جستجوی مقالات مرتبط با کلیدواژه « کراتین کیناز » در نشریات گروه « تربیت بدنی »

The aim of this study was to compare two methods to reduce exercise volume after four weeks of glycogen depletion training on cortisol stress levels and CRP in inactive healthy males.
The current research is semi-experimental with a pre-post-test design including a control group. The statistical population of this study consists of inactive, healthy male students from Qom University who have completed the physical education unit. Thirty healthy male students, who were not engaged in regular physical activity, were randomly selected and divided into three groups. The first group underwent a 50% reduction in training volume (n=11), the second group a 75% reduction in training volume (n=11), and the third group served as the control (n=8). Following four weeks of glycogen depletion training, a week of training adjustment was carried out. Blood samples were collected at three stages: at the beginning of the training protocol period, and 48 hours after the final training session, from the Antecubital vein. ELISA and immunoradiometric techniques were utilized to assess the serum concentrations of IGF-1 and creatine kinase, respectively. To analyze differences between and within groups, the analysis of variance test with repeated measurements was conducted at a significance level of α=0.05.
No significant difference was observed between the three groups in serum IGF-1 and creatine kinase levels after the training volume reduction period. However, a significant difference was observed in IGF-1 levels between the pre-test stage, post-test stage, and follow-up (P<0.05).
Reducing the volume of training for one week following four weeks of glycogen depletion training does not have an effect on serum IGF-I and creatine kinase levels in inactive men.

In this meta-analysis, the effect of beta-hydroxymethylbutyrate (HMB) supplementation on muscle damage and body composition markers was investigated.

A systematic search was conducted from PubMed, Google scholar, Sciencedirect, SID, Scopus, IranMedex, Irandoc databases, all randomized controlled clinical trials, which were related to HMB supplementation on creatine kinase (CK), lactate dehydrogenase ( LDH) and body composition indices, fat mass (FM), fat free mass (FFM) and body mass (BM) were selected. Fixed and random effects models for meta-analysis of average effect size (difference in mean with 95% confidence interval), in research related to creatine kinase (16 studies), lactate dehydrogenase (14 studies), body fat mass (17 studies), fat-free mass Body (20 studies) and body weight (23 studies) were done with the help of CMA2 software.  

The meta-analysis results showed that HMB supplementation significantly reduced CK (ES = -0.22, 95% CI = -0.86 to 0.41, p = 0.034), LDH (= 0.34) ES, 95% CI = 0.31 to 0.57, p = 0.022) and FM (ES = 0.43, 95% CI - 0.74 to - 0.119, p = 0.007), and it was associated with a significant increase in FFM (ES=0.31, 0.007 to 0.61% CI 95, p=0.045), but there was no effect on BM (ES=0.054, 0.09 -0 to 0.20 =%CI 95, p=0.46).

In general, the results of the meta-analysis showed that chronic supplementation of HMB causes a significant decrease in muscle damage index enzymes such as CK and LDH after exercise, and it was also associated with a significant decrease in FM and an increase in FFM.

Black grape seed extract (GSE) is a supplement known for its potent antioxidant effects and flavonoid properties that can help prevent or reduce cell damage. This study aimed to examine the impact of grape seed extract supplementation and resistance training on oxidative stress indicators in bodybuilders. The research followed a semi-experimental design, with participants divided into supplement and control groups for blood sampling before and after supplement intake in a double-blind fashion. The study included 24 male bodybuilders aged 15-19 years. Blood samples were collected during fasting sessions to measure antioxidant capacity (TAC), malondialdehyde (MDA), creatine kinase (CK), and lactate dehydrogenase (LDH) levels. Data distribution normality was assessed using Shapiro-Wilk tests. The results revealed that resistance training in bodybuilders led to a significant increase in cell damage markers (CK and LDH) and MDA levels, along with a notable decrease in TAC (P<0.05). However, grape seed extract consumption was found to boost TAC levels. The study suggests that bodybuilding activities can elevate cell damage and oxidative stress indicators, while daily intake of grape seed extract (100 mg) can enhance total antioxidant capacity in male bodybuilders.

The mechanisms involved in old age are largely unknown. Although there are no effective therapeutic interventions to increase life expectancy and prevent aging, it seems that physical activity can play an important role in preventing aging. Therefore, the aim of this study was to investigate the effect of aerobic and combined exercise on growth factor beta and creatine kinase caused by muscle injury in elderly men. In this study,30 elderly men with a mean age of 66 years were divided into three groups of aerobic, combined and control exercises. Exercises were performed for 8 weeks with a frequency of 3 sessions per week. Aerobic exercises were performed with an intensity of 60-74% of the maximum heart rate and resistance exercises with an intensity of 60% of a maximum repetition (1RM), which had reached 75% during the training weeks. Blood samples were collected 24 hours before the start of training and 48 hours after the last training session. Analysis and comparison between groups were performed by analysis of covariance and for in-group comparison of data by paired t-test at a significance level of P <0.05. TGF-β1 values in two groups of aerobic (P=0.006) and combined (P=0.003) and CK values in the combined group (P=0.03) had a significant increase compared to the control group. But there was no difference in CK values between aerobic and control groups (P=0.11). Increasing the appropriate levels of TGF‐β1 has resulted in more proper muscle regeneration in this age group.

Despite the proving of the negative effects of dehydration, many athletes use of this strategy yet. The aim of this study was to investigate the effect of dehydration with different degrees on serum levels of enzymes biomarker muscle damage in professional wrestlers in Ahvaz city. Among the professional wrestlers in Ahvaz city, after screening, 40 wrestlers were selected and randomly divided into three experimental groups and one control group. Experimental groups underwent dehydration at three levels of mild, moderate and severe. The plasma levels of Creatine Kinase (CK) and Lactate Dehydrogenase (LDH) were measured by enzyme kinetics method. for intragroup comparison and intergroup comparison, were used of the dependent t-test and analysis of variance (ANOVA) test respectively at a significance level of 0.05. The results showed that plasma CK levels increased significantly in the moderate and severe dehydration groups and LDH levels increased only in the severe dehydration group (P <0.05). Also, in the intergroup comparison of CK levels, it was observed that there was a significant difference between the severe dehydration group and other groups, as well as the moderate dehydration group and other groups (P <0.05). But no significant difference was observed between the moderate and severe dehydration groups (P <0.05). Also, the results of comparison between groups of LDH showed that only the difference between the severe dehydration group with other groups was significant (P <0.05) and the difference between the other groups was not significant (P <0.05). According to the results of this study, it is suggested that to prevent the possibility of muscle damage and consequently reduced the exercise performance, avoided the dehydration of more than 1% in one session and if necessary, dehydrate in more sessions and for longer.

  studies have demonstrated a protective effects of female sex hormones against muscle membrane disorders in compared to men following high-intensity exercises. The aim of this study was to evaluate the creatine kinase, estrogen and progesterone responses to a single bout of high-intensity interval training (HIIT) and as well as the relationship between sex hormones and CK response in inactive young women.

24 young inactive women (18–30-year-old and VO2max<30 ml/kg/mil) with regular menstrual cycles were randomly divided in 2 groups: HIIT or experimental (n = 12) and control (n = 12). The experimental group performed HIIE by a treadmill with a slope of 2% in six repetitions (3 sets) for one minute with an intensity of 90-95% HRmax with a total rest time of ten minutes between sets and repetitions. Before and ten minutes after exercise, blood samples were collected to measure creatine kinase (CK), estrogen, progesterone and hemoglobin (plasma shift). Data analysis was performed by using ANCOVA test and linear regression at the statistical level of P <0.05 and SPSS 23.

 Significant increases were recorded in CK and estrogen in experimental group compared with control group (P<0.05). There was a significant relationship between baseline progesterone levels and CK response (P= 0.016). According to the results of linear regression, CK response to HIIE in women can be predicted based on the baseline progesterone level (31.8%).

 Given that progesterone led to decreased CK response, it seems that it is better to perform vigorous intensity exercises in the menstrual phases with high levels of progesterone (mid-luteal phase) in order to reduce further muscle damage in women.    However, due to the low predictive power of progesterone (31.8%), more studies are needed with more samples.

The aim of the present study was to investigate The effect of HMB-FA supplementation on the muscle damage markers after soccer matches. 24 male soccer players (age: 23±3 years, BMI: 22.8±2 kg/m2) were voluntarily selected as the statistical sample of this study and were divided into two Suppplement and Placebo groups (n=12). In this study, subjects participated in a weekly soccer microcycle with two matches. Subjects in the supplement-training group consumed three grams of HMB-FA daily during a weekly soccer cycle. Blood samples were taken in seven times (before supplementation, before the first match, immediately after the first match, 24 hours after the first match, before the second match, immediately after the second match, 24 hours after the second match). Plasma concentrations of creatine kinase (CK) and lactate dehydrogenase (LDH) were measured by ELISA kits. Data analysis was performed using Friedman, Wilcoxon, Kruskal-Wallis and U Mann-Whitney tests with a significance level of p ≥ 0.05. After supplementation, a significant decrease in plasma levels of lactate dehydrogenase (before and after the first match) and creatine kinase (in the times immediately after the first match and before the second match) was observed (for all, p <0.05). Intaking HMB-FA supplement reduced the markers of muscle damage, which is essential for recovery from injuries caused by training and competition during a two race cycle. In addition, inaking HMB-FA supplement may have other effects, including reducing neuromuscular fatigue, reducing the inflammatory response, and rapid skeletal muscle regeneration, which requires further study.

Intense physical activity is associated with the production and increase of lactate, lactate dehydrogenase and creatine kinase. In the present study, the effects of consuming honey Rosa Canina L. solutions were investigated in comparison with Red Bull on the levels of lactate, lactate dehydrogenase and creatinine kinase after three quasi-competitive kickboxing matches in kickboxing men. A practical and semi-experimental study method was applied. The statistical population of this study consisted of athletes from Mazandaran province, from which 32 athletes were randomly divided into 4 groups of placebo, honey, Rosa Canina L. and Red Bull. Blood samples were collected before, immediately, 60 and 120 minutes after the test and the above variables were measured by enzymatic calorimetry. Repeated measures ANOVA was used for data analysis. Lactate levels increased immediately after training in the Red Bull group compared to placebo and in the honey and Rosa Canina L. groups showed a significant decrease compared to Red Bull. Lactate (120 min) showed a significant decrease in honey and Rosa Canina L. groups compared to placebo and red bull. The levels of lactate dehydrogenase (60 and 120 minutes) in honey and Rosa Canina L. groups compared to placebo and also Red Bull and creatine kinase in honey and Rosa Canina L. groups compared to red bull (60 and 120 minutes) showed a significant decrease. The results of this study show the effectiveness of honey and Rosa Canina L. solutions compared to Red Bull in increasing the performance of athletes and reducing fatigue indices.

The aim of the present study was to investigate the effect of short-term use of taurine supplementation on muscle strength and response of muscle injury indices and hs-CRP with one session of intense resistance activity in resistance training men.

20 resistance training men (age: 25.60 33 3.33 years and body mass index: 25.75 36 1.36 kg / m2) were selected as the available sample and randomly divided into two complementary groups of taurine and placebo. Were. The first and second blood samples were collected before and after the first HIRE session, respectively. Subjects then took 3 1000 mg capsules of supplement or placebo daily for 2 weeks and followed their usual exercises, the volume and intensity of which were similar between the two groups. Intragroup changes were analyzed using dependent t-test and changes in blood factors were analyzed using repeated measures analysis of variance and Bonferroni post hoc test. Also, intergroup differences were examined by independent t-test.

Findings showed that CK values before supplementation and after supplementation, LDH before supplementation and after supplementation were statistically significant. Plasma changes in hs-CRP before and after supplementation were not statistically significant. Also, no significant difference was seen between the two groups in any of the measured variables.

2 weeks of taurine intake appears to have a significant effect on maximal strength of upper and lower torso muscles as well as hs-CRP response and CK and LDH enzymes of trained men with no resistance following a HIRE session.

After an eccentric resistance exercise, athletes experience some degree of muscle soreness such as delayed muscle soreness. Following this damage, inflammatory factors are released into the bloodstream. The aim of current study was to find out the effect of ZMA supplementation on inflammatory factors of muscle injury (CK and LDH) following a bout of eccentric resistance exercise in non-athlete women. For this purpose, young and healthy women aged 18 to 28 years with a body mass index of 20 to 25 were used. Individuals were randomly divided into three groups of ten, including: 1- eccentric resistance exercise and ZMA supplementation, 2- eccentric resistance exercise and placebo, and 3- eccentric resistance exercise without supplementation and placebo. All three groups participated in an eccentric resistance exercise (lying leg curl muscles training hamstring yo-life supreme) the day before the test. Individuals underwent group-specific supplementation for two weeks. Then, the groups participated in the same eccentric resistance exercise as before. Blood samples were collected before and after physical activity and CK and LDH levels were assessed. The results showed that CK and LDH levels increased after eccentric resistance exercise in each group, although it was not significant for all studied groups and no significant difference was observed between the three groups after supplementation (P> 0.05). Eccentric resistance exercise seems to increase muscle injury as an indicator of muscle contusion in non-athlete women, and 14 days of supplementation with ZMA does not significantly reduce muscle injury.

Considering the impact of HMB supplement on sport performance, the tendency to consume it in order to achieve more efficiency has increased. Accordingly, the present study investigates the impact of a 6-day consumption of HMB-FA supplement on factors that influence hypertrophy and recovery in inactive men. 20 inactive men with a body mass index of 21.5±1 kg/m2 and age of 25.1±4 years were classified into the following two groups: sport with placebo and sport with supplement. The subjects started to consume HMB-FA supplement 6 days before resistance exercises. The muscle biopsy samples were taken from the subjects immediately before and 10 minutes after resistance exercise. Similarly, blood samples were taken immediately before and after as well as 48 after the exercise. The Results of independent t-test indicated that there is a significant increase (p =0.001) between serum levels of testosterone before and immediately after exercise in sport with placebo group in comparison with sport with supplement group. In addition, there is a significant increase (p =0.001) in P70S6K values and a significant decrease (p =0.001) in serum levels of creatine kinase (CK) and lactate dehydrogenase (LDH) between sport with supplement group and sport with placebo. Therefore, acute consumption of HMB supplement before resistance exercise can increase P70S6K values as the index of hypertrophy. By the same token, it decreases CK and LDH as the indices of muscle damage

The results of the studies indicated that strenuous acute exercise can lead to increased inflammatory indices, muscle injury and decreased performance in athletes. Nevertheless, it has been suggested that the nutritional intervention may diminish inflammation and muscle cell damage. Hence, the aim of this investigation was to study the acute effect of ginkgo biloba extract on creatine kinase (CK) and lactate dehydrogenase (LDH) levels, as muscle soreness markers, and C- reactive protein (CRP) after high intensity interval training (HIIT) in active girls. In a quasi-experimental study 24 active girls (mean age: 24.06±3.43 years; weight: 57.56±6.03 kg; height: 159.98±4.87 cm and body mass index: 22.51±2.41 kg/m2) randomly assigned into two Ginkgo biloba supplement and placebo groups. Subjects in supplement group consume 160 mg/day of ginkgo biloba extract daily for 3 weeks while the placebo group received the same amount of placebo. All subjects of both groups underwent in high intensity interval exercise RAST (including two sets of 6 repetitions of two fast running 35 meters and with a maximum intensity performed after the rest interval of 10 seconds in each repetition) after 3weeks of supplementation. Venous blood samples were collected for assessment of CK, LDH and CRP indices at four stages. Data was analyzed by repeated measure ANOVA and Bonferroni post-hoc test at α ≤ 0.05. The results showed that the HIIT increased the levels of CK, LDH and CRP at the immediately and 24 hours after exercise in both placebo and supplement groups (p<0/05). Nevertheless, ginkgo biloba supplementation attenuated their increase of CK and CRP indicators following high intensity exercise compared to control groups (p<0/05). The results of this study indicated that ginkgo biloba supplementation can be effective in alleviates the inflammation and muscular damage by the HIIT in active girls.

The aim of this study is effect of active recovery time on creatine kinase and lactate dehydrogenase changes in response to one session high intensity intermittent exercise in female swimmers.

In this quasi-experimental study, 10 female swimmers with an age range of 20 to 26 years were placed in two experimental groups 1 (10 people) and experimental 2 (10 people) with a crossover design. Subjects swam 25 meters at maximum speed, the active recovery period in experimental group 1 was three times the duration of swimming and in experimental group 2, it was four times the duration of swimming. The intensity of activity during active recovery is considered to be 50-60% of the heart rate of the subjects, the subjects swam 25 meters until they stopped. Blood samples were collected before the start of the training session and after the recovery phase. ANOVA test with repeated measurements was used to analyze the data at a significance level of P<0.05.

The results showed that there is no significant difference between the two recovery modes (1 to 3 and 1 to 4) in terms of effects on creatine kinase (P≥0.05) and lactate dehydrogenase (p≥0.05).

No difference was observed between triple and quadruple recovery after a bout of intense intermittent swimming activity on the decreasing changes of muscle damage indicators (creatine kinase and lactate dehydrogenase); therefore, it seems that athletes in this field can benefit from both types of recovery according to the conditions of the competition.

 Regular physical activity can be effective in preventing and rehabilitating cardiovascular disease. The aim of this study was to determine the effect of aerobic training and curcumin consumption on serum troponin I and creatine kinase levels in male rats treated with isopretrenol. 

40 male rats were randomized in four groups including: control, HIIT, curcumin, HIIT+curcumin. HIIT were conducted for 8 weeks (5 d/w, 60 min/session (with 4 min running at 85-90% of Vo2max and 2 min recovery at 50-60% of Vo2max intervals) and curcumin 15 mg/bw.day, were consumed orally for entire the study period.

Only curcumin and Concomitant interventions significantly reduced serum cTnI levels  (P=0.04, P=0.001) and exercise alone had no effect (P=0.44). Also, only the effect of curcumin and  Concomitant (curcumin and HIIT) caused a significant decrease in CK-MB levels (P=0.002, P=0.008). However, HIIT alone had no significant effect on serum CK-MB levels (P=0.27).

According to research, HIIT increases the markers of heart damage (troponin I and creatine kinase) and curcumin is able to reduce the markers of heart damage to some extent, However, more researches remains to be done because of the study limitations and lack of similar evidence in myocardial infarction populations.

The aim of this study was to investigate the changes in creatine kinase lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase enzymes about recovery with two types of rolling foam after a training session and a disinfectant in futsal men. The subjects of this study, 24 futsal players of Isfahan Province League with an average age of 26.08 ± 2.34 years and a height of 179.03 ± 3.58 cm, were randomly divided into three homogeneous groups (soft foam, hard foam, control). Initially, the subjects performed exhausting exercise, Then the soft foam and hard foam groups did the recovery protocol. And the control group rested. The enzymes were measured in four steps (baseline, immediately after exercise, immediately after recovery, and 24 hours after exercise). Although the activity of all the enzymes in the present study decreased significantly after recovery in both soft foam and hard foam groups, no significant difference was observed between these two groups in the changes of these indicators (p> 0.05). but, all changes in enzymes except lactate dehydrogenase within 24 hours after exercise were significant for both soft foam and hard foam compared to the control group (p≤0 / 0001). As a result, according to the findings of the present study, the physiological effect of these two types of rolling foam is very close. Also, the use of active recovery method using rolling foam compared to inactive recovery has reduced the indicators of muscle damage more and more. And it will get athletes back to basics faster.

The purpose of this study was to compare the responses of testosterone, cortisol and creatine kinase in two types of resistance training with and without blood flow restriction. For this purpose, 36 adolescent gymnast boys aged 10 to 14 years participated in a quasi-experimental research design. The subjects (weight 37.11 ± 8.11 kg, height 145.16 ± 11.58 cm, body mass index 17.40 ± 1.77 kg/m2) were randomly divided into three groups; control (n=12), traditional resistance training (n=12), and resistance exercise with blood flow restriction (n=12), respectively. Training protocol includes three motions included leg extension, elbow flexion and bench press. The results of intergroup showed that a variable testosterone after acute exercise in traditional resistance training groups (p=0.653) and resistance exercise with blood flow restriction (p=0.107), was not significant. But changing of cortisol in both groups, traditional resistance training groups (p=0.015) and resistance exercise with blood flow restriction (p=0.015), was significant. creatine kinase increased significantly only in traditional resistance training group (p=0.001). The results showed that in both of them protocol, there was no significant difference between groups in levels of testosterone and cortisol, but in varying creatine kinase was significantly different (p=0.05).

The purpose of this study was to defining effect of two different GIcarbohydrates and Glutamine usage on Creatine kinase and the exhaustion time in active female subjects. For this purpose 40 subjects with the average age of 24.82 3.4 year, the height of 165.25 5.1 cm were participated voluntary in this study. Subjects were divided into 4 groups of carbohydrate with low glycemic and glutamine,carbohydrate with high glycemic and glutamine, glutamine and placebo groups randomly. lentil was used as carbohydrate with low glycemic, and potato as high glycemic food and the consumed glutamine for each three groups with the amount of 0.5 g/kg BW in solution form in water and placebo.Blood samples was collected before and after laboratory Bruce test.For allP

Oral supplements are common among athletes to relieve muscle damage from exercise. 30 wrestlers were selected voluntarily .The present study was performed with an experimental group (n = 15) and a control group (n = 15) in the pre-competition season. Subjects in the experimental group performed an acute resistance exercise consisting of eight stations in three sets of 8 to 10 repetitions with 80% of one repetition maximum (1RM). Subjects in the experimental group took 20 gram of colostrum powder with 200 ml water for two weeks, every other day. Blood samples were taken from all subjects after 10 hours of overnight fasting in three stages: 1. Before supplementation, 2. 24 hours after completing supplementation, 3. 24 hours after resistance activity session. Data analysis was done by ANOVA with repeated measures and two-way analysis of variance tests using SPSS software at the significant level of 0.05. the results showed that the levels of creatine kinase (P = 0.001) and lactate dehydrogenase (P = 0.02), respectively, after two weeks of colostrum supplementation and acute resistance training were significantly different in the training group and supplementation compared to control group, but the amount of malondialdehyde in the exercise and supplement group did not show any significant difference in the three measurement steps compared to the control group (P = 0.09). It can be concluded that although resistance exercise increases muscle injury indices, but supplementation with colostrum may prevent it.

: Exercise training with blood flow restriction (BFR)is a modern method of training that has been developed in two recent decades and has been used for improvement of performance. Therefore, this study was conducted to identify the effect of 4 weeks rock climbing with blood flow restriction on athletic performance and some muscle damage indictors  in elite rock climbers. : In a semi experimental research method, 12 male and 12 female elite rock climbers with at least 4 years rock climbing experience and age range of 23 to 27 years and a fat percentage of 10 to 20 percent purposefully selected among the climbers, and allocated in two equal BFR and none-BFR groups. Both groups performed 4-week rock climbing training program consisting three sessions per week and each session was 90 minutes, severity of each session was 60 to 80% of climbing grades. Blood samples were obtained in baseline and after four weeks of climbing training to determine the amount of lactate dehydrogenase (LDH), creatine kinase (CK) and lactate. Also, hand grip, explosive anaerobic power, body fat percent, adduction strength in upper body and degree of climbing was measured. For data analysis, independent T test was used at α ≤ 0.05. After 4 weeks of climbing with and without limitation of blood flow, the index of muscular damage of LDH, CK did not show significant difference in response to climbing exercise. But lactate level was lower in BFR rather than NBFR. There are not any difference in Hand Crip strength, explosive anaerobic power, body fat percent, adduction strength in upper body between BFR and NBFR groups. But in degree of climbing, the result showed the better performance in BFR than NBFR (P <0.05). According to the results of this study, rock climbing training with or without BFR, do not increase muscular damage. and it could influence on performance.

The aim of this study was to determining the effect of ischemic pre-conditioning )IPC) before and during training on some physiological factors. Thirty female athletes voluntarily selected. Firstly, the subjects were divided on the basis of maximum power output by an incremental test to 3 groups; normoxia (Nor=10), ischemia before (BHIT=10) and during training (DHIT=10). Accordingly, the interval training and IPC were conducted for 7 weeks. Blood sampling, functional tests and legs’ muscles strength were measured in the first and eighth weeks. and to compare the differences between baseline and week 8th the dependent t-test and to determine differences of between groups variables, one-way ANOVA with post hoc Bonferroni test were carried out. The results showed that the effect of exercise on variables Pmax, VO2max, time to exhaustion and muscle strength in the legs and BHIT Nor groups improved. Compare Bonferroni test at VO2max values, Pmax, leg muscle strength, lactate and creatine kinase in three groups improved significantly in the group BHIT of the two groups and DHIT Nor was the exception of creatine kinase. It seems 7 weeks of training IPC before exercise would be useful to Improve physical and physiological but, probably the IPC during exercise will not improve the Physiological ability.