جستجوی مقالات مرتبط با کلیدواژه « glutathione peroxidase » در نشریات گروه « تربیت بدنی »

Targeted exercise training plays an essential role in cardiorespiratory function by improving antioxidant capacity. The aim of this study was to evaluate the effect of 8 weeks of cross-fit training with spirulina supplementation on serum levels of malondialdehyde, glutathione peroxidase and superoxide dismutase in young male athletes.

In this quasi-experimental study, 20 athletes with an Average of 22.95 88±1.88 years were selected and randomly divided into two groups of placebo (n = 10) and supplement (n = 10). The supplement group participated in an 8-week crossfit exercise program for 3 sessions of 60 minutes while taking four spirulina tablets (500 mg) daily. Blood samples were taken 24 hours before and 48 hours after the intervention period to measure the above indicators. Data analysis was performed using paired t-test and analysis of covariance.

After eight weeks of training, malondialdehyde levels decreased (P=0.02) and glutathione peroxidase and superoxide dismutase levels showed a significant increase in the supplement group compared with the placebo group (crossfit training).( P=0.01). Covariance test showed that there was a significant difference between the groups. Malondialdehyde (P=0.01), superoxide dismutase (P = 0.02) and glutathione peroxidase (P=0.03) were improved in the supplement group compared with placebo group.

It seems that crossfit training along with spirulina supplementation can improve antioxidant status and reduce oxidative damage and possibly improve cardiac and respiratory performance of athletes

 Despite the positive effects of HIIT training but it causes oxidative stressdue to high intensity; Therefore, the aim of this study was to investigate the effect of 6 weeks of High intensity interval training with fenugreek supplementation on plasma levels of malondialdehyde and glutathione peroxidase of obese and overweight women.  

 Accordingly 48 obese and overweight women with age average of 29.79± 7/8 years and a body mass index of 29.29 ± 2.6 kg / m2 were purposefully selected and randomly divided into 4 groups of 12. Individuals received exercise + placebo, exercise + supplement, supplement and placebo. supplement consuming groups consumed 500 mg fenugreek capsule daily for 6 weeks. The training groups performed an exercise protocol of HIIT training with maximum speed during 6 weeks  and three session per week. Blood samples were taken 48 hours before and  48 hours after the training period and  supplement consumption, and ELISA method was used to measure the research variables. Statistical analysis of data was performed by analysis of covariance and Scheffe post hoc tests at a significance level of P<0.05.

Significant decrease in malondialdehyde in exercise + supplement group (P = 0.048) compared to placebo group and significant increase in  exercise + placebo groups (p = 0.0001),  exercise + supplement (p = 0.0001)  and supplement groups (p=0/0001) were seen compared to the placebo groups But no significant difference was observed between the other groups.  

Fenugreek consumption along with regular High intensity interval training is a more appropriate intervention to improve the antioxidant status of obese or overweight people.

Anabolic androgenic steroids are often used by athletes to improve sports performance. Kidney damage has been reported as a side effect of abuse of these substances. Therefore, the aim of the present study is to investigate the effect of propolis consumption during eight weeks of resistance training on Glutathione peroxidase activity in kidney tissue in male rats consuming testosterone enanthate.

In this experimental study, 32 male mice with an age of 8 weeks and an average weight of 250 ± 50 grams were prepared. after two weeks of familiarization and weighing twice a week, the mice were randomly divided into 4 groups: Control(C), sham(RT), resistance training +testosterone(RT+T) and resistance training+testosterone+propolis(RT+T+P) group were divided. The resistance training program was carried out 5 days a week with two rest days a week. The weights were 60% of body weight in the first week and 20% of body weight was added every week. Rats receiving steroids received 20 mg of testosterone enanthate intramuscularly. The receiving group received 400 mg of propolis cleanser by gavage. After dissection, kidney tissue was sampled to measure GPX concentration. Data analysis was done using one-way analysis of variance with SPSS24.

The results of one-way analysis of variance showed that there is a significant difference in the research groups (P=0.0001). According to Bonferroni's post hoc test, GPX levels in the exercise+testosterone and exercise+testosterone+propolis groups have significantly decreased compared to the control and sham groups.

It seems that testosterone consumption can be effective in increasing oxidative stress factors in the kidney tissue of resistance-trained rats. The use of propolis to treat the side effects of steroids has not had the desired effect in the short term.

Moderate to severe exercise trainings may damage most of the body’s tissues, but the use of antioxidant supplements can modulate the exercise-induces oxidative stress. The purpose of the present study was to investigate serum changes of glutathione peroxidase (GPX) and superoxide dismutase (SOD) in sedentary females consumed coenzyme Q10 following a moderate or severe acute resistance training.

The present research was a semi-experimental study. Twenty seven female students were randomly divided into three groups including two resistance training groups and one control group. Two intervention groups performed one session of resistance training with moderate intensity (70% 1RM) and severe intensity (85% 1RM) at the beginning and end of two weeks of the research protocol. During these two weeks, they orally consumed 30 g/day coenzyme Q10 supplement. Blood sample was taken immediately after the acute training and supplementation. GPX and SOD activity were measured by enzymatic colorimetric method. The results were extracted using repeated measure ANOVA and LSD tests at the p<0.05 significant level.

Moderate and severe acute resistance training did not cause a significant changes in serum enzyme GPX (p=0.06, p=0.19 respectively) and SOD (p=0.42 and p=0.61 respectively) activity, but after two weeks of coenzyme Q10 supplementation it was associated with increases in the activity of SOD (p=0.01, p=0.006) and GPX (p=0.01). Comparing the effect of the two types of training, intensive resistance training resulted in a further decrease in GPX index (p=0.002).

The use of short-term coenzyme Q10 supplementation improves antioxidant status of sedentary individuals and can alleviate the anxiety of practitioners to avoid the damaging effects of oxidative stress after intense acute resistance training (above 85% 1RM) and can be included with other supplements as a nutritional strategy.

Aerobic training and berberine chloride both have antioxidant characteristics, therefore the present study aimed to evaluate the changes in lung tissue antioxidant enzymes after endurance training with the use of berberine chloride in diabetic vestibular rats. For this purpose, 40 adult male Wistar rats weighing approximately 200-250 g were randomly divided into 5 groups including healthy control ,diabetic control group (with STZ injection), diabetic experimental group+physical Exercise, diabetic experimental group + berberine Intake (50 mg/kg), diabetic experimental group+physical exercise+berberine Intake. 24 hours after the last exercise session, the animals were anesthetized with an intraperitoneal injection of Ketamine and lung tissue was harvested to measure the antioxidant enzyme activity of superoxide dismutase, catalase, and glutathione peroxidase. Paired t-test and ANOVA were used to analyze the data using SPSS software (version 22) with significant level α=0.05. The results showed that compare to control group, the level of CAT, SOD and GPX activity was significantly higher in all of the experimental groups (P=0.001). In comparison to the diabetic + training group and the diabetic + berbine group, the effects of intervention was significantly higher in the diabetic+training+berberine group. The final conclusion indicated that endurance training with berberin chloride consumption can cause a significant increase in the anti-oxidant enzyme activity in the lung tissue of diabetic rats.

Considering the importance of preventing heart disease and conflicting information about the effect of exercise training on glutathione peroxidase and catalase gene expression, the aim of this study was to investigate the effect offour training methods on Glutathione peroxidase and catalase expression in heart tissue of rats. For this purpose, 40 male wistar rats with age of 8-weeks were randomly divided into 5 groups including control group, moderate intensity training, high intensity training, high intensity interval training and moderate-intensity swimming training. To analyze of the data, one-way ANOVA and Tukey was used. The results showed that there was a significant increase in the Glutathione peroxidase and catalase expression as a result of all four exercise training program compared to the control group (P=0.001), Also, a significant increase in GPX expression was observed between HIIT and HIT groups compared to MIT and MIST groups (P=0.001). On the other hand, there was a significant increase in CAT expression between MIST group compared to MIT and HIIT groups (P=0.001 and P=0.030, respectively) and between HIT group compared to MIT and HIIT groups. There was also a significant difference between MIT and HIIT groups (P=0.001). All four training methods were able to improve the antioxidant system, causing favorable changes in the heart tissue of Wistar rats. It seems that HIT، HIIT & MIST by creating a beneficial adaptation in the antioxidant system, has made the body more resistant to the oxidative stress and has a more favorable effect on the heart tissue.

The aim of this research was to study the effect of different doses of licorice root with resistance training on blood glutathione peroxidase activity and total antioxidant capacity in sedentary and overweight men. In a semi-experimental trial with double-blind, 90 sedentary and overweight men were divided in six groups of fifteen people: (G1: NRT+SG250mg in the day, G2: NRT+SG500mg in the day, G3: SG250mg in the day, G4: SG500mg in the day, G5: NRT+P250mg in the day and G6: C+P250mg in the day). The resistance training program was conducted for 8 weeks and three sessions per week. Within-group results indicate a significant increase in glutathione peroxidase and total antioxidant capacity in the NRT+SG250mg (P=0.023), NRT+SG500mg (P=0.014) and NRT+P250mg (0.038) group. The highest percentage significant incremental changes of glutathione peroxidase (4.10%) and total antioxidant capacity (29.71%) was related to NRT+SG250mg group. Between-group results showed that there was incremental significant difference between the NRT+SG250mg, NRT+SG500mg, and NRT+P250mg with SG500mg, SG250mg and control groups in the mean concentration of glutathione peroxidase and total antioxidant capacity (P<0.05). Probably, performing resistance training along with taking licorice supplementation can be effective in enhancing the antioxidant status of sedentary and overweight men.

Some studies suggest that saliva could be a good alternative to blood in medical research and sport sciences. Therefore, the aim of the present research was to evaluate the effects of aerobic training and a single bout exhaustion exercise on blood and salivary superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) levels in non-active men.Twenty-seven healthy men (18-21 years) were randomly allocated to training (n=15, three training sessions per week, for 8 weeks, running at 50-70% of Heart Rate Reserve) or control (n=12) groups. After the training course, they performed acute exhaustive exercise on treadmill. Blood and salivary samples that collected at pre- and post-training period and also after exhaustive exercise, were analyzed for SOD, CAT and GPx levels. Data were analyzed by analysis of variance (ANOVA) with repeated measure, Bonferroni as post-hoc test and Pearson correlation at P0.05). Salivary and blood SOD activity significantly increased after the exhaustive exercise in both control and training groups (p˂0.05). Salivary CAT and GPx levels were not significantly altered by training and exhaustive exercise in both groups (p>0.05). Generally, aerobic training could lead to promote antioxidant enzymes in blood and SOD in saliva. Also, salivary and blood SOD activity increases in response to exhaustive exercise. However, in order to use saliva as a non-invasive method in exercise and sport studies, more research is needed.