جستجوی مقالات مرتبط با کلیدواژه « آب انار » در نشریات گروه « پزشکی »

Prostate cancer is the second leading cause of cancer mortality among men worldwide and in Iran. This study aims to assess the effect of eight weeks of aerobic training and consumption of pomegranate juice on some MicroRNAs and a tumor suppressor protein (P53) in men with prostate cancer.

This quasi-experimental study was conducted in 2021 on 40 men with prostate cancer with a mean age of 61 years who were randomly divided into four groups (10 indivituals): control, exercise, exercise + supplementation, and supplementation. Exercise groups performed aerobic exercises for eight weeks, three sessions per week, each for 60-90 minutes with an intensity of 50-70% of maximum heart rate. Supplementation groups consumed 100 cc of pomegranate juice for 8 weeks, three times per week. Blood samples were taken from the participants 48 hours before and after the implementation of the exercise protocol. Dependent t-test and one-way ANOVA with the least significant difference post hoc test were used to analyze the data, considering a significance level of P≤0.05.

Eight weeks of aerobic exercise combined with consumption of pomegranate juice caused a significant decrease in serum levels of miR-21 (P= 0.001) and miR-155 (P= 0.001) and a significant increase in P53 protein level in men with prostate cancer..

Aerobic exercise and consumption of pomegranate juice simultaneously can reduce miR-21 and miR-155 levels and increase the P53 protein level in men with prostate cancer.

Breast cancer is one of the most common cancers and the first leading cause of cancer death (25.5%) among women across the world. Oxidative stress and overproduction of free radicals are among the most important reasons for the progression of cancers. This study aimed to investigate the effect of eight weeks of aerobic exercise with pomegranate juice on Serum microRNAs levels related to the oxidant/antioxidant system of women recovering from breast cancer.

In this semi-experimental study, 40 women recovering from breast cancer with a mean age of 42.45±1.95 were randomly assigned into four equal groups (n=10), including control, pomegranate juice, aerobic exercise, and aerobic-pomegranate. The aerobic and aerobic-pomegranate groups performed eight 60-90-min sessions of exercises three times a week with an intensity of 50% to 70% of the target heart rate. The pomegranate juice group received 100 cc of juice before each training session. Blood samples were collected 48 h before and after the intervention. Oncogenic microRNAs, such as miR-21 and miR-155, were assayed by RT-PCR. The obtained data were analyzed using one-way ANOVA, ANCOVA, and Bonferroni post hoc test at a significance level of P≤0/05.

In total, eight weeks of aerobic exercise with the consumption of pomegranate juice caused a significant decrease in miR-21 (P=0.001) and miR-155 (P=0.001) levels in women recovering from breast cancer, compared to the control group.

Aerobic exercise and consumption of pomegranate juice simultaneously reduced oncogene microRNAs, such as miR-21 and miR-155, in women recovering from breast cancer.

Increasing oxidative factors and reducing antioxidants is one of the main causes of breast cancer.The purpose of this study was to investigate the effect of eight weeks of aerobic exercise and pomegranate juice on serum enzyme levels related to the Oxidant-Antioxidant system of women saved from breast cancer.

In this blinded randomized control trial which was conducted in rasht in 2019, 40 women with breast cancer were selected who were randomly were assigned into four equal groups control groups (n=10), pomegranate juice (n=10), aerobic exercise (n=10) and aerobic exercise and pomegranate juice (n=10). The aerobic exercise group and the aerobic exercise and pomegranate juice group, performed training programs including 8 weeks and 3 sessions per week with intensity 50 to 70% of the maximal heart rate for 60 to 90 minutes of training. Two groups of pomegranate juice consumers received 100 cc of pomegranate juice before each training session. In order to investigate the variables of research (MDA, SOD, GPX), blood samples were collected 48 hours before and after the intervention in fasting state. The obtained data was analyzed using of one-way analysis of variance (ANOVA) and bonferroni post hoc test analysis. The significant level was P<0/05

The results showed that 8 weeks of aerobic exercise caused a significantly decreased MDA levels and significantly increased SOD and GPX levels in women with breast cancer (P = 0/0001).aerobic exercise without use of pomegranate juice, only led to a significant decrease in MDA (P=0.0001) level, and pomegranate juice consumption alone, no significant changes were observed at the three variables investigated in women with breast cancer.

According to the results, Aerobic exercise and consumption of pomegranate juice simultaneously, reduce oxidative factors and increase anti-oxidant factors in women Rescued from Breast Cancer

Eight weeks of resistance training with pomegranate juice supplementation on inflammatory / anti-inflammatory agents and some lipoproteins are for women with type 2 diabetes.

In this study, 40 type 2 diabetic women aged 40-55 years were selected by purposeful sampling and were randomly divided into four groups: control group (n = 10), resistance group (n = 10), water use group. Pomegranate (n = 10) and resistance training and water consumption group (n = 10). The experimental group performed resistance training three times per week for eight weeks at 30% of maximum repetition frequency and at the end of the eighth week reached 80% of maximum repetition frequency and the group consumed 100 cc pomegranate juice daily. Analysis was performed by one-way ANOVA with significance level (p˂0.05).            

The results showed that eight weeks of resistance training with pomegranate juice consumption significantly increased IL-10 levels (P = 0.000) and significantly decreased TNF-a, IL-6, and CRP levels (P = 0.000). There was also a significant decrease in LDL levels (P = 0.000) and a significant increase in HDL levels (P = 0.000) in women with type 2 diabetes.

The results showed that eight weeks of resistance training combined with pomegranate juice intake reduced inflammatory factors and increased anti-inflammatory markers in women with type 2 diabetes.

Myocardial Infarction is one of greatest cause of death worldwide which cause enlargement of left ventricle and loss of capillaries. Angiogenesis and adequate growth of capillaries after MI is essential. The mechanism of exercise-induced benefit and angiogenesis in ischemic heart disease remains poorly defined. This study was designed to investigate the effects of eight weeks of high intensity interval training on endothelial constitutive nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF) and Platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) in rats with myocardial infarction.

13 male Wistar rats weighing 250 to 300 grams were assigned into two groups: the experimental group or HIIT (42 minutes running on a treadmill on an interval basis, each interval four minutes with intensity of 85-90 and three minutes of active recovery with 40- 50 % VO2max, Five days a week for eight weeks) and the control group (without training intervention). Genes expression of eNOS, VEGF were investigated by the PCR technique and protein expression of CD31 was investigated by western blotting test. Data were analyzed using SPSS (version 16) with Independent sample t-test (P≤0.05).

Endothelial constitutive nitric oxide synthase in high intensity interval training group (8.43) was significantly higher than the control group (2.85) (P=0.001) vascular endothelial growth factor in high intensity interval training group (0.097) was significantly higher than control group (0.019) (P=0.05) and Platelet-endothelial cell adhesion molecule-1 in high intensity interval training group (1.345) was significantly higher than control group (0.626) (P=0.01).

Eight weeks of high intensity interval training with intensity 85-90 % VO2max increased endothelial constitutive nitric oxide synthase and vascular endothelial growth factor and Platelet-endothelial cell adhesion molecule-1.

Pomegranate tree has been originated in east Asia and Iran. The consumption of pomegranate is curative and prevents many sicknesses, therefore pomegranate has a special place in human diet.

In this investigation, the effect of foliar spray application of different forms of Zinc in different concentrations on some characteristics of pomegranate fruit, has been studied. The application of spray was carried out during May and July of 2016. This study was at based on a randomized complete block design with seven treatments and three replications. Zinc sulphate fertilizer and nano-Zn chelate fertilizer were applied in 500, 1000 and 1500 mgl-1 concentrations.

The application of 500 mgl-1 nano-Zn chelate significantly increased fruits grains weight and fresh weight of 100 grains. 1500 mgl-1 ZnSO4 increased the pH, total acidity and ascorbic acid contents of the juice but 500 mgl-1 nano-Zn chelate had a toxic effect on all of the factors and decreased them. 1000 mgl-1 ZnSO4 significantly increased anthocyanin and EC of the juice, although 1500 mgl-1 nano-Zn chelate decreased anthocyanin and 500 mgl-1 nano-Zn chelate decreased EC.TSS and TSS/TA was increased by 500 mgl-1 ZnSO4 whereas 1500 mgl-1 nano-Zn chelate decreased both of them.

Although different concentrations of ZnSO4 fertilizer improve the chemical characteristics of pomegranate fruit, but totally the best foliar spray application is at 500 mgl-1 nano-Zn chelate.

black peel pomegranate is one of the indigenous cultivars in Iran, which is approximately rare in comparison with other cultivars and is used as an herbal therapy.  In this research, the aim was study of polyphenol compounds and antioxidant activity of pomegranate juice, condensed juice with freeze dryer, and vacuum oven and the choice of the best pomegranate juice condensation method.   For this purpose, pomegranate fruits were washed, squeezed for obtaining the juice, and after the juice was condensed by two methods, freeze dryer and vacuum oven, then antioxidant activity using DPPH assay, total phenol using Folin-Ciocalteu reagent, flavonoids using aluminum chloride method, and detection and quantity of polyphenol compounds using HPLC in the samples were determined.   Results showed that the highest polyphenol compound of the condensed black peel pomegranate juice was punicalagin B. In addition, the highest antioxidant activity (70.0±0.40%), total phenol (2517.0±0.75 mgGa/100ml), and flavonoid (390.50±0.00 mgQ/100ml) were belonged to the condensed pomegranate juice with freeze dryer in comparison with natural pomegranate juice and condensed pomegranate juice with vacuum oven, respectively. The results showed that there are the significant differences in the amounts of antioxidant activity, polyphenol compounds, total flavonoid, and total phenol of the condensed pomegranate juices and natural pomegranate juice (p<0.05).   The condensed black peel pomegranate juice with freeze dryer had the highest polyphenol compounds and antioxidant activity values in comparison with the pomegranate juice with vacuum oven. Therefore, the condensation of pomegranate juice using freeze dryer because of preserving of polyphenol compounds and their antioxidant activities are proposed for its application in food industry.

Diabetes increases oxidative stress in different tissues and leads to increased levels of oxidation of DNA, proteins and lipids. Paraoxonase is an esterase enzyme that is carried along with HDL-C. This enzyme prevents of the peroxidation of LDL-C and therefore effective in reducing the risk of atherosclerosis.
Subjects and In this clinical trial study the subjects of this research included diabetic postmenopausal women in the city of Babol with the age range between 50 and 60 years old. Who were selected with coordination of Diabetes Association. The statistical sample included 33 subjects who were randomly divided into four groups (n=7 to 9). These groups were randomely divided into: control, pomegranate juice, exercise and exercise-pomegranate juice. Program of aerobic training groups was for six weeks, three times in a week and for 45-65 minutes/day and in four afternoon was carried out. Subjects consume 150 ml of pomegranate juice daily at eight oclock every morning.. For the analysis data from the Dependent t-test and analysis of variance one way ANOVA was used.
There was a highly significant increase in the paraoxonase-1 (P activity of paraoxonase enzyme and Plasma lipid profile can be influenced by dietary factors and lifestyle.

Pomegranate is a medical plant with antioxidant effects. The aim of the study was to investigate the effect of pomegranate juice on pituitary- thyroid axis in adult male rats.
In this experimental study, 50 adult male rats with mean weight body of 200±20 gr were divided in to 5 groups of 10 rat each: control, sham, and three experimental groups which received in minimal pomegranate juice (3ml per day), medium (6ml per day), and maximal amounts (9ml per day), respectively, for 10 days using gavage method. One day after the last gavage, the blood sample collected by bloodletting from the heart. After preparing serum, the level of T3, T4, and TSH hormones were measured using ELISA method.
Mean body weight in experimental groups didnt show any significant difference in comparison with control and sham groups. Serum levels of T3 hormone in groups receiving maximum dose of pomegranate juice showed significant decrease compared to control and sham groups. Serum level of T4 hormone in experimental groups received pomegranate juice showed significant decrease compared to control and sham groups. Serum level of TSH hormone in minimum dose of pomegranate juice showed significant increase compared to control and sham groups.
Pomegranate juice reduced pituitary-thyroid axis activity in adult male rats.

Diabetes mellitus is one of the prevalence metabolic disorders in the worldwide. Studies have shown that fruits, vegetables and drinks that are rich in phenolic and antioxidants components may reduce cardiovascular and diabetes diseases. One of these fruits is Pomegranate that is rich in phelavonoid. Therefore, this study was designed to determine pomegranate juice effect on fast blood sugar, lipid profile, anthropometry, total antioxidant capacity and blood pressure in diabetic patients.
In the present study, 50 patients with diabetes aged 30-50 were recruited into the study and randomly assigned into 2 groups:1) intervention group (n=25) that fed 240cc pomegranate juice daily, 2) control group (n=25) that fed 240cc water daily. Weight, hip circumstance, waist circumstance, lipid profile (HDL-C, LDL-C, TG, TC) glucose, HbA1C, GPX, total antioxidant capacity, systolic and diastolic blood pressure were measured at the baseline and end of 8 weeks.
Insulin resistance, systolic and diastolic blood pressure, body weight, hip circumstance, waist circumstance decreased significantly and GPX increased in intervention group whereas pomegranate juice had no significant effect on glucose, HbA1C, lipid profile and total antioxidant capacity.
These findings indicate that beneficial effect of pomegranate juice on insulin resistance, systolic and diastolic blood pressure, body weight, hip circumstance, waist circumstance, GPX

Cardiovascular diseases are one of the causes of mortality. The aim of the present study was to investigate the effects of pomegranate juice consumption on blood pressure, inflammation factors, and vascular function. This before and after clinical trial study was conducted on 13 patients aged 39–67 years with blood pressure above 140/90 mmHg referring Hypertension Clinic of Isfahan Cardiovascular Research Center. All patients consumed fasting 150 mL Pomegranate juice. The level of inflammation factors including E-selectin, high-sensitivity C-reactive protein, intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), interleukin-6 (IL-6), Systolic blood pressure (SBP), diastolic blood pressure (DBP), and flow-mediated dilation (FMD) was measured at baseline and 4-6 hours after PJ consumption. The patients consumed 150 ml pomegranate juice. All 13 patients cooperated to the end of study. The short-term consumption of Pomegranate juice decreased significantly systolic and diastolic blood pressure from 125.38±11.80 to 116.15±7.94, and from 82.69±5.25 to 78.08±3.25, respectively (P<0.05). Inflammation factors (VCAM, ICAM, CRP, IL-6, and E-selectin), and FMD didn’t reveal significant changes. Short term consumption of fresh pomegranate juice could have hypotensive properties in patients suffering from high blood pressure. It seems Pomegranate juice could be effective on preventing and treating cardiovascular diseases.

Diabetes is one of the diseases resulting from defects in insulin secretion or action. Pomegranate juice is a nutrient used in the treatment of some diseases in traditional medicine. Thus، thepresent study investigated the effects of pomegranate juice on blood glucose and insulin levels in adult malerats. The present study was an empirical one in which 90 adult male Wistar rats،weighing 200 to 220 g each، were randomly divided into five groups of control، sham، experimental (diabeticand non –diabetic) 1، 2 and 3. The control group (n=9) and the sham (n=9) received only distilled water، butthe diabetic and non-diabetic groups 1، 2 and 3 received 1، 2 and 4cc of pomegranate juice for 21daysthrough gavage. As for diabetic rats، diabetes was induced through intraperitioneal injection of 60 mg/kg ofstreptozotocin into each. In the experimental groups، the animals were each treated to a singl dose ofpomegranate juice every day for 21days. At the end of the 21st day، blood samples were taken from theexperimental and control groups and their serum levels of insulin and glucose were measured. The obtaineddata was analysed by means of SPSS (v: 18) using ANOVA and LSD softwares. It was found that minimum، average or maximum dose of pomegranate juice caused a significantreduction in their glycemia at the levels of P=0. 05، P=0. 005 and P=0. 0005، respectively; but it increasedinsulin at the levels P=0. 023، P=0. 015، and P=0. 002، respectively in the diabetic group compared to thecontrol group. However، it had no significant effect on the non-diabetic rats. Pomegranate، due to having antioxidant compounds such as polyphenolic compounds، increasesinsulin and thus، decreases blood glucose levels in streptozotocin-induced diabetic group.

Edible parts of pomegranate fruit can be eaten fresh or used for production of fresh juice, caned drinks, jellies, jams and purees and also used to enhance color and flavor of beverages. In this research, effect of pomegranate peel extract as natural antioxidants, polyphenolic ingredients and vitamins on viability of probiotic bacteria in pomegranate juice is studied. Two differents strains of probiotic bacteria (Lactobacillus plantarum, Lactobacillus delbrueckii) were used in this study. Flavor, odore and overall acceptability of probiotic pomegranate juice containing the highest number of viable bacteria were compared with control sample by hedonik scale divided into nine and results by a completely randomized design (CRD) and the F test were evaluated.The mean comparsons was performed by Duncan method at the significance level α=5% by SPSS software(version=11.0). The results showed that the highest rate survival of L. Plantarum and L. delbrueckii was seen when bacteria were incubated in MRS broth for 48h, inoculated in nutrient medium containing pomegranate peel extract 0/1% and incubated in anaerobic conditions for 72 hours at 37°C and stored at room temperature for 2 weeks. The highest number of live bacteria for L. Plantarum and L. delbrueckii was obtained respectively 4.74×106 and 4.74×106 (cfu.ml-1). The sensory properties of probiotic products were not significant difference with similar non-probiotic products and wereAcceptable in terms of consumer (P>0.05). Using of appropriate percent of pomegranate peel extract not only did not produce undesirable flavors but also led to Increasing survival of bacteria.

The intake of antioxidant supplementations can have key role in prevention of oxidative stress in healthy individuals. Pomegranate has antioxidant effects and may play a role in reduction of oxidative stress in healthy males. Therefore, this study examined the effect of pomegranate juice supplementation on oxidative stress in young healthy males. In semi-experimental study, 14 healthy students living in Dormitories of Ardabil University of Medical Sciences were included. Subjects were given one cup of pomegranate juice supplementation per day for two weeks. Fasting blood samples were taken both at the start and the end of 2-week period to measure the antioxidant enzyme activities such as superoxide dismutase, glutathione peroxidase, paraoxonase-1, aryl esterase, and the values of serum total antioxidant capacity, glutathione, and lipid profiles. Data were analyzed using descriptive and paired t-tests. The level of serum total antioxidant capacity and activities of enzymes such as superoxide dismutase, glutathione peroxidase, arylesterase, and standardized arylesterase activity were significantly increased at the end of two weeks (p<0.05). The serum level of malondialdehyde was significantly decreased after intervention (p<0.05). Changes were not significant, although the serum levels of glutathione and HDL-cholesterol increased and LDL- cholesterol decreased at the end of two weeks period. The results of this study showed that the pomegranate juice supplementation had beneficial effects in helping body's antioxidant defense system and reduction of oxidative stress in young healthy males. This study suggests that the pomegranate juice supplementation can be useful against oxidative stress included in dietaries of young healthy males.

An imbalance between the production of free radicals and antioxidant defense system causes oxidative stress which can create different diseases. This study has attempted to measure the possible effect of pomegranate juice (PJ) as an antioxidant on oxidative stress.

This semi experimental study was performed on 30 girl students, 15-17 years old. They were asked to complete a questionnaire based on study criteria and then were asked to drink 100 ml of PJ per day for 14 days. The oxidative stress parameters (total antioxidant capacity, total thiol and lipid peroxidation levels) were measured before and 14 days after using the PJ. Paired t-test was used for data analysis.

The students showed a significant reduction in lipid peroxidation (11.3±5.93 versus 6.4±3.3, P<0.01). The total serum antioxidant capacity (1.95±0.36 versus 2.26±0.54) and total serum-thiols (0.3±0.19 versus 0.43±0.27) were also significantly increased (P<0.05).

PJ has a remarkable antioxidant characteristic, and due to its poly-phenolic flavenoids has antioxidant characteristic and reduces oxidative stress.

Diabetes causes hypertension in most diabetic patients. Pomegranate juice is known to have antioxidant and antiatherosclerotic properties the purpose of this study was to determine the effects of pomegranate juice consumption on blood pressure of type 2 diabetic patients. In 1384, in a randomized clinical trial study, 61 diabetic patients (54.9±8.4 years old), attending the Special Diabetic Affairs Foundation and the Iranian Diabetic Society, were recruited, and were randomly allocated to either the pomegranate juice consumption or the control group. Patients in the pomegranate juice group consumed 200ml of pomegranate juice (sugar or additives free) daily for six weeks. The questionnaires for general characteristics, semi-quantitative food frequency and 24-hour food recall were completed by interview. Blood pressure and anthropometric measurements, including weight and height, were measured at baseline and at the end of the study. SPSS software was used for data analysis and Paired T-test, Independent T-test, Covariance analysis and Chi Square test were conducted. The mean body mass index, nutrients and fiber intake, drug intake and physical activity of patients did not change during the study. In the pomegranate juice consumption group, the mean systolic blood pressure (P< 0.001) and diastolic blood pressure (P< 0.05) were significantly decreased compared with baseline. The mean systolic blood pressure (P< 0.02) and diastolic blood pressure (P< 0.03) were significantly different between the pomegranate and control groups after intervention. Considering the positive effect of pomegranate juice consumption in reducing systolic and diastolic blood pressure in diabetic type 2 patients it may be recommended for hypertension prevention in these patients.

Epidemiological findings have shown that consuming foods and beverages having high levels of phenolic compounds decreases the risk of many diseases such as cardiovascular ones. During recent years, there has been considerable interest in identifying natural sources with antioxidant activities to prevent oxidative stress- induced damages. The aim of this study was to measure phenolic compounds and antioxidant properties of pomegranate juice, its antioxidant capacity and scavenging effect on free radicals in comparison with other juices. In this experimental and laboratory study, antioxidant properties of pomegranate concentrate and also nine brand juices were evaluated. Phenolic compounds of pomegranate juice and the other samples were evaluated by means of Folin-Ciocalteu method, their antioxidant properties by FRAP method (Ferric Reducing/Antioxidant power Assay), and their power in scavenging the radical DPPH (1, 1-Diphenyl-2-Picrylhydrazyl) was measured. Besides, the capacity of pomegranate juice inhibitory effect on peroxidation of plasma lipids by copper ions and its inhibitory effect on controlling the hemolysis of erythrocytes induced by H2O2 were studied. The obtained data was analyzed by means of SPSS software. The most amount of phenolic compounds was found in pomegranate juice (205.05.0 mg Gallic acid equivalent to 100 ml of diluted pomegranate juice). Pomegranate also showed the highest total antioxidant capacity (11.170.3 mmol/l). In DPPH method whose radical scavenging activity was evaluated by the specific sample, pomegranate also showed its most capacity (96%).Correlative studies have shown that there is a positive and significant correlation between phenolic compounds content of the studied samples and their total antioxidant capacity in inhibiting or scavenging of DPPH radical. Studying the effect of different dilutions of pomegranate juice on inhibiting the formation of conjugated diene in plasma lipids and hemolysis of erythrocytes showed that in a dose-bound process the more the concentration of pomegranate juice, the more its inhibitory effect on hemolysis. On the basis of the results of this study, compared with other fruit juices studied pomegranate juice has more phenolic compounds and its total oxidant capacity is high besides, it has great strength in inhibiting different radicals and can have beneficial effects on improving antioxidant defence of the body and decreasing oxidative stress of it.