جستجوی مقالات مرتبط با کلیدواژه "اینترلوکین ها" در نشریات گروه "پزشکی"

Chronic obstructive pulmonary disease (COPD) is a respiratory disease in which inflammation plays a significant role in its progression. Exercise and nutritional strategies are effective in improving inflammation; therefore, the aim of this study was to determine the effect of a combined exercise program and N-acetylcysteine supplementation on inflammatory markers in patients with COPD.

In this semi-experimental study, 80 male patients with COPD were randomly divided into 4 groups (20 subjects each): combined exercise, combined exercise with supplementation, supplementation, and placebo. The exercises were performed for 12 weeks, 6 sessions per week, for 60 minutes. 1800 mg of N-acetylcysteine supplement was administered daily along with 3 main meals. The levels of interleukin-6, interleukin-8, and C-reactive protein were measured in the blood at pre- and post-test.

After 12 weeks of intervention, the mean values of interleukin-6, interleukin-8, and CRP decreased significantly by 12.9%, 20.3%, and 5%, respectively, in the exercise + supplement group (P=0.001). Interleukin-6 (P=0.001), interleukin-8 (P=0.001), and CRP (P=0.04) levels were significantly lower in the exercise + supplement group compared to the placebo group. Moreover, interleukin-6 (P=0.001) and interleukin-8 (P=0.001) levels were significantly lower in the exercise group compared to the placebo group.

It seems that combined exercise and N-acetylcysteine supplementation have a positive effect on interleukin-6, interleukin-8, and CRP markers in patients with COPD.

Resistance exercises with high loads of HLRT cause physiological changes in body systems, including the immune system. On the other hand, little research has been done on the effect of high-intensity bodybuilding exercises on women's immune systems. The present study investigated the effect of resistance activity in a single bout with two different intensities and recovery on TNF-α and interleukin-6 gene expression, hs-CRP, and systemic immune-inflammatory marker SII on female bodybuilders.

In this semi-experimental study, 12 healthy female athletes (aged 30 ± 5) volunteered. The samples performed weekly resistance training at 70% and 85% of 1RM in two recovery times of one and two minutes. Thirty-six hours after training, sampling was done following a ten-hour fasting period. The samples were centrifuged at 3000 rpm and kept at -20 ℃. Ultimately, all levels of TNF-α and interleukin-6, hs-CRP, and systemic immune-inflammatory markers SII were checked in the medical laboratory. A consent form was obtained from the participants.

The results of resistance training using the HLRT method compared to moderate-intensity resistance training showed an increase in training intensity of up to 85% 1RM and a one-minute recovery. There was a significant decrease in the level of interleukin-6, TNF-α (P < 0.001), and hs-CRP (P < 0.025) and a significant increase in the level of SII systemic immune-inflammatory markers (P < 0.001).

It seems that increasing the intensity of resistance training - with increasing load - HLRT does not hurt the immune system, and it reduces pro-inflammatory factors interleukin-6, TNF-α and hs-CRP, as well as increases SII in female bodybuilders.

Regenerative treatments in endodontics are biological treatments to manage immature teeth, remove inflamed and necrotic tissue, and create a suitable environment for tissue repair. In these treatments, substances with reparative properties of dental pulp and dentin are placed on the pulpal tissue. Interleukin-6 is one of the cytokines secreted in response to various immune activities of the body and studies have demonstrated its vital role in mineralization induction and hard tissue formation. Recently, calcium silicate-based materials have been widely implemented in dentistry due to their great biocompatibility and hard tissue formation induction. Considering the role of IL-6 in the regulation of stem cells, the purpose of this study is to compare the effect of CEM cement, Biodentine, TheraCal LC, and MTA on the level of IL-6 secretion by dental pulp stem cells.

In this laboratory study, 4 types of cement were used as the main groups, and 1 control group contained culture medium without cement. Discs were prepared under sterile conditions in six-well plates with a diameter of 35 mm and a height of 2 mm and they were given time to set for 48 hours. Human pulp stem cells were obtained from Iran's Center for Biological Resources and cultured in a culture medium containing DMEM with 15% FBS and 1% penicillin-streptomycin (10,000 units/ml) as antibiotics. Pulp stem cells at passages 3-5 were used for experiments. Discs of each cement were prepared under sterile conditions and according to the manufacturer's instructions. To prepare the extract of each cement, the DMEM cell culture medium was placed near these discs for 24 hours. Then, human dental pulp stem cells (hDPSCs) were cultured in the vicinity of the disc extract for 72 hours. After that, this extract was collected and the level of IL-6 secretion in it was measured by the ELISA method. The experiments were repeated 3 times. Then the obtained data were entered into SPSS 16 software and analyzed using analysis of variance and the Kruskal-Wallis test.

The results showed that the highest level of IL-6 secretion by cells was in the presence of TheraCal LC, Biodentine, and CEM, respectively; But there was no significant difference between the groups. The average level of IL-6 secretion in the presence of MTA was lower than in other groups and this difference was significant (P<0.01).

The results of the present study showed a lower level of IL-6 cytokine secretion by pulpal stem cells in the presence of MTA compared to TheraCal, CEM, and Biodentine types of cement. Considering the role that IL-6 can have in osteogenic and odontogenic activities, the results of this study can be useful in establishing information in the field of introducing the most suitable cements for clinical procedures.

Parkinson's disease is associated with a dysfunction in the inflammatory system. This study aims to evaluate the effects of eight weeks of aerobic training combined with garlic supplementation on the expression of interferon gamma (IFN-γ) and interleukin 4 (IL-4) genes in the brain tissue of reserpine-induced parkinsonian rats.

In this experimental study, 32 reserpine-induced parkinsonian rats (administered an intraperitoneal injection of 2 mg/kg reserpine) were divided into four groups: 1) reserpine, 2) aerobic training (AT) for eight weeks, 3) garlic supplementation (G), and 4) AT + G. Additionally, eight healthy rats were included in a healthy control group. The aerobic training regimen consisted of five sessions per week for eight weeks, with each session lasting between 15 and 48 minutes at a speed of 10 to 24 m/min. Rats received 500 mg/kg/day of aqueous garlic extract via gavage. The gene expression levels of IFN-γ and IL-4 in the brain tissue were measured using the RT-PCR method. Motor balance was assessed using a rotarod device.

IFN-γ gene expression was significantly lower in the G, AT, and AT + G groups compared to the reserpine group (P < 0.001). Furthermore, IL-4 levels and motor balance scores were significantly higher in these groups than in the reserpine group (P < 0.001). Notably, the combined effect of eight weeks of aerobic exercise (AT) with garlic supplementation (G) on reducing IFN-γ gene expression levels and enhancing motor balance was significantly more favorable than that of garlic supplementation alone (P ≥ 0.05).

Both aerobic exercise and garlic supplementation seem to exert beneficial effects on the inflammatory and anti-inflammatory systems in the brain tissue, as well as on motor balance in neurological diseases. These findings suggest that integrating aerobic training with garlic supplementation may enhance therapeutic approaches for managing Parkinson's disease.

Physical activity has a dual effect on inflammation and the results of studies are very contradictory. The aim of this study was the interactive effect of six weeks of TRX training and oral intake of mango tree leaf extract on interleukin-12 and anterometric indices of overweight and inactive obese male students.

In a semi-experimental research, 48 overweight and inactive obese students with an age range of 20-25 years were purposefully selected and divided into 4 groups of 12: control, extract, exercise and exercise+extract. For six weeks (three sessions per week), they did TRX exercises and took 500 mg capsules containing mango leaf extract twice a day lunch and dinner. Blood sampling was done 24 hours before and 48 hours after the last training session. Interleukin-12 serum level was measured by ELISA method using human kit. Data were analyzed with dependent t-test and one-way analysis of variance and significance level less than 0.05 in SPSS-25 software (P<0.05).

A significant difference was observed in the levels of interleukin-12 in the exercise, exercise+extract and extract groups compared to the pre-test (p=0.001). The pre- and post-test differences between the groups using one-way analysis of variance on weight, fat percentage, body mass index and interleukin-12 levels showed a significant difference between the research groups (p < 0.05 between groups).

Six weeks of TRX training and consumption of mango leaf extract may be effective in reducing weight, fat percentage, body mass index and interleukin-12 serum levels. On the other hand, one of the ways to control inflammation is to do TRX exercises with mango leaf extract.

 Chronic obstructive pulmonary disease (COPD) is one of the respiratory diseases in which inflammation plays a key role in its development. Exercise training has acritical role in improving chronic inflammation. Nonetheless, the effects of various exercise training on inflammatory markers in these patients are not clear. Therefore, the present study aimed to assess the impact of exercise on the inflammatory markers, including IL-6, TNF-α, and c-reactive protein in patients with COPD.

A systematic search was conducted on PubMed, Web of Science, SID, Magiran, and Google scholar databases for articles published until July 2023. A meta-analysis was performed for the impact of exercise on inflammatory markers in COPD patients. Effect size (SMD) and 95% confidence interval were calculated using random effect model. Moreover, I2 test was employed to determine heterogeneity, while Funnel plot test and Egger test were used to check publication bias.

The results of the data analysis of 11 studies on 578 patients with COPD demonstrated that exercise led to a non-significant decrease in circulating CRP values [SMD=-0.413 (-0.100 to 0.175), P=0.16], IL-6 [SMD=-0.164 (-0.69 to 0.36], P=0.54], TNF-α [SMD=-0.358 (-1.44 to 0.72), P=0.51) in COPD patients. Furthermore, the results of the subgroup analysis pointed out that aerobic training [SMD=-0.55, P=0.1] compared to resistance training [SMD=-0.09, P=0.7] led to a decrease in CRP in patients with COPD. Nonetheless, this difference was not significant.

The findings of the present meta-analysis illustrated that aerobic exercise is probably an effective exercise intervention to reduce CRP in patients with COPD.

Irritable bowel syndrome (IBS) is a prevalent functional disorder of the gastrointestinal tract that affects approximately 11% of people worldwide. The exact mechanisms underlying IBS remain unclear, but evidence suggests that low-grade inflammation is involved in its pathophysiology. Interleukin-6 (IL-6) is a key cytokine that mediates inflammatory responses in the intestinal mucosa and has been linked to the development of IBS. Our study aimed to provide an overview of the current knowledge on the role of IL-6 in IBS.

The present study was conducted based on a search on the PubMed database, where only 26 articles investigated the role of IL-6 in irritable bowel syndrome were found.

Our review revealed that patients with IBS had higher levels of IL-6 in their serum/plasma. Furthermore, increased expression of IL-6 mediated by cholinergic signalling was associated with increased abdominal pain/discomfort and bloating. More recently, an interaction between IL-6 and corticotrophin-releasing factor was shown to provide more insight into the mechanisms underlying IBS symptoms during stressful periods, which are experienced by almost two-thirds of patients with IBS. Elevated levels of IL-6 were also correlated with increased fatigue and intestinal inflammation. Targeting IL-6 expression or IL-6 signalling pathway using probiotics, vitamin D3 or a replacement diet may offer a novel therapeutic strategy to improve IBS symptoms, abdominal pain, bloating and fatigue after consumption of ancient wheat products.

Further studies are needed to elucidate the causal relationship between IL-6 and IBS, as well as the molecular pathways and cellular targets of IL-6 in the gut.

Interval exercises with high intensity and consumption of plant extracts probably have beneficial effects on inflammatory indicators. The aim of this study was to investigate the effect of eight weeks of High-Intensity Interval Training (HIIT) and the consumption of Loquat leaf extract on the serum levels of TNF-α and interleukin-18 in obese men with non-alcoholic fatty liver disease.

In this semi-experimental study, forty men with non-alcoholic fatty liver disease with body mass index (33.92 ± 1.82) with informed written consent were randomly selected and assigned into four groups: control, training, Extract, Extract + training (Each group of 10 people). Exercises were performed for eight weeks and three sessions per week for 60 minutes with intensity between 80-95% of the reserve heart rate. Two capsules of 250 mg of Loquat leaf extract were also prescribed daily. Paired t-test and analysis of covariance were used.

A significant decrease in the levels of TNF-α (15.3%) and interleukin 18 (14.9%) was observed in the training + extract group (P<0.05). A significant difference was observed in the levels of TNF-α (P=0.001) and interlock 18 (P=0.001) between the groups, and these changes were more significant in the Extract + training group than in the training and extract groups.

It is concluded that performing intense intermittent training along with Loquat leaf extract will be able to improve TNF-α and interleukin 18 indices related to fatty liver in people with non-alcoholic fatty liver disease. However, confirmation of this hypothesis requires more research.

The COVID-19 pandemic, caused by the coronavirus, has emerged as one of the most pressing healthcare challenges of this century. The role of laboratory data in diagnosing severe forms of COVID-19 remains inconclusive. This research aimed to find ways to quickly prevent COVID-19. This research involved 43 COVID-19 patients monitored from March 2022 to May 2022 at the Mehregan Private Center in Khuzestan Province. Hematological and biochemical tests of the patients were performed. Measurements of D-dimer and Interleukin-6 were performed using the Biotek ELX 800TS analyzer, while fibrinogen levels were determined through the Clauss coagulation method. Data analysis was carried out using SPSS version 22 and GraphPad Prism version 9. There is a significant difference in the levels of interleukin 6, D-Dimer, and fibrinogen, which was equal to 0.0001 (P<0.05). Threshold level and area under the receptor operating characteristic curve (ROC) interleukin-6 was 20.06 pg/ml and 0.837, D-dimer 952.5 ng/ml and 0.929, and fibrinogen was 206.5 mg/dL and 0.768, respectively. The specificity and sensitivity of predicting the severity of COVID-19 interleukin 6 were 67.44% and 100%, D-dimer 60.47% and 97.67%, and fibrinogen 53.49 % and 95.35%, respectively. Interleukin-6 and D-dimer had the highest specificity and sensitivity for early prediction of the severity of COVID-19, but for fibrinogen, this level was not as obvious as the other two factors. D-dimer and interleukin-6 had more pronounced effects on the             severity of this disease, while fibrinogen had a lower impact.

Aging is generally associated with a progressive decrease in physical activity, which can affect the quality of life and lead to negative structural and functional changes in different body tissues and reduce their efficiency.High levels of interleukin-10 and interleukin-15 cytokines are related to longevity. The aim of this study is the effect of 12 weeks of resistance training on the serum levels of interleukin-10 and interleukin-15 in middle-aged women.Subjects and

40 middle-aged women (40-59 years old) were selected and randomly divided into2 equal experimental and control groups. The experimental group performed a resistance training program with a training load of 65% to 80%1RM for 12 weeks.Finally,48 hours after the last exercise, the levels of interleukin-10 and interleukin-15 were measured by ELISA method. The Kolmogorov Smirnov test was used to compare the data, and the independent t-test was used for the effectiveness of the exercise at a significance level of P<0.05.

The findings showed that there is no difference in weight and BMI between the experimental and control groups before the start of the research (P<0.05). But after training, it was statistically significant (P< 0.05).Also, a significant increase was observed in the levels of interleukin-10 and interleukin-15 after training(P=0.001).

It seems that the increased regulation of anti-inflammatory cytokines can have a positive effect on the improvement of physiological conditions caused by resistance training in middle-aged women. Therefore, it is recommended to use strength training to improve the levels of cytokines to increase the strength and performance of muscle mass.

Cytokines play an important role in my disease and are considered an important target for therapeutic interventions. the purpose of this research is to investigate the effect of a period of resistance training on the serum level of 17 and interferon beta in young women with MS. Was.

The present study was conducted in a semi-experimental way with a pre-test and post-test design. 30 women with MS with age range of 30-35 years were randomly selected in two exercise and control groups. Resistance exercises were performed for 8 weeks and three sessions a week, each session lasting 60 minutes with an intensity of 60-70% of the maximum heart rate. Blood samples were taken before and after the training protocol with 12 hours of fasting and the levels of interleukin 17 and beta interferon were measured by ELISA method. Data were analyzed using SPSS version 22 software and covariance test.

The results showed that after 8 hours of resistance training intervention, the amount of interleukin 17 in the training group decreased significantly and the amount of beta interferon showed a significant increase compared to the control group

Since moderate intensity resistance training decreased interleukin 17 and increased beta interferon in patients with MS, it seems that exercise intervention can be used to treat and prevent the progression of MS along with used drug treatments.

Multiple sclerosis (MS) is a progressive inflammatory disease in which inflammatory markers play an effective role in the development of this disease. In contrast, exercise training may lead to improved chronic inflammation. However, the effect of exercise training on inflammatory markers is not clearly understood. Therefore, the purpose of this meta-analysis is to investigate the effect of exercise training on IL-6, TNF-α, and IL-10 as well as CRP in patients with MS.

A comprehensive search was conducted in the three principal databases of PubMed, Web of Science, and Scopus for English and Persian articles published until December 22, 2022. To determine the effect sizes of the effect of exercise training on inflammatory markers IL-6, IL-10, TNF-α, and CRP, standardized mean difference (SMD) and 95% confidence intervals (CIs) were calculated.

Sixteen studies involving 687 patients with MS were included in the meta-analysis. Exercise training resulted in a significant decrease in levels of IL-6 [P = 0.002, (CI: -0.14 to 0.65: -0.40)] and CRP [P = 0.02 -0.04 to 0.70 CI: -0.37], but did not lead a significant effect on the levels of TNF-α [P = 0.20, (0.14 to 0.68 CI: -) -0.27] and IL -10 [P = 0.94, (0.43 to 0.40 CI: -0.15)].

Exercise training may lead to improvement of chronic inflammation status by reducing IL-6 and CRP in patients with MS. Therefore, prescribing regular exercise may be a suitable approach for disease management in patients with MS.

Acute appendicitis is one of the common reasons for abdominal surgery in any age group, and most cases are rarely diagnosed, which causes unnecessary surgery (negative appendectomy). The aim of this study is to determine the diagnostic value of C-reactive protein (CRP) and interleukin-6 (IL-6) in the prevention of negative appendectomy.

This cross-sectional study was conducted on 208 patients with acute abdominal surgery and primary diagnosis of acute appendicitis at Fatemi Hospital in Ardabil in a period of 6 months. C-reactive protein (CRP) and interleukin-6 (IL-6) levels were measured before surgery in all patients. Patients were divided into positive and negative groups based on pathology results. Then the laboratory results were compared with histopathological findings after surgery.

The level of IL-6 in the positive group was 107.25±3.54 and in the negative group was 75.50±2.41, and the difference was statistically significant (p=0.032). The mean CRP was 35.5±12.1 in the positive group and 11.1±5.3 in the negative group (p<0.001). There was a statistically significant relationship between IL-6 in normal patients and IL-6 in positive patients with purulent (p=0.006) and gangrene (p<0.001) pathology. There was a significant relationship between IL-6 positive patients with follicular hyperplasia pathology and IL-6 positive patients with purulent and gangrene pathology (p<0.001). Moreover, there was a statistically significant relationship between IL-6 positive patients with inflammatory pathology response and IL-6 positive gangrene patients (p<0.001). Sensitivity, specificity, positive predictive value, negative predictive value for IL-6 were 83, 88, 86, 79 and for CRP were 83, 85, 89, 81, respectively.

The results of the study showed that the simultaneous measurement of CRP and IL-6 are useful biomarkers in the diagnosis and prevention of negative appendectomy.

Sports activity is one of the non-invasive ways to rehabilitate and prevent complications and consequences of diseases related to Covid-19. The purpose of this study was to investigate the effect of moderate intensity aerobic exercise on the serum levels of interleukin-6, interleukin-10 and C-reactive protein in patients recovered from Covid-19.

For this purpose, 24 men recovered from Covid-19 were voluntarily selected and placed in two groups of experimental (12 people) and control (12 people) in a simple random manner. The experimental group participated in an eight-week aerobic training program, three sessions per week, each session lasted about 40 to 55 minutes with an intensity equal to 60 to 80% of the maximum heart rate. Serum levels of IL-6, IL-10 and CRP (before and 48 hours after the protocol) were measured. The data was analyzed using the covariance statistical test (ANCOVA) at the (p<0.05) level.

The results showed that aerobic exercise did not lead to a significant change in the serum levels of IL-6 (p>0.05) and IL-10 (p>0.05) in the experimental group compared to the control group; however, it caused a significant decrease in the serum levels of CRP (p<0.05) in the experimental group. In addition, examining intra-group changes in IL-10 and CRP indicated that there is a significant change between the mean score before and after implementation of the protocol in the experimental group (p<0.05). While there was no significant difference between the before and after values in IL-6 (p<0.05).

Based on the results of this study, aerobic exercises can regulate and balance anti-inflammatory and inflammatory cytokines and adjust the amount of C-reactive protein through the recovery of physical fitness in patients who have recovered from Covid-19.

Covid-19 is considered a new disease across the globe. Physical activity reduces risk factors, and with anti-inflammatory and antioxidant properties, saffron is used as a traditional herbal medicine to treat cough and asthma. Therefore, the present study aimed to assess the effect of saffron supplementation and endurance training on the concentration of C-reactive protein, interleukin-8, and clinical symptoms in outpatients with COVID-19.

The present research was conducted based on a randomized, double-blind, four-group, pretest-posttest design. The statistical population of this research entailed all outpatients with COVID-19 referred to the health center of Keshkosrai. Among this population, 36 cases were randomly selected. The research hypotheses were evaluated using SPSS software at a significance level of P<0.05 using the statistical test of analysis of covariance (ANCOVA) and paired T-test.

The results of ANCOVA demonstrated that after adjusting the effect of baseline values, height, and body mass index, there was a statistically significant difference between the groups in terms of the mean change of interleukin-8, C-reactive protein, partial oxygen pressure (SpO2), and body temperature (P<0.05). That is, the type of intervention can markedly affect the change of interleukin-8, C-reactive protein, partial oxygen pressure, and body temperature.

As evidenced by the obtained results, it is possible to use saffron as an auxiliary therapeutic method, as well as regular sports activity, which helps to control pathogens, including COVID-19, by boosting the body's immunity.

Considering the role of inflammatory mediators in both orthodontic movements and the development of periodontal diseases and taking into account the role of Interleukin 17 as an important inflammatory mediator in orthodontic treatments and the impact of low-level laser therapy (LLLT) as a new and appropriate adjuvant therapy, the aim of the present study was to investigate the effect of LLLT on IL-17 levels in gingival cervicular fluid (GCF) during orthodontic treatment. Materials &

In this clinical trial study, 12 patients in need of orthodontic treatment were selected. In these patients, one side of the mouth was randomly selected for laser irradiation and the other side as a control. Diode LLL irradiation with a wavelength of 810 nm was performed throughout the gingival Cervicular on days 0, 2, 18, and 30 after orthodontic treatment. Sampling was performed on days 0, 2, 18, and 30 by placing paper points in distal, mesial, palatal, and buccal sulcus of the maxillary fifth molar on the both sides for 30 seconds. All samples were then transferred to the laboratory and IL-17 level was determined by ELISA reader. Data were analyzed using Paired t-test and One-way ANOVA.

Mean IL-17 levels at day zero (p value = 0.62) and day 2 after orthodontic treatment (p value = 0.19) were not significantly different between the control and laser treated sides, however they were significantly lower in the laser-treated group than the control group on days 18 and 30 after orthodontic treatment (p value < 0.001). The mean IL-17 levels decreased in both groups during the treatment period, but this decrease was significant on day 18.

The results of the present study indicate the therapeutic role of diode LLL in reducing inflammation, and Il-17 levels in both sides of the mouth gradually decreased over time, and this decrease was more pronounced in the laser-treated side than in the control side.

Diabetes mellitus is a prevalent disease affecting a large population worldwide. Inflammation plays a crucial role in the development and progression of this disease. Interleukin-4 (IL-4) is an anti-inflammatory cytokine that can reduce inflammation. The aim of this study was to investigate the association between IL-4 gene VNTR polymorphism and type 2 diabetes in Gonabad city, Iran.

This study was a case-control study. One hundred individuals who referred to Alameh Behlol Hospital Gonabad city of Iran were included in two groups: case (patients with type 2 diabetes) and control (healthy individuals). The participants were randomly selected and entered the study after obtaining informed consent and meeting the inclusion criteria. Two milliliters of blood were collected from each participant using EDTA-containing tubes, and DNA was extracted using the salting-out method. To investigate the VNTR polymorphism, the target fragment was first amplified using appropriate primers and then identified using electrophoresis.

The mean age of the study participants was 61.98 ± 7.30 years, and half of them were male. The results of the VNTR polymorphism analysis demonstrated no significant association between IL-4 gene VNTR polymorphism and type 2 diabetes (p > 0.05).

In our study population, we found no significant association between IL-4 gene VNTR polymorphism and type 2 diabetes.

The prevalence of obesity is one of the most important health issues in the world. The aim of this study was to determine the effect of intermittent resistance training with different intensities on the levels of interleukin-10 (IL-10) and interleukin-1 beta (IL-1β) in obese men.

In this study, 44 obese men (20-30 years old) were assigned into four groups of control, low-intensity intermittent resistance training, moderate-intensity intermittent resistance training, and high-intensity intermittent resistance training. Subjects trained for 12 weeks, 3 sessions per week with three different intensities (80% 1RM with 10 repetitions, 60% 1RM with 13 repetitions and 40% 1RM with 20 repetitions). IL-10 and IL-1β indices were measured 48 hours before the first and 48 hours after the last resistance training session.

A significant difference was reported in IL-10 and IL-1β levels between the intermittent resistance training groups with different intensities. After the training period, IL-1β had a significant decrease in the low (P=0.001), moderate (P=0.01) and high (P=0.001) intensity intermittent resistance training groups. A significant increase in the IL-10 was observed in the resistance training groups with low (P=0.01), moderate (P=0.01) and high (P=0.001) intensity.

According to the present findings, it may recommend intermittent high and moderate intensity resistance training as an effective method for treating obesity and having a favorable effect on its indicators.