جستجوی مقالات مرتبط با کلیدواژه "bdnf" در نشریات گروه "زیست شناسی"

Obesity and cardiovascular disease are the leading causes of death in the world. The aim of this study was to investigate the effect of various resistance training (traditional, circuit and Interval) on BDNF and SPARC in obese men.For this purpose, 44 obese male volunteers after homogenization were randomly divided into 4 groups based on individual characteristics: control (n = 11), traditional (n = 11), Circuit (n = 11) and Interval (n = 11). Subjects performed three sessions of resistance training each week for 12 weeks. Blood samples were taken before first training session and 48 hours after the last training session and were used to analyze the factors. Examination of intergroup differences for BDNF and SPARC showed that there was a significant difference between groups (p < 0.001). The results of Bonferroni test for BDNF showed that there was a significant difference between control with interval (p < 0.001) and circuit (p < 0.001) and traditional (p = 0.012) groups. Also, the study of intragroup changes showed that BDNF values were significantly increased in the traditional training groups (p = 0.008), the circuit resistance training group (p < 0.001) and the interval training group (p < 0.001). The results of Bonferroni test for SPARC showed that there was a significant difference between control with interval (p < 0.001) and Circuit (p < 0.001) groups. Also, the study of intragroup changes showed that SPARC values were significantly reduced in the traditional training groups (p < 0.001), the interval training group (p < 0.001) and the circuit training group (p < 0.001). In the present study, it was shown that 12 weeks of traditional, circuit and interval resistance training, increased plasma BDNF levels and decreased SPARC plasma levels in obese men. It should be noted that the desired changes in circuit and interval resistance training protocols were better than the traditional type.

Neurodegenerative diseases induce apoptosis in neurons by affecting the central nervous system. Glia cells play an important role in preventing the progression of these diseases and increasing neuronal survival. The most important function of glia cells after neuronal survival is the secretion of neuroprotective factors. Neuroprotective factors secreted by astrocytes include TGFβ1, TGFβ2, GDNF, BDNF, and NT3.In this study, we investigate the possible role of vortmanine in the expression of neuroprotective factors BDNF and NT3 secreted by microglia and oligodendrocytes in vitro. For this purpose, cultured microglia and oligodendrocytes were treated with concentrations of 8,12,16 μmol / L for 72 hours.

A 1-2-day-old Wistar rat was used to culture astrocyte cells. Thus, after disinfecting the skin of the body and hands of infants with 70% alcohol-soaked cotton, the infant's head was cut with scissors, the scalp was completely removed and the skull was cut from the neck to the forehead. To reveal the cerebral cortex. The brain was then removed from the skull and placed in Hanks buffer.Concentrations of 8, 12, and 16 mol / L of vortmanine are added by sampler to microglia and oligodendrocyte cells cultured in 6-well plates and The expression of neuroprotective factors was measured by R-T PCR

Vertmanine-treated astrocyte cells showed significant morphological changes.However, morphological changes were much less observed in control cells compared to treated cells.

Millions of people worldwide have Alzheimer's disease, and with the disproportionate growth of the elderly population, the disease, which is the most common form of dementia among the elderly, is becoming a public health crisis. This study aimed to investigate the effect of endurance training before and after Alzheimer's induction on some neuroplasticity-related factors in the hippocampus of male Wistar rats. Before inducing Alzheimer's disease, 32 8-week-old male rats weighing an average of 250 g were randomly allocated into two groups: rest (16 heads) and exercise (16 heads). Each group was divided into two subgroups after four weeks (the first and second weeks at a speed of 10 meters per minute in two 15-minute shifts, the third week at a speed of 15 meters per minute in three 15-minute shifts, and the fourth week at a speed of 15 meters per minute in four 15-minute shifts with 5-minute intervals).1. amyloid beta injection and 2. without injection. After 72 hours, the animals were killed and their hippocampus was removed for examination. Real Time PCR measured BDNF, PKG, and cGMP gene expression.Data were analyzed by one-way analysis of variance and Tukey post hoc test at the significant level of p <0.05. The results showed that the levels of BDNF, PKG and cGMP in the exercise group were significantly higher than the rest group in the stage after Alzheimer's induction (p = 0.001). According to the results, it seems that aerobic exercise can help improve neuroplasticity in the hippocampus of Alzheimer's mice.

In patients with breast cancer, low serum brain-derived neurotrophic factor (BDNF) levels and high serum tumor necrosis factor (TNF)-α level have been reported. Therefore, the present study aimed to investigate the effect of eight weeks of high-intensity circuit training on serum levels of BDNF and TNFα and aerobic power in breast cancer survivors.

This randomized controlled trial was conducted at Shahid Rahimi Hospital Oncology Center in Khorramabad in 2018. Seventeen breast cancer survivors were selected from a group of 55 women who had undergone chemotherapy and radiation therapy and randomly divided into an exercise (n = 9) or a control (n = 8) group. The exercise group performed high-intensity circuit training (HICT) three sessions per week for eight weeks. Data were analyzed using a paired-samples t test and an analysis of covariance.

The results of the t test showed that after eight weeks, serum levels of BDNF and TNF-α were significantly increased in both groups (p ˂ 0.05), although the difference between the groups was not significant. Aerobic power significantly increased only in the exercise group (p = 0.0005). In addition, the results of the analysis of covariance showed only a significant difference in aerobic power between the two groups (p ˂ 0.05).

Eight weeks of HICT training in breast cancer survivors can increase aerobic capacity without affecting serum levels of BDNF and TNFα.

With increased age, the process of destruction and weakening of the functioning of the organs, including the brain, is predictable. Physical activity and proper nutrition are factors that play an important role in the health of the nervous system. Boswellia serrata is one of the most important herbs in traditional medicine to enhance memory and prevent Alzheimer's disease. The purpose of this study was to assess the effect of aerobic exercise course combined with the use of B. serrata on the amounts of brain-derived neurotrophic factor (BDNF) and alpha-tumor necrosis factor (TNFα) in elderly men. In this quasi-experimental study, 40 elderly men aged 60-70 yr old who were in complete physical and mental health were randomly divided into four groups (exercise, supplement, exercise + supplement, and control). Participants in the training groups participated in the aerobic walking training program for 8  and 3 wk each week. Moreover, the daily supplementary groups received B. serrata 300 mg in chewing and packaged form. The control group did not participate in any intervention during this period. Fasting blood samples were collected before and 24 h after the last intervention. Data were analyzed using t-test, analysis of variance and Tukey at a significance level of 0. 05. In the exercise, supplementation, and exercise + supplementation groups after 8 wk, the levels of BDNF and TNFα increased and decreased significantly, respectively (P≤0. 05). In addition, there was a significant difference in BDNF and TNFα levels in the exercise + supplement group compared to other groups (P≤0. 01). Doing walking and consuming B. serrata independently and combined significantly increase the expression of BDNF and significantly reduce the inflammatory factors in elderly men. Therefore, it is recommended that the combination of walking and consumption B. serrata as a more effective way to maintain health and extend the cognitive and functional benefits of the brain and the nervous system to the elderly.