جستجوی مقالات مرتبط با کلیدواژه "سروتونین" در نشریات گروه "تربیت بدنی"

In this study, the effect of aerobic exercise and crocin on the gene expression of BDNF, TrKB, dopamine, and serotonin in the cerebral cortex of rats induced with methamphetamine was investigated.

In this research, 40 female Wistar rats (age, eight weeks; weight 140-160 grams) were divided into five groups including healthy control, methamphetamine, methamphetamine+aerobic exercise, methamphetamine+crocin, methamphetamine+crocin+aerobic exercise. 15 mg of methamphetamine was given to the subjects every 12 hours for four days. Moreover, the dose of crocin was 80 mg per kilogram of body weight, which was mixed intraperitoneally with distilled water and injected over five days. The aerobic exercise program included running on a treadmill with a 0% incline until the third week and a 5% incline from the fourth to the eighth week, which was performed three days a week for eight weeks. The duration of the aerobic exercise protocol increased from 20 min in the first sessions to 30 min in the final sessions. Furthermore, the speed of running increased from 20 meters per minute in the first weeks to 25 meters per minute in the final weeks. After anesthesia, an autopsy was performed and samples of cerebral cortex tissue were taken. The gene expression of BDNF, TrkB, dopamine and serotonin in the cerebral cortex was measured by the real-time technique with the rotor gene Q device. Y-maze tests were also used to evaluate the behavioral data. The data were analyzed by using one-way analysis of variance and Tukey's post hoc-test at the significance level of P≤0.05.

The results showed that the mean expression of BDNF, TrkB, dopamine and, serotonin genes in the cerebral cortex in rats induced with methamphetamine were significantly lower than the control group (P=0.001). The average expression of BDNF, TrkB, dopamine and, serotonin genes in the methamphetamine+aerobic exercise, methamphetamine+crocin and methamphetamine+crocin+aerobic exercise groups were significantly higher than the methamphetamine group (P=0.001). However, methamphetamine+crocin+aerobic exercise group had a significantly higher average expression of BDNF, TrkB, dopamine and, serotonin genes compared to methamphetamine+aerobic exercise and methamphetamine+crocin groups (P=0.001). The results in the model validation section by examining the behavioral data, showed no significant differences in the average total number of arms entering and the average non-repetitive frequency among the different groups (P<0.05). However, the comparison between before and after methamphetamine induction shows a significant decrease in the average total number of arms entering and the average of non-repetitive frequency (P<0.0001).    

The results of the present research showed that methamphetamine was associated with a decrease in the expression of the genes of neural factors in the cerebral cortex tissue. In addition, eight weeks of aerobic training, consumption of crocin, and aerobic exercise plus crocin supplementation can have a neuroprotective effect in rats induced with methamphetamine, and lead to increases in the expression of BDNF, TrkB, dopamine and serotonin genes in the cerebral cortex in rats.

In recent studies, balance and postural instability have been reported as a common motor disorder in Parkinson's patients, which leads to frequent falls, decreased quality of life, and mortality in these patients. On the other hand, evidence has shown that training is effective in treating motor and cognitive symptoms of neurodegenerative patients.

For this purpose, 24 male Wistar rats were randomly divided into three groups of eight rats including Healthy Control, Parkinson’s Control, and Parkinson’s Training. The animals in the training group were placed on a treadmill for four weeks. At the end of the course, motor disorders (balance and motor behavior) were evaluated using Rotarod and Open-Field tests, and biochemical factors were assessed by ELISA method. Data analysis was done using one-way ANOVA and Tukey's post hoc test at a significant level of P<0.05, via SPSS version 19 software.

The results showed that although the Parkinson's group without training was significantly lower in terms of motor performance than the other groups (P<0.05), four weeks of moderate-intensity aerobic training increased the balance (P<0.05), and improved the motor disorders in Parkinson's rats (P<0.05). Also, training significantly increased the amount of serotonin (P<0.05), and tyrosine hydroxylase (P<0.05).

In general, the findings of this study showed that moderate-intensity aerobic training can reduce the biochemical and motor disorders induced by 6-hydroxydopamine injections in rats’ models of Parkinson's disease.

 hypothyroidism in addition to menopause has a double effect on depression in postmenopausal women, and sports activity improves mood by increasing neurotransmitters. The aim of this study was to determine the effect of a period of whole body vibration course on depression, the levels of serotonin and norepinephrine indices in postmenopausal women with hypothyroidism.

In this semi experimental study, 20 postmenopausal women with hypothyroidism aged 46 to 57 were selected from Khorramabad city and divided into two groups of 10: control (C) and whole body vibration training (V). Group V performed these exercises for 12 weeks and three times a week, with a frequency of 30 to 50 Hz, with a range of 1 to 2 mm, applying 20 to 30 minutes of vibration and 5 to 15 minutes of upper and lower limb training. At the beginning and end of the study, blood serum serotonin and norepinephrine levels were measured using the ELISA method, depression was measured using the Beck questionnaire, body fat percentage, body mass index, and body weight. Due to the normality of data distribution, independent t and covariance statistical methods were used for analysis at a significance level of 0.05.

12 weeks of whole body vibration training in group V significantly increased the serum levels of serotonin (P=0.001), norepinephrine (P=0.001) and decreased depression (P=0.018) compared to the control group. There was also a significant decrease in body fat percentage (P=0.041), body mass index (P=0.044) and weight (P=0.047).

 It seems that vibration training may reduce depression in postmenopausal women with hypothyroidism by increasing serum serotonin and norepinephrine levels.

The herb valerian is from family of valeriana officinalis which hydro alcoholic extracts of this plant has enhancing effect on hormones such as melatonin and neurotransmitters such as serotonin and gamma-aminobutyric acid.

48 rats selected as sample randomly and base on their body weight divided in to six groups of eight rats including (1) Sham, (2)control, (3) doses of 100, (4) doses of 200, (5) doses of 400 and (6) diazepam. Group 1 drug by injection of 0. 5 ml saline fluid for each rat, Group 2 Failing to get medication or serum, Group 3 injected with a dose of 100 mg valerian extract per kg, group 4 injection of extract at a dose of 200 milligrams per kilogram of body weight, group 5 injecting extract at a dose of 400 milligrams per kilogram of body weight, 6 diazepam injection at a dose of 1.2 mg per kilogram of body weight. Injection for 22 days as an in between was done. (p=0/05). For analysis of data used one way ANOVA and tukey post hoc test.

The results showed that levels of melatonin, valerian extract in groups at doses of 100, 200, 400 and diazepam significantly higher than the control group (0.001) as well as diazepam has similar effects with the use of valerian extract with doses of 100, 200 and 400. Serotonin levels in groups valerian extract at doses of 100, 200, 400 and diazepam significantly higher than the control group (0.001) as well as diazepam has the same effect with doses of valerian extract 100 ,200 and 400.

The results of this study concluded valerian extract at doses of 100, 200 and 400 have the same effects as well as increased levels of serotonin and melatonin similar to diazepam in rats are.

Migraine as a one of the most common types of high frequency headaches has a significant impact on people's living conditions. The purpose of this study was to investigate the effect of 8-weeks of yoga exercises on migraine headache induces serum levels of serotonin and nitric oxide in women with migraine.

In this quasi-experimental study, 30 female (age: 36±3.2 years) with migraine were randomly divided into experimental (n=15) and control groups (n=15). The experimental group performed yoga training for 8 weeks (5 days/60 min session). Indicators included frequency of headache, duration of migraine, pain intensity (by questionnaire) and quality of life (HIT-6) were measured at pretest and posttest and blood samples were taken 48 hours before and 4 days after the last secession of exercise program in fasting state. The ANCOVA test used to examine changes in between groups.

Yoga exercise significantly reduced headache severity (P=0.002), number of headaches (P=0.006), headache duration (P=0.041) and increased quality of life (P=0.001) and nitric oxide levels in the experimental group compared to the control group significantly, but there was no significant change in serotonin levels (P≥0.05).

Eight weeks Vinyasa yoga exercises as a complementary method of life style appear to have a positive effect on improving migraine symptoms and enhancing quality of life in people with migraine.

Hydrotherapy has positive effects on the behavior of people with autism. Studies show people with autism have serotonin deficiency. The aim of this study was to determine the effect of hydrotherapy on the serum serotonin level in children with autism spectrum disorders. In this semi-experimental and applied study, a pretest-posttest, control-group design was applied. Considering the control variables, 32 autistic children were randomly assigned to the control (n=16) and experimental (n=16) groups as the sample. The Halliwick hydrotherapy intervention continued for 8 weeks, 3 sessions per week for 60 minutes. Blood samples were collected to measure the serum serotonin level before and after 8 weeks of intervention. The results of covariance test indicated no significant difference in the serotonin level between the experimental and control groups in the pretest and posttest (P≥0.05). Also, serotonin reduced in the experimental group more than the control group. According to these results, it can be concluded that hydrotherapy reduces the serum serotonin level of children with autism. In other words, a reduction in serotonin level is associated with an increase in serotonin absorption of the body.

Depression is one of the psychiatric consequences of myocardial infarction (MI). Increased inflammatory factors after MI change limbic system volume through cell death and neurogenesis imbalance. Brain derived neurotropic factor (BDNF) and serotonin are effective neurogenesis factors in depression. It is accepted that training can increase neurotrophic factors. The aim of this study was to investigate the effect of high intensity interval training (HIIT) on hippocampus serotonin and BDNF in post MI rats. 32 adult male rats were randomly divided into 4 groups: ischemia/reperfusion control (MI-CTL), ischemia/reperfusion HIIT (MI-HIIT), HIIT/healthy rats (HIIT) and sham. Ischemic modeling was induced by the left anterior descending coronary artery (LAD) ligation. HIIT started 4 weeks of recovery after LAD ligation. Rats had the training for 40 min., 3 days a week for 8 weeks. The results showed a significant increase in exercise capacity and cardiac function indices (ejection fraction and shortening fraction) in MI-HIIT group compared with MI-CTL group (P<0.05). HIIT significantly increased the expression of serotonin and BDNF in MI group (P<0.05). HIIT increased serotonin and BDNF following MI.

Serotonin and dopamine are the effective monoamine neurotransmitters in controlling emotions and appetite. The purpose of this study was to investigate the effect of 8 weeks of selected yoga exercises on serum levels of serotonin and dopamine in non-athlete obese women. In this quasi-experimental research, 20 non-athlete obese women with body mass index equal or greater than 30 kg/m2 and age range 25-35 years old volunteered to participate in the study. The subjects were divided randomly into two equal groups including control (regular life) and experimental (yoga exercises) groups. The experimental group did 8 weeks selected yoga exercises, 3 sessions per week and each session lasted 60-75 minutes. Before and after intervention, blood samples were collected from cubital vein at 12 h. fasting state. Serum levels of serotonin and dopamine were determined using by ELISA method. Data were analyzed using the paired t-test and ANCOVA at the significant level of p<0.05. Eight weeks selected yoga exercises lead to significant increases in serum levels of serotonin (p=0.02) and dopamine (p=0.0001) in experimental group while they did not change significantly in the control group. It seems that yoga exercises may have positive effects on some neurotransmitters affecting appetite and food intake behaviors in obese women.

The aim of the present study was to compare the serum serotonin level and some physical fitness factors in the active elderly in Qom city. The sample comprised of male elderly over 60 years old in Qom city who were assigned to aerobic (n=15), weight training (n=15), zurkhaneh (n=15) and control (n=15) groups. In order to assess physical fitness, 4 factors including balance (single leg balance test), muscle endurance (swimming on hand), flexibility (Wells flexibility test) and power (Sargent jump) were studied. Blood serotonin was measured with ELISA test. Data were analyzed using one-way ANOVA (P0.05). The level of physical fitness in active subjects was better than the control group. In addition, weight training group showed a higher level of fitness in balance and muscle endurance tests (P

The aim of this study was to investigate the effect of acute resistance exercise with different movement orders on fatigue parameters (serotonin and RPE test) in non-athlete men (normal weight and obese). 26 male university students were purposively selected and assigned to obese (n-11) and normal weight groups (n=15). In the first session, half of the subjects (both obese and normal) randomly performed resistance protocol A (resistance exercise from large to small muscles) and the rest of the subjects performed resistance protocol B (resistance exercise from small to large muscles). The second session was three days later with reverse protocols. In each session, subjects performed 3 sets to exhaustion for 9 movements with 10RM. In each session, blood samples were collected before, immediately after and 30 min. after the exercise. Results using ANOVA with repeated measures showed that serum serotonin concentration significantly increased in both obese and normal groups (P<0.05) immediately after the protocol B (not protocol A) and returned to the baseline after 30 min of recovery. However, resistance exercise order had no effect on serum cortisol changes. In addition, both groups had higher RPE during resistance protocol B (P>0.05) although the difference was not significant compared with the protocol A. Overall, the findings of this study showed that when the resistance movements are preceded by small muscles, greater fatigue will happen, but obesity is ineffective in this regard, although obesity was associated with milder cortisol changes.

The aim of this research was to determine the effect of continuous aerobic activity in comparison with interval aerobic activity on serum serotonin and to rate the perceived exertion (RPF) according to Borg scale. Ten athletic girl(22.9±2.3 years, weight 53.8±2.5 kg, body mass index 20.6±1.0 kg⁄m2, fat percent 20.8±3.7and VO2max 41.7±1.8 ml.kg-1.min-1) selected to attend in studying. Blood samples were given before and 10 minutes after the end of the test include of 10 minutes warming conducted interval or continuous aerobic activity on treadmill for 40 minutes. Statistical analysis of data by using variance analysis of repetitive measurement showed that there is significant difference between different stages of serum Serotonin sampling (P=0/05). LSD post hoc test for couples comparison showed that interval aerobic activity caused significant increase in serum serotonin (P=0/028) but there wasn’t significant difference in serum serotonin amount before or after continuous aerobic activity test (P>0/05). Using of one way ANOVA showed that, in variation width of serum serotonin, there wasn’t significant difference between both aerobic activity types (P 0/05). On the other hand results of paired sample t test showed that rate of perceived pressure in interval aerobic activity was significantly more than continuous aerobic activity (P=0/01). Thus it seems that central fatigue level in interval aerobic activity is more than continuous aerobic activity because the amount of serum serotonin increase in interval activity is more than that of continuous activity, and rate of perceived pressure is more in interval activity.

The aim of this research was to study the effect of eight weeks of selected aerobic exercises on depression and serum serotonin concentration in depressed female university students aged between 18 and 25 in Aligudarz city. For this purpose, using Beck depression questionnaire, 20 female students with moderate depression were selected in two groups (experimental n = 10 and control n=10). To evaluate the impact aerobics Selected the concentration of serotonin in plasma, In order to investigate the effect of selected aerobic exercise on the concentration of plasma serotonin, the experimental group performed aerobic running for eight weeks (3 sessions per week) with 60-65% HRmax. The research variables were measured 24 hours before the first and 96 hours after the last session. The student t test and ANOVA were used to analyze data at P<0.05. Results showed that plasma serotonin level increased 50% in the experimental group although this increase was not statistically significant. Depression significantly decreased in experimental group compared to control group. Also, there was a significant relationship between increased serotonin and decreased depression. It can be concluded that selected aerobic exercise significantly decreased depression and increased concentrations of serotonin and proper physical activity can effectively treat depression.