bacterial collagenase was induced at the superficial digital flexor tendon (SDFT) of all rabbits, and the treatment was performed 48 hours after collagenase induction. Group 1 was treated with allogeneic bone marrow mesenchymal stem cells (BMMSCs). Group 2 was treated with adipose-derived stem cells (ADSCs) from the patellar ligament fat pad. Group 3 (sham group) was treated with 0.9% normal saline, and group 4 (control group) was left with no treatment. All rabbits were euthanized 2 and 4 weeks after surgery, and tendon samples were harvested. The histopathology was assessed by hematoxylin-eosin, Masson’s trichrome, and Vangieson’s dye, and tendon structure, fiber arrangement, cell nuclei, tissue inflammation, vascularity (angiogenesis), and density were surveyed.

The tendon healing process in the BMMSC and ADSC groups revealed better regeneration than the control and sham groups (P≤0.05). Significant changes (P≤0.05) in some microscopic parameters were seen by comparing the BMMSC and ADSC groups.

According to the present study, the injection of mesenchymal stem cells (BMMSCs or ADSCs) showed beneficial results in tendon tissue healing. Furthermore, ADSCs showed better regeneration of the injured tendon tissue than BMMSCs.

By paying attention to the correspondence between the levels of existence and the levels of perception in Suhrawardi's thought, a new definition of science can be presented, the validity of which is generally different from other theories in the field of knowledge. In the school of enlightenment, "intuition" is considered as a great support for understanding the deep degrees of truth, which can be achieved through the world of imagination and the promotion of the realm of human enlightenment. The present article intends to study the coordinates of this type of scientology in the wisdom of illumination with a descriptive-analytical method, and through this it can explain its educational results in accordance with the results of this research "Gradual evolution" The degree of "perception" and, consequently, the "recognition of different understandings of a single truth" in such a way that it does not lead to skepticism and reprehensible relativism. There are two main consequences of the theory of intensity science, the realization of which depends on the implementation of the definition and dimensions of the theory of intensity science and the adoption of appropriate solutions in the educational system; Therefore, it seems that the vast capacity of the wisdom of enlightenment in inferring the various dimensions of education and improving the components of the educational system, such as the principles, results and strategies of education, is undeniable.

The relation between self-knowledge and theology is one of the most important issues in the field of cognition of man and theology. This is important to the extent that in our narrative societies, we have given many traditions to this issue, such as the noble Hadith "everyone who knows himself, has known his Lord". Considering the importance of self-knowledge and its effect on the identification of the Lord, the present article, using an analytical-descriptive method, to achieve the effect of self-knowledge on the recognition of the Lord, firstly refers to the four-dimensional views that Allameh Hassanzadeh has presented from the hadith of self-knowledge and then reviewed the semantic implications of human attributes on the attributes of the Lord in the field of both beauty and glory attributes, and it has been concluded that, for example, the recognition of beauty attributes such as science, power, life, and …, and the recognition of glory attributes such as Failure to combine, lack of sight, lack of soliloquy and unity, lack of notion and neglect, and ... in human, it is possible to recognize such qualities in the Lord.

The comprehensive concept of God has been debated in various books of the divine religions; in the Muslim Qur'an titled "Allah", in the Avesta Zoroastrian holy book entitled "Ahura Mazda"; in the Jewish holy book, Torat, entitled "Jehovah " In the Gospel of the Christian holy book, entitled "heavenly Father". The present study seeks to determine whether all of the titles refer to one fact and are completely consistent or that there are differences. For this purpose, a descriptive-analytical-comparative method compares the various titles of the concept of God in the scriptures of other divine religions with the title of the concept of God in the Qur'an ("Allah") and has concluded that However, all of these titles point to one truth, and they all represent the holistic concept of God in that religion but in the scriptures of other divine religions, there are many distinctions with the Qur'an in describing the essence, attributes and verbs of God. The comprehensive concept of God in the Qur'an expresses a truth that is  unique

The issues of Avicenna's philosophy begin with the topicality of being qua being; in the works of Avicenna, the human mind can draw the actualized external existence away into two distinct concepts of existence and whatness. Later this basic question was raised: Which one of the two concepts mentioned in the work of Sheikh is objective and which one is ideational. The following analytical-critical research, while explaining the conceptual principles, is looking for an answer to the question; is the distinction between the existence and the quiddity (whatness) an ontological question or is it merely an epistemological argument? Thus, by analyzing and critiquing recent articles on the field of Avicenna's belief about the question that what is the reality: the primacy of existence or primacy of quiddity is concluded that this argument -the question of the primacy of existence or quiddity- has no place here; Because these two have an identity with each other in the objective world; So with no external changes, talking about the fundamentality of existence and ontological fundamentality of quiddity is merely an epistemological problem. So in Avicenna's work, actualized external existent is a reality and in that sense it is authentic; so, it is separated into existence and quiddity in the mind of the perceiver.

Numerous books have been written or translated on the "relationship between science and religion" or "the relationship between science and theology." One of these books is "The Relevance of Natural Science to Theology" by William H. Austin. This book is one of the few books that deals with the relationship between natural science and theology in a specialized and detailed way. The book has been translated by Ali Haqqi as "Relation of Natural Science to Theology". The author sought to translate the content of the book into Persian, but found the translation so vague, inaccurate, and erroneous that he preferred to critique the book's translation in a critical-analytical way instead of criticizing the book's content. The translation of this book is not suitable for any textbook or even research source. to providing such translations with this volume of errors, for publication by the esteemed translator, and for publication by the esteemed publisher without prior professional judgment or at least without eliminating the apparent flaws, it is reflective.

Recurrent bacterial cystitis is a common infection in women and there are concerns about its antibiotic therapy. Platelet rich plasma has antimicrobial and tissue repairing effects. We investigated the effect of platelet rich plasma as an intravesical therapy to prevent recurrence of bacterial cystitis.

Thirty women with a history of recurrent bacterial cystitis were randomly assigned into two groups: 1) platelet rich plasma and 2) control groups. The first group received 10 mL of platelet rich plasma with intravesical instillation plus 40 mL of normal saline. The control group only received 50 mL of normal saline. We did the instillation once a week for four weeks in both groups. We followed up the participants two and 12 months after the last instillation with a questionnaire (the international consultation on incontinence questionnaire in overactive bladder) and result of their urine culture.

A significant decrease was observed in the number of bacterial cystitis recurrences in the platelet rich plasma group compared to the control group 12 months after the instillation (4 vs. 1, P = 0.004). Also, there was a significant improvement in the questionnaire’s score two (3.6 ± 2.58 vs. 0.66 ± 1.63, P = 0.002) and 12 months (3.4 ± 2.77 vs. 0.006 ± 1.83, P < 0.001) after instillation in the platelet rich plasma group compared to control group. There was no adverse effect 12 months after instillation.

Platelet rich plasma can significantly decrease the recurrence of bacterial cystitis up to a year after instillation without any side effect

Mulla Sadra has claimed in some of his writings that there is no difference between the unity of the existence and the difference of it in the transcendentalist wisdom, with the theory of difference of existential truths in the peripatetic philosophy. The present article aims to investigate and explain this claim by analytical-critical method. the Mashayyans have counted three type distinctions: the distinction to all nature, the distinction in nature and the distinction between the effects of nature, that the difference between existential can not be placed in either of these three categories. Hence, in order to explain the difference between existential, we go to the fourth type of distinction, namely, gradation of distinction. Ibn Sina has revoked gradation of nature and has not explicitly discussed about gradation of existence. But his points to topics such as the Severity and weakness of existence and the Principle of causation, suggest that, in order to explain the difference between existential, one can attribute a gradation of existence to Ibn Sina. Therefore, it can be said that Mulla Sadra's claim that there is no discrepancy between the theory of the difference between existential of the Mashayyans and his theory, namely, the unity of the existence and The difference of it (gradation of existence), is a correct claim, but It can be said that this is the same between these two theories.

In Fakhr Razi’s thinking, on the one hand, the causality argument and the mutual effects of the creatures on one another are discussed. On the other hand, the arguments of unity of actions and the general nature of God's causality and agency over all actions and causes, and the monopoly of God’s causality and agency have been raised. Some believe there is a conflict between these two statements. The present article aims at providing a clearer explanation and makes an attempt to investigate this issue with an analytical method within the framework of Fakhr Razi’s perspective. The analysis shows that although the unity of actions, the principle of causality and its derivatives are not incompatible, the principle of causality and its derivatives originate from the philosophical foundations of the Unity of Divine Acts and provide a better explanation for the issue. But the view of unity of divine actions and the acceptance of the principle of causality and some of its derivatives in Fakhr Razi's thought reflects an internal inconsistency in his epistemic system. It is possible, however, to distinguish between the philosopher Fakhri Razi and the theologian Fakhri Razi. His argument of the principle of causality may be considered philosophical while his argument of the unity of divine acts falls within his theological perspective. Nevertheless, his theological views dominate philosophical ones in his works.

One of the topics whose roots have a long history in the words of philosophers is the discussion of material and physical causes. Philosophers believe that physical causes cannot have unlimited effects. In order to prove this claim, they have argued the need for "position and parallel" as a prerequisite for influencing these causes. Some later philosophers, such as Sabzevari and Tabatabai, have made other arguments for this claim on the basis of a substantial motion. Based on these arguments, if the effect of the physical cause is finite, the passivity of physical activity can't be unlimited. Because what is claimed to be finite is the effect of the subject and the physical cause. This effect, requires an affected one, which is the passivity of the physical that due to the limited effect of the cause, it can't be unlimited. But on the other hand, there are some examples of religious teachings that, according to some assumptions, there is no physical limit to passivity and affection. In this article, by descriptive and analytical method, the reasons for proving the limitation of the effects of physical causes are evaluated. By expressing some religious and philosophical evidence, the incompatibility of this evidence with the finiteness of physical effects is explained. The result of the research shows that the two proofs are incomplete in proving the finiteness of the effects of the physical cause. And infinite passivity of material objects according to some religious and philosophical doctrines is not impossible.

Tissue engineering has been investigated as a potential method for healing traumatized tissues. Biomaterials are material devices or implants used to repair or replace native body tissues and organs. The present study was conducted to evaluate the effects of decontamination methods on biological/mechanical properties and degradation/adhesion test of the platelet‑-rich fibrin (PRF) membranes to compare these properties with intact membranes as a biological biomaterial.

The in vitro degradation tests were conducted by placing the equal sizes of (i) intact PRF membrane, (ii) PRF membrane sterilized by autoclave (iii), ultraviolet (UV), and (iiii) gamma irradiation in phosphate buffer solution on a shaker. The degradation profiles were expressed. Adhesion test was performed by counting adhered mouse fibroblast and sterilized fibrin membrane was compared to normal fibrin membrane by different sterilization methods.

The preliminary findings of sterilized PRF membranes showed that UV exposure (p Sterilization of fibrin membrane with different protocols does not have any adverse effects on cell adhesion; however, cell adherence is naturally very weak even in normal membranes. Also, it seems that ultraviolet ray polymerizes fibrin filaments and merges them to each other and increases the ability of fibrin membrane against degradation. Autoclaved fibrin membrane content proteins are denatured because of pressure and heat and show an increase in hardness and stability against degradation.

The mesenchymal stem cells (MSCs) of peripheral blood (PB) have been recognized as a promising source for allogeneic cell therapy. The objective of the present study was to isolate and characterize MSCs derived from non-mobilized PB, and evaluate their differentiation potential.
The buffy coat mononuclear fractions of the PB were concentrated using the Ficoll-Paque density gradient centrifugation and were grown on primary and secondary culture media, respectively. The isolated cells were characterized using a multidisciplinary approach which was based on morphology, immunophenotyping, gene expression, and multipotentiality. Flow cytometry and Reverse transcription polymerase chain reaction (RT-PCR) were used to identify the expression of different MSC markers. Finally, after culturing in osteogenic and adipogenic induction media, the isolated cells were stained by Alizarin red and Oil-Red O.
In spite of absence of any bone marrow stimulating factor, the isolation approach in this study yielded a rather homogeneous and spindle-shaped mononuclear cell population (the yield of passage 0 was 0.65 ± 0.15) that stained positive for CD90, CD105, and CD73, and were negative for CD45 and CD34. These cells have high proliferative capacity (confirmed by the expression of Oct-4, Nucleostemin, and Nanog genes) and were able to differentiate into lineage-specific committed cells, when exposed to the appropriate medium.
Overall, it can be concluded that conventional, labour-intensive and time-consuming approaches are not necessary in isolating MSCs from PB. This relatively accessible and minimally invasive source, PB, represents a good alternative reservoir of homogeneous MSCs that could open a new era for practical exploitation in regenerative medicine.

The meaning of life, as a significant issue, has been considered by Ostad Motahari and Allameh Jaafari. The analytic-descriptive study of these two Muslim thinkers’ views shows that, in spite of considerable similarities, there are essential differences between their approaches to this issue. The differences are classified under three categories: (1) The theological and transmitted approach of Ostad Motahari to this issue in comparison with the rational and philosophical approach of Allameh Jaafari; (2) Motahari’s non-independent and reductionist attitude to the issue of meaning of life versus Jafari’s independent and pivotal attitude toward it; (3) Motahari’s lack of attention to the issue of meaning of life and his approach to take it for granted versus the serious attention of Allameh Jaafari to this question and his efforts to derive the answer through analyzing the question. These fundamental differences represent two different ways through which the meaning of life is discussed in the realm of Islamic- Iranian thinking thought.

Acute myeloblastic leukemia (AML) is a clonal disorder due to bone marrow failure and uncontrolled proliferation of myeloid lineage. Acute promyelocytic leukemia (APL) is a subtype of AML. Heterocyclic compounds, such as indole, are considered as attractive candidates for cancer therapy, due to their abundance in nature and known biological activity. Sal-like protein (SALL4) is a zinc finger transcription factor involving in the multi-potency of stem cells, in the NB4 cell line. This study was aimed to evaluate the effects of basal indole and its new derivative, 2-(1-((2, 4-Aril)imino)-2,2,2-trifluoroethyl) phenyl-1H Indole-3- carbaldehyde (TFPHC), on the expression of SALL4.
Cells were cultured and treated with different concentrations (75, 150, and 300 µg/mL) of the new indole derivative and DMSO, as a vehicle control, for 24 and 48 hours. Cell proliferation was evaluated by using Trypan blue exclusion and MTT assays. The percentage of apoptotic cells was determined by flowcytometry analysis using the Annexin V/PI apoptosis detection kit; mRNA expression of SALL4 was studied using absolute quantitative RT-PCR.
Our findings demonstrated the effects of new indole derivatives on SALL4 mRNA expression. Expression of SALL4 mRNA was significantly decreased at 75, 150, and 300 µg/mL concentrations.
SALL4 plays a role in the survival of APL cells. SALL4 expression could be suppressed by the novel indole derivative. Additionally, SALL4 gene suppression can serve as a target in APL therapy.

One of the most important questions in philosophy of religion and modern theology is the salvation of the followers of other religions, well discussed by Karl Rahner and professor Motahhari. Comparing the ideas of the two great scholars, I have proved that we can talk of a theory of anonymous Muslims similar to the general model of the theory of anonymous Christians of Karl Rahner. Professor Motahhari poses innate and real Islam, compared with regional and formal Islam, and says the followers of other religions who are not officially and nominally called Muslims because they have not understood the rightfulness of Islam, but have innate Islam and cordial submission, are considered unofficial and anonymous Muslims and thus benefit salvation which is similar to the inclusion of the theory of anonymous Christians for non-Christians.

The Principle of the Unity of Divine Acts which can be defined as conditionality of everything to Divine permission, Providence and will, has caused numerous objections. Fakhr al-Din al-Razi has tried to respond to the aforementioned objections. In this article, in order to review these responses and provide a proper explanation of the Unity of Divine Acts, I shall include the objections into three categories which are (1) objections based on restriction of the domain of divine power, (2) those which are based on restriction of the Knowledge and the Will of God, and (3) those which are based on rationality of good and evil. I shall then reread and analyze al-Razi’s ideas about these objections. It is concluded that none of the objections cast doubt on the principle of the unity of divine acts. Furthermore, while some of al-Razi’s responses are satisfactory, his other responses are based on doubtful foundations.

Cold antibody induced platelet clumping is a rare in-vitro phenomenon that causes EDTA independent pseudo thrombocytopenia. This pre-analytical problem leads to a challenge in the clinical laboratory. In such a case platelets tend to easily aggregate in vitro, giving rise to lower platelet counts. The error is detected simply by examining peripheral blood smear. This report describes a 77 year old man with colon cancer who has received 10 units of random donor platelets due to an analytical error.
Case report: Blood sample was collected on EDTA and sodium citrate anticoagulants and counted in different times and various temperatures by cell counter to detecting the cause of thrombocytopenia. The patient had no signs of bleeding. Platelet count was 164000/µl immediately after sampling but declined sharply after 5 minutes. Platelet clumps was seen at the end of peripheral blood smear. We conclude that cold agglutination induced pseudothrombocytopeniais rare phenomenon which resulting in misleading laboratory results.
This condition should be considered in severe thrombocytopenia without abnormal bleeding manifestation. Since the cold coantibodies did not affect platelet function, this patients will not suffer complications from their platelet cold agglutinin, but it could pose a problem under circumstances such as extensive surgery with associated with hypothermia

There has been controversy on compatibility or incompatibility of transcendent Philosophy teachings with the teachings of the Quran and revealed. This paper aims to investigate the coordination of transcendent Philosophy teachings with the teachings of the Quran, examined the purposefulness from the perspective of the Holy Quran and the transcendent Philosophy, in three domain; the principle of finality, ultimate cause and goal of acts of God, with the analytical comparative method, and came to the conclusion that the creation is purely teleological from the perspective of the Holy Quran and the transcendent Philosophy; the ultimate cause of the creation of the world is human and The ultimate cause of the creation of the human is Essence of God; the purpose of The Divine Acts is the same Essence of God. so it can be said in general, the ultimate cause and purpose of God's actions, is The Unique nature of God. Therefore the viewpoint of the transcendent Philosophy is Coordinated with the teachings of the Holy Quran and there is no conflict even differences in this field.

Leishmaniasis is a protozoan parasitic disease and a global health problem. The aim of this study is to diagnose the parasitic infection in humans for epidemiological identification and providing control programs using proprietary co-designed primers in three species of Leishmania.
30 common Leishmania isolates were gathered from different centers in Iran. Having been cultured in RPMI-1640 Medium, DNA was extracted and the gene ITS2-rRNA was amplified by PCR. The amplicons were examined by electrophoresis on agarose gel 2%. Also, in FLASH PCR method, a specific probe and florence colour were used to investigae the amplicon existence on sample.
The results of the investigations by PCR and FLASH PCR methods show that these methods are sensitive and specific for diagnosis of Leishmania
In this study, identification of Leishmania parasite using specific primer pairs was successful and TaqMan could be one of the most sensitive diagnostic methods to identify parasite load for the ITS2 region of Leishmania.

The present paper aims at examining the issue of determinism and free will from the perspective of Faiz Kashani. The conclusion is that he is a proponent of the notion of meliorism; however, his delineation is different from the ones provided before him. To explain this theory, he has drawn on an innovative notion entitled "delegation of free will to human beings". Despite his efforts to reject determinism and free will and provide proof for meliorism, he has apparently got very close to the notion of delegation though his view of delegation is different from the ones commonly used, because delegation means man’s independence in his voluntary acts and the denial of God's agency. In contrast, his notion of "delegation of free will to humans" is not incompatible with God's agency; because as God has the authority to force man to do a specific act, He could delegate free will to him. This notion is not only compatible with the generality of divine agency and divine ordination but it does reiterate it.

Background & Mycoplasmas are one of the causative aetiologies of infertility in human beings. Genital Mycoplasmal infections can damage reproductive systems and lead to infertility infant mortalities. The aim of this study was molecular identification of Mycoplasma hominis isolated from genital system of infertile men and women in Kerman.
Materials & This descriptive study was performed on 100 infertile men and 100 infertile women with a six month purposive sampling from the patients who referred to Infertility Center of Kerman. Semen and vaginal swab were tested by PCR assay for the presence of M. hominis. PCR product of positive samples were selected for sequencing. Sequence alignment was performed using MEGA 5 software and Neighbor-joining method.
In this study 45% of the samples taken from men were infected to Mycoplasma. Among them, 33% of the isolates belonged to M. hominis. Furthermore, 43% samples taken from women were infected to Mycoplasma, among them 41.8% belonged to M. hominis. Based on sequencing analysis, these M. hominis isolated from the patients were categorized into 5 different strains.
In this study, M. hominis was indicated as the main microbial reason of infertility in this group. Sequence analysis of different M. hominis showed significant variability among the isolates. Therefore, these isolates can be reported as the local strains of Iran.

Among Ashari scholars، Fakhr Razi explicitly used the term «Unity of The Divine Acts» and tried to prove this issue through several rational and traditional reasons. This article، by studying the different versions of the «Unity of The Divine Acts» from Fakhre Razi’s viewpoint، assessed his rational reasons in four categories - existential reasons; monotheistic reasons; anti conferment reasons; deterministic reasons - and it was concluded that although the «Unity of The Divine Acts» is a quit discursive issue from his viewpoint، but all his reasons، doesn’t able to prove the correct versions of the «Unity of The Divine Acts»; some reason proves the «Unity of The Divine Acts» means Unity of God''s Creativity and Agency (denying partner agency); some، proves the «Unity of The Divine Acts» means direct or indirect agency of God to all actions; some، proves the two former means; some، is just a reason for rejection of the conferment and man dependency in actions; some، proves the deterministic reading of the «Unity of The Divine Acts»; and some also is incomplete so that it can''t afford to prove none of the readings of the «Unity of The Divine Acts».

The question of determinism or free will has been a challenging problem in theology. Shii and Mutazili theologians defend free will and Ashari's defend determinism and sometimes give a theory named Kasb (acquirement) in this relation. Fakhre Razi is a great Ashari theologian. But he attemts to avoid pure determinism. In this paper we show how he tries to combine human power and freedom with determination that originates from divine omnipower. We will discuss that sometime he moves from Kasb theory to the theory of amrun bayn al-amrayn (a thing between determinism and free will), which is a characteristic of shii theology. But he cannot explain this theory. So he remains on the dilmma of determinism and free will and cannot give a clear explanation in this relation.

The purposefulness of the creation is one of the main subjects of the muslim philosopher and theologists. Having goal is one of the inseparable necessities of the action of the wise creator. One group of the philosophers has exonerated God from having a goal, since they have treated purposefulness as deficiency or need. But the other group has proved the necessity of having goal for the actions of God, because of the wiseliness of the creation. According to the teachings of the transcendentphilosophy (Hekmat-e Motaaliyye) there is no contrast between these two views, since goal is beside the nature and the Supreme God is innocent from it; but if the goal should not be beside the nature there is no objection. So the ultimate goal of the God's action is his nature which the muslim philosophers have tried to define and prove. Some think that the claim of the muslim philosophers in defining God's nature as the goal of creation though proves the act's goalof God's nature, on the other hand denies the creator's goal. This paper, by using Mulla Sadra's ideas, reveals the incorrectness of this view and proves that God's nature is both act's goal and creator's goal.

Documented history shows that the majority of the ancient Greek scientists were concern about the first creature which came to existence. At that period, the material elements such as water, fire, air were introduced as the primary source of the world. Peripatetic philosophers through philosophical theories, such as theory of future possibility and theory of the One concluded that intellect is the first emanation; because it is the one, indivisible and superior. On the other hand, Muslim mystics emphasized on the unfolded existence and muhamadan reality. While the Quran does not stipulate to the first creature; narratives point to the intellect, light, spirit, and pen as being the first creature. Studies show that this interpretation is not inconsistent with what philosophers and mystics have expressed, but they all show different manifestations of the same concept. As plenty of divine names and attributes are abstracted from the divine simple essence, His first appearance is also considered similar. This paper seeks to demonstrate the harmony between religious traditions and intellectual achievements on the first emanation.