جستجوی مقالات مرتبط با کلیدواژه « ldl » در نشریات گروه « پزشکی »

This study aimed to investigate the effect of Vitex agnus-castus (VAC), and Salvia officinalis extracts on serum lipids in postmenopausal women referred to the Bone Densitometry Center, Namazi Hospital, Shiraz, Iran.

This randomized clinical trial was conducted on 89 postmenopausal women in 2016 using random permuted blocks with a block size of 3 in the three groups, including the VAC group (3.2-4.8 mg/q8h), S. officinalis group (100 mg/q8h), and placebo group for three months. Women were finally compared in terms of low-density lipoprotein, triglycerides (TG), and highdensity lipoprotein before and after the intervention. Data were analyzed using SPSS-16 software. Descriptive statistical tests and paired t test were used to compare the groups.

A significant decrease in serum cholesterol, low-density lipoprotein, and triglycerides levels and also increase in mean serum high-density lipoprotein levels were observed in VAC and S. officinalis groups before and after the intervention (P = 0.0001). In comparison, no significant change was observed in serum level of any lipoproteins in the placebo group.

Considering the decrease in the level of cholesterol, low-density lipoprotein, triglycerides, and increased highdensity lipoprotein after using VAC and S. officinalis in this study, these herbs can be proposed as blood lipid-lowering agents in postmenopausal women.

 In diabetic patients, lipid profile (LP) management is crucial. Quercetin (QUE), as an antioxidant supplement, has received a great deal of attention in improving the LP.

 The current study aimed to investigate the simultaneous effect of high-intensity interval training (HIIT) and QUE on LP in male diabetic rats.

 Fifty Wistar male rats were randomly assigned to healthy control (HC; n = 10), diabetic control (DC; n = 10), high-intensity interval training (HIIT; n = 10), quercetin supplement (QS; n = 10), high-intensity interval training and quercetin (HIIQ; n = 10). QUE was given (20 mg/kg/d) to the animals daily for six weeks. HIIT has performed five sessions per week for six weeks in 8-10 sets with 85 - 65% of the maximum oxygen consumption (VO2max) on the treadmill. Blood samples were taken directly from the animal’s heart 48 hours after the last training session, and high-density lipoprotein (HDL-C), low-density lipoproteins (LDL-C), triglycerides (TG) cholesterol (CHOL), and fasting blood glucose (FBS) were measured in the serum. To analyze the data, two-way analysis of variance (ANOVA) and Tukey's post hoc test were used.

 There was no significant difference between HIIQ with HIIT, QS in LDH-C and LDL-C (P > 0.05). Also, no significant difference was seen between HIIT, QS, and HIIQ in TG concentration after intervention (P > 0.05). CHOL was significantly lower in HIIT than QS (P = 0.001), while there was no significant difference between the HIIQ with QS (P > 0.05). Also, there was no significant difference between QS and HIIQ in FBS (P > 0.05).

 It seems that high-intensity interval training and quercetin alone can be effective in improving lipid profile. However, quercetin does not have a synergetic effect with high-intensity interval training in ameliorating lipid profile in diabetic male rats.

 The aim of this study was to compare moderate- versus high-intensity statin therapy in patients with type 2 diabetes and low-density lipoprotein (LDL) cholesterol less than 130 mg/dL.

 This was a randomized, open-label, parallel design trial comprised of 79 patients randomly allocated into two groups receiving high-intensity [atorvastatin 40 mg (A40) or rosuvastatin 20 mg (R20) daily] or moderate-intensity [atorvastatin 20 mg (A20) or rosuvastatin 10 (R10) mg daily] statins for eight weeks. The variables investigated were lipid profile, high sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6).

 The percentage of decrease in LDL levels (±SD) for the high-intensity group (-35.5±25.5) was significantly greater than the moderate-intensity group (-24.6±23.5) (P=0.04). While 38.1% (n:8) of patients receiving A20 and 55% (n:11) of those being on R10 achieved the targets of≥30% reduction in the LDL level, these figures were 63.2% (n=12) and 73.8% (n=14) for A40 and R20 subgroups, respectively. Subsequently, the likelihood of achieving LDL reduction≥30%, was significantly greater with high-intensity statin therapy (OR: 3.1, 95% CI: 1.09, 8.90, P=0.03). Logistic regression analysis also showed that for every 1 mg/dL increase in the baseline LDL level, the odds of achieving the LDL reduction≥30% increased by 1.04 times [95% CI: (1.01, 1.07), P=0.003].

 Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.

Noise induced hearing loss (NIHL) is an irreversible occupational disease among industrial workers. Recent studies have reported that changes in some metabolic factors such as the serum level of sugar and lipids might have a role in suffering from NIHL among workers exposed to noise. We designed this study to assess the association between lipid profile changes and NIHL occurrence among noise-exposed workers.  

This case-control study has been conducted according to noise-exposed workers registry data in one of the Iranian automobile factories between 2007 and 2017. We classified study workers into the NIHL and control groups. We assessed the impact of lipid profile parameters across the study groups using the independent samples t-test, chi-square, and regression.  

The mean serum level of cholesterol was significantly higher in the NIHL group than in workers of the control group (215.27 ± 60.30 vs 204.49 ± 63.69 mg/dL; P = 0.041). Moreover, the serum level of HDL was significantly lower in workers in the NIHL group compared with the control group (35.21 ± 6.87 vs 37.43 ± 7.28 mg/dL; P < 0.001). Although other lipid profile parameters (LDL, TG, LDL/HDL ratio) were higher among workers of the NIHL group, their differences were not significant.  

A cholesterol level lower than 200 mg/dL is known as a protective factor and an HDL level lower than 40 mg/dL is an NIHL risk factor. More attention should be paid to controlling serum levels of cholesterol and HDL.

In multiple sclerosis (MS), oxidative stress (OS) performs a vital role in the neurodegeneration process. Cholesterol and lipids in the myelin sheath supplied by low-density lipoprotein (LDL) are also vital for nerve cells. In OS, lipid peroxidation occurs in LDL. To investigate the OS biomarker such as prooxidant-antioxidant balance (PAB), malondialdehyde (MDA) and their correlation with LDL and oxidized LDL (Oxi-LDL) in patients with relapsing-remitting MS. Blood samples from 18 patients with relapsing-remitting MS and 18 healthy subjects were collected to measure the OS biomarkers. In the patients' group in comparison to the control group: PAB, white blood cells (WBC), and neutrophils significantly increased (P<0.05), but there was no difference between the relapsing and remitting phase; MDA significantly increased in the relapsing phase (P=0.013), but marginally significant in remitting (P=0.068). There was no significant difference in LDL and Oxi-LDL between the two groups. Only the lymphocytes were different between the relapse and remission phases. The importance of OS in the process of MS disease was confirmed and a PAB assay can be used for the determination of OS levels.

Elevated low-density lipoprotein cholesterol (LDL-C) is a significant risk factor for cardiovascular diseases. LDL-C can be directly measured using various methods, but this requires expensive equipment. Currently, clinical laboratories estimate LDL-C based on Friedewald’s formula (FF). We aimed to develop a modified formula based on directly measured LDL-C (D-LDL-C) values in a large population in Southern Iran and compare the results with various other estimation formulas. The participants of this cross-sectional study were adults aged >18 years living in Southern Iran. Blood samples from 15,200 individuals were collected, and the measured lipid parameters were randomly divided into training (n=10,184) and validation (n=5,016) datasets. A new formula was developed using a linear regression model, and its accuracy was validated. Pearson’s correlation and Cohen’s kappa were used to determin the relationship between D-LDL-C and calculated LDL-C (C-LDL-C). The developed formula for the estimation of LDL-C was 0.857 total cholesterol (TC)-0.915 high-density lipoprotein cholesterol (HDL-C)-0.115 triglycerides (TG). Based on our proposed formula, for TG<150 and TG≥150 mg/dL, there was a significant correlation between mean values of D-LDL-C and C-LDL-C (r=0.985 and r=0.974, respectively). Compared to other formulas, C-LDL-C obtained from the proposed formula had the highest correlation with D-LDL-C. The agreement between D-LDL-C and C-LDL-C for TC<200, 200-239, and ≥240 mg/dL was 80.8%, 63.2%, and 67.4%, respectively, indicating a higher level of agreement than other formulas. The new formula appears to be more accurate than FF when applied to the population of Southern Iran.

Olive leaf extract, due to its beneficial chemical compounds, has been used as an effective herbal medicine in the treatment of various human and animal diseases. In this study, the effect of olive leaf nutrition in different weeks of breeding period on performance and metabolic abnormalities was investigated using 336 male Arian strain chickens in a completely randomized format with six treatments, four replications and 14 birds in each replication for of broiler blood, such as triglycerides, cholesterol, heavy lipoproteins (HDL), light lipoproteins (LDL), total protein and blood glucose, based on the AOAO 1990 method, were assessed. The results showed that the mean difference of blood metabolites such as triglyceride and HDL between different treatments were not significant (P˃0.05), however, for LDL and blood cholesterol levels this difference was significant (P <0.05). Regarding the anti-diabetic and hypoglycemic function of olive leaf extract in regulating blood glucose and increasing serum insulin, as well as the average total protein, the results showed no significant difference. In conclusion, olive leaf can be used in diets of broilers and further studies on-farm conditions may justify its impact on growth performance.

To review the antioxidant and anti-atherosclerotic potential of whole banana, banana flour, and its bioactive compounds.

A non-systematic review of the literature covering the past 20 years, using the following databases and searching bases: PUBMED/MEDLINE: https://www.ncbi.nlm.nih.gov/pubmed/; Google Scholar: https://scholar.google.com.br/; and “Literatura Latinoamericana em Ciências da Saúde”/Latin American Literature in Life Sciences [LILACS]: http://lilacs.bvsalud.org/, was done. Studies with incomplete methodology and design were excluded.

Bananas from different species are a good source of carbohydrates, dietary fiber, proteins, polyunsaturated fatty acids, potassium, carotenoids, flavonoids, vitamin C and E, phytosterols, gallocatechin, catechin, and other polyphenols. Some of these compounds play trigger important biological roles as antioxidants or anti-atherosclerotic and cardiovascular protective substances. This review summarizes and explains thirteen protective biological mechanisms of banana bioactive compounds and banana products.

Including banana and its products in dietary menus, in food products and nutraceuticals should improve cardiovascular health of the populations.

Diabetes mellitus (DM) is a leading cause of morbidity and death worldwide. DM will affect 570.9 million people worldwide by 2025. The usefulness of vitamin C in improving diabetes control has been a point of contention.

This clinical-trial double-blind study with control groups was conducted on 164 patients with type 2 diabetes mellitus (T2DM). The intervention group received 1000 mg of oral vitamin C daily, and a placebo was administered to the controls. To analyze the obtained data, one-way ANOVA was used in SPSS software (version 20). A P< 0.05 was considered statistically significant.

Fasting blood sugar (FBS), hemoglobin A1c (HbA1C), triglyceride (TG), and high-density lipoprotein (HDL) were improved significantly in the intervention group (P< 0.05), while the low-density lipoprotein (LDL) and cholesterol were unaffected (P> 0.05). HbA1C and LDL levels in the control group increased significantly (P< 0.05). Meanwhile, this group's HDL levels decreased considerably.

Our findings support the consumption of vitamin C to complement the primary treatment for DM. According to our results, vitamin C provides a clear benefit over a placebo in the treatment of diabetic patients' serum parameters.

Background

This meta-analysis was performed to investigate the effect of serum lipids on the risk of breast cancer incidence.

PubMed, Web of Science, Scopus, and EMBASE were searched systematically from January 1998 to April 2019. Inclusion criteria were English observational studies (cohort or case-control) and the concentration of at least one of the lipid profile components (total cholesterol/triglycerides/low‑density lipoprotein cholesterol/high‑density lipoprotein cholesterol) measured before a diagnosis of breast cancer (BC). The studies were included in which the relative risk (RR) had been reported with 95% confidence intervals (CIs). A random-effects model was used.

Results:

 A total of 25 studies were found, including 2,882,789 participants in cohort studies with 45,481 cases with BC, and 1983 BC cases and 2963 case-control studies. Combined RR of cohort studies for the highest versus lowest for the BC was LDL-C: 0.95 (95% CI: 0.89–1.01), triglycerides (TG): 0.95 (95% CI: 0.91–0.99; P = 0.02), total cholesterol (TC): 0.98 (95% CI: 0.91–1.05), and HDL-C: 0.86 (95% CI: 0.63–1.18). Combined RR of case-control studies for the highest versus lowest was LDL-C: 1.08 (95% CI: 0.78–1.48), TG: 1.73 (95% CI: 0.94–3.18), TC: 1.02 (95% CI: 0.80–1.29), and HDL-C: 0.79 (95% CI: 0.65–0.97).

Conclusions:

 Based on the results, it can be concluded that only TG but not TC and/or LDL‑C had a significant inverse association with the risk of BC incidence. HDL‑C showed a significant protective effect against breast cancer in postmenopausal women and case-control studies.

Globally, cardiovascular diseases (CVDs) are the leading cause of death and disability. Elevated low-density lipoprotein-cholesterol (LDL-C) and more specifically, elevation of its small, dense phenotype (sdLDL-C) has been regarded as the key modifiable risk factors associated with atherogenesis. This study aimed to determine the association of LDL-C and sdLDL-C with the development of CVDs in the next six months to establish their predictive efficacy. 

A batch of 162 anonymized serum samples sent for analysis of lipid profile parameters, were classified into tests and controls based on the calculated LDL-C values obtained by Fried Ewald formula. Direct LDL-C was also estimated automatically using assay kits. Using the formula provided by Srisawasdi et al., sdLDL-C was then computed for all samples. Six months later, samples were deanonymized, and the lipid profiles were compared with cardiovascular outcomes of these patients, to determine which parameter had the greatest correlation. 

Four control group patients and three test group patients developed the outcome (any cardiovascular event) during the 6-month follow-up period. Binary logistic regression analysis showed that none of the lipid profile parameters: calculated LDL-C (OR= 0.99; 95% CI= 0.97-1.01; p= 0.826), direct LDL-C (OR= 0.99; 95% CI= 0.97-1.01; p= 0.818) or sdLDL-C (OR= 0.99; 95% CI= 0.93-1.04; p= 0.734), were significantly associated with the occurrence of outcome. The median % sdLDL-C both with respect to direct and calculated LDL-C was slightly higher in patients with the outcome. 

The levels of LDL-C or its individual phenotypes may not be used singly as indicator of cardiovascular morbidity in the next six months.

Diabetes mellitus is a chronic metabolic disorder characterized by defect in insulin secretion and action resulting in hyperglycemia. Diabetic patients have deranged body metabolisms particularly for lipids which may result in abnormal levels of serum levels of lipids.

The aim of this study is to find any possible correlation between the the glycosylated hemoglobin and the lipid profile in patients with type 2 diabetes mellitus in Duhok city. A total number of 235 patients with type 2 diabetes were included.

The mean age was 56.19 years, and females constituted 73.2%. The mean duration of diabetes was 101.30 months, and the mean level of HbA1c was 8.0297 %. About 58.30% had good glycemic control, 28.51 % had poor control, and 13.19% had excellent control.
The mean level of the serum cholesterol was normal (180.63 mg/dl), and the mean level of serum triglycerides were elevated (188.46 mg/dl), the mean level of the LDL was elevated (102.07 mg/dl), and the mean HDL level was normal (47.30 mg/dl).
There was a significant correlation between the mean level of HbA1c and LDL levels (P value 0.005) while the correlation was not significant for other types of serum lipids such as triglycerides, cholesterol, and HDL (P values 0.879, 0.091, and 0.253) respectively,

Elevated glycosylated hemoglobin may be an indicator of derangement of the lipid metabolism and elevated levels of serum lipid profiles which indirectly may indicate high risk factor and as a predictor for increased risk of end stage vascular disease.

Parkinsonchr('39')s disease (PD) is defined as a long-lasting, neurological illness. Low levels of serum lipid fractions are related with a high risk of PD. Current investigation was designed to evaluate the concentration blood lipid fractions in patients suffering from PD and compared with healthy subjects.

This case-control study was conducted from February 2016 to September 2018 in Tabriz University of Medical Sciences, Tabriz, Iran. The present investigation consisted of 75 persons who had PD and 75 normal people. The blood levels of lipid fractions were measured by concentrations of total cholesterol (TC), serum triglycerides (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and total cholesterol. The results were analyzed with SPSS software using Kolmogorov-Smirnov, chi-square, and studentchr('39')s t-test.

Serum level of TG was remarkably lower in patients with PD (111.92±8.75 mg/dL) compared with healthy subjects (123.64±9.97 mg/dL, P=0.008).  Furthermore, we saw an important difference in the level of LDL-C (P=0.001) and TC (P=0.004) between the two groups. However, there was not any observed meaningful difference in the serum concentrations of HDL-C between the studied groups (P=0.135).

Our results showed that the serum concentration of TG, LDL-C, and TC are noticeably lower in the PD suffering patients. Further investigations are needed to provide comprehensive information on the participantschr('39') cognitive layout and subsequent actions.

Few pieces of evidence are available about the association between occupational exposure to vegetable oil and the risk of blood lipid problems. This study was aimed to investigate the relationship between exposure to vegetable oil and blood lipid profile in a vegetable oil factory.

This retrospective cohort study was carried out on 30 male workers exposed to vegetable oil as an exposed group and 30 male office workers as an unexposed group in a vegetable oil factory. Blood lipid profiles as total cholesterol, triglycerides, Low-Density Lipoprotein (LDL), and High-Density Lipoprotein (HDL) were measured by analyzing the blood samples in both groups in a clinical laboratory.

There were no significant differences between the two groups in terms of age, body weight, height, Body Mass Index (BMI), and physical activity. The results showed significantly higher mean levels of triglyceride and LDL in the exposed group compared to the unexposed group (P < 0.001), while HDL mean levels in the exposed group were significantly lower than the unexposed group (P < 0.001).

The findings revealed the possible association between blood lipid disorders and occupational exposures to vegetable oil. Further researches are proposed to study the mechanisms of occupational respiratory and skin lipid absorptions in different types of vegetable oils.