shokouhsadat hamedi

Exogenous hydrogen sulfide (H2S) has a positive effect on respiratory diseases. Oleo-gum of Ferula assa-foetida contains this compound. This study assessed the effects of Ferula assa-foetida L. oleo gum resin and tragacanth (Phytopaj) on patients with COVID-19. 

A randomized, single-blinded, controlled trial (RCT) phase 2 was conducted in Mashhad on hospitalized COVID-19 patients. In this RCT, 122 patients were randomly assigned to either receive a 14-day oral phytopaj plus ordinary treatment or ordinary treatment only. Changes in peripheral blood lymphocyte count (LC) and blood oxygen saturation (PO2) were the endpoints.

Mean±SD of PO2 in Phytopaj comparison ordinary treatment before intervention was 91.86±4.62 and 91.41±9.18, after the intervention it was 93.22±4.26 and 91.91±5.92 mmHg; before intervention, mean±SD of peripheral blood lymphocyte count was 1015.90±500.55, and 1104.28±543.61, and after intervention, it was 1652.27±921.38 and 1326.12±719.28/μL respectively. Participants' age, comorbidity, gender, and stage of

Phyopaj is most useful in moderate stages of Covid19, and it is not recommended for elderly patients and patients with comorbidity until more insight is gained.

Sexual satisfaction is a person's positive evaluation of the sexual relationship. Decrease in sexual satisfaction is one of the common complaints of the postmenopausal period. Flaxseed is a phytoestrogen and contains lignan. The present study was conducted with aim to investigate the effect of vaginal cream of flaxseed and conjugated estrogen on sexual satisfaction in postmenopausal women.

This single-blind randomized clinical trial study was conducted in 2018-2019 on 60 married postmenopausal women aged 40 to 65 years referred to the clinics of Qaem and Imam Reza hospitals in Mashhad, Villa Shahr Health Center and the health center of Khalilabad city of Kashmar. The research units were randomly assigned in two groups of 30 people, vaginal cream of flaxseed and conjugated estrogen for 8 weeks. The intervention group received 4% vaginal gel in the form of one gram per day, and the flaxseed group received one gram per day for up to 8 weeks. Sexual satisfaction was calculated based on Larson's questionnaire before, 4 and 8 weeks after the study. Data analysis was done using SPSS statistical software (version 22) and Independent t-test, Friedman and Mann-Whitney tests. P<0.05 was considered statistically significant.

The mean sexual satisfaction 4 weeks after the intervention was 24.2 ± 10.4 in the flaxseed group and 23.4 ± 12.1 in the conjugated estrogen group (P=0.576), and after 8 weeks, it was 37.7 ± 18.2 in the flaxseed group and 37.8 ± 18.3 in the conjugated estrogen group, which did not show a significant difference between the two groups (P=0.638).

Vaginal cream of flaxseed without any side effects compared to the side effects of hormone therapy can be as effective as conjugated estrogen vaginal cream in increasing sexual satisfaction.

Chemical agents, such as Chlorhexidine are used as one of dental plaque control strategy. Researchers are looking for a natural and economic substitute with same antibacterial efficacy and less complications. The aim of this study was to evaluate the antimicrobial efficacy of the Khorasan Razavi walnut green husk extract with and without adding ZnO nanoparticles (nZnO) on  (S. mutans).

In this in vitro study, antimicrobial effect of the Hydro-ethanolic extract of WGH, was evaluated. Broth Dilution and Agar diffusion methods were used with 90 tubes containing different dilutions of WGH extract (100 to 0.006 mg/ml). ZnO nanoparticles (nZnO) were added to 45 tubes. Streptococcus mutans was exposed to 15 different serial concentrations of study extracts, from 100 mg/ml to 0.006 mg/ml. Minimum inhibitory concentration (MIC) of the study extracts were determined and zone of inhibition diameter was compared to positive controls (chlorhexidine 0.2%, nZnO), and negative control (sterile distilled water). The differences between the mean diameters, were analyzed by independent sample T- teS.

Minimum inhibitory concentration (MIC) of study extract was found to be 50 mg/mL, with adding nZnO, MIC was reduced to 3.12 mg/mL. Mean diameter of inhibition zone at 3.12 mg/ml with and without adding ZnO nanoparticles were 17.67±0.57 mm and 8±0.001 mm, respectively, (p-value< 0.001).

Adding nZnO could be enhanced antimicrobial efficacy of the WGH extract against S. mutants, while it was still less effective than chlorhexidine.

Many women suffer from bloating and abdominal distension after cesarean section. This study was performed with aim to investigate the effect of Anethum graveolenseed extract on intestinal function after cesarean section.

This single-blind clinical trial study was performed on 80 cesarean section women in the hospitals of Mashhad University of Medical Sciences in 2019. Pregnant women were divided into intervention and control groups. The intervention group received Anethum graveolenseed extract 4 hours after cesarean section. Intestinal function was measured before the intervention up to 12 hours after cesarean section. It was measured using visual scale of bloating, tape meter and check list containing the first time of hearing intestinal sounds, flatulence and excretion. For the control group, only the intestinal function was measured as the intervention group. Data were analyzed using SPSS software (version 24) and Mann-Whitney, independent t, Chi-square, and Fisher's exact tests. P<0.05 was considered statistically significant.

Mean of intensity of bloating was significantly different between the intervention and control groups (p<0.001). There was no statistically significant difference between the two groups in mean scores of abdominal distension (p<0.05). The mean time of hearing first intestinal sounds, flatulence and excretion after the surgery was significantly different between the intervention and control groups (p<0.001).

Consumption of dill seed drops improves the intestinal function after cesarean section.

 Postpartum hemorrhage (PPH) is a leading cause of mortality and morbidity worldwide. Anethum graveolens (dill) is one of the recommended herbs to reduce bleeding.

 This study aimed to evaluate the efficacy of rectal suppository of Anethum graveolens on the postpartum hemorrhage (PPH).

 Following a randomized clinical design, 70 eligible pregnant women admitted for vaginal delivery to Umm-al-Banin Hospital in Mashhad (Iran) in 2018 were recruited in this trial. Subjects were selected by available method and randomly assigned into two groups of intervention and control. Both groups, immediately after the delivery, received routine hospital interventions. Instantly after the expulsion of the placenta, the intervention group received the first dose of rectal suppository and the subsequent doses up to five doses at intervals of 30 min. PPH was measured by weighing the blood bags and pads for 4h after labor. Data were collected using a sample selection checklist, demographic and pregnancy information forms, birth, infant, and placenta information forms, and partograph sheets. Data were analyzed by SPSS version 22 using an independent t-test or the Mann-Whitney test.

 The two groups were homogeneous in terms of mediating variables. The mean bleeding rate at the end of the first fourth after delivery was 306.2 ± 11.2 cc in the control group and 282.4 ± 9.6 cc in the intervention group. Therefore, there was a statistically significant difference concerning post-delivery bleeding between the two groups (P = 0.001).

 Based on the findings, the rectal suppository of Anethum graveolens could effectively reduce the PPH without any adverse effects. Therefore, this efficient herbal approach is suggested to overcome the PPH.

Resistance of oral pathogenic bacteria to chlorhexidine mouthwash is increasing; therefore, researchers are looking for a replacement of chlorhexidine with suitable herbal mouthwash. This study aimed to investigate the antimicrobial effect of hydroalcoholic extract of Plantago major (a native strain of Khorasan, Iran) with and without zinc oxide nanoparticles on Streptococcus mutans.

In this in vitro study, the samples were tested in two groups of hydroalcoholic extract of Plantago major leaves with and without zinc oxide nanoparticles. To determine the minimum bactericidal concentration and minimal inhibitory concentration, agar diffusion and broth dilution methods were applied, respectively. A concentration of 500 ppm zinc oxide nanoparticles with a 0.4 nm diameter was used continuously in all stages of the experiment. The materials used in this study consisted of a standard strain of Streptococcus mutans (ATCC 25175), chlorhexidine 0.2% as a positive control, and distilled water as a negative control.

The mean diameter of the growth inhibition zone was obtained as 15±1 mm for the hydroalcoholic extract of Plantago major leaves with zinc oxide nanoparticles at a concentration of 1.56 mg/ml. The same extract at the same concentration, however without zinc oxide nanoparticles, showed the mean diameter of growth inhibition zone of 7.67±0.57 mm. The results of the t-test were indicative of a significant difference between the two groups (P-value<0.001).

In this study, the antimicrobial effect of Plantago major leaves extract with or without zinc oxide nanoparticles was well established. This research is peculiar since it revealed the effectiveness of low concentrations of this plant in killing Streptococcus mutans.

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by decreasing platelet count with the normal bone marrow and the absence of specific causes of thrombocytopenia. Corticosteroids are the first line of treatment and costly and complicated methods, such as splenectomy or immunosuppressive agents, are used as the second line of treatment. Alfalfa with scientific name of Medicago Sativa has warm temperament that traditional physicians have used as haemapoietic food from thousands years ago and its use with anticoagulants reduces their effectiveness. The aim of this study was to determine the effectiveness of alfalfa syrup on platelet count in patients with ITP.

This is a randomized, double-blind, placebo-controlled clinical trial that was done in Hematology Clinic Imam Reza Hospital, Mashhad, Iran. Forty patients were randomly divided into two groups of alfalfa syrup and placebo syrup. They received 5 cc of alfalfa or placebo syrup each 8 hours for 15 days. Blood samples were taken from patients before and at the end of treatment. Blood samples were taken for CBC, BT and platelet counts. The statistical method used was Paired-samples T test and independent-samples T test.

The results showed that there were no significant differences between the two groups in the laboratory tests at first, but after the intervention, the mean number of platelets and BT differences between the two groups was statistically significant (p=0.013 and p=0.018, respectively).

The use of a cheap and available vegetable as alfalfa can be effective in improving the platelet count in patients with ITP.

The most prevalent endocrine disorder in women of reproductive age is polycystic ovary syndrome (PCOS). The purpose of this study was to evaluate the efficaciousness of a Persian herbal remedy, as well as electroacupuncture and the combination of them on metabolic profiles and anthropometric parameters in these patients.

Eighty overweight women with PCOS were randomly divided into four groups. All of them received metformin 1000 mg and the second group received 5 g of herbal medicine per day (main components: Foeniculum vulgare, Urtica dioica, and Daucus carota), the third group were subjected to 20 electroacupuncture sessions, and the fourth group received both therapies.

After 12 weeks, the body fat and body mass index decreased the most in the herbal medicine+electroacupuncture group, and waist to hip ratio decreased the most in the electroacupuncture group. A significant decrease was also observed in fasting insulin, homeostasis model assessment of insulin resistance. A significant increase was seen in the quantitative insulin sensitivity check index in all intervention groups, but there was no noteworthy difference in these parameters in the control group. Total cholesterol and lowdensity lipoprotein cholesterol decreased significantly in the electroacupuncture groups and herbal medicine+electroacupuncture. Also, a significant decrease was observed in triglycerides, aspartate aminotransferase, and alanine aminotransferase in the herbal medicine groups and herbal medicine+electroacupuncture.

It is advisable to use this herbal remedy and electroacupuncture for better treatment of metabolic complications and overweight problems in these patients.

Vaginitis is a general term for vaginal disorders which is caused due to infection, inflammation or a change in the normal vaginal flora. Trichomonas vaginalis is the third most common cause of vaginitis. Antibacterial, antifungal and anti trichomoniasis effects of ferula have been shown by in vitro and in vivo studies. This study was performed with aim to compare the effects of ferula oral capsule and metronidazole oral pill on improving clinical symptoms of trichomonas vaginalis infection.

This clinical trial was performed on 70 non-pregnant women referred to gynecology clinics of Imam Reza and Ommolbanin hospitals due to vaginal infection symptoms in 2019. The subjects were placed in two groups: ferula and metronidazole. Trichomoniasis vaginalis infection was detected by wet smear test. Oral ferula capsule was prescribed to ferula group and oral metronidazole tablet to second group for 7 days. Data were collected by observation and interview forms. Data were analyzed by paired and independent t-tests, Chi-square, Mann-Whitney, Mcnemar and Wilcoxon tests. P<0.05 was considered statistically significant.

The findings of the study indicated that improvement of clinical symptoms was 100% in the ferula group and 40% in the metronidazole group ( p<0.001).14 cases (40 %) of metronidazole group had drug side effects including digestive disorders (54.3%) and nausea (45.7%). In ferula group, none of cases showed side effects (p<0.001). Moreover, 19 cases in metronidazole group (54.3%) and all in ferula group (100%) were agree to reuse the medicine or to suggest it to others (p<0.001).
 

The improvement percentage in clinical symptoms caused by oral ferula capsule is higher than oral metronidazole tablet. Therefore, by performing further studies, ferula capsule can be a replacement for metronidazole in order to improve the clinical symptoms of Trichomonas vaginalis infection for.

Despite numerous studies aimed at finding a new treatment for cutaneous leishmaniasis (CL), glucantime remains the first-line approach. Side effects, drug resistance, and high cost are the challenges of glucantime treatment. A simple treatment method with the fewest side effects, minimum cost, and maximum efficacy is ideal. In Iranian traditional medicine (ITM), dry CL lesions are categorized as rashes, and for treatment, corrosive and keratolytic agents should be used, including garlic. The current study was conducted to assess the effects of an ITM treatment on CL. Methods and Results: In this experimental study, 10 patients with 20 dry CL lesions received treatment based on ITM. For this purpose, some garlic poultices were used. The mean age of the patients was 36.2 years, and the average bout was nearly four months. Based on the findings, garlic poultices could treat all dry skin lesions completely during 14 days. Also, after 40, 70, 100, and 190 days of follow-up, 95% of cases were completely treated. On the 70-day follow-up, a nodule with negative direct smear and PCR results recurred in one patient. Overall, the applied treatment was cost-effective with no systemic side effects. Garlic poultices can be used as an alternative for glucantime. Topical use, shorter course of treatment, and lower number of applications, side effects, and treatment cost are the main advantages of this regimen. We suggest similar multi-centered clinical trials with a larger sample size to further evaluate this treatment regimen.

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women. Since no similar study was published so far to evaluate the symptoms and diagnostic model of the disease from the view of Iranian traditional medicine, therefore, this study was performed to adapt the symptoms and achieve the diagnostic model of PCOS from the view of Iranian traditional medicine in order to achieve the prevention methods and more effective treatment in these patients.
In this comparative study with content analysis approach, all signs and symptoms of PCOS from the view of classic medicine were collected from Textbooks of Obstetrics and various papers and 14 Textbooks of Traditional Medicine. Thereafter, the relevant codes were produced by the software program Max.Qda2. PCOS was classified based on these signs.
Given diagnostic criteria of PCOS in classic medicine and searching for signs associated with these criteria in Textbooks of Traditional Persian Medicine, extremely warm dystemperament or warm and dry in uterine, ovaries or in the whole body, extremely cold dystemperament or cold dystemperament with phlegm in reproductive organs or in the whole body associated with the concentrations of humors lead to the signs relevant to hyperandrogenism and menstruation disorder.
Based on the findings, two major patterns were proposed for patients. The first group included those who have "cold" and "humid" dominance while the second group consists of those with "heat" dominance in their temperament. Each group with respect to their temperament need to specific and different pharmacological or non-pharmacological treatments and strategies according to warm and cold degree of drug constituents.

Epilepsy is one of the most serious neurological disorders that due to chronic, often it requires long-term treatment. At the moment despite existence of many anti-epileptic drugs, side effects of these drugs and their restriction causes lack of access to appropriate therapeutic effects. Due to the increasing tendency of patients to traditional and complementary medicine, use of current treatments for epilepsy in the context of traditional medicine with a history of thousands years can be a good solution in this disease. In this paper we will evaluate the different treatments of traditional medicine and modern medicine; so that a combination of two methods, places a good solution in front of patients.
This study is a literature review and the work on traditional medicine literature that separately matters related to epilepsy and its treatments. On the other hand new papers and researches will be reviewed.
Regard the principles of hygiene is essential from the viewpoint of Iranian traditional medicine scholars for the treatment of epilepsy. The modification of lifestyle and dietary is recommended. The single and compound drugs are prescribed oral and topical forms, and finally manual practices such as bloodletting, cupping, massage and many oils are advised. While in modern medicine often oral medications and sometimes electrical treatments and surgery can be used.
Discussion & The use of oral and topical drugs of natural origin with common medications in the treatment of epilepsy can be considered as a complementary therapy and this would require further clinical studies.

Context: Constipation is one of the most prevalent gastrointestinal disorders and is characterized by stiffness of waste and difficult defecation. In modern medicine, different laxative drugs are used for the treatment of constipation, but they are not without side effects. Nonetheless, the appropriate use of herbal medicines can be beneficial for treating this disorder. Therefore, this study attempted to draw together some pharmacological and medical insights into the management of constipation through the use of Iranian traditional medicine (ITM)..
Evidence Acquisition: In this review article, we initially researched constipation and laxative herbs using some of the most famous ancient medical and pharmacological textbooks pertaining to Iranian medicine written from the 10th to 18th century AD. This includes The canon of medicine by Avicenna (10th and 11th centuries, Beirut publication), Makhzan-ol-advie by Aghili (18th century, Tehran University of Medical Science Press), and Al-shamel by Gharashi (13th century, Caltural foundation Publication). Then we extracted the names and laxative mechanisms of some herbs prescribed for constipation through ITM. Finally, a search of scientific databases such as PubMed and Google Scholar was performed to find related works concerning laxative mechanisms..
In ITM doctrine, laxatives are weak purgatives that lead to the defecation of waste from the gastrointestinal tract. From this perspective, laxative herbs can be classified into two groups based on their nature: laxative herbs with a hot nature cause the dilution and flowing of humors, but herbs with a cold nature function as laxatives due to their mucilage properties. Each of the laxatives was used in accordance with the primary reason for constipation..
This study presents medical and pharmacological approaches in ITM for dealing with complications arising from constipation. Considering the optimistic results, these herbs can be used as a means of constipation management and further investigation into this area can potentially lead to the formulation of new drugs..

Zoufa is one of the most consumed herbs in the Iranian traditional medicine (ITM) that has been used to treat many diseases including bronchitis, chronic cough, asthma and colic [1], [2]. The botanical description of these medicinal plants exists in some ITM literatures; however in the herbal market of Iran, two different plants have been sold as Zoufa, one is Hyssopus officinalis and another is Nepeta bracteata. The aim of the present study is to determine the exact scientific name of Zoufa according to its botanical description in ITM literatures. For this purpose, major traditional Iranian herbal literatures were searched to find information about the habitat, appearance, and botanical characteristics as well as pharmacological activities and indications of “Zoufa.” The modern botanical books were also searched for the mentioned items about H. officinalis and N. bracteata. The results obtained from TIM literatures were compared with the findings from modern resources. The comparison of botanical description, habitat and pharmacological activity of H. officinalis and N. bracteata with those of Zoufa in ITM showed that Zoufa in ITM is approximately equivalent to H. officinalis; however, the most of samples sold as Zoufa in herbal shops of Iran is N. bracteata.

Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.
Everydiscs containing 70 mg stem bark extract of Ziziphus jujuba were formulated by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation and direct compression. Discs were standardized based on the total phenol. Properties such as in vitro and in vivo mucoadhesion, drug release, water uptake, and disintegration were carried out.
Discs showed excellent mucoadhesion and released high amount of the active ingredients (47%) immediately and completed after approximately the first hour. They had a good adhesion in buccal cavity.
This study showed that the kinetics of release of the active substance from the mucoadhesive disc obeyed the zero order kinetic and didn’t follow the fick’s law. The water uptake and dissolution (DS), increased with the passing of time.

Context: Recurrent aphthous ulcer (RAU) is an oral disease and the most common oral lesion, with 2% to 66% of the world’s population infected annually. Its prevalence is about 25% in Tehran and 27.6% in Mashhad. The etiology of RAU is multifactorial. Aphthous risk factors include: immunological factors, psychological factors, stress, trauma, sensitivity, family history, blood disorders, malnutrition, and use of certain medications, It should be noted that the best treatment for RAU is the topical application of drugs. The use of topical treatments is recommended not only because the drug can directly impact the source of the disease, but also systemic side effects of the drug are reduced. Treatment of RAU has been considered in Iranian traditional medicine (ITM), and is covered in therapeutic books. The use of herbs in RAU has a centuries-old history; accordingly, extensive research should be conducted for this treatment of the disease.
Evidence Acquisition: Iranian medical sources were reviewed and effective plants used in the traditional treatment of RAU were found and compared with new findings. Finally, we have created a table listing the plants that are part of the therapeutic protocol for RAU.
Based on this article we can explain some of traditional pharmacological effects of plants and how these plants can be a source for a cure.
The plants listed can be used as a prediction of RAU management. Of course, there are is no evidence for curing RAU by some of these plants in allopathic medicine, and the further investigations in this area could lead to the discovery of a new drug.

Iranian Traditional Medicine (ITM) has a long history in the prevention and treatment of diseases. Clinical uses, side effects, and toxic effects of many singular and compounds were known to scientists of ITM and articular books on toxicology and detoxification of drugs has been written by scientists, but their measurement tools to evaluate chronic toxicity of drugs are limited. Hab-o Shefa is a combination drug which has an important place in Iranian Traditional Medicine to cure drug addiction. According to the attention of people to traditional medicine and expanding the use of natural drugs, and also, more attention to treatment of addicts, clinical studies on its toxicology are required. However, we decided to do oral toxicity study of this combination in rats. Acute oral toxicity of Hab-o Shefa in male Wistar rats was evaluated using doses of 200, 500, 1500, 2000, 3000, 4000, and 5000 mg per kg of body weight. Protocol that we used to define acute toxicity and determine LD50 of Hab-o Shefa was based on the method that proposed by Mr. Smith and colleagues (1960) and the changes to it ​​by Mr. Van Dan Howell in 1990. Results and The results showed apparently no toxicity and mortality in rats. Histopathological studies of the vital organs of rats at these dosages did not show any histological abnormalities.