جستجوی مقالات مرتبط با کلیدواژه "iron oxide" در نشریات گروه "پزشکی"

In the last decades, magnetic nanoparticles have been considered and are being studied for employment in tumor therapy and imaging. Also, alongside their utilization in the role of MRI contrast factors, investigations of targeting tumor cells with biomolecules like anticancer drugs, antibodies, and siRNA, the utility of magnetic nanoparticles is evaluated. This preliminary work aimed to investigate the effects of iron oxide NPs on embryo growth and development with an emphasis on brain morphology and teratogenic effects. 

After recognizing the air sac with candling, one hundred sixty fertile eggs of the Ross 308 broiler strains were divided into 8 groups (n=20). Group 1 (control) received 0.3 mL serum normal. Groups 2, 3, and 4 received iron oxide nanoparticles as maghemite with doses of 100, 250, and 500 ppm, respectively. Groups 5, 6, 7, and 8 received iron oxide NPs as magnetite with doses of 100, 250, 500, and 2500 ppm, respectively. Twenty days after injections, death day, chicken, brain, liver, heart, bursa of Fabricius, and spleen weights and teratogenic samples were recorded, and brain tissues from all chickens were collected for histological evaluations. 

The results demonstrated that iron oxide NPs had teratogenic effects such as the lack of formation of abdominal wall muscles and exposing the heart out of the thorax. Also, alterations were observed in the weight ratio of the liver, spleen, and bursa of Fabricius in experimental groups compared to the control group. In the microscopic assessment of the brain tissue, hyperemia, neuronophagia, edema around vessels, necrosis, and vacuolation of neurons were noticeable. 

It can be concluded that iron oxide NPs affect the growth and development of embryos and can cross the BBB and penetrate the brain tissue by affecting brain morphology.

The interaction between nanoparticles (NPs) and viruses is attracting interest because of the antiviral potential of NPs. This study aims to investigate the antiviral potential of NPs against Herpes simplex virus types 1 (HSV-1).

Molecular docking studies were conducted by Molegro virtual docker software. An extract of Juglans regia green husk was utilized to biosynthesize copper-oxide nanoparticles (CuNPs). The cytotoxicity of NPs was evaluated by MTT assay. Different treatment assays were conducted. Another assay was designed to employ the concentration of 300 μg/ml of CuNPs, which is the highest concentration that did not precipitate. Finally, chemically synthesized Iron oxide nanoparticles (FeNPs) were utilized to adsorb CuNPs. The antiviral effect of FeNPs was investigated, separately.

Docking results confirmed that NPs could interact with the HSV-1 glycoproteins and prevent viral entry. MTT assay results illustrated that the minimum non-toxic concentration (MNTD) of CuNPs is 100 μg/ml which did not exhibit antiviral properties. Employing a noncytotoxic concentration of FeNPs (300 mg/ml) in combination with cytotoxic concentration of CuNPs (300 μg /ml), eliminated the cytotoxicity effects of CuNPs. Exposure of the virus with the combination of CuNPs and FeNPs resulted in 4.5 log10 TCID50 reductions in HSV-1. While treating HSV-1 with only FeNPs reduced the titer of virus by 3.25 log10 TCID50.

The results highlight that combination of CuNPs and FeNPs have antiviral activity against HSV-1. Moreover, FeNPs demonstrated antiviral properties against HSV-1 separately.

Superparamagnetic iron oxide nanoparticles (SPIONs) have been considered promising non-invasive imaging tools in medicine. However, their high surface energy leads to NPs aggregation, while non-targeted SPIONs can cause cytotoxic effects on normal cells. In this work, we evaluated the in vitro potential of polyethyleneimine (PEI)-SPIONs targeted by PNC27 peptide as a double targeting agent throughout early cancer diagnosis.

Initially, PEI was conjugated to PNC27 with HDM-2-binding domain. Then, SPIONs were loaded into PEI-PNC27 through the ligand exchange method. The physicochemical characteristics of the synthesized NPs were evaluated. The cytotoxicity and targeting efficiency were assayed against HT-29 and CT-26 cell lines along with NIH-3t3 as normal cells by MTT method and Prussian blue staining test, respectively. 

The mean diameter of synthesized carriers was obtained in the range of 86.6 – 116.1 nm with a positive charge. According to the cytotoxicity results, the binding and uptake abilities of the PNC27 peptide by cancer cells were significantly higher than that of the NIH-3t3 cells. However, the results were indicative of the more toxic impacts of targeted synthesized NPs against CT-26 cancer cell line when being compared with HT-29 cells, which may be caused by the different cytotoxicity mechanisms of NPs. In addition, the targeted carriers and SPIONs were present inside and around the cells with HDM-2 expression along with only a few non-targeted vectors, while displaying no appearance throughout the normal cell.

The results indicated the efficiency of targeted PEI-coated SPIONs for cancer diagnostic applications.

Magnetite (Fe3O4) is a magnetic Iron Oxide encountered in many technological applications. The particle size and shape of magnetite nanoparticles allow tuning their properties to different applications such as targeted drug delivery, cancer diagnostic, magnetic resonance imaging, catalysts, pharmaceuticals, biomedicine, and agriculture. During the last two decades, the biosynthesis of nanoparticles has received considerable attention due to the growing need to develop environmentally sociable technologies in nanoparticle synthesis. Therefore, there is a need for the development of an eco-friendly process to synthesize nanoparticles through green chemistry using plants and microorganisms. The research work involves the development of a simple and reliable method for the bio-fabrication of magnetic Iron Oxide nanoparticles (IO-NPS) through the green method using Achillea Nobilis extract. The crystalline structure and morphology of IO-NPS were studied using various characterization techniques i.e. Fourier Transform Infrared Analysis (FTIR), Ultraviolet spectroscopy studies (UV–vis), X-ray diffraction, and FESEM. The antibacterial and antioxidant activity of the iron oxide nanoparticles was determined. Iron Oxide nanoparticles exhibited potent antibacterial activity against gram-positive and gram-negative bacterial strains tested. From the results, this method can be applied to different medical and industrial applications.

The purpose of this study was to investigate and compare the effect of iron oxide nanoparticles on the adsorption of sulfur dioxide by modified zeolite with hydrochloric acid. In this investigation was used modified zeolite with HCl with and without iron oxide nanoparticles (Iron Oxide Nanoparticles@Clinoptilolite/HCl) as adsorbent.

Structural characteristics, chemical composition and specific surface area of adsorbent were determined using the FTIR, FESEM, EDX, Mapping, XRD, XRF and BET techniques. Glass cylinder filled with zeolite seeds and SO2 cylinder balanced with N2 gas was used for experiments. It was evaluated factors affecting SO2 uptake process including temperature and contact time, also thermodynamics and kinetics of adsorption. Sulfur dioxide adsorption of real sample was taken with both adsorbents.

Adsorption efficiency of SO2 in the synthetic and actual sample were %82.8±5.5 and %67.2±7.21 respectively, by modified zeolite with HCl and iron oxide nanoparticles in the optimum conditions of temperature of 25 °C and duration 28.5 min. As well as, removal percentage average was obtained in the synthetic and actual sample %46.1±4.34 and %35.8±5.85 respectively, by modified zeolite with HCl without nanoparticles in optimum condition of temperature of 25 °C and contact time of 20.5 min.The results showed that SO2 adsorption is an exothermic and spontaneous process and adsorption kinetics of sulfur dioxide by both adsorbent is more consistent Pseudo-second order kinetics model.

The use of iron oxide nanoparticles on the zeolite can increase SO2 removal efficiency from the gas phase.

The spread of pathogenic microorganisms in food and beverage and their resistance to antibiotics have raised major concerns for public health. The aim of this study was to investigate the antimicrobial activity of various metal oxide nanoparticles (NPs) including zinc oxide (ZnO), magnesium oxide (MgO), and iron oxide (Fe2O3) NPs against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Furthermore, the antimicrobial activity of these NPs in milk was studied along with mild heat.

In this experimental study, the antibacterial activity of ZnO, MgO, and Fe2O3 NPs were initially evaluated by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) methods. Later, the antimicrobial effect of these NPs was investigated in milk along with mild heating. To determine the morphological changes in S. aureus and E. coli, electron microscopy scanning was applied before and after the antimicrobial treatments.

The MBC and MIC values presented by Fe2O3, ZnO, and MgO NPs against pathogenic bacteria showed that MgO NPs were the most potent substances for inhibiting the growth of S. aureus and E. coli. The results also indicated that use of these NPs had synergistic effects in combination with the heating treatment. Electron microscopy scanning also revealed that treatment with MgO NPs could distort and impair the cell wall of the pathogenic bacteria, leading to the leakage of intracellular components and bacterial death.

The results suggest that MgO, ZnO, and Fe2O3 NPs can be applied for industrial food processing as effective antimicrobial compounds to decrease the temperature required for pasteurizing milk