جستجوی مقالات مرتبط با کلیدواژه "سرطان سلول سنگفرشی" در نشریات گروه "پزشکی"

Fascin is a protein that is increased in many epithelial cancers, and this increased expression is related to the more aggressive behavior and metastasis of many of these cancers. Considering the relatively high prevalence of oral lichen planus (OLP) and the inconsistencies regarding its malignant transformation potential, this study aimed to investigate the expression level of fascin in OLP and oral squamous cell carcinoma (OSCC).

 In this experimental study, 27 samples of erosive OLP and 30 samples of OSCC were immunohistochemically stained with fascin. The extent of fascin expression (epithelial cells with cytoplasmic immunoreactivity) in OLP was categorized into 4 scores based on the extent of epithelial staining. SCC specimens were scored according to the intensity and percentage of staining, and the sum of these two numbers was finally considered the total score, which ranged from 0 to 7. Fascin expression in two groups was compared using the Kruskal-Wallis test.

  About half of the lichen planus samples (48.15%) received a score of 3. Most of the SCC samples received a score of 5 or 6. The comparison of the expression of fascin between the two groups demonstrated a statistically significant difference (P<0.001).

 The increased expression of fascin in lichen planus and SCC may indicate the role of fascin in carcinogenesis.

Squamous cell carcinoma (SCC) accounts for 85% of laryngeal cancers. In some cases, lymph nodes do not show any specific symptoms despite being involved by cancer. Previous studies showed that patients undergoing selective neck lymph node dissection (SND) had significantly lower recurrence rates. We investigated the prevalence of occult neck lymph node involvement in patients with laryngeal SCC, and this is an important step in performing targeted selective neck lymph node dissection (SND) in these patients.

This is a descriptive, retrospective, cross-sectional study involving the clinical records of patients with laryngeal carcinoma referred to Amir Alam Hospital from 2012 to 2017. Clinical and radiologic data showed that 66 patients had laryngeal SCC and were in the N0 stage. This group of patients was considered as the statistical sample of the study. A number of patients with similar status were excluded because of incomplete case data. Data analysis was done with SPSS v.22 software.

Of the total number of patients 29(44%), were diagnosed with glottic cancer, 29 (44%) with supraglottic cancer and 8 (12%) with subglottic cancer. 26 (39.5%) of these patients had lymph node metastasis (occult metastasis approved by post-operative pathology report). No metastasis in lymph nodes was found in 40(60.5%) patients. Of the 66 targeted patients, only 13 underwent radiotherapy before surgery. Of the 26 patients who had lymph node metastasis, 11 were diagnosed with glottic cancer and 13 patients with supraglottic cancer and 2 cases with subglottic cancer.

Considering the nearly 20% prevalence of occult lymph node metastasis in patients with laryngeal squamous cell carcinoma who are in the N0 stage, it is recommended to selectively excise the neck lymph nodes in addition to the tumor surgery as this will reduce the recurrence rate of the disease.

In modern societies, the incidence of oral cancer is increasing. It may be due to the increased population, life expectancy, and exposure to risk factors. This increase can particularly be seen in women and in our own country, Iran. The aim of the present study was to explore the status of care and treatment of patients with oral cancer referring to Shariati educational hospital in Tehran, during the years 2003-2013.
The present study was a cross-sectional descriptive survey on oral cancer patients attending the Shariati hospital in Tehran during a ten-year period. Data were collected through patient records and statistically analyzed by SPSS21 software.
Regression analysis was performed in 5 models, where variables such as age, gender, location of the tumor, stage and grade was entered as independent variables and delay in treatment (time interval from diagnosis to treatment) entered as the dependent variable. The analysis showed that the elapsed time from diagnosis to treatment had a positive association with age of the patients. It means that the higher the age, the more delay in treatment (P Considering the consequences of oral cancer for patients, there was necessity to formulate plans for preventing, early detection and improving quality of life in oral cancer patients.

Malignancies are the main cause of death in developed countries and the second cause of death in developing countries. Head and neck squamous cell carcinoma is the sixth most common cancer worldwide and standard treatments have failed to improve its survival rate in the past four decades. In addition, these treatment modalities give rise to various complications. Recently, research has focused on natural substances with anti-neoplastic properties that are specifically directed against malignant cells and have less potential for complications. The aim of this study was to evaluate the selective inhibitory and cytotoxic effects of violet extract on malignant cells compared to normal cells.
In this in vitro study, photometry and optical density (OD) techniques were used for MTT test to assess the cytotoxicity of violet extract at a wavelength of 560 nm using an ELISA reader. The cell survival rate was calculated by dividing the difference of blank OD in the treated cells by the difference of blank OD in control cells. Data were analyzed with two-way ANOVA to evaluate the concomitant effect of violet extract concentration and cell type on the percentage of residual viable cells; one-way and two-way ANOVA were used to evaluate the effect of the concentration of the extract on the percentage of residual viable cells separately for each cell line by using SPSS.
The results showed a significant relationship between the percentage of residual viable cells and the different concentrations of the extract (p value 0.26).
Based on the results, the cytotoxicity of violet extract on malignant cells (SCC) was similar to that on normal cells. Therefore, violet extract may not be useful as a natural substance, with less side effects, to selectively inhibit malignant cells.

Tumor associated tissue eosinophilia (TATE) is observed in several types of neoplasms, however, its relation with cancers such as Squamous Cell Carcinoma (SCC) which is the most common malignancy of head and neck has not been identified; This study aims to evaluate the relationship between TATE and histologic grading of head and neck SCC (HNSCC) by Luna’s histochemical staining. In this descriptive study, 67 slides of 4μ HNSCC tissue sections were stained with hematoxylin and eosin. Samples were reviewed to evaluate histologic grading and then were divided into three groups as follows: Well-Differentiated, Moderately-Differentiated and Poorly-Differentiated. Eosinophil infiltration in tumor was assessed with Luna’s histochemical staining technique and eosinophils were counted and classified as follows: none (0), low (1-4), moderate (5-19), high (≥20). They were randomly evaluated per 10 microscopic fields. Kruskal-Wallis test and Spearman correlation coefficient were used to analyze the results. Tissue eosinophilia was found to be zero in only one case (1.5%) whereas in other 66 patients (98.5%) it was reported to be positive. The mean±SD number of counted eosinophil cells was 5.41±4.74. There was a significant correlation between the degree of histopathologic grade and TATE (P=0.04), but no significant relationship was detected between TATE and age, sex and lesion location. Tissue eosinophilia in Poorly-Differentiated group of HNSCC patients was lower than the other two groups, but no relationship associated with other clinicopathologic factors was found.

Epidermolysis bullosa (EB) is a group of dermatological conditions characterized by development of bullae and ulcers following trivial trauma. One of the most important complications of EB is squamous cell carcinoma. While occurance of skin squamous cell carcinoma is common in epidermolysis bullosa, its occurence on mucosal surface is rare. Herein, we report two members of a family who developed squamous cell carcinoma on their esophagus and tongue.

Transitional cell carcinoma is the most common bladder tumor that can be treated by surgery, BCG instillation, chemotherapy, and radiotherapy. This study deals with urethral squamous cell carcinoma (SCC) in a patient with history of transurethral resection (TUR-T) of bladder transitional cell carcinoma treated by BCG instillation. Case: A 68-year-old man was admitted with gross hematuria, lateral prostatic lobe kissing, and a pedunculated 2×3mm mass in bladder in cystoscopy. He had undergone TUR-T and BCG instillation and had been followed regularly every 3 months with cystoscopy. In the follow up, 9 months later, several pedunculated tumors in penile urethra that were of SCC type were indicated in pathological analysis. : Since membranous urethra is the most common site and TCC is the most common type of urethral cancers in this site, SCC in penile urethra was unexpected. This could be because of chronic inflammation due to treatment and cystoscopic follow ups.

Today, toxic effluents have created ecological and health problems in and around the industrial cities resulting in death of nearby living organisms. The aim of this research was to increase the elimination of copper and zinc from copper factory effluents in Kerman/Iran through mutation inducing in metal-resistant bacteria by using Acriflavine, Acridine orange and Ethidium bromide. A total of 20 strains of Pseudomonas spp. were isolated from water and soil of the factory and subjected to microbiological identification. Maximum Inhibitory Concentration (MIC) to Cu and Zn were determined by agar dilution method. Those strains with the highest MIC to these metals (5mM) were subjected to 400-3200mg/L of the above mutagenic agents. After determination of MIC those colonies which were capable to grow on 20mM copper were selected for atomic absorption spectroscopy. According to the atomic absorption spectroscopy of dried biomass obtained from resistant strains after exposure to mutagenic agents, strains 6,7,8,9,10,13 & 16 showed the highest accumulation of CU and Zn (10mM for Cu & 20mM for Zn). Strain 13 had the highest absorption of Cu (0. 35%/mg biomass) and strain 10 showed the highest accumulation of Zn (0.33%/mg biomass). Elimination of heavy metals by artificially mutated bacteria can be suggested as a cost effective solution to this environmental health issue.

Tumor development is identified by an imbalance between proliferation and apoptosis. The mutation of suppressor genes such as P53 and overexpression of C-erb-B2 as an oncogene are important factors in carcinogenesis. The overexpression of ki67 has been demonstrated in different tumors. Our knowledge about C-erb-B2 and its correlation with cellular proliferation in oral Squamous Cell Carcinoma (SCC) has not been elucidated.

The aim of study was the comparison of Ki67, P53 and C-erb-B2 immunoreactivity in well – differentiated SCC of tongue.

This study was a descriptive. Five sections of well differentiated SCC were prepared and stained by immunohistochemical (IHC) method. IHC slides were examined for Ki67, P53 and C-erb-B2 for positive staining by counting positive cells per 1000 epithelial cells labeling indexes (LI) were calculated and LI means were achieved. The correlation test was used to compare the results.

The mean numbers of Ki67, P53 and C-erb-B2 positive cells were 399.4±42.97, 221.4±330.32 and 26.8±27.22, respectively. The correlation test was shown the positive correlation between Ki67 and P53 (p<0.02, r=91.5%). There was not any positive correlation between Ki67 and C-erb-B2 (p<0.97, r= -1.7%) and also P53 and C-erb-B2 (p<0.8, r= -13%).

Immunoreactivities of P53, ki67 and C-erb-B2 were positive in tongue well-differentiated SCC. The positive correlation was seen between P53 and ki67 expression.

Previous studies showed that basement membrane pattern is structuraly different in SCC and BCC tumors. BSCC is an epithelial malignant tumor with two histopathologic pattern similar to SCC and BCC. This study was aimed to compare the basement membrane pattern in SCC, BCC and BSCC tumors. In this laboratory study, the medical files of patients from central pathology department of Imam Khomeini Hospital in Tehran from year 2000 to 2003 were evaluated. Seven sample sections with pathologic diagnosis of SCC, BCC and BSCC were selected and stained with Hematoxylin-Eosin (H&E), Periodic acid schiff (PAS) and Reticulin stains. In the next step, the sections were evaluated by two separate pathologists for basement membrane pattern. In the staining by H&E, PAS and Reticulin, the basement membrane of normal epithelium was continuous and thick. The basement membrane of invasive part of SCC was not continuous with H&E, PAS and Reticulin. On the other hand the epithelial mass in deeper part of lamina propria had a continuous and sharp basement membrane. With H&E, PAS and Reticulin the basement membrane of BCC was continuous and sharp. Basement membrane of BSCC was continuous and sharp in the staining by PAS, H&E and Reticulin. The BSCC basement membrane was similar to BCC by application of PAS and Reticulin stains.