جستجوی مقالات مرتبط با کلیدواژه « هموسیستئین » در نشریات گروه « پزشکی »

Chronic inflammation is associated with the development of various diseases,including atherosclerosis and diabetes. The aim of this study was to investigate the effect of longtermselected aerobic exercises on changes in cystatin C and homocysteine in inactive and overweightmiddle-aged women.

Thirty non-athlete middle-aged women (mean age: 46.06±6.97 years, weight:71.82±9.11 kg, height: 156.9±5.24 cm, and body mass index: 29.2±4.11kg/m2) voluntarily participatedin this project and were randomly divided into the experimental and control groups The experimentalgroup performed selected aerobic exercises (65-75% of maximum heart rate) for eight weeks. Bloodsamples were taken before and 24 hours after the completion of the research protocol to measure thelevels of cystatin C and homocysteine. Analysis of covariance was used for intergroup comparisons andpaired t-test was used for intergroup comparisons.

The results showed that there was no significant difference between the experimental and controlgroups in cystatin C (P=0.09) and homocysteine (P=0.07) after eight weeks of selected aerobic exercises.A significant decrease was observed in weight (P=0.001) and body mass index (P=0.002) in theexperimental group compared to the control group.

Overall, the results of the present study showed that although the eight-week activity programimproved the body composition of overweight middle-aged women, longer periods of aerobicexercise are required to examine clearer biochemical results.

Food and sports supplements are used by athletes all over the world, and correct and optimal consumption improves performance and prevents sports injuries. In this regard, creatine and ginseng supplements can be effective on physiological indicators and sports performance. Therefore, considering that no research has been done on the use of these supplements on blood indicators on fencers. The present study compares the effect of creatine and ginseng supplements on blood ammonia, HDL, LDL and homocysteine indices of the male players of the Iranian Epe fencing team.

In the present study, 14 male players of the Epe national fencing team were divided into two creatine supplement groups (7 people) and ginseng supplement group (7 people). Subjects in two groups performed their normal exercises with the team during the research, and on the day before the measurement, after a specific activity in a sitting position, blood was taken from the arm vein of the subjects by a specialist. The statistical significance difference was determined at the level of P ≥ 0.05 and ANCOVA test was used to determine the differences between groups and the data was analyzed by SPSS software, version 25.

This article was approved by the Ethics Committee of Islamic Azad University, Shahrood Branch (Code: IR.IAU.SHAHROOD.REC.1400.073).

The results showed that after six weeks, there is a significant difference between the creatine and ginseng groups in the blood indices of ammonia, LDL, HDL and homocysteine (P≥0.05). so that the average of creatine supplement group in ammonia, LDL, HDL and homocysteine index in terms of mg/dL respectively (2.56±0.83, 1.16±0.33, 7.45±0.48, 8.89±0.18) and Gensing group (2.05±0.29, 1.46±0.78, 8.11±0.27, 7.63±0.45).

The results showed that there is a significant difference in the average of blood ammonia, HDL, LDL and hemocytin between the creatine supplement group and the ginseng supplement group. Therefore, the role of ginseng supplement in reducing blood ammonia and homocysteine and in increasing HDL was more than that of creatine supplement, and the role of creatine supplement in reducing LDL was more than that of ginseng supplement. So it can be concluded that the role of ginseng supplement in the changes of blood ammonia, homocysteine and HDL is more than the role of creatine supplement.

Food and sports supplements are used by athletes all over the world, and correct and optimal consumption improves performance and prevents sports injuries. In this regard, creatine and ginseng supplements can be effective on physiological indicators and sports performance. Therefore, considering that no research has been done on the use of these supplements on blood indicators on fencers. The present study compares the effect of creatine and ginseng supplements on blood ammonia, HDL, LDL and homocysteine indices of the male players of the Iranian Epe fencing team.

In the present study, 14 male players of the Epe national fencing team were divided into two creatine supplement groups (7 people) and ginseng supplement group (7 people). Subjects in two groups performed their normal exercises with the team during the research, and on the day before the measurement, after a specific activity in a sitting position, blood was taken from the arm vein of the subjects by a specialist. The statistical significance difference was determined at the level of P ≥ 0.05 and ANCOVA test was used to determine the differences between groups and the data was analyzed by SPSS software, version 25.

This article was approved by the Ethics Committee of Islamic Azad University, Shahrood Branch (Code: IR.IAU.SHAHROOD.REC.1400.073).

The results showed that after six weeks, there is a significant difference between the creatine and ginseng groups in the blood indices of ammonia, LDL, HDL and homocysteine (P≥0.05). so that the average of creatine supplement group in ammonia, LDL, HDL and homocysteine index in terms of mg/dL respectively (2.56±0.83, 1.16±0.33, 7.45±0.48, 8.89±0.18) and Gensing group (2.05±0.29, 1.46±0.78, 8.11±0.27, 7.63±0.45).

The results showed that there is a significant difference in the average of blood ammonia, HDL, LDL and hemocytin between the creatine supplement group and the ginseng supplement group. Therefore, the role of ginseng supplement in reducing blood ammonia and homocysteine and in increasing HDL was more than that of creatine supplement, and the role of creatine supplement in reducing LDL was more than that of ginseng supplement. So it can be concluded that the role of ginseng supplement in the changes of blood ammonia, homocysteine and HDL is more than the role of creatine supplement.

One of the important goals of therapeutic interventions is to control obesity and vitamin D deficiency, which are associated with the occurrence of cardiovascular disease, metabolic disorders and increased homocysteine. In this study, the effect of high-intensity interval resistance training (HIIRT) and vitamin D on homocysteine and total antioxidant capacity (TAC) ​​levels in overweight women with vitamin D deficiency was investigated.

In this clinical trial study, overweight women with vitamin D deficiency were investigated. The subjects were randomly divided into four groups of 13 (control, exercise, vitamin D and exercise+vitamin D). The exercise groups performed HIIRT with an intensity of 80% of one maximum repetition, and the vitamin D groups consumed vitamin D once a week. The collected data were analyzed using one-way analysis of variance and paired t-tests.

After 8 weeks of research interventions, homocysteine level decreased and TAC significantly increased in the experimental groups (P<0.001). In addition, combined intervention was associated with more changes in homocysteine and TAC levels compared to HIIRT and vitamin D intervention (P<0.001), but HIIRT and vitamin D had a similar effect on the changes of these variables (P>0.05).

It seems that part of the optimal effects of HIIRT and vitamin D consumption in the health development of overweight women with vitamin D deficiency can be induced by increasing TAC and decreasing homocysteine.

Reduction of any mobility and activity can cause many diseases as cardiovascular diseases. The aim of the present study was investigation of the effect of a combined training period (aerobic and High Intensity Interval Training) and high intensity interval training on Homocysteine and ESR in cardiovascular patients.

In the current experimental study, 32 cardiovascular patients were selected voluntarily and were randomly divided into 3 groups: combined training group (n = 10), HIIT training group (n=11), and control group (n = 11). Inclusion criteria included injection fraction greater than 30, lack of tachycardia and bradycardia, and lack of functional capacity less than 5 met, and the exclusion criteria included unwillingness to continue the activity and diagnosis by a physician. The protocol of the HIIT training group included performing 2-3 times a week of HIIT training during the first 4 weeks and performing 3 times a week of HIIT training during the second 4 weeks.Blood samples were taken 24 hours before the first training session and 48 hours after the last training session, under the same conditions for all the three groups. Data analysis was performed using paired sample t-test, ANOVA, and post hoc with a significance level set at P˂0.05.

The performing of combined exercises and HIIT was found to have a significant effect on reducing serum homocysteine levels (combined exercise (baseline values of 19.7± 1.3, after intervention 13.8 ± 2.3, P˂0/00), HIIT exercise (baseline values: 20.0± 1.3, after intervention: 16.3± 1.5, P˂0/001)) and ESR levels (combined exercise (baseline values: 27.7 ± 2.1, after intervention: 22.13 ± 1.27, P˂0/005), HIIT exercise (baseline values: 26.2 ± 2.8, after intervention: 22.9 ±2.0, P˂0/004)) compared with the control group (Homocysteine P˂0/619, ESR P˂0/306) of cardiovascular patients.

Combined and HIIT trainings seem to be effective in reducing homocysteine and ESR in cardiovascular patients, while the effect of combined exercise is greater than that of HIIT.

The purpose of this study was to investigate on the effect of continuous and interval cardiac rehabilitation training on functional capacity homocysteine and Atrial natriuretic peptide (ANP) in Coronary artery bypass surgery patient.

According to the aim of the study, 30 patients with inclusion criteria were selected and divided into three groups: continuous and interval training and control group. Individuals were trained for 8 weeks according to their special program. Before and after training protocol, blood sampling was used to measure homocysteine and ANP and functional capacity was assessed. To analyze the data, mixed design analysis of variance was used and when differences was significant Bonferroni post hoc test was used to determine the place of difference. All statistical analyzes were performed using SPSS software version 20.

Serum homocysteine decreased significantly after 8 weeks of training in both experimental groups, this decline was higher in interval training group than continuous training group (p <0.05). The intervention of continuous and interval exercises significantly reduced the level of serum ANP and improved functional capacity in experimental groups, which interval group experienced more improvement of functional capacity than continuation training group (p <0.05).

In this study, it was observed that interval training could increase functional capacity and cause to decrease the inflammatory factors, thereby preventing further complications in these patients like heart attacks.

The Liver is one of the most important body organs. Some of its most important functions include, detoxing the taken medications, expulsion of the remains of destruction of the red blood cells in form of bile, producing blood coagulation components, preserving sugar in the form of glycogen and also preserving and burning of the fat and sugar in body. There are two kinds of fatty liver diseases, namely, alcoholic, and non-alcoholic fatty liver. The most common liver ailment is non-alcoholic fatty liver disease which happens when more than 5%-10% of the liver weight would consist of fat. This disease can be categorized into three different levels, 1,2 and 3. Emergence and development of such disease is affected by genetic factors in addition to having a low activity lifestyle and bad eating habits. Genetic factors play an important role in being overweight and having NAFLD. 16%-50% of the NAFLD patients are affected by the genetic factors. One of the genetic factors is the Methylene tetrahydrofolate reductase gen (MTHFR). This is the coding gen of the Methylene tetrahydrofolate reductase enzyme which it’s common polymorphismis C677T. Gen MTHFR is one of the effective genes in producing active oxidants and therefore, effective in Steatosis, inflammation and fibrosis. It is possible that in case of an increase in C677T which will result in decreasing the functionality of MTHFR in a fatty liver, and considering that the considered enzyme is only functional in high temperatures, would result in an increase in this enzyme function and hence, increase of the temperature during an exercise. In case of an increase in C677T, a less functioning MTHFR is produced which will result in an increase in blood Homocysteine.In order to study the effect of eight week's compound exercises (aerobic and resistance) on homocysteine serum level on three genotypes (CC, CT, TT) of C677T polymorphism of Methylenetetrahydrofolate reductase gene's (MTHFR) was conducted.

In this semi-experimental study, the homocysteine serum level of 60 obese male between the age of 30 to 40 with the BMI of 30 to 35(K⁄m^2 ) whom were diagnoests with grade 1 NAFLD which also were devided in six groups (3 control groups, 3 experimental groups), before and after of eight weeks of compound exercises were observed. The compound exercises were executed as the combination of aerobic and resistance exercieses for 3 seperated (non- consecutive) days in the way that at the first half of the session the aerobic exercieses were took place and in the second half the resistance exercieses. The aerobic exercises with the intensity of 65 percent of the maximum Save heart rate in the first sesseion and 75 percent of the maximum Save heart rate of the last session and the resistance exercises were based on non-linear base with emphasis on endurances and total readiness with the mean of Kramer and Flak with the intensity of 45 percent of the first session and the 60 percent of the last session have had happened. To compare the groups with eachother, the Statistical method of analysis of variance method, with repetitious size was used. If there were ment to be a difference between the groups for the means to compare them with eachother the Post hoc test LSD method, with errore of (05/0 ˂α) was considered, and the SPSS19 softwear was used to analyzing the experiment data.

After 8 weeks, the results have shown that the different exercise groups have a noticeable variation in Homocysteine index(p=0/000). By analyzing the variance of the data, we can see that there is a meaningful difference between different groups. There is a meaningful difference between the groups, even disregarding the test cases (p=0/000). Due to the difference between the groups, the LSD test method is used to find the difference position. Based on this method, it have been resulted that the density of Homocysteine in TT genotype group was meaningfully reducted in comparison to other genotype groups, such as CT genotype group(p=0/000) and CC genotype group(p=0/026), however the CT genotype group did not show a noticeable differenc rather than CC genotype group(p=0/815), further result suggest that there is a noticeable difference between pre-test and post-test in TT genotype group(p=0/025) and also the same situation was happened with the CT exercise group(p=0/041), but there was no meaningful differences between pre-test and post-test of the CC group.

  after eight week's compound exercises (aerobic and resistance) level homocysteine serum on genotype reduction performance of TT was better in reduction comparison to genotype CT and CC. this finding shows that, because of the reduction level of the homocysteine serum, probably the function of the liver in non-alcoholic fatty liver patients will improve.Overall conclusion Eight week's compound exercises (aerobic and resistance) can significantly reduce the level of Homocysteine.considering the results of this study, it can be concluded that combined exercise of aerobic and resistance exercise could be used in curing the non-alcoholic fatty liver in the obese male patience in order to avoid wight gain and it’s comorbidities and also the lack of exercise in addition to curing the disease. These results also indicate that a reduced level of Homocysteine serum will probably result in better functionality of a fatty liver in the patience.

Cardiovascular disease is estimated the cause of 17.3 million deaths annually in the world and 27.4% of deaths in Iran. Since the common risk factors cannot currently predict all causes of cardiovascular disease, researchers have suggested that other factors such as oxidative stress, trace elements, inflammation, and homocysteine may be potential contributors to cardiovascular disease. Therefore, in this study, we assess the association of serum level of homocysteine with the severity of coronary artery involvement.

In this cross-sectional study, 347 patients referred to Ghaem Hospital for angiography and 103 healthy individuals without cardiac symptoms were evaluated. Subjects were divided into five groups with more than 50% stenosis of one (1), two (2), and three (3) arteries, individuals with normal angiography or less than 50% involvement (4), and healthy subjects (5). Serum homocysteine level was measured by ELISA at Bou-ali Research Institute. Statistical data analysis was performed using SPSS software version 21.

In this research, 106 healthy people, 91 normal people, and 80, 87, and 89 people with stenosis in one, two, and three arteries, respectively were studied. The mean homocysteine in the groups with stenosis of one, two, and three vessels was significantly higher than the normal and healthy groups (P <0.001). The results of logistic regression analysis showed that increment of one unit of homocysteine raised the chance of vascular involvement in people with one, two, and three-vessel involvement into 1.235 (1. 053-1. 273), 1.289 (1.125-1.414), 1.461 (1.326-1.611), respectively (P <0.001)

The results of the present study showed that increase in concentration of homocysteine as an independent risk factor can lead to greater prevalence and progression of vascular stenosis.

Anxiety is a prevalent neuropsychiatric disorder caused by excitation or destruction of various areas of the brain, including the hippocampus. Homocysteine (Hcy) has recently been identified as a potentially excitatory amino acid and a risk factor for central nervous system disorders. Therefore, this study was designed to investigate the effects of homocysteine administration on anxiety-like behavior in rats. Also, we aimed to investigate the possible protective role of folic acid administration as a potent antioxidant on alterations elicited by hyperhomocysteinemia in the hippocampus.

The rat pups were divided randomly into four groups. Group I received normal saline, group II received Hcy subcutaneously twice a day at 8-h intervals (0.3- 0.6 µmol/g body weight), group III received Hcy + folic acid (0.011 µmol/g body weight) and group IV received folic acid on postnatal day (PD) 4 until 25. On the 26th day, anxiety and exploratory behavior of animals was examined using the open field and elevated plus maze tests, respectively. Also, histological study was performed.

Hcy administration increased the plasma total Hcy level. Folic acid significantly reduced plasma Hcy level. Hcy induced anxiety-like behavior. The number of rearing significantly reduced following Hcy administration (p < 0.05). The percentage of time spent in the open arms of the elevated plus maze significantly reduced and percentage of time spent in the closed arms increased following Hcy exposure in the rats (p < 0.001) as the control group. Folic acid treatment significantly elevated the percentage of time spent in the open arms and reduced the percentage of time spent in the closed arms in Hcy + Folic acid exposure rats as Hcy rats (p < 0.05). Histological study indicated that there was no significant change in number of hippocampal cells among groups.

Hcy can induce anxiety-like behavior and folic acid has protective effect against Hcy- induced anxiety.

Homocysteine and Insulin resistance increase and adiponectin reduction are the risk factors for cardiovascular and metabolic diseases. In contrast, regular physical exercise is the effective intervention for reducing these risk factors. The purpose of the present study was to investigate the effect of eight weeks of upper body, lower body, and mix resistance-training on adiponectin, homocysteine concentration, and insulin resistance in healthy untrained female students.

A total of 56 healthy females (age: 21± 3 years old, weight: 60± 5 kg, height: 160± 5 cm, Body Mass Index: 21 /5 ± 3/5 kg m) voluntarily participated in the current study. After two sessions of getting familiar with each other and identifying maximum power, participants were randomly divided into four groups (upper body resistance, lower body resistance, mix [upper and lower] resistance, and control group). Training groups performed six resistance exercises for upper body, lower body, mixed upper and lower body three sessions per week for eight weeks. To measure adiponectin, homocysteine, and insulin resistance, blood samples were obtained before trainings and four weeks after training sessions and at the end of the training period.

It was shown that adiponectin levels increased significantly after eight weeks of resistance exercises in the upper body, lower body, and mix groups. The highest increase was observed in lower body and the lowest one was found in upper body training groups. Also, lower body and mix groups’ homocysteine levels reduced significantly. Moreover, insulin resistance index had significant reduction in all the training groups.

Eight weeks of upper, lower body, and combined resistance training resulted in significant increase in adiponectin levels and a significant decrease in insulin and homocysteine resistance levels in untrained women, which directly affected the involved muscle mass and the length of exercise. In other words, the more the muscle mass is used over a longer period of time, the greater the benefits of increasing serum adiponectin and decreasing insulin resistance and decreasing homocysteine, and thus, in general, overall improving risk factors for preventing cardiovascular and metabolic diseases.

The purpose of this study was to investigate the effect of eight weeks of aerobic exercise and supplementation of gensing on homocysteine levels, tiroid hormon and insulin resistant in obese women with hypothyroidism. This study is quasi-experimental study. For this purpose, 40 obese women with hypothyroidism with an average age of 34.62 ± 3.55 years, weight 80.47 ± 3.85 kg and BMI of 32.2 ± 2.27 kg / m2, were randomly divided into four groups including aerobic training (10), ginsing (10), aerobic exercise and ginsing (10) and placebo (10) were divided.Aerobic exercise included 8 weeks of aerobic training, 3 sessions per week, 45 to 70 minutes, and 55 to 75% of maximum heart rate. Patients in the ginseng group and aerobic exercise with ginsing consumed each day a Jinsen's capsule containing 250 mg of granule Risomy ginseng powder was taken orally after 8 weeks for 8 weeks, while subjects in the placebo group received flour powdered capsules.Blood samples from the anterior vein were used to measure homocysteine, TSH, T3, T4, glucose and insulin before and after 8 weeks in four groups. For data analysis, dependent t-test and variance analysis were used (P≤0/05). The results showed that the plasma homocysteine, TSH, glucose concentrate, insulin resistance and insulin resistance were significantly decreased in all three experimental groups while T3 and T4 increased (P <0.05). These indices in the control group were not changed (P <0.05). Therefore, aerobic exercise, along with supplementation with ginsing, can have an important role in preventing an increase in cardiovascular risk factors and hypothyroidism in obese women with hypothyroidism.

Menopause is associated with increased cardiovascular risk factors. This investigation examined the effects of resistance training on cardiovascular risk factors in ovariectomized rats.
Material & In this experimental study, 16 adult ovariectomized female Wistar rats were randomly allocated into control (n=8) and resistance training (n=8) groups. The progressive resistance training protocol was administered for 10 weeks (5 sessions per weeks). Training protocol consisted of 8 series of climbs on the ladder with progressive overload attached to the tail and each series contained an average of 8 to 12 climbing movements (repetitions). Forty eight hours after the last training session, animals were anesthetized, blood was taken directly from the heart. Then serum homocysteine levels and lipid profile were measured and insulin resistance index was calculated. All variables were compared by unpaired t-test) p serum homocysteine levels (p = 0.013) and insulin resistance index (p = 0.019) were significantly decreased in resistance training group compared with the control group, but lipid profile did not differ among rat groups (p˃0.05).
It seems that ten weeks of progressive resistance training reduced serum homocysteine levels and insulin resistance index in ovariectomized rats, but did not effect on the serum lipid profile.

Methylene Tetrahydrofolate Reductase (MTHFR) gene, as an important genetic factor affecting infertility, encodes Methyl Dihydrofolate Reductase enzyme which helps to regulate the levels of homocysteine in the body. Mutations in this gene can reduce the activity of the enzyme, which leads to increase levels of blood homocysteine and may cause infertility. The purpose of this research was to investigate the relationship between C677T polymorphism of MTHFR gene and infertility.
Material & In this study, 100 samples from infertile and fertile women with a history of abortion and 100 healthy pregnant were selected. After extracting the DNA from peripheral blood, the genotype of the samples was analyzed by PCR-RFLP method. SPSS software was also used to investigate the relationship between C677T polymorphism and infertility (using t. test, Chi-square test and logistic regression).
C677T polymorphism of MTHFR gene, resulted in a significant increase in the level of homocysteine and decrease levels of folate and vitamin B12 in homozygous women. However, there was not any relationship between the genotype of heterozygous patients with the level of homocysteine, folate and vitamin B12.
C677T polymorphism of MTHFR gene may be associated with the increased levels of homocysteine and decreased levels of folic acid and vitamin B12 in the body, which can cause fetus recurrent miscarriage syndrome.

Homocysteine is an amino acid sulfur-containing that its amount under androgenic hormones effect changed. With regard to homocysteine effect on the growth of bone tissue, the study aimed to investigate the prenatal and neonatal effects of testosterone on serum homocysteine and growth of Femur & Humerus bones length and diameter of rats’ born were performed.
The experimental study on 256 born of 40 male and female rats divided into 4 groups: control (no treatment), sham (treatment with drugs), experimental perinatal and neonatal by dosing 600 μg/kg in pregnancy and lactation periods under treatment testosterone were done. Then the different groups of both males and females’ born in the days 7,14,21 and maturation of testosterone levels, homocysteine, and length and diameter of Femur & Humerus bones were evaluated and the results obtained using SPSS-20 software and t-test, ANOVA were analyzed and the significant differences of data at P The results of data analysis showed that the significant increase in rats’ born treated with testosterone, serum levels of homocysteine and testosterone at P The results showed that injection of testosterone during pregnancy and lactation increases testosterone levels and homocysteine and reduce the Femur & Humerus bones length and diameter.

In type 1 and type 2 diabetes, oxidative stress increases in the body. Oxidative stress is an imbalance between the production of free oxygen radicals and the antioxidant defense in the body. Hyperglycemia elevated the level of glucose oxidation in the several ways that leads to more radical production. Levels of some pro-oxidants such as ferritin and homocytine increase in diabetes. The increaed production of free oxygen radicals play an important role in the induction of vascular damages in the diabetic patients.
Materials ad . The population of this cross-sectional study was the selected diabetic patients referred to Diabetes Clinic of Birjand University of Medical Sciences. Blood samples were collected from 81 patients and 35 healthy subjects. Levels of hemocysteine and total antioxidant serum were measured by EIA and FRAP methods, respectively.
The mean of hemocystein for the neprhropathy patients was 13.8 ± 10.9, retinopathy patients; 11.7 ± 4.9, diabetic paitients;16.6 ± 9.5;control group; 13.2 ± 7.4, p= 0.153. The mean of antioxidant levels in the nephropathy, retinopathy, diabetic, and control groups were 848.9 ± 2.22, 860.8± 150.51, 812.1 ± 171, 986 ± 260 respectively, p= 0.007. The results showed that there is a statistically significant difference between groups.
Conclussion:This study showed that there is no relationship between homocysteine ​​level and type 2 diabetes, but the antioxidant level in type 2 diabetes is reduced.

Elevated plasma levels of homocysteine and fibrinogen are considered cardiovascular risk factors. The aim of the present study was to investigate the effects of short-term supplementation of omega-3 on homocysteine and fibrinogen levels in response to a single session of circuit resistance training in non-athlete obese women.
In a quasi-experimental research with a pretest-postest design, 20 non-athlete women with body mass index ≥30 kg/m2 participated as subjects. The participants were divided randomly into two equal groups of 1) placebo and 2) omega-3 supplement. The training intervention consisted of a single session of circuit resistance training at nine stations with intensity of 40% 1RM at the end of one week omega-3/placebo supplementation, consumed orally, 3 capsules (each containing 3000 mg) per day for one week. Blood samples were collected in two phases before and after the resistance training. Plasma levels of homocysteine and fibrinogen were assayed using ELISA methods, and data were analyzed using ANCOVA test (p There was a significant difference between the groups at in their postest values of homocysteine (p=0.0001) and fibrinogen (p=0.0001). The omega-3 supplement group showed less increase in the research variables.
It is concluded that short-term consumption of the omega-3 supplement may be useful in preventing increase in homocysteine and fibrinogen levels in response to a single session of circuit resistance training in non-athlete obese women.

Stroke is the third most common cause of death in the world. The risk of emerging factors for stroke is plasma homocysteine.
Subjects & A descriptive-analytic study was performed on patients with ischemic stroke referring to Tabriz hospitals. We entered the patient's information, including demographic information of patients, hypertension and etc along with laboratory results of homocysteine assay for patient's blood samples into SPSS v16 statistical analysis program.
A total of100 patients with ischemic stroke were evaluated who their average age was 65.83±15.32 years and also 54.54% were men and 46% were women, 45% were with one risk factor, 50% had hypertension, 13% diabetes, 18% hyperlipidemia, 14% a recent MI history and 31% had smoking history. Overall 74% of patients were with no stroke history, homosystein level in studied patients was 20.40±12.24 mmol/lit and 49% had normal level of homosystein. Homosystein level was evaluated with gender (p=0.876), age (p=0.004) and NIHSS (p=0.745) and also NIHSS level with gender (p=0.058), age (p=0.876), HTN (p=0.070), HLP (p=0.103), DM (p=0.999), and history of MI (p=0.262) and history of CVA (p=0.964), NIHSS level with smoking (p=0.109) and homosystein level (p=0.013). Data analysis showed that the level of homocysteine with hypertension (P=0.021) has a significant relationship.
The results of this study showed that increased homocysteine has a high prevalence in patients with stroke.

Obesity is obviously related to incidence of cardiovascular problems. Novel risk factors of cardiovascular diseases, such as fibrinogen and homocysteine, have attracted the attention of many researchers. The purpose of the present study was to investigate the effect of 8 weeks of selected Pilates exercises on plasma levels of fibrinogen and homocysteine in non-athlete obese women.
Twenty non-athlete obese women (age, 29.6±3.6years; body mass index, 32.6±1.6kg/m2) voluntarily participated in this quasi-experimental study. The participants were randomly divided into two equal groups of control (daily activities) and experimental (selected Pilates exercises). The intervention of experimental group consisted of performing 8 weeks of selected Pilates exercises, 3 sessions per week, with each session lasting 60-75min. Before and after 8 weeks of Pilates exercises, blood samples (5cc), were taken from all participants in a 10-hour fasting state. Plasma levels of fibrinogen and homocysteine were assessed using ELISA method. Data were analyzed using independent and paired t-tests (p Significant differences were observed in concentration of plasma fibrinogen (340.1±40.98mg/dl before vs 309.5±34.65mg/dl after) and plasma homocysteine (15.01±1.15µmol/l before vs 12.26±1.47µmol/l after) (p Overall, it seems that probably selected Pilates exercises can have beneficial effects on some cardiovascular risk factors.