جستجوی مقالات مرتبط با کلیدواژه « موکوزیت دهانی » در نشریات گروه « پزشکی »

Oral mucosa is one of the most debilitating complications of chemotherapy during the treatment period, which strongly affects the nutritional status of these patients. Therefore, this study aimed to evaluate the effect of sodium bicarbonate mouthwash on the prevention, incidence, and severity of oral mucosa in cancer patients undergoing chemotherapy in one oncology clinic affiliated to the University of Medical Sciences in western Iran from April 2019 to June 2020.

The present study was a quasi-experimental study with a pretest-posttest design. In this study, patients with cancer undergoing chemotherapy were allocated to the intervention and control groups by the random block method. Patients in the intervention group mixed two times every 8 hours and 7.5 ccs of sodium bicarbonate mouthwash each time. The Scales were completed for patients.

Findings showed that sodium bicarbonate mouthwash has been able to prevent the incidence of oral mucositis or reduce its severity of oral mucositis in patients undergoing chemotherapy that had no symptoms of oral mucositis at the beginning of the study. Therefore, there is not statistically significant difference in the objective evaluation score (F=4.21, P=0.74) and the subjective evaluation score (F=3.67, P=0.61) during the study in the sodium bicarbonate group. However, there was a statistically significant difference in the severity of oral mucositis in the objective and subjective assessment between the sodium bicarbonate group and placebo on follow-up days (P=0.01).

Sodium bicarbonate mouthwash maintains and promotes oral health by preventing the incidence and severity of oral mucositis in patients undergoing chemotherapy for three weeks. Therefore, the recommendation is to use sodium bicarbonate mouthwash as a therapeutic care measure in clinical settings at the beginning of chemotherapy for these patients.

Oral mucositis, inflammation, and painful wound of oral mucosal membranes is commonly known as a serious side effect of chemotherapy and radiotherapy. The aim of this study was to prepare and evaluate physicochemical hydrogel containing glycyrrhizin, hyaluronic acid, and polyvinylpyrrolidone for treatment and prevention of oral mucositis.

The hydrogel containing glycyrrhizin 0.2% w/v was prepared by adding 1, 3, and 1 percent hydroxyethyl cellulose, polyvinylpyrrolidone, and hyaluronic acid in deionized water. Different percentages of preservatives were also added to the formulation. Physicochemical characteristics such as viscosity, pH, stability, and antimicrobial effectiveness were evaluated in details. Finally, the efficacy of the formulation was evaluated in Wistar rats with chemotherapy-induced mucositis.

Macroscopically, the formulation was found to be without particles, it was touchable and transparent, and also had good consistency and uniformity in terms of physical appearance. The viscosity and pH was obtained 6.5 ± 0.2 and 1500 cp, respectively. Glycyrrhizin was completely released during 3 hours. The viscosity, pH, and physical appearance did not significantly change during stability studies. Oral mucositis was induced in rats after seven days intraperitoneal injection of fluorouracil. In the group received the formulation, the severity of mucositis significantly reduced more compared to control group.

The current formulation successfully reduced the severity of oral mucositis in rats, and its efficacy was comparable with commercial formulation (Gelclair® ). Therefore, the developed formulation has the potential to be used in the treatment of oral mucositis and other oral or subcutaneous wounds.

Oral mucositis is very painful and in severe cases it interferes with the nutrition of patients as well as the daily life of the patient. The only way to treat and prevent mucositis is to identify timely illness, recommend oral hygiene and proper oral mucosal administration. The purpose of this study was to develop a questionnaire for oral mucositis.

This study is an analytical descriptive study. To design the content scope of the questionnaire, a first questionnaire was developed after extensive field research and a comprehensive library of 22 items. To determine the content validity index and content validity ratio, a questionnaire was provided to 12 professors of the faculty member of Hamadan University of Medical Sciences. Then, for internal consistency and repeatability, To 80 patients with oral mucositis dental clinics in Hamedan were given a questionnaire. One week later, the questionnaire was returned to this group and finally, reliability was determined Using the Kuder Richardson test.

Six items from the initial questions, which had a low content validity rate, were excluded from the study. The final questionnaire was designed with 16 items and the content validity ratio was ultimately 0.68 and content validity index was 77% simpler, 80% relevant and 79%, respectively. The final index Content validity was calculated to be 78/6%. Reliability of the questionnaire was calculated using Kuder Richardson test (0.85).

The final Oral mucositis questionnaire with 16 items has high validity and reliability, and it is a standard tool for use in the field of Oral mucositis.