جستجوی مقالات مرتبط با کلیدواژه « عفونت انگلی » در نشریات گروه « پزشکی »

Parasitic infections in children are one of the most important health and health problems worldwide, especially in developing countries. Diarrheal diseases such as those caused by Entamoeba histolytica are among the causes of death in children, so the purpose of this systematic review and meta-analysis is to determine the prevalence of Entamoeba histolytica in Iranian children.

This study is a systematic review and meta-analysis by examining the Scientific Information Database (SID), Medline (PubMed), Scopus and Google Scholar until March 2023.

In a review of 12 studies with a sample size of 10,982 Iranian children, the prevalence of Entamoeba Histolytica in Iranian children was reported to be 1% (95% CI 0.6-1.7%). The meta-regression results showed that in examining the factors influencing the heterogeneity of studies and examining the effect of sample size on this heterogeneity, it was reported that with increasing sample size, the prevalence of Entamoeba histolytica in Iranian children decreased (P<0.05) and also with the increase in the year of conducting studies, the prevalence decreases in Iranian children (P=0.289).

The results of the present study show that the prevalence of Entamoeba histolytica in Iranian children is not at a very high level, but to continue preventive measures and reach lower levels, it still requires the attention of health policymakers in this area to carry out extensive information and screening to prevent the effects of this parasitic disease on children.

In endemic areas, some parasitic infections may be related to cancer induction or induction of immune responses against cancer. In some cases, parasites cause disease in their host, and in other cases, they reach a biological balance with them. Parasite invasion of the host depends on some factors such as parasite species, life cycle, enzyme production, and host immunity. The results of various studies in different parts of the world have shown that some parasites such as Schistosoma, Opisthorchis, Clonorchis, Strongyloides, Leishmania, Blastocystis, and Cryptosporidium could induce cancer in their host under certain conditions. However, others like Toxocara, Hydatid cyst, Mesocestoides, Taenia crassiceps, Fasciola, and Plasmodium initiate an anti-tumor immune response in the host. Some others, such as Trichomonas, Trypanosoma, and Toxoplasma, have both tumoral and anti-tumoral activity. A better and more complete understanding of these interactions could lead us to a clear future in the treatment of cancer, therefore, in this study, the role of parasites in the induction and prevention of cancer has been investigated.

Infection with Strongyloides stercoralis is common in tropical and subtropical regions. To prevent and treat these diseases, information on the distribution and frequency of these parasites in different geographical areas is needed. Due to the importance of diseases in the northern provinces of Iran, the present study was performed to determine the prevalence of Strongyloides stercoralis.

From April 2011 to March 2020, stool samples from patients who were referred to Rouhani hospital in Mazandaran province, Babol, were gathered. For stool samples, microscopic detection was performed immediately using the wet expansion method, followed by a formal-ether concentration process. Based on the sample size calculation, the minimum number of patients with Strongyloides stercoralis infection was considered to be 380 patients from the years 2011-2020. Mean and standard deviation indices were used to describe quantitative data and numbers and percentages were used to describe qualitative data.

Out of the total number of 39,800 archived patient files that were reviewed, a total of 420 (1.05%) patients were confirmed for the presence of Strongyloides stercoralis in their feces. The age range of patients was 3 to 89 years. The population of male patients (249 patients) was higher than females (171 patients). In patients with positive Strongyloides stercoralis, disease symptoms were positive in 206 patients and negative in 214 patients. The most common underlying disease in patients was abdominal pain (220 patients). 271 patients received steroids.

Strongyloides stercoralis infection was detected in the northern region of Iran. The prevalence of this parasite was higher in men, the elderly, and people with underlying comorbidities. These results can be used to identify and compare areas where the prevalence of infection is higher. Therefore, revealing the effect of Strongyloides stercoralis infection on public health makes the need for in-depth clinical and diagnostic studies important. People with chronic diseases, whether symptomatic or asymptomatic, should be screened for parasitic diseases.

The aim of this study was to evaluate the therapeutic effect of platelets lysate on leishmaniasis lesions.

In this study, we used hamster as an animal model and Leishmania major to create an infection in vitro condition. The presence of Leishmania in the site of infection was confirmed by Real-time PCR. We investigated the effect of platelet, plasma, and platelets’ lysate on leishmaniasis lesions and finally, the therapeutic effects of these biomaterials were screened by histological methods.

Real-time PCR method confirmed the presence of parasites in the site of infection. The results of histopathological investigation revealed that in lesions treated with platelet, there were inflammatory response, tissue necrosis and high amount of Leishmania. The wounds extent in both groups treated with plasma and platelet lysate was significantly reduced. However, the result showed that the amounts of Leishmania were significantly reduced in lesions of hamsters treated with platelet lysate.

The results showed that platelet lysate had a better and higher performance than other biomaterials in the treatment and healing of leishmanial lesions.