جستجوی مقالات مرتبط با کلیدواژه « lh » در نشریات گروه « پزشکی »

Primary dysmenorrhea significantly affects the daily lives and performance of girls. This study aimed to investigate the effects of resistance training and melatonin consumption on sex hormone levels, PGF2α, FSH, LH, pain intensity, and sleep quality in girls with primary dysmenorrhea.

This semi-experimental study included 60 girls with moderate primary dysmenorrhea randomly assigned to four groups: exercise + melatonin, exercise + placebo, melatonin, and control (15 girls in each group). Participants in the exercise + melatonin group received 10 mg of melatonin daily, while the placebo group received an equivalent amount of carbohydrates. The resistance training program involved 50-60 minutes of weight training daily, three days a week for eight weeks. Pain intensity was evaluated using the McGill questionnaire, and sleep quality was assessed using the Pittsburgh questionnaire. Serum levels of sex hormones, PGF2α, FSH, and LH were also measured.

The exercise + melatonin group exhibited a significant increase in estrogen (P<0.001), progesterone (P<0.001), LH (P<0.001), and FSH (P<0.001) levels compared to all other groups. Additionally, both the exercise + placebo group and the melatonin group showed higher levels of these hormones compared to the placebo group. The melatonin group demonstrated reductions in PGF2α (P<0.001), pain intensity (P<0.001), and sleep quality (P<0.001) compared to all other groups. Similar improvements were observed in the exercise + placebo group and the exercise + melatonin group compared to the placebo group.

The findings reveal that hypothalamic and corticotropin hormone release may play a role in primary dysmenorrhea. Melatonin appears to modulate sex hormone fluctuations associated with primary dysmenorrhea, leading to improved sleep quality and reduced pain intensity by decreasing PGF2α levels.

Melon seeds have estrogenic, anti-cancer, anti-diabetic, anti-obesity, and antioxidant effects. The present study aimed to investigate the effect of the hydroalcoholic extract of melon seeds on the pituitary-gonadal axis and the tissue changes of the testis in adult male rats.

In this experimental study, 50 adult male Wistar rats weighing 210-230 g were assigned to five groups (n=10). The Control group received no extract or solvent; Sham group: 1 ml of distilled water as a solvent; experimental group 1: Melon seed extract (50 mg/kg), experimental group 2: Melon seed extract (100 mg/kg), Experimental group 3: Melon seed extract (150 mg/kg). After 21 days of treatment by the intraperitoneal method, blood was taken from the animals. The serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone were measured by radioimmunoassay (RIA). Thereafter, the testicles were removed, and tissue changes were examined by hematoxylin-eosin staining. The collected data were analyzed in SPSS software (version 18) using a one-way analysis of variance and post hoc Tukey's test.

The mean body weight in experimental groups 2 and 3 demonstrated a significant decrease compared to the control and sham groups (P<0.001). The mean weight of the testes in experimental groups 2 and 3 displayed a significant increase compared to the control and sham groups. The mean concentration of testosterone hormones, FSH, LH, the number of spermatogonial cells, primary spermatocytes, spermatids, Sertoli, and Leydig cells, as well as the number of sperm cells in experimental group 3,  had a significant increase compared to the control and sham groups (P<0.001).

As evidenced by the results of this study, the hydroalcoholic extract of melon seeds had stimulating effects on the pituitary-gonadal axis and testicular tissue in adult male rats.

The function of the hypothalamus-pituitary-gonadal axis plays an important role in regulating fertility. This study aimed to investigate the effect of intracerebroventricular (ICV) injection of salmon calcitonin (sCT) on sex hormones and sperm quality in rats.

This experimental study was conducted in 2023 at Shahid Chamran University of Ahvaz and Shiraz University. Twelve rats divided into two groups (n = 6). Rats of the first group (control) injected with artificial cerebrospinal fluid with a volume of 5 microliters ICV. Rats of the second group injected ICV with sCT at a dose of 1.5 nmol with a volume of 5 microliters. 72 hours after ICV injections, the serum levels of LH, FSH and testosterone measured. Also, sperms from the epididymal region were used to determine sperm quality.

ICV injection of sCT decreased the levels of LH, FSH, and testosterone significantly. The sCT reduced sperm density significantly, but not motility, compared to the control group. The sCT decreased significantly intact acrosome and increased damaged acrosome compared to the control group.

ICV injection of sCT can reduce sperm quality, probably through induction of an imbalance in FSH and LH production as well as testosterone.

Vitamin D has antioxidant and anti-inflammatory activities. The present study aimed to investigate the protective effect of vitamin D on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), testosterone hormones and testicular tissue changes induced by methotrexate in adult male rats.

In this experimental study, 30 adult male Wistar rats weighing 230-260 g were divided into six groups (n=5). Control group: They received no extract or solvent, sham group: 1 ml of distilled water as a solvent, treatment group 1: methotrexate (5 mg/kg) (gavage), treatment group 2: vitamin D (1000 IU/kg), treatment group 3: methotrexate (5 mg/kg) + vitamin D (500 IU/kg), and treatment group 4: methotrexate (5 mg/kg) + vitamin D (1000 IU/kg). After 28 days of treatment in the form of gavage, blood was taken directly from the heart to measure the serum concentration of LH, FSH, and testosterone hormones. The testes were removed and tissue changes were examined with hematoxylin-eosin staining. The collected data were analyzed using SPSS (version 18), one-way analysis of variance, and post hoc Tukey's test.

In the group receiving methotrexate, the level of testosterone hormone, the number of spermatogonia (P>0.001), spermatocytes (P>0.001), sperm (P>0.001) and Leydig cells (P>0.001) decreased and the serum level of LH (P>0.001) and FSH (P>0.001) increased significantly compared to the control and sham groups. In groups receiving methotrexate + vitamin D, vitamin D was able to compensate for the adverse effects caused by methotrexate.

Our results showed that vitamin D could improve LH, FSH, testosterone hormones, and testicular tissue changes induced by methotrexate in adult male rats.

Primidone is effective in the treatment of epilepsy. In this research the effects of primidone on LH, FSH, testosterone hormones, body weight and testicular tissue in adult male rats, was studied.

In this experimental study, 50 adult male Wistar rats, weighing approximately 180-200 g were divided into 5 groups of 10 animals. Groups: control group, Sham group and treatment at doses of 20, 40, 60 mg/kg, orally for 42 days (every other day) respectively. At the end, after determining the animal's body weight, blood samples was collected from the heart. Hormone concentrations of LH, FSH and testosterone were measured by RIA.Their testis were removed and weighed to evaluate the histological changes after hematoxylin-eosin staining.

The body weight, testis weight and leydig and sertoli cells in all experimental groups showed no significant changes compared to the control group. The plasma levels of LH and FSH in all experimental groups increase significantly compared to the control group. The plasma level of testosterone Hormone and number of  spermatogonia,primary spermatocyte and spermatid in all experimental groups decrease significantly compared to the control group (P<0.05).

primidone reduced levels of testosterone and increase levels of LH and FSH hormones.

Tranylcypromine is a monoamine oxidase inhibitor (MAOI)-it is a nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO). It is used as an antidepressant and anxuolytic agent in the clinical treatment of mood and anciety disorders, respectively. In this research, the effects of Tranylcypromine the serum concentrations of LH, FSH and Testosterone as well as changes in body weight and testicular tissue were studied in rats.

50 adult male Wistar rats with approximate weight of 200-250 gr were divided into 5 groups of 10 animals: the control ,sham group and three experimental groups receiving 40, 20 and 10 mg/ kg Tranylcypromine, respectively. The drug was orally administered for 21 days. Following wighting at the end of this period, blood samples were taken from each rats, centrifuged to obtain serum, and testis were removed,weighted and fixed to examine their possible histological changes. Serum samples were frozen at -20 Ԩ to be studied later. The serum cocentrations of LH, FSH and testosterone were measured by RIA. After tissue sectioning and staining with hematoxylin-eosin, testicular tissues were examined by light microscope. The SPSS and Excel software and ANOVA and Tukey tests were used for statistic analyze.

The results showed that 21 days consumption of maximum doses of Tranylcypromine, significantly increases concentrations of LH and FSH hormones and significantly reduce testosterone concentration in maximum doses and leydig cells in all three experimental groups (P≤0.05). In addition, no significant effect was observed in the body weight, testicular weight as well as Sertoli cells. Moreover, testicular tissue study indicates that 21 days of Tranylcypromine consumption significantly reduces spermatogony,spermatid , spermatocyte and thus, affects spermatogenesis.

Tranylcypromine drug reduced levels of testosterone and increase levels of LH and FSH hormones.

Regarding wide range of saffron applications in traditional medicine and its proved effects on male sex hormones and also the importance of muscle contraction in stimulating the secretion of sex hormones, the aim of this study was to study the interactive impact of saffron supplement and resistance training on sex hormones levels (testosterone, LH and FSH) in young adults.

In the form of semi-experimental design, 30 young men were selected as samples and randomly assigned to two resistance training groups: one with mere resistance training (n= 15) and the other with both resistance training and saffron supplements (n= 15) groups. These two groups carried out a resistance training protocols of 60 to 70% 1 RM. In this manner, the latter participants were consuming 150 mg pure saffron tablets per day, in the same period. Bloodletting was performed, before and after six weeks, to assess variables. Thereafter, the research findings were analyzed using independent t-test at a significance level of 0.05.

Data analysis showed that training and training with saffron supplements has significantly increased levels of testosterone, LH and FSH (p≤0.05). Also, significant difference in levels of testosterone, LH and FSH between mere resistance training and resistance training with saffron supplement groups was observed (p≤0.05).

Generally, it could be concluded that synergistic effect of saffron supplements and resistance training would further increase the sex hormones in young men.

Gonadotropin is the most important hormones controls reproductive activity and thus regulates the activity of the gonads. One of the aspects of hormone disorders which caused by lead is its effect on the gonads and it leads to reproductive hormone imbalance and fertility reduction. This study aimed to investigate the effect of parsley’s leaf extract (Petroselinum crispum) on serum levels of gonadotropin and testosterone hormones in male rats which have received lead acetate.

In this study, 36 male Wistar rats that were divided into six groups: control group, witness group, receiving lead acetate, group six receiving distilled water with 150 mg/kg dose, the experimental groups 1, 2 and 3 treated with lead acetate concentrations of 100, 150 and 200 mg/kg and received parsley’s extract in 8 days by daily intra-peritoneal injection. After 28 days, animals were weighted and blood samples were taken from them. Serum concentrations were measured using ELISA method.

Lead acetate increased serum levels of testosterone, LH, and FSH, respectively. Increasing dose of parsley’s extract leads to decrease serum levels of LH and FSH (P

Parsley effect on gonadotropin hormones and testosterone in male rats receiving lead acetate is justified.