The effect of different intensity circuit resistance training on gremlin-1, Macrophage migration inhibitory factor and some cardiovascular risk factors in obese men

More Adipose tissue is associated with the increase of inflammatory markers in obesity. This study aimed to evaluate the effect of different intensity circuit resistance training on gremlin-1, Macrophage migration inhibitory factor and some cardiovascular risk factors in obese men.

In a semi-experimental trial, 44 obese men were selected and randomly divided into four groups including control (n=11), low intensity circuit resistance training (n=11), moderate intensity circuit resistance training (n=11) and high-intensity circuit resistance training (n=11) groups. Resistance training was performed in different intensities included 1) High-intensity circuit resistance training (80% 1RM) 2) Moderate intensity circuit resistance (60% 1RM) and 3) Low intensity circuit resistance training (40% 1RM), three sessions per week for 12 weeks. Serum levels of gremlin-1, MIFand Lipid profile (cholesterol, triglyceride, LDL and HDL) were measured using kit and ELISA method. Data were analyzed with Analysis of variance with repeated measures, dependent t-test and Bonferroni post hoc test at the P < 0.05.

12 weeks of circular resistance training with low, moderate and high intensity caused a significant decrease in gremlin-1 and MIF levels, significant decrease in cholesterol, triglyceride and LDL-c levels and significant increase in HDL-c levels (P = 0.001).

It seems that circular resistance training with different intensities and especially high intensity can be an effective factor in counteracting the increase in observation of cardiovascular risk factors in obese people.