جستجوی مقالات مرتبط با کلیدواژه « حافظه » در نشریات گروه « پزشکی »

The importance of examining consumers' behavior, according to the research history, proves its high necessity. Considering that consumer behavior models consist of two internal and external dimensions and the investigation of factors only through self-reporting methods and even observation has not sought the necessary accuracy and adequacy, the use of neuroscience methods can be used in collecting Sufficient data to help researchers. Visual data in the form of biometric information can provide all dimensions of the consumer at the disposal of the researcher, the lack of ability to verbally express, the unwillingness to express and unconsciously examine are obstacles in investigating the behavior of consumers, which in all dimensions, the analysis of visual behavior It has come to the aid of researchers. This research is an exploratory review, in which sources have been identified through Google Scholar and selected based on the number of citations and the impact factor, regardless of the historical period.

According to the power of visual benchmarking and the possibility of modeling behavior with biometric data, the approach of visual consumer behavior has covered all the shortcomings of traditional methods, thanks to visual data, the consumer's self-concept has become clearer for behavioral science researchers Adaptability and cultural adaptation in communication, separation of visual behavior by gender and age group, visual-motivational systems, visual emotional responses, visual behavior consistent with personality, visual patterns of learning, visual impact on memory, visual perception and finally attitude change by Manipulation the stimulus, the result of CVB is for analyzing consumer behavior, Until now, due to the lack of integration due to the multiplicity of developed models, it has not been able to comprehensively help in solving problems and decisions making for consumers.

Stroke and chronic cerebral hypoperfiusion (CCH) is one of the most common problems following ageing. Using the suitable treatment has been one of the issues in treating these complications. Therefore, in this study, we investigated the effects of citicoline on memory and neuronal survival in CCH rats. 40 rats were divided into four groups (n=10) including: 1) Control, Rats that received vehicle after sham surgery 2) Citicoline: Rats that received citicoline after sham surgery 3) Hypoperfusion: which underwent CCH surgery and received vehicle and 4) Hypoperfusion+Citicoline group, which underwent CCH surgery and then received citicoline.for 10 days  (100 mg/kg). Morris water maze (MWM) and Nissl staining were used to evaluate spatial memory and hippocampal neuronal density in rats, respectively. For data analyzing, two-way ANOVA (for trial test of MWM) and one-way ANOVA (for the other data) were used. The results of the Morris water maze test showed that citicoline treatment increases the time spent in the target zone in hypoperfused rats (P<0.05). Histological studies (Nissl staining) showed that treatment with citicoline increases the number of hippocampal neurons in the CA1 region in CCH rats (P<0.05). Citicoline treatment improves spatial memory and hippocampal neurodegeneration in CCH rats.

Stress is a stimulus that leads to a physical or psychological reaction. Stress affects memory and cognition. Common drugs for treating stress and memory disorders have limited effects and many side effects, so the search for new effective compounds with natural origin and fewer side effects is of interest. Various studies have shown that Terminalia chebula) T. chebula (and crocin are effective in improving memory. Several proteins, including synapsin-1, synaptophysin, and PSD95, are involved in the transmission of nerve messages in synapses involved in memory. In this study, the effect of the hydroalcoholic extract of T. chebula and crocin in improving memory and stress and the expression of synaptophysin, PSD 95, and synapsin-1 genes in the hippocampal tissue of male rats of the immobility stress model has been evaluated.

25 adult male Wistar rats were randomly divided into five groups, including a control group, a stress group, treated with hydroalcoholic extract of T. chebula group, treated with crocin group, simultaneously treated with hydroalcoholic extract of T. chebula, and crocin group. All groups except the control group were subjected to immobility stress for 14 days.  Crocin was injected intraperitoneally (30 mg/kg) and hydroalcoholic extract of T. chebula was given as intragastric gavage (50 mg/kg). After fourteen days, the shuttle box test was performed to check the memory, then the animals were anesthetized and their hippocampal tissue was isolated, and the expression changes of synapsin-1, synaptophysin, and PSD 95 genes in the tissue were analyzed by Real-time PCR method.

Immobility stress caused disruption in two memory indicators, i.e. increased the duration of staying in the dark chamber (P˂0.01) and decreased the latency time to enter the dark chamber compared to the control group (P˂0.0001). Treatment with the alcoholic extract of T. chebula did not affect the duration of staying in the dark chamber (P>0.05), but crocin decreased it compared to the stress group (P˂0.05). The hydroalcoholic extract of T. chebula and crocin increased the latency time to enter the dark chamber compared to the stress group (P˂0.01 and P˂0.001, respectively). As a result, both of them affected memory improvement parameters. The combination of the hydroalcoholic extract of T. chebula and crocin decreased the duration of staying in the dark chamber (P˂0.05) and increased the latency time to enter the dark chamber compared to the stress group (P˂0.001). Also, Immobility stress decreased the expression of synaptophysin, synapsin-1, and PSD95 genes in the hippocampus tissue compared to the control group (P˂0.001 for all genes). The expression of synaptophysin, synapsin-1, and PSD95 genes in the hippocampus tissue of groups treated with hydroalcoholic extract of T. chebula (P˂0.01, P˂0.01 and P˂0.001, respectively), crocin (P˂0.001, P˂0.01 and P˂0.001, respectively), and their combination (P˂0.001, P˂0.001 and P˂0.01, respectively), increased compared to the stress group.

treatment with crocin and hydroalcoholic extract of T. chebula separately or their combination was effective in improving memory and reducing stress by increasing the expression of synapsin 1, synaptophysin, and PSD95 genes.

Klotho, an elixir of life, beneficially affects several bodily systems, including the brain. During the past two decades, positive effects of klotho in systemic and neurodegenerative diseases have been frequently reported. In this review, we summarized published data addressing these protective effects in neurodegenerative diseases along with associated improvement in cognitive performance. Klotho, a product of the Klotho gene, is a pluripotent protein and exists in soluble, secretary, and transmembrane forms in various types (α, β, and γ). Klotho receptor is localized in several cerebral regions, including the choroid plexus, limbic system, Purkinje cells, hippocampus, and basal ganglia. Klotho has been shown to induce anti-aging effects through the activation of several pathways. Moreover, a growing body of evidence supports its protective and cognition-enhancing effects in different Alzheimer's models. These effects mainly emerged via enhanced synaptic plasticity and clearance of amyloid beta plus improving neuronal energy balance by affecting astrocytes metabolic pathways. Growth factors-related pathways along with Wnt signaling are the most important pathways relating to Klotho functions. Klotho also promotes antioxidant systems, such as superoxide dismutase, to diminish reactive oxygen species and consequently restricts apoptotic cell death.

Due to its low regenerative capacity, the brain is of great importance for therapeutic explorations aiming to replace dead neurons. In sum, comprehension of precise mechanism of this protein actions could be promising tool to develop Klotho based-novel therapeutic approaches for treatment of neurodegenerative diseases in the future.

Alzheimer's disease (AD), a progressive neurodegenerative disease, is the most common type of dementia. Polycystic ovary syndrome (PCOS) is associated with metabolic and hormonal disorders, obesity, inflammation, gut microbiota dysbiosis, and an elevated risk of mood disorders and depression. Therefore, patients with this syndrome may be exposed to cognitive and memory disorders, followed by AD. The aim of this review was to focus on the cognitive function, memory, and the risk of dementia and AD in women with PCOS and to identify the factors affecting the risk of progression to these complications in women with this syndrome. Reviewing the literature on the relationship between PCOS and the occurrence of cognitive and memory disorders showed that several disorders linked with PCOS and some drugs used to treat these patients could positively or negatively affect the risk of the development of cognitive and memory disorders. While some reports have declared positive effects for androgens and oral contraceptive drugs on cognitive function and memory, others have argued that insulin resistance, obesity, inflammation, oxidative stress, gut microbiota dysbiosis, and depression may negatively affect cognitive and memory function in women with PCOS, predisposing them to AD. More studies are needed to estimate the risk of cognitive disorders, memory deficits, and AD in women with PCOS and to identify the factors involved in the development of these disorders. The early identification of PCOS patients at risk of developing these cognitive disorders can help prevent the progression of these conditions and appropriately treat them.

The present study was conducted to investigate the effectiveness of neuropsychological rehabilitation of executive functions on students' memory.

This research is semi-experimental using a computerized Wechsler working memory intelligence test prepared and compiled from the Farakhnai subscale of the Wechsler intelligence scale, which was used to measure working memory. The statistical sample consisted of 20 high school students who were randomly selected from high school boys in Varamin in the academic year of 1400-1999 in public high schools in mathematics, experimental and human subjects. The subjects were in two control groups (10 subjects) and the experiment (10 subjects) were randomly replaced.

Neuropsychological rehabilitation of executive functions is effective in improving students' auditory memory/forward repetition, auditory memory/reverse repetition, visual memory/forward repetition, visual memory/reverse repetition, auditory memory, visual memory, and auditory memory span. Visual memory of students is not effective. Also, there was a statistically significant increase in the average score of all dimensions of working memory from the time before the intervention to the follow-up period, and only in the visual dimension / reverse repetition of the average before the intervention (p≤0.001).  There was no significance between the two means (p≥0.001).

In general, the results show the effectiveness of neuropsychological rehabilitation of executive functions on students' memory

Background and

Alzheimer's disease is a neurodegenerative disorder associated with the accumulation of amyloid plaques in neurons. Increase in blood cholesterol leads to an increase in the deposition of these proteins in neurons and results in memory degradation. In the present study, the effect of rosuvastatin as a cholesterol-lowering drug was investigated in Alzheimer's rats.

Animals were divided into four groups: control, streptozotocin (to induce Alzheimer's), rosuvastatin, and rosuvastatin with streptozotocin. In intracerebroventricular injection, the groups received saline (1 μg/rat) or streptozotocin (3 mg/kg). Daily gavage of saline (1 mg/kg) or rosuvastatin (10, 20 mg/kg) started one day before cannulation and continued for two weeks. At the end of the treatment period, the rats' memory, number of healthy neurons in CA1 area, and serum oxidative stress indices were measured.

Intraventricular injection of streptozotocin significantly decreased memory recall, the number of intact neurons in CA1 area, total antioxidant power, and superoxide dismutase enzyme level; and increased serum malondialdehyde levels compared to the control group (P<0.001). In the group receiving rosuvastatin (20 mg/kg), the above indexes were significantly reversed compared to the streptozotocin group (P<0.001), which means improved memory. In rosuvastatin groups (10 and 20 mg/kg) alone, there was no significant difference in the above indexes compared to the control group (P>0.05).

Streptozotocin leads to cell death in the CA1 region and memory dysfunction through various mechanisms such as increasing oxidative stress. It seems that rosuvastatin is able to prevent the destructive effects of streptozotocin on memory and learning by inhibiting oxidative stress indicators.

Diseases caused by infection in the immune system can result to psychological disorders. The perevalance of the acute respiratory syndrome coronavirus (COVID-19) has been associated with psychiatric consequences. The aim of this study is to investigate the effectiveness of treatment based on emotional regulation on problems. Cognitive and emotional (memory, mood) and cognitive helplessness (stress, depression, anxiety) in patients who recovered from Covid-19 with Remdesivir treatment in Rafsanjan city.

A semi-experimental research design with a pre-test-post-test design with a control group, the statistical population includes patients with covid-19 in the city of Rafsanjan in 1400 who were treated with Remdesivir. The study sample includes 30 recovered patients who were randomly selected to participate in the study based on their desire and satisfaction and were replaced in two experimental and control groups. Treatment based on emotional regulation was performed in 8 sessions of 1:30 for the experimental group and the control group did not receive any psychological treatment. Both groups answered the depression, anxiety and stress scale (DASS) (1992), the Mood and Feeling Questionnaire (MFQ) (1987) and the memory capacity questionnaire before and after the training process. The data collected on They were analyzed based on SPSS-21 software with descriptive and inferential statistics

The results of the research showed that the treatment based on emotional regulation has a significant effect on improving memory function and mood, as well as depression and anxiety in recovered patients with COVID-19. Treatment based on emotion and stress did not have a significant effect on the recovered patients (P>0.05).

Considering the alarming effect of COVID-19 infection on mental health, it is recommended and emphasized to evaluate the psychopathology of the survivors of COVID-19 in order to diagnose and treatment psychological disorders and problems.

The main purpose of this research is to explore and analyze changes in various frequency bands of brain signals among two distinct groups: memorizers and non-memorizers of the Quran. This investigation focuses on the execution of visual memory tests using Cantab software, with an emphasis on selecting optimal feature channels and employing different classifiers.

First, brain signals were recorded from 15 Quran memorizers and 15 non-Quran memorizers during the performance of delayed matching to sample (DMS), Paired Associates Learning (PAL), and Spatial Recognition Memory image memory tests using Cantab software. Following appropriate pre-processing, non-linear features such as Lyapunov profile, correlation dimension, entropy, and detrended fluctuation analysis parameters were extracted. The selection of relevant channels was performed using T-TEST, Sequential Forward Selection, and Genetic Algorithm (GA) methods. Classification involved the use of multi-layer perceptron (MLP), Support Vector Machine, and naïve Bayes algorithms.

The selected optimal channels were primarily associated with frontal, parietal, and occipital brain regions involved in the attention network and visual memory of Quran memorizers. In most instances, the average power of low-frequency components in brain signals was found to be higher in memorizers than in non-memorizers. The MLP neural network, utilizing optimal channels selected by the GA method, demonstrated the highest accuracy between memorizers and non-memorizers at 94.79%.

Analysis of EEG data revealed that the power ratio of low-frequency components, the power ratio of low-to-high-frequency components, and the power ratio of theta to beta bands indicated an increase in relaxation and patience among the memorizer group during the retrieval phase of visual memory. This enhanced concentration and attention, leading to a higher percentage of correct answers and increased reaction time in the memorizer group during the implementation of visual memory tests using Cantab software. The MLP neural network, employing features selected by the GA method, particularly sample and approximate entropy in D, A5 sub-bands, and in the occipital, parietal, and central brain regions, achieved a superior accuracy percentage in the implementation of the DMS test.

Diabetes mellitus is associated with memory impairment. Ellagic acid (EA) is a natural polyphenol with anti-diabetic and neuroprotective effects. The aim of the present study was to investigate the protective effect of ellagic acid on diabetes induced memory impairment and to evaluate the role of its antioxidant effect. Male Wistar rats were randomly divided into four groups (n=8): control, diabetic, diabetic receiving 25 mg/kg of EA, and diabetic receiving 50 mg/kg of EA. Diabetes was induced by a single intraperitoneal injection of 60 mg/kg of streptozotocin (STZ). After receiving EA (once a day) by oral gavage for four weeks, passive avoidance learning (PAL) test was used to evaluate memory. Finally, oxidative stress related factors including malondialdehyde (MDA) and total antioxidant capacity (TAC) were evaluated in the hippocampal tissue separated from the animal brains under deep anesthesia. Diabetic animals showed marked reductions in step-through latency (STLr) and elevation in time spent in the dark compartment (TDC)  in the retention trial and elevation of MDA level and diminution of TAC compared to controls significantly. Treatment of diabetic rats with EA markedly increased STLr, decreased TDC and enhanced TAC (by both EA doses) and reduced MDA (at a dose of 50 mg/kg of EA). The results displayed learning and memory improving effect of EA in diabetic rats via attenuating oxidative stress.

With the increasing use of computers and the Internet, computer game addiction has been suggested as a new psychiatric disorder. Much evidence has shown that at the level of neural circuits, computer game addiction is similar to drug addiction, although there are very few studies comparing brain functions. The present study aimed to compare cold executive functions between people addicted to gaming, patients addicted to drugs (Heroin and methamphetamine), and normal people.

The sample consisted of 180 men (45 subjects in 4 groups of heroin-addicted patients, methamphetamine-addicted patients, people addicted to computer games, and normal people) who were selected by the available sampling method. N-back test, continuous performance test, and Passat test were used to determine visual working memory, sustained attention, and auditory working memory. Multivariate variance analysis and univariate variance analysis were used for data analysis.

The results showed that the values of visual working memory, sustained attention, and auditory visual working memory in substance-dependent groups were significantly lower compared to normal and game-dependent groups.

It seems that the game-dependent group is completely similar to the normal group in terms of cold executive functions, and there is no similarity between the game-dependent group and the substance-dependent groups.

Globally, stroke ranks as the second most common cause of death and places a substantial financial burden on society. Stroke imposes a significant burden on the global health system. Clinical manifestations of stroke can quickly cause mild to severe nerve damage, which is mainly caused by lack of blood flow, but the impact of a stroke goes beyond the initial brain damage. The progression of cognitive decline may be even more important than stroke, as post-stroke cognitive impairment affects stroke survivors. The purpose of the present study was to examine the impact of neuropsychological rehabilitation on memory and mood regulation among stroke patients residing in Yasuj, Iran.

A semi-experimental research design was employed in the present study, which included a pretest, posttest, and a 6-month follow-up. The study focused on stroke patients between the ages of 20 and 60 residing in Yasuj, Iran, from 2021 to 2022. Thirty individuals were purposefully selected from the statistical population, and then, using random sampling were divided into two groups, experimental (15 individuals) and control (15 individuals). The experimental group underwent 22 sessions of 90-minute treatments. To collect research data, the following measures were used: Folstein Mini-Mental State Examination (MMSE), the protocol for neuropsychological rehabilitation treatment, the Wechsler Memory Scale (WMS), the Wechsler Adult Intelligence Scale (WAIS), Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), Harrington's frustration tolerance questionnaire, and the go/no-go test. The statistical analysis of the research data was conducted by utilizing the covariance or variance test with repeated measurements along with the Bonferroni post hoc test and SPSS-21 software.

The results indicated that the neuro-psychotherapeutic rehabilitation approach had a significant effect on memory (F=92.37, p=0.001), as well as on the components of mood management, including anxiety (F=90.42, p=0.001), depression (F=85.6, p=0.001), learned helplessness (F=68.9, p=0.001), and reactivity (F=46.8, p=0.001) in individuals with stroke.

Based on the findings of the present study, it can be concluded that among the therapeutic methods useful for memory rehabilitation and mood management, neuropsychological rehabilitation is one of the most effective methods.

Today, traumatic brain injury and defects in cognitive functions and memory are the most frequent problems after brain injury. This study aims to examine the effectiveness of emotional and cognitive rehabilitation on cognitive performance and memory in patients with traumatized brain injury.

This study is an applied study in terms of purpose and experimental in terms of collecting information method. Considering purposive sampling and random selection of samples, we used the randomized block experiment with a pre-test-post-test design with a control group. We used the emotional cognitive rehabilitation protocol based on Gross model (2002) and Nejati cognitive rehabilitation to train emotional and cognitive rehabilitation (2017). The study's statistical population included all brain-injured patients with cognitive defects and memory problems referred to Neurology Clinic, Shahid Motahari Hospital, and Razmehr Psychiatric Clinic, Shiraz City, Iran, from June 22, 2019, to January 20, 2020. This study consisted of 3 groups (2 experimental and 1 control group) at three levels (mild, moderate, and severe patients). The study participants were 45 patients selected after a brief mental examination with a mini-mental state examination test. 

 Cognitive rehabilitation significantly (P<0.001) increased the brain-injured patients' cognitive performance. Also, emotional and cognitive rehabilitation significantly (P<0.001) affected the brain-injured patients' cognitive performance. Finally, cognitive rehabilitation significantly (P<0.001) increased the brain-injured patients' memory performance.

 It seems that through delivering necessary training and education regarding effective interpersonal skills, computer drills, practices at home, and so on, emotional and cognitive rehabilitation helps the brain injured people to properly manage emotions, effectively establish interpersonal communication, and lighten the load of negative emotions, and consequently memory gets improved will less stress. In fact, emotional and cognitive rehabilitation is a complete collection of training for regulating emotions and enhancing and growing memory. Thus, emotional and cognitive rehabilitation's significant effect on memory enhancement is logical and acceptable. In conclusion, this protocol effectively improves brain-injured people's cognitive performance.

Parkinson’s disease (PD) as a progressive disorder caused by degeneration of dopamine (DA) neurons leads to bradykinesia, tremor, and cognitive dysfunction. The administration of Z. jujuba in animal models of nervous system disorder had favorable effects on memory ability and oxidative stress biomarkers. Accordingly, we assessed the influence of Z. jujuba aqueous extract administration on learning, memory, locomotor activity and oxidative stress biomarker in rats with Parkinson’s disease.

In this study forty adult Wistar rats allocated into four groups were sham group, untreated Parkinson study group and two groups treated with aqueous extract of Z. jujube at two different concentrations of 500 and 1000 mg/kg/days. PD induction was done by injecting 6-hydroxydopamine (6-OHDA). Rotations activity was assessed by injection of apomorphine. Morris water maze was utilized to evaluate spatial learning and memory. Also, oxidative stress was evaluated by malondialdehyde (MDA) biomarker.

Our data showed that the 6-OHDA-induced PD led to the learning, memory and rotations activity dysfunctions. Administration of 1000 mg/kg of Z. jujube improved the learning and memory (P<0.0001). In addition, 500 and 1000 mg/kg of Z. jujube decreased the apomorphine-induced rotations (P<0.0001). Also, Z. jujube decreased malondialdehyde level in midbrain and hippocampus (P<0.05).

aqueous extract of Z. jujube administrated by the animal model of PD can has favorable potentials on memory, learning, apomorphine-induced rotations and brain malondialdehyde level.

Due to the high prevalence of different levels of memory disorders and amnesia, many psychiatry and psychology referrals are due to the fear of diseases that cause dementia, including Alzheimer's disease. However, many of these disorders have internal causes and can be classified as functional cognitive disorders. Although the diagnosis of cognitive disorder is made by ruling out organic causes, it is difficult to diagnose functional disorders, thus most of these disorders are not diagnosed. It has been determined that depression, anxiety and behavioral disorders can be precursors of mild cognitive impairment, but it has not been determined whether functional cognitive impairment can also be a trigger or precursor for organic cognitive disorders related to dementia. The typical form of functional cognitive disorder overlaps with the components of attention and concentration. The coexistence of these disorders with depression can make the diagnosis of functional cognitive disorders more difficult. Therefore, it is important to rule out pseudodementia due to depression before making such a diagnosis. Since functional cognitive impairment occur in the midlife period, these disorders are differentially diagnosed with early-onset neurodegenerative disorders. Regardless of the research conducted in the field of diagnosing functional cognitive disorders, no definitive diagnostic criteria have been determined for these disorders, and the long-term prognosis of these disorders is also unknown.

Bisphenol A (BPA) is a toxic chemical that is used as a monomer in the production of plastic products. The BPA has an endocrine-disrupting effect and ‎induces damage to the nervous system. Crocin, an active ingredient of Crocus sativus L. has ‎neuroprotective effects. Therefore, this study aimed to evaluate crocin’s effects on BPA-induced ‎memory impairment in rats and the levels of Extracellular Signal-Regulated Kinases (ERK), Ca2+/Calmodulin-Dependent Protein Kinase-II (CaMKII), and Cyclic AMP-Response Element-Binding Protein (CREB) proteins in the hippocampus.

Bisphenol A (100 mg/kg, gavage) and crocin (10, 20, and 40 mg/kg, IP) were administered to adult male rats for 28 days. Memory and learning functions were evaluated by the Morris water maze, and the level of proteins was determined using the Western blot method.

Administration of the BPA (100 mg/kg) significantly induced memory impairment and reduced the levels of ERK, p.ERK, CaMKII, and p.CREB proteins in the BPA group, compared to the control group. On the other hand, crocin (20 mg/kg) markedly improved learning and memory impairment and increased the levels of ERK, p.ERK, and CaMKII proteins in the hippocampus, compared to the BPA (100 mg/kg) group.

Administration of crocin (20 mg/kg) improves memory and learning defects induced by BPA (100 mg/kg). The enhancement of the ‎p.ERK, ERK, and p. CaMKII protein levels in the hippocampus has an important role in crocin protective effects

Long-term exposure to glucocorticosteroids is associated with brain damage through augmenting oxidative stress and apoptotic cell death. Due to the anti-oxidative and anti-apoptotic effects of ferulic acid (FA), its effect on learning, memory, and protection of the hippocampus in dexamethasone (DEX) treated rats were investigated in this study.

This experimental study was conducted on 32 male Wistar rats. Neural injury was induced by injection of 500 µg/kg/day of DEX for 3 weeks. Treatment groups received oral FA (50 mg/kg/day) for 3 weeks. At the end of 3rd week and following evaluation of learning and memory by passive avoidance and novel object discrimination (NOD) tests, some related factors of oxidative stress and apoptosis in hippocampal homogenate were measured and number of neurons in hippocampal CA1 area was also counted.

Step-through latency and discrimination index were significantly higher in FA-treated DEX group than DEX group. FA-treatment of DEX group was associated with lower levels of MDA, caspase 1, and caspase 3 but higher activity of superoxide dismutase (SOD). Meanwhile, CA1 neuronal density was significantly higher in FA-treated DEX group.

Taking ferulic acid simultaneously with long-term administration of dexamethasone prevents the occurrence of learning and memory disorders and hippocampus damage, and part of its beneficial effect is done through reducing oxidative stress and apoptosis.

Insomnia is a common sleep disorder with negative consequences such as decreased quality of life. In this study, the effect of sleep deprivation on memory in both young and older adults was investigated using functional magnetic resonance imaging (fMRI).

In this retrospective study, fMRI data of 40 healthy subjects (17 young and 23 older people) who had a one-month sleep deprivation period (during the experiment they woke up three hours earlier than usual) were obtained. Then, pre-processing was done to remove artifacts and noise. Finally, data processing was completed in order to extract the brain activity map focusing on brain areas related to memory.

Findings showed that the brain activity of most areas are reduced due to insomnia. In the young group, 17 functional connections were obtained at the beginning of the study which decreased to only one connection after the insomnia period. In older adults there were seven connections at the beginning of the study that decreased to four after the insomnia period (P< 0.05).

Brain map analysis, including connections and activity levels of memory-related areas, showed that sleep deprivation affects the brains of young and old people. Our findings can pave the way for future studies to understand the effect of insomnia on memory and brain.

Brain trauma is one of the most common causes of damage to the central nervous system which can lead to death and long-term disability. The present study aimed at investigating the effect of 8 weeks of swimming exercise on the level of memory and interleukin 10 (IL-10) in the hippocampus and prefrontal cortex of mice with brain trauma.

40 male NMRI mice were randomly divided into four groups (control, swimming, trauma, swimming + trauma). After completing the exercise protocol, induction of trauma was performed by the weight -drop method. Ten days after trauma induction, the mice were evaluated for spatial memory with Y-maze test. The IL- 10 level was measured using ELISA technique. One-way analysis of variance and Tukey post hoc test were used for statistical analysis at a significance level of p<0.05 and using SPSS software version 26.

The study results indicated that eight weeks of swimming exercise significantly increase memory in mice with brain trauma (p=0.001). Furthermore, eight weeks of swimming exercise significantly increase the level of IL-10 in the hippocampus of mice with brain trauma (p=0.001). However, this increase was not significant in the prefrontal cortex (p=0.126).

The results of the present study showed that swimming exercise before induction of brain trauma reduces inflammation and memory disorders and facilitates recovery after injury. Previous exercise training can probably reduce inflammation by increasing the amount of anti-inflammatory cytokines, including interleukin-10, and limit secondary damage with its protective effect.