جستجوی مقالات مرتبط با کلیدواژه "combined exercise" در نشریات گروه "پزشکی"

The aging process is typically associated with a decline in motor function and an increased incidence of certain diseases, particularly metabolic syndrome and diabetes. This study aimed to determine the effects of an 8-week combined exercise program on metabolic syndrome markers, motor function, and postural control in elderly men with type 2 diabetes.

In a semi-experimental study, 20 elderly men (mean age 67.18 ± 4.43 years) with type 2 diabetes were randomly assigned to two groups: experimental (10 subjects) and control (10 subjects). The experimental group performed combined exercises for 8 weeks, 3 sessions per week, for 90 minutes (aerobic exercise at 50-70% of maximum heart rate; resistance exercise at 40-70% of 1 repetition maximum). Serum levels of glucose, lipid profile, motor function, and postural control were measured before the intervention and 48 hours after the last exercise session.

Combined exercise significantly reduced serum levels of glucose (P=0.001), total cholesterol (P=0.001), triglycerides (P=0.02), and LDL (P=0.001) in elderly men with type 2 diabetes. Additionally, there was a significant increase in HDL (P=0.01) in the exercise group. Motor function (P=0.01) and postural control (P=0.01) also improved significantly after the exercise intervention.

Combined exercise appears to be an effective and appropriate strategy for controlling blood glucose, improving lipid profile, and enhancing motor function and postural control in older men with type 2 diabetes.

 Lifestyle modification and the use of nanotechnology are considered therapeutic strategies for cancers. Therefore, the aim of the present study was to determine the effect of combined exercise and curcumin supplementation on the expression of T cell factor 1 (TCF-1) and glycogen synthase kinase 3 beta (GSK3β) genes in the brains of mice with glioblastoma multiforme.

In the present experimental study conducted in 2023 at the Islamic Azad University, 40 male Wistar rats were divided into 5 healthy control groups, glioblastoma multiforme (GBM), GBM+ combined training (CT), GBM+ nanocurcumin supplement (N-CUR) and GBM+CT+N-CUR (8 rats in each group). Glioblastoma was injected into the frontal cortex of rat. Exercise training was performed for 4 weeks and 3 days per week as a combination of aerobic and resistance training. Nano curcumin supplement was gavage with a dose of 80 mg/kg for 4 weeks, 5 days per week. At the end, rats sacrificed and TCF-1 and GSK3β genes of brain glioblastoma were analyzed by Real-time PCR method. The collected data were analyzed using Shapiro-Wilk, Levin, one-way analysis of variance, Tukey's post hoc test and Pearson correlation.

The results of the present study indicated that the expression of TCF1 mRNA and GSK3β mRNA in the brain tumor tissue of rats showed a significant increase compared to the healthy control group (p<0.0001 for both). However, compared to the GBM group, all the treatment groups, especially the GBM+CT+N-CUR group, indicated a significant decrease in the expression of TCF1 mRNA and GSK3β mRNA in the brain tumor tissue (p<0.05). The correlation between these two factors was not confirmed in different research groups (p>0.05). Based on histological image, tumor induction caused tissue integrity destruction and the level of inflammatory factors and lymphocytes infiltration in this tissue also expanded. However, exercise training and nano curcumin supplementation led to control of tumor tissue damage and reduction of tumor tissue, and these changes were greater in combination therapy.

It seemed that the combination of exercise and Nano curcumin supplement could be an effective treatment method in down regulation of some effective genes in brain tumor tissue. Therefore, they can be used during the recovery period or cancer treatment with the doctor's order. However, in this field, more studies are needed, especially in human samples.

Chronic obstructive pulmonary disease (COPD) is a respiratory disease in which inflammation plays a significant role in its progression. Exercise and nutritional strategies are effective in improving inflammation; therefore, the aim of this study was to determine the effect of a combined exercise program and N-acetylcysteine supplementation on inflammatory markers in patients with COPD.

In this semi-experimental study, 80 male patients with COPD were randomly divided into 4 groups (20 subjects each): combined exercise, combined exercise with supplementation, supplementation, and placebo. The exercises were performed for 12 weeks, 6 sessions per week, for 60 minutes. 1800 mg of N-acetylcysteine supplement was administered daily along with 3 main meals. The levels of interleukin-6, interleukin-8, and C-reactive protein were measured in the blood at pre- and post-test.

After 12 weeks of intervention, the mean values of interleukin-6, interleukin-8, and CRP decreased significantly by 12.9%, 20.3%, and 5%, respectively, in the exercise + supplement group (P=0.001). Interleukin-6 (P=0.001), interleukin-8 (P=0.001), and CRP (P=0.04) levels were significantly lower in the exercise + supplement group compared to the placebo group. Moreover, interleukin-6 (P=0.001) and interleukin-8 (P=0.001) levels were significantly lower in the exercise group compared to the placebo group.

It seems that combined exercise and N-acetylcysteine supplementation have a positive effect on interleukin-6, interleukin-8, and CRP markers in patients with COPD.

Aging and obesity have common symptoms, including glucose and lipid metabolism changes. Activation of sirtuin 1 and FOXO1 (Forkhead Box Protein O1) can positively affect metabolic disorders associated with aging and obesity. This research aimed to investigate 16 weeks of combined exercise on the plasma levels of sirtuin 1, FOXO1, and glucose homeostasis in obese elderly.

40 obese elderly men with an average age of 61.90 ± 2.84 were selected and randomly divided into two experimental and control groups. The participants trained three days a week (each session 90 minutes) for 16 weeks. 48 hours before and after exercise, anthropometric characteristics and plasma values of sirtuin 1, FOXO1, fasting blood sugar, insulin, HOMA-IR (Homeostatic Model Assessment for Insulin Resistance), and HOMA-B (Homeostasis Model Assessment of β-Cell) were taken from the samples and measured by ELISA method. Data analysis was done using SPSS 16 software, independent and dependent t-tests at a significance level of P˂ 0.05.

Levels of fasting blood sugar (P=0.04), and insulin (P=0.008) in the experimental group decreased significantly compared to the control group, while the serum levels of sirtuin1 (P=0.0001) and FOXO1 (P=0.0001) had a significant increase. Correlated t results in the experimental group showed a significant decrease in insulin, HOMA-IR, and HOMA-B (P = 0.001) and a significant increase in the serum levels of sirtuin1 (P = 0.0001) and FOXO1 (P = 0.0001) (P ˂ 0.05).

Based on the results of this study, it seems that 16 weeks of combined training has a favorable effect on improving glucose homeostasis, increasing sirtuin 1 and FOXO1 levels in elderly obese men.

AKT, PI3K and IL-1 are related to diabetes and cardiac inflammatory. The aim of this study was to investigating cardiac inflammatory markers via AKT, cardiac PI3K gene expression and serum IL-1β with combined exercise and consumption of taurine supplementation in diabetic male Wistar rats.

in this experimental study, 30 male adult Wistar rats weighing 250-300 grams and 6 weeks old were randomly divided into 3 groups including: diabetic exercise+supplement group (T+S) (10 rats), diabetic control group (CD) (10 rats), and healthy control group (CH) (10 rats). To make rats diabetic, 55 mg/kg body weight of streptozocin was injected. Blood sugar above 250 mg/dL was considered as diabetes. Combined exercises and taurine supplementation were performed for eight weeks and 5 times a week. Taurine supplement was taken as a 1% solution in water daily. To compare the inter-group and intra-group changes of the variables, two-way ANOVA and Tukey's follow-up were used. The significance level was 0.05.

PI3K gene expression was significantly increased in the diabetic exercise+supplement group compared to the diabetic control group (P=0.001). The serum level of IL-1β factor in the diabetic exercise-supplement group had a significant decrease in comparison with the diabetic control group (P=0.001). However, there was no significant change in AKT gene expression in the diabetic exercise+supplement group compared to the diabetic control group.

It seems that combined exercises with consumption of taurine supplementation may lead to the improvement of heart inflammatory factors in diabetic people while increasing PI3K, decreasing IL-1β and creating favorable changes in glucose metabolism. Therefore, it is suggested to use combined exercises and consumption of taurine as a non-invasive and low-cost method in improving cardiac inflammatory markers in diabetic persons.

Overweight and obesity are some of the basic problems accompanying people in old-age. Exercise leads to increased levels of IGF-1 and improved motor performance and cardiorespiratory fitness. The aim of this research is investigating the effect of 16 weeks of combined training on cardiorespiratory fitness, IGF-1, motor performance, and muscle cross-sectional area of obese elderly men.

This semi-experimental study was conducted on 40 obese elderly men with an average age of 61.90 ± 2.84 years in two exercise groups (20 people) and a control group (20 people). The exercise group was included in the combined exercise protocol (16 weeks and three sessions per week, each session lasting 90 minutes), and the control group participated in the research without any intervention. = Anthropometric characteristics, IGF-1, and selected factors of cardiac and physical fitness were taken from the samples 48 hours before and after training.

The results showed that 16 weeks of combined training (aerobic and resistance) led to a significant decrease in systolic blood pressure and WHR, and increased VO2 max and motor performance in intragroup and intergroup studies (p≤ 0.05).

In general, it seems that combined exercises are effective in improving cardiorespiratory fitness, motor performance, and body composition of obese elderly men.

Obesity is one of the problems of today's world and has become a global epidemic. The aim of this study was to compare the effect of 6 weeks of traditional Iranian medicine with modern medicine along with combined exercise on weight loss and serum lipid profile in obese women.

In this applied study, 24 obese women with a BMI above 30 were randomly divided into two groups of 12 in traditional Iranian medicine and modern medicine with combined training. In the traditional Iranian medicine group, the method of using temperament correction and modern medicine using a balanced low-calorie diet were used. The combined exercise program of the two groups was performed for six weeks, three sessions per week and each session lasted 60 minutes with moderate intensity. Body weight, waist to hip ratio (WHR), blood sugar and lipid profile were measured before and after the study and were analyzed using independent and dependent t-test.

The results of the study showed that in the traditional Iranian medicine group with combined training, only the LDL variable changed and decreased significantly. In the group of modern medicine, along with combination training, HDL increased and the other variables decreased significantly. Also, in comparing the two intervention groups, a significant difference was observed only in body weight and HDL.

Modern medicine diet was more effective in reducing body weight, reducing WHR, improving lipid profile and reducing blood sugar compared to Iranian traditional medicine diet.

With aging, muscle strength decreases, and older people try to stay healthy as much as possible while maintaining their independence. Regular exercise is needed to control and delay the negative effects of aging. This study aims to investigate the effect of a combined exercise program on balance and respiratory fitness of active older men.

In this quasi-experimental study, 40 active older men (Mean age= 62±12.74 years) participated who were selected by a convenience sampling method and randomly assigned into control and exercise groups. Their balance and respiratory readiness were measured using a static balance gauge and spirometry test, respectively before and after the intervention. The exercise group participated in combined exercise program (aerobic, resistance, and balance exercises) for eight weeks, three sessions per week, each for 60 minutes. The control group continued to perform their daily activities during this period. Data analysis was performed in SPSS software version 22 using paired t-test and independent t-test. The significance level was set at 0.05.

The combined exercise program had a significant effect on improving static balance in both groups (P=0.002), but not on forced vital capacity (P>0.05). Regarding the forced expiratory volume over 1 second, its effect was significant only in the exercise group (P<0.05).

It seems that the combined exercise program can improve static balance and respiratory fitness of older men. It is suggested that the older men use this combined exercise program to increase their balance and respiratory fitness.

Growth differentiation factor-15 (GDF-15) is a marker of inflammation, oxidative stress and it is associated with adverse prognosis in cardiovascular disease. GDF-15 as a predictor for various types of cardiovascular diseases such as heart failure, are affected by training and sports activity. The effect of eight weeks of resistance, aerobic, and combined training on the salivary levels of GDF-15 in active older men was investigated.

The 36 cases were randomly divided into three groups of 12 (1. resistance training, 2. aerobic training, and 3. combined training). The serum GDF-15 salivary value in cases was estimated and recorded using a sandwich ELISA by special kits. After eight weeks of training protocols the datawere analyzed by paired t-test and Scheffe post hoc test to examine the differences between groups by SPSS software.

The results showed that the amount of salivary GDF-15 significantly increased after aerobic exercise by 6.4%, decreased after resistance training by 18.05%, and was unchanged after combination training.

Based on our findings, surprisingly, resistance exercise had a positive and significant effect on enhancing risk factors and reducing the salivary levels of GDF-15.

Parkinson's disease is a chronic brain disorder that occurs as a result of the loss, reduction or damage of dopamine-producing nerve cells in the substantia nigra located in the midbrain. The purpose of this study is to determine the effect of 8 weeks of strength-endurance training with olive oil consumption on motor performance and oxidative stress level in the brain of male parkinsonian rats.

48 male rats were randomly divided into 8 groups including control, Parkinson's disease, Parkinson's disease + olive oil, Parkinson's disease + corn oil, Parkinson's disease + exercise, Parkinson's disease + exercise + corn oil, Parkinson's disease + exercise + olive oil, healthy group + exercise. + olive oil. 0.4 ml of olive oil and corn oil were orally fed to rats daily for 8 weeks in the desired groups. Endurance exercise included exercising on a treadmill for 30 minutes at a speed of 11 meters per minute and strength exercise included climbing a ladder with weights three times. Malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, brain tissue and motor performance were measured.. One-way analysis of variance was used to analyze the data.

Super oxymesmutase, catalase, glutathione peroxidase significantly   increased in the exercise group with olive oil supplementation compared to Parkinson's control group (p <0.05). In addition, a decrease in the amount of malondialdehyde after exercise was observed (p <0.05). Improvement of motor function was also observed in rats with training and consumption of olive oil compared to Parkinson's control group (p <0.05).

Endurance strength training with olive supplementation improves motor function and the amount of antioxidants in Parkinson's rats

Cardiovascular diseases are one of the most common deaths in the elderly, but the molecular mechanism of initiating the process of capillary network development and reducing the risk factors for cardiovascular disease in response to exercise is still not well understood. This study aimed to compare aerobic and combined training on changes in angiogenesis, alkaline phosphatase and CRP in elderly men.

30 elderly men with a mean age of 65-75 years were divided into three groups of aerobic, combined and control exercises. Exercises were performed for 8 weeks with a frequency of 3 sessions per week. Aerobic exercises with 60 to74% of maximum heart rate and resistance exercises with 60-75% of 1RM were performed. Blood samples were collected 24 hours before training and 48 hours after the last training session to assess changes in ALP, CRP and TGF-β factor levels. Analysis and comparison between groups were done by ANCOVA test and for in-group comparison of data by paired t-test at a significant level of P<0.05.

Results of significant decrease in serum concentrations of CRP (P=0.03), TGF-β (P=0.005) in the aerobic group and the combined group compared to the control group and Showed a significant decrease in pre-test compared to post-test in serum ALP concentration in the aerobic group (P=0.027).

decrease in CPP, ALP and an increase in TGF-β1 due to exercise appropriate to the age and condition of these individuals, caused adaptation to physical stresses such as exercise and improved health in the elderly.

This study aimed to investigate the effect of eight weeks of combined exercise on CAF and some sarcopenia factors in CABG patients.

Twenty-four CABG middle-aged men participated in this study. Then, participants were randomly divided into two groups of 12-individuals of combination exercise group (mean age 54.58 ±6.47 years, height 173.04 ±3.15 cm and weight 74.75 ±6.60 kg) and control group (mean age 50.70 ±7.70 years, height 173.50 ±3.69 cm and mean weight of 76.16 ±5.23 kg). Anthropometric indices and serum CAF and IGF-1 blood parameters were prepared and analyzed before and after the training. The eight-week combined exercise program was conducted in three sessions with the supervision of cardiac rehabilitation specialists. Data were analyzed using repeated measures analysis of variance and Bonferroni post hoc test and significant level was considered less than 0.05.

In combined exercise group, serum levels of CAF and IGF-1 significantly increased in the post-test compared to the pre-test (p<0.001). Also, after exercise, serum levels of CAF (p<0.001) and IGF-1 (p=0.017) in patients in the combined exercise group were significantly higher than the control group. While serum levels of CAF (p=0.365) and IGF-1 (p=0.679) before training did not differ significantly between the two groups.

A short-term combination training in CABG patients increased CAF but no change in IGF-1 levels. Further research is needed to determine whether CAF or IGF-1 biomarkers can reflect the muscle quality of adaptation.

Lack of evidence is very important in preventing exacerbation in patients with deep vein thrombosis. Contradictory information about the effect of various sports activities on physiological factors affecting the body. Therefore, the aim of the present study was to compare the effect of a six-month combined care program with garlic supplementation on coagulation factors (fibrinogen and platelets) in middle-aged men with DVT.

The present study was an experimental study with a clinical trial design (with clinical trial code: IRCT20210718051924N1 from Iran Clinical Trial Registration Center). The statistical population included middle-aged men with deep vein thrombosis. Samples: 40 middle-aged men with deep vein thrombosis in Kermanshah who participated in this study as a sample available and voluntarily. The method of assigning the subjects to the groups was an alternative randomization that was divided into four groups: 1. Combined exercise, 2. Combined exercise +garlic supplement, 3. Garlic supplement 4. Controls were divided. The time of conducting the research was winter of 2021. Combined exercise was performed for 24 weeks with 3 sessions per week. 1200 mg daily garlic supplement was used. Fibrinogen and platelets factors were measured before and after 24 weeks. Covariance, paired t-test and Tukey post hoc test were used at a significant level (α = 0.05).

The results showed that both combined exercise and garlic consumption had a significant effect on reducing fibrinogen levels and platelet count (α < 0.001), but these changes were not significant in the control group (α = 0.863, α = 0.434 respectively). Also, 24 weeks of combined training with garlic consumption had the highest reduction in fibrinogen content and platelet count compared to other groups in people with deep vein thrombosis (α < 0.001).

Garlic combined with combined exercises (resistance-aerobic) intensified the fibrinogen levels and platelet count in DVT Iran who were undergoing drug treatment. Therefore, these individuals should be used in combination exercises with garlic due to the effect on fibrinogen levels and platelet count and the useful and important role of these factors in rebalancing homeostasis.

This study aimed to investigate the effect of eight weeks of combined exercise on P3NP, CAF and some sarcomopia factors in CABG patients.

24 CABG middle-aged men participated in this study. Then the participants were randomly divided into two groups of 12-person combination exercise (mean age 54.58 ±6.47 years) and control group (mean age 50.70 ±7.70 years). Anthropometric indices and serum P3NP, CAF and IGF-1 blood parameters were prepared and analyzed before and after training. The eight-week combined exercise program was conducted in three sessions with the supervision of cardiac rehabilitation specialists. Repeated measures statistical test was used for data analysis.

Combined exercise was associated with a significant decrease in serum P3NP levels (p=0.001), but these changes were not significant compared to the control group (p=0.334). But these changes were not significant compared to the control group (p=0.334). There was also a significant increase in serum CAF levels in the post-test compared to the pre-test (p=0.02) and the differences between the control group and the training group were significant (p=0.038). On the other hand, a significant increase in serum IGF-1 levels was observed in the post-test compared to the pre-test (p=0.001), but the serum levels of IGF-1 were not significant in the control group (p=0.280).

A short-term combination training in CABG patients increased IGF-1 and CAF, but no change in P3NF levels. Further research is needed to investigate the effect of combined exercise on CAGB patients on these indices.

Aerobic and resistance training have different effects on the characteristics of the cardiovascular system. The aim of this study was to the role of exercise order in increasing the beneficial effects of combined (aerobic and resistant) training on arterial stiffness in prehypertensive young men.

Twenty male participants with pre-hypertensive levels in the age range of 30-45 years were available in 3 groups: control (Cl; n = 5), aerobic-resistance combination (ART; n = 7) and resistance-aerobic combination ( RAT = 8) performed 8 weeks of combined training protocol. The aerobic part of the training consisted of 20 minutes of activity on a treadmill or bicycle with an intensity of 89-60% of the reserve heart rate (HRR) and the resistance part consisted of working with weights with 84-70% of a maximum repetition (1RM). Arterial stiffness was measured using pulse wave-pulse index (PWV). Statistical comparisons were performed using paired t-test and analysis of covariance.

Intragroup results showed that exercise in both experimental groups caused a significant reduction in arterial stiffness, but in comparison between the groups, only the RT sequence was significantly different from the control groups (P = 0.008) and AR (P = 0.137). ) And the differences between the two groups CL and AR (P = 0.330) were non-significant (P <0.01) and Yang schema therapy was effective only in emotional regulation (P <0.01). The results also showed that there was a significant difference between the effectiveness of the native schema therapy package and Young's schema therapy on reducing the desire for divorce at the level of P <0.01, but there was no significant difference between the effectiveness of these two methods on improving emotional regulation (P <0.01).

It is suggested that combined exercise with resistance-aerobic sequence be performed so that individuals can enjoy the benefits of reducing the risks of cardiovascular disease.

Osteoarthritis is a joint disease characterized by pain, joint swelling, muscle disorders, and functional disability associated with stability. This study aimed to investigate the effect of eight weeks of Pilates and combination exercises on pain management, improving motor function and quality of life in middle-aged women with knee osteoarthritis.

Using a purposive and accessible sampling method, 30 individuals were selected and randomly divided into three groups of 10 patients with Pilates training, combined exercises, and control group. Visual analog scale tests were used to measure pain and the KOOS questionnaire was used to measure motor function and quality of life. Then the training groups performed the exercises for 8 weeks and at the end of the eighth week, these tests were measured and repeated as the pre-test. During the eight weeks, the control group did not experience any of the training protocols (Pilates or combination exercises) and did their daily activities. Also, a dependent t-test was used to compare the means in two stages before and after the test, at the significant level of P ≤ 0.05.

A comparison of the combined group with the control group showed that there was a significant difference in pain and Pilates training on quality of life. In addition, both exercises had a significant difference in motor performance.

The results show that eight weeks of Pilates and combination exercises have a significant effect on pain, motor function, and quality of life in middle-aged women with osteoarthritis of the knee, but the effectiveness of combined exercises was better.

Exercise can play a supportive role in the improvement of breast cancer by regulating and modulating cytokines. Interleukin 10 is an anti-inflammatory and anti-tumor cytokine that plays an important role in inhibiting tumor growth. This study was performed with aim to evaluate the effect of 12 weeks of combined exercise (aerobic_pilates) on the serum level of interleukin 10 and blood platelets in women with breast cancer.

This experimental study was performed on 30 women with breast cancer who had undergone at least 6 months of surgery and had received chemotherapy and were under treatment with medication in Azarbaijan Shahid Madani University in 2019. The subjects were divided into experimental and control groups. The experimental group performed 3 sessions of exercise each week (aerobic-pilates) for 12 weeks. During this time, the control group did not participate in any exercise or physical activity program. Blood samples were obtained before and 48 hours after exercise intervention to extract the variables. Data were analyzed by SPSS software (version 20) and independent and correlated t-test. P<0.05 was considered statistically significant.

The results of correlated t-test showed that the serum level of interleukin 10 (P =0.001) and the number of blood platelets (P =0.041) significantly increased in the experimental group after 12 weeks of combined training (aerobic-Pilates) compared to the pre-test, while this change was not significant in the control group (p> 0.05).

Performing combined exercises (aerobic_Pilates) by improving the status of interleukin 10 as an anti-inflammatory and anti-tumor cytokine can be useful in improving the health status of women with breast cancer. Therefore, designing and performing such exercises in this population can solve many problems of these loved ones.