جستجوی مقالات مرتبط با کلیدواژه "ویتامین ها" در نشریات گروه "پزشکی"

Vitamin D has been shown to reduce exercise-induced muscle damage and muscle soreness; however, further research is needed to establish definitive conclusions. The aim of this study was to investigate the effect of vitamin D supplementation on muscle soreness and recovery after exercise.

A systematic review and meta-analysis was conducted to evaluate the effects of vitamin D intake on muscle soreness and biochemical markers of muscle damage, including myoglobin (MB), creatine kinase (CK), lactate dehydrogenase (LDH), and inflammatory factors such as TNFα and IL-6. Data were sourced from PubMed, Scopus, and Web of Science databases up to February 2024. Analyses were performed to compare vitamin D with placebo, and weighted mean differences (WMD) were calculated.

A total of 11 studies involving 358 athletes and non-athletes were examined. Changes in muscle soreness immediately after exercise due to vitamin D intake were not statistically significant [P=0.70, WMD=-0.07]. However, vitamin D significantly reduced muscle soreness 24 hours after exercise [P=0.04, WMD=-0.40]. No significant changes were observed in CK [P=0.30, WMD=-3.22 U/L], LDH [P=0.30, WMD=-11.86 U/L], or MB [P=0.50, WMD=10.66 ng/ml] immediately after exercise.

Vitamin D may be effective in reducing muscle soreness 24 hours post-exercise, but it does not appear to significantly affect markers of muscle damage, including CK, MB, and LDH, in the timeframes studied. Further research in this area is recommended.

Recent studies show a connection between serum vitamin D levels and the onset of asthma, as well as markers of disease severity in children with asthma. This study explores the relationship between serum vitamin D levels and the severity of asthma in children.

In this case-control study, 210 children aged 5 to 15 entered the study after obtaining informed consent from their parents. Participants were divided into three groups: healthy (control) = 70, moderate asthma (case) = 70, and severe asthma (case) = 70. The diagnosis of asthma and its severity were determined based on clinical signs and spirometry. At the same time, the serum levels of 25-hydroxyvitamin D were measured using a standard DIA source kit and the ELISA method.

The mean serum level of vitamin D in healthy individuals was 28.92 ± 9.54, which was higher than in those with asthma. On the other hand, the vitamin D level in patients with severe asthma was 13.24 ± 21.61, significantly lower than that in patients with non-severe (mild and moderate) asthma, who had levels of 28.44 ± 9.97. The results indicated a statistically significant difference in serum vitamin D levels among the study groups (P<0.001). Furthermore, there was a negative correlation between serum vitamin D levels and asthma severity among the subjects (r=-0.25), which was also statistically significant (P<0.05).

In conclusion, assessing vitamin D levels in patients with asthma is recommended. If a deficiency is identified, it is important to implement the necessary treatment.

Osteoporosis is a well-known problem in patients with spondyloarthropathy that may begin even in the early stages of the disease and cause debilitating complications. The aim of this study was to investigate the relationship between disease severity and low bone density in patients with axial spondyloarthropathy.

In this study, 65 patients with axial spondyloarthropathy were included in the study, and the data including age, gender, BMI, CRP, 25(OH) vit.D, HLAB27, MRI of the sacroiliac joint and bilateral hip, disease duration, disease activity and the last BMD test was extracted from their records and analyzed with statistical software.

Mean (and standard deviation) age, BMI, the duration of the disease, CRP, and ASDAS- CRP were 37.5±5/9 years, 24.7±1.8 kg/m2, 73.9±33.5 months, 14.2±3.2, and 2.2±0.5, respectively. 21.5% of patients had osteoporosis, 90/8% were HLAB27 positive, 78.5% had sacroiliac joint involvement and 66.2% had vitamin D deficiency. Gender (p=0.75), age (p=0.11), involvement of sacroiliac joints (p=0.13) and positive HLAB27 (p=0.75) were not significantly different in patients with and without osteoporosis. While, vitamin D deficiency (p<0.001), BMI (p<0.001), disease duration (p=0.01), CRP (p<0.001), and disease activity (p=0.004) were significantly higher in patients with osteoporosis.

The results of this study showed that disease activity, CRP, disease duration, BMI and vitamin D level are related to osteoporosis in these patients. Therefore, patients who have these risk factors should be prioritized to check bone density.

Glucose transporter4 (GLUT4) is the main glucose transporter in skeletal muscle. Impaired GLUT4 expression plays a role in the disorders of glycemic homeostasis. The aim of the present study was to investigate the combined effects of aerobic training and vitamin D3 supplementation on Glut4 protein levels and insulin resistance in the soleus muscle of diabetic rats with STZ and high-fat diet.

In 40 male Wistar rats type 2 diabetes was induced by 6 weeks high-fat diet followed by streptozotocin injection. Then rats were randomly divided into five groups: Healthy control (HC), Diabetic control (DC). Diabetes+Aerobic training (DAT), Diabetes+Vitamin D3 (DVD) and Diabetes+Aerobic training+ Vitamin D3 (DVDAT). The rats underwent eight weeks of aerobic training and vitamin D3 supplementation. 24h after last session of training and, the rats were anesthetized and soleus muscle was isolated for measurement of Glut4 protein concentrations and serum levels of insulin, glucose, vitamin D3 index were measured.

One-way ANOVA showed that GLUT4 protein levels in DC group was significantly lower than HC group (P<0.001), but in DVDAT group was significantly higher than DC group (P<0.04) and DVD group (P<0.005). Also in DAT group was significantly higher than DVD (P<0.018). The HOMA-IR index also in DVDAT, DAT and DVD groups was significantly lower than DC group (P<0.001).

It seems that Eight weeks of aerobic training with vitamin D3 supplementation improves glucose metabolism in diabetic rats via increasing Glut4 protein levels and improving insulin resistance index.

Hypocalcemia is a common complication of total thyroidectomy. It has many consequences for the health of patients and negatively affects the patient’s quality of life. The purpose of this study was to investigate the predictive role of vitamin D serum levels before total thyroidectomy in the occurrence of hypocalcemia.

This cross-sectional study was conducted on 82 patients who were candidates for total thyroidectomy surgery and referred to 5 Azar Hospital in Gorgan in 2022. Demographic information, laboratory variables, and clinical symptoms of hypocalcemia before surgery, and 24 hours and two weeks after surgery were collected using a checklist. Data were analyzed with SPSS18 software, independent t-tests, U-Man-Whitney, Wilcoxon, paired t-tests, and a Chi-square test at a significance level of 0.05.

The mean serum calcium level was significantly reduced 24 hours and two weeks after surgery. The average serum level of phosphorus also decreased significantly 24 hours after surgery. About 32.9% showed symptoms of hypocalcemia 24 hours after surgery. Hypocalcemia was not related to the serum vitamin D level. The mean serum calcium level was significantly lower in patients with hypocalcemic symptoms. The average parathyroid hormone one day after surgery was significantly higher in patients with normal calcium levels.

Vitamin D serum level before total thyroidectomy is not related to hypocalcemia after total thyroidectomy. Serum levels of parathyroid hormone and phosphorus are related to serum calcium changes after surgery.

Serum vitamin D levels before thyroidectomy cannot predict hypocalcemia after total thyroidectomy. Serum levels of parathyroid hormone and phosphorus are related to serum calcium changes after surgery. Therefore, long-term follow-up of calcium, vitamin D, parathyroid hormone, and phosphorus levels is recommended for these patients.

Extensive research is underway to find effective treatments for clinical manifestations of COVID-19. Given the proven effectiveness of certain micronutrients, such as vitamins, in antimicrobial activity and immune system modulation for treating or preventing infectious diseases, the potential role of vitamins in the treatment or prevention of COVID-19 should be considered. The present study aimed to assess the correlation between serum folate levels in patients hospitalized with COVID-19 and the severity of the disease, emphasizing the importance of relevant awareness regarding different folate levels.

In this cross-sectional study, folate levels were measured in 117 COVID-19-infected patients hospitalized from January 2020 to November 2020 at Sina Hospital, Hamadan. Patients were categorized based on disease severity into three groups: mild to moderate, severe, and critical. Group differences were statistically analyzed using appropriate tests.

Our study revealed a statistically significant difference in folate levels among the three examined groups. Logistic regression analyses demonstrated that for every one microgram per milliliter increase in folate, the probability of severe COVID-19 symptoms decreased by 23%. The large area under the ROC curve (0.864) indicates that mortality in COVID-19 patients can be well predicted based on folate levels.

As evidenced by the obtained results, it can be stated that a reduction in serum folate levels among hospitalized patients with COVID-19 is common and is recognized as a predictive factor for COVID-19-related mortality. Consequently, monitoring folate levels and considering supplementation, if necessary, should be considered for hospitalized COVID-19 patients.

Benzopyrene is a well-known environmental carcinogen that induces oxidative stress, inflammation, and other metabolic complications. This study aimed to investigate the protective effects of chia seeds against oxidative damage caused by benzopyrene in mice.

In this experimental study, 55 male mice were divided into 11 groups of 5 each. The first three groups served as negative control (normal food), olive oil (benzopyrene solvent), and positive control (benzopyrene), respectively. Benzopyrene (75 mg/kg) was administered by gavage with olive oil. The fourth group received vitamin E (250 mg/kg via gavage) alone, while the fifth group received vitamin E along with benzopyrene. The remaining three groups were given chia seeds orally at doses of 10%, 20%, and 30% w/w, respectively. The three intervention groups received high doses of chia seeds along with benzopyrene. All treatments were carried out for 4 weeks. After 1 month, blood was collected from the heart, and oxidative stress parameters, including TAC (total antioxidant capacity), SOD (superoxide dismutase), GPx (glutathione peroxidase), and MDA (malondialdehyde), were measured in serum using a colorimetric method.

Administration of benzopyrene in rats induced oxidative toxicity and significantly decreased TAC, SOD, and GPx while significantly increasing MDA (caused by lipid peroxidation) (P < 0.05). These changes were significantly improved in groups treated with high doses of chia seeds (P<0.05). However, treatment with vitamin E was unable to correct the oxidative stress caused by benzopyrene.

The present findings suggest that chia seeds play a significant protective role against oxidative toxicity caused by benzopyrene by increasing antioxidant capacity, which can be more effective than vitamin E in benzopyrene poisoning.

The serum level of vitamin D on preterm delivery has been investigated in a number of studies, and this relationship is still debatable. The present study was conducted to systematically review the studies conducted in the region of the relationship between serum levels of vitamin D in mothers and preterm delivery.

In this systematic review to find related studies, the English databases PubMed, Google Scholar, Web of Science, SID, and Magiran, which were published from 2015 to 2023. The quality of the articles was assessed using the Newcastle-Ottawa checklist.

A qualitative evaluation of the remaining 55 articles was performed after reviewing the title, abstract, and text. Finally, 9 articles were included in the systematic review. According to the results of the studies, there is a relationship between the serum level of vitamin D and premature birth.

Low serum levels of vitamin D are significantly associated with an increased risk of preterm delivery.

The purpose of this study was to investigate the effect of sports rehabilitation exercises with vitamin D consumption on fatigue, sleep quality and depression level of people with osteosarcoma cancer after bone marrow stem cell transplantation.

In this study, 27 women with osteosarcoma cancer with body mass index above 30 kg/m2, age 24.90±4.03 years, height 163.85±3.62 cm and weight 82.17±4.5 kg were randomly divided into four groups. (patient-exercise), (patient-exercise-vitamin D), (patient-exercise-placebo) and (control) were divided. The training protocol includes ten weeks of Pilates exercise. The supplement group took 500 IU of vitamin D three days a week for 10 weeks. Data were analyzed using dependent t-test and one-way analysis of variance.

The results of the covariance analysis of the research of three exercise groups showed that after ten weeks of sports rehabilitation with vitamin D consumption, the indicators of fatigue and the level of depression decreased significantly (P≤ 0.05). Also, the results of covariance analysis of the three training groups showed that the overall sleep quality of people with osteosarcoma cancer increased significantly (P≤ 0.05).

Based on the obtained results, it is suggested that the consumption of vitamin D along with exercise rehabilitation can be an effective treatment method for fatigue, sleep quality and depression in people with osteosarcoma cancer.

Dry eye disease is a common age-related disease in the world. Vitamin B12 is an essential factor in maintaining eye health and has antioxidant properties that protect the surface of the eye from damage caused by harmful factors, such as reactive oxygen species. Hyaluronic acid polymer is also similar to natural eye tears with its biocompatibility and physical properties. This polymer is one of the important components of the extracellular matrix. 

Due to the lack of formulations containing the combination of vitamin B12 and hyaluronic acid in the country and the appropriate effects of these two compounds for dry eyes, this study formulates and analyzes the stability of eye drop formulation based on hyaluronic acid and vitamin B12.

First, the formulation of hyaluronic acid and vitamin B12 solution with borate buffer was prepared and the stability of vitamin B12 was evaluated. Next, the physicochemical properties of the prepared formulations were evaluated and a sterile ophthalmic solution was prepared from the selected formulations under aseptic conditions. Finally, by choosing the final formulation, accelerated stability was achieved. 

Accelerated studies after six months showed that the amount of vitamin B12 and its ultraviolet absorption did not decrease, and the physicochemical properties, such as solution pH, color, and viscosity did not change.

This formulation could be a good candidate for industrial production and long-term stability studies are recommended.

Infertility is actually a lack of fertility in couples that has not conceived despite a year or more of trying to reproduce. The present study was performed with aim to investigate the effect of 8 weeks of swimming training, cell therapy and vitamin E consumption on testosterone and Lc31 and P62 genes in the testicular tissue of azoospermia model rats.

In this experimental study, forty 6- to 8-week-old rats were randomly selected, and then the azoospermia model was induced with the busulfan at a dose of 40 mg. After one month, the rats were divided into 8 groups: 1) control, 2) patient, 3) sham, 4) patient + exercise, 5) patient + supplement, 6) patient + cell, 7) patient + supplement + exercise, and 8) patient + cell + exercise. Stem cells were transplanted in the vas deferens at the rate of one million cells for each mouse, they received an oral solution of vitamin E at the rate of 100 mg/kg by gavage, also the training groups performed swimming training continuously with a constant intensity of 60% of the maximum heart rate for 8 weeks, 30 minutes a day, 5 day of the week. Testosterone levels were measured by ELISA and the expression of P62 and LC31 genes in testicular tissue was measured by Real Time PCR technique. Data were analyzed using SPSS statistical software (version 26). P<0.05 was considered statistically significant.

Induction of azoospermia significantly decreased testosterone levels and the expression of Lc31 and P62 genes in testicular tissue compared to the control group (P≤0.05), but showed a significant increase in the supplement, cell, exercise, exercise+supplement and exercise+cell groups compared to the patient and sham groups (P≤0.05).

In the present study, the synergism of swimming exercise with vitamin E and mesenchymal stem cells derived from bone marrow in improving the autophagy flux in experimental rats with azoospermia was observed, which may be effective in increasing testosterone or even fertility.

Periodontal inflammatory disease is one of the most common chronic inflammatory diseases that can affect individuals of any age. The results of some studies have shown that both type 1 (T1DM) and type 2 diabetes may be associated with an increased risk of periodontal inflammation. Inflammatory status and vitamin D deficiency create a suitable environment for the progression of chronic diseases such as diabetes and periodontitis in children. This study aimed to investigate the association between vitamin D levels and gingivitis in children with T1DM.

This case-control study was conducted in the city of Ilam to examine the association between 25-hydroxyvitamin D (25(OH)D) levels and gingivitis in 148 children with T1DM. The case-control group was randomly selected from all children aged 6 - 12 years. Participants were classified into two groups, healthy and T1DM, based on the presence of gingivitis. Fasting blood sugar, calcium, and serum 25(OH)D levels were assessed in this study.

The results of the Mann–Whitney showed that 25(OH)D levels were significantly lower in the group with gingivitis (20/72±12/77) compared to the group without gingivitis (29/57±10/72) (p<0.05). In addition, there was no statistically significant difference in the level of 25(OH)D according to gender between the group with gingivitis and the group without gingivitis (p=0.673 and p=0.350). Also, the results of the chi-square test showed that there was no significant difference between the two groups with gingivitis and those without gingivitis in terms of gender and age distribution. (p>0.05)

The results of this study show that vitamin D deficiency is an effective factor in high gingivitis in children with T1DM. Timely monitoring of the level of this vitamin in patients with gingivitis is essential.

Psoriasis is a common skin disease that presents with papulosquamous lesions (scaly papules and plaques) and can have psychological and physical consequences. Due to the anti-inflammatory role of vitamin D, studies have been conducted on the relationship between serum levels of this vitamin and psoriasis. In recent years, conflicting results have been obtained, all of which emphasize the importance of investigating this issue. This study aimed to investigate the relationship between serum 25-hydroxy-vitamin D levels and psoriasis.

We conducted a case-control study with psoriasis patients from Vasei Hospital's dermatology clinic and healthy people from Sabzevar Blood Transfusion Center in Iran. Patients with chronic psoriasis (more than 6 months) aged 18 to 65 years were included in the study regardless of the type of psoriasis. This study had a sample size of 177 people (88 cases, and 89 controls). The data collection methods were a questionnaire and blood samples. In both groups, the amount of 25-hydroxy-vitamin D was measured by ELISA method.

This study recruited 177 individuals: 78 (44.10%) males and 99 (55.90%) females. The mean age in the case group was 36.95±13.30 and in the control group, it was 21.34±12.60 years. The mean vitamin D levels had no significant difference between the case (19.68±13.60) and the control groups (21.34±12.60) (P>0.05).

The findings of this study showed that there was no significant difference in vitamin D levels between the case group and the control group, which did not support the hypothesis that vitamin D deficiency is associated with psoriasis.

 Parkinson's disease (PD) is associated with disruption of neurotrophins. Previous studies have reported the favorable effect of exercise and some antioxidants. But their simultaneous effect is still not well known. Therefore, the aim of the present study was to investigate the effect of eight weeks of aerobic exercise with vitamin E supplementation on some neurotrophins in the hippocampal tissue of rats with Parkinson's disease.

 In this experimental study, 40 Sprague-Dawley male rats (age 14-16 months and weight 250-270 grams) were given parkinsonism with 2 mg/kg reserpine (Rse) into groups (1) pd, ( 2) AT, (3) VE and (4) AT+VE were divided. In order to investigate the effects of Res on the variables, 8 rats were included in the healthy control group (HC). Aerobic training was done for eight weeks, five sessions a week and each session lasted 15-48 minutes at a speed of 10-24 meters per minute. VE was also taken orally at 30 mg/kg daily. To analyze the data, one-way analysis of variance and Tukey's post hoc test were used (P≥0.05).

BDNF and NGF gene expression values in VE, AT and VE+AT groups were significantly higher than PD group (P=0.001). Also, the increase of these two nortrophins in the AT+VE group was significantly higher than the VE and AT groups (P=0.001).

 According to the results of this study, it seems that although aerobic exercise and vitamin E alone improve the expression of neurotrophins. However, these two interventions can strengthen each other's effects in the expression of neurotrophins in the conditions of Parkinson's disease modeling.

High body mass index and vitamin deficiency are considered to be the main factors of thyroid and fat tissue dysfunction. The aim of the present study was to investigate the effect of a period of high intensity running training with vitamin D consumption on TSH and MCP-1 levels in overweight women with vitamin D deficiency.

This semi-experimental study was conducted on 26 overweight young women with vitamin D deficiency in Babol city, in 1400. After the accessible and purposeful selection, the subjects were randomly divided into two intervention and control groups. The main training consisted of 8 weeks of high intensity running with an intensity of 80-90% of the maximum heart rate and one minute of active rest with an intensity of 50% of the maximum heart rate during 8 weeks, and vitamin D was taken at a dose of 50,000 units weekly. Serum levels of TSH and MCP-1 were determined before and after 8 weeks. Independent t and paired t tests were used to analyze the data at a significance level of P≤0.05.

Data analysis showed that the serum levels of TSH and MCP-1 decreased significantly in the intervention group after 8 weeks. In addition, a significant difference in the mean of TSH and MCP-1 between the intervention and control groups was observed (p<0.001).

Based on the results, the simultaneity of intense intermittent running and vitamin D intake can help increase the health of overweight people with vitamin D intake, by improving thyroid function and reducing the inflammatory index of MCP-1.

Depression is a predictor of cognitive impairment in aged people. This study aimed to compare the effect of Vitamin D, integrated cognitive rehabilitation therapy (CRT), transcranial alternating current stimulation (tACS), and a combination of CRT and tACS on depression in patients with mild cognitive impairment (MCI).

The present study is a semi-experimental clinical trial study in which 32 people with mild cognitive impairment were randomly assigned to four treatment groups after completing the Beck Depression Test and the Mocha Test. CRT, tACS, and CRT + tACS interventions were held twice a week for 12 sessions each. Each session of CRT and tACS lasted 20 minutes, and each session of cognitive rehabilitation treatment plus TACS was performed for 40 minutes, and the group receiving vitamin D; received 20 micrograms equivalent to 800 IU of vitamin D daily for six weeks. Before conducting the research, the Beck depression test (BDI) and MoCA test were taken, and at the end of the research, BDI was taken to check the effectiveness of treatments on reducing depression. To analyze the results, the repeated measurement statistical test with a significance level of less than 0.05 was used.

The results showed that the depression scores decreased significantly in the cognitive rehabilitation intervention group from 11 to 9. However, no significant difference was observed in the transcranial alternating current stimulation (tACS) and combination of CRT and tACS and vitamin D groups.

According to the present study, CRT decreased depression scores in MCI, and it is more effective in reducing depression compared to tACS, CRT+tACS, and vitamin D.

The dysfunction of pancreatic islets plays a crucial role in the development of diabetes. Considering the positive effects of aerobic training and the protective role of vitamin D3 in reducing metabolic disorders, including diabetes, this study aimed to investigate the impact of aerobic training and vitamin D3 supplementation and their interactions on pancreatic islet morphology and insulin resistance index in type 2 diabetes rat model induced by high-fat diet (HFD) and low-dose streptozotocin (STZ).

In this experimental study, 40 male Wistar rats were randomly assigned to non-diabetic included in this experiment. Eight rats were assigned to the normal control group (C) and fed a standard diet. To induce type 2 diabetes, the remaining rats (n = 32) were fed a HFD for 6 weeks, followed by a single intraperitoneal (i.p.) injection of streptozotocin (STZ) at a dose of 40 mg per kilogram of body weight. Diabetic rats were divided into four equal groups: diabetic (DC), aerobic training (DE), vitamin D3 supplementation (DD3), and aerobic training combined with vitamin D3 supplementation (DD3E). Aerobic training consisted of treadmill running five times a week. Vitamin D3 supplementation involved a weekly i.p. injection of 10,000 units. Plasma insulin and fasting glucose levels were measured. Statistical analyses were performed using One-way ANOVA followed by Bonferroni's post-hoc comparisons tests. Values are reported as mean ± SD and the level of significance has been considered at (p < 0.05).

Type 2 diabetes resulted in a reduction in the number and size of pancreatic islets. Both aerobic training and vitamin D3 supplementation increased the level and number of pancreatic islets, compared with the diabetic group (8.48 ± 0.16) insulin resistance in all three groups of DE (3.99 ± 0.51), DD3 (5.15 ± 0.32) and DD3E (3.80 ± 0.30) showed a significant reduction (p˂0.0001). Additionally, in the intervention group DD3E, the fasting plasma insulin (0.25 ± 0.03) and glucose (277 ± 26.58) levels were significantly lower compared to the DC group (p ˂ 0.0001).

It seems that based on the results of this study, aerobic training and vitamin D3 supplementation, as well as Their Interaction, led to a reduction in insulin resistance index and an increase in the size and number of pancreatic islets in type 2 diabetic rats induced by high- fat diet and streptozotocin.

20 October every year is named "World Osteoporosis Day". Osteoporosis is the most common metabolic bone disease. This disease is asymptomatic. Diagnosis and screening of this disease is very important, especially in postmenopausal women. If it not diagnosed and treated on time, these patients will suffer from fractures. Fractures in hip or multiple vertebrae, the patients become bedridden and occur the significant complications including immobility, and complications related to immobility such as Deep Vein Thrombosis, stroke, heart attack, bedsores. One of the most important effective factors in the treatment and prevention of osteoporosis, which plays an important role in preventing falls in the elderly, is vitamin D. In this article, we discuss the importance and how to use vitamin D.