سید حسین ابطحی ایوری

This study aimed to investigate the protective effects of aqueous and ethanolic extracts of Caryophyllus aromaticus on DNA damage in mononuclear white cells of human blood using the COMET method.

Mononuclear white blood cells were isolated from blood samples taken from 15 healthy volunteers. Cells were treated with H2O2 (25, 50, 100, and 200 μM), as well as with aqueous and ethanolic extracts of aerial parts of cloves (0.05, 0.1, 0.5, 1, and 2.5 mg/ml). Finally, to induce DNA damage the cells were incubated in a combination of 100 μM H2O2 with each of the two aqueous and alcoholic extracts at a concentration of 2.5 mg/ml at 4°C for 30 minutes. The extent of DNA migration was measured using the alkaline single cell gel electrophoresis approach assay, and DNA damage was expressed as tail length (µm), percentage of tail DNA, and tail moment (µm).

DNA damage in the mononuclear white blood cells exposed to the combination of hydrogen peroxide with aqueous extract of clove plant was significantly less than that in the mononuclear white blood cells treated with H2O2 alone. Tail length (µm) was 5.30±1.21 versus 21.84±3.91, percentage of tail DNA (%) was 4.29±1.21 versus 16.21±4.18, and tail movement (µm) was 0.24±0.08 versus 2.35±0.72, respectively (p < 0.001).

The results showed that the aqueous extract of clove plant (2.5 mg/ml) can prevent oxidative DNA damage in human mononuclear white blood cells, which is probably due to the presence of antioxidant compounds in the extract.

Helicobacter pylori infection is known as one of the health problems in the world, and the concurrent infection of diabetics with Helicobacter pylori contributes to health and economic problems in the world. The present study was conducted to investigate the prevalence of Helicobacter pylori in patients with type 2 diabetes in Gonabad City, Iran.

This case-control study was conducted in Gonabad City, Iran. The number of participants in the study was 168. The method was simple random sampling and the study population was typing 2 diabetic and non-diabetic people who were referred to Gonabad health centers. After obtaining informed consent from the patients, 4 milliliters of venous blood were collected from the patients with type 2 diabetes and the control group, and IgG antibodies against Helicobacter pylori and Fasting Blood Sugar and Glycosylated Hemoglobin (HbA1C) were measured by ELISA and Colorimetric method, respectively. After entering the data into SPSS version 16 software, they were analyzed using independent tests, chi-square tests, and logistic regression tests.

In the present study, 71.4% of type 2 diabetes patients had IgG antibodies against H. pylori bacteria. The odds ratio of diabetes in the patients with positive IgG was 1.37 times that of patients with negative IgG, and this relationship was statistically significant (P=0.003).

The present study showed that H. pylori was more common in diabetic patients than non-diabetic ones, and in diabetic patients, there was no statistically significant relationship between the duration of diabetes, family history of diabetes, and smoking history with Helicobacter pylori infection.

The present study aimed to explore the shielding effects of aqueous and ethanolic extracts of Zataria multiflora Boiss on human lymphocyte DNA damage using the comet assay.

This study was conducted as a laboratory experiment to investigate the protective effects of thyme in preventing DNA damage. Peripheral blood lymphocytes were isolated from 16 healthy volunteers. First, the cells were treated with 100 μM H2O2 and aqueous and alcoholic extracts of thyme leaves with a concentration of 2.5 mg/mL separately. Finally, the cells were incubated in a mixture of H2O2 to cause DNA damage with each of the two aqueous and alcoholic extracts at 4°C for 30 minutes. The amount of DNA migration in cells was measured using the Comet method, and DNA damage was expressed as three indicators: sequence length, percentage of DNA in the sequence, and the amount of sequence movement.

The results showed that the DNA damage of lymphocytes exposed to the ethanolic extract of Z. multiflora Boiss was significantly lesser than the H2O2-treated lymphocytes. In addition, tail length (µm) was 5.48±1.62 versus 22.82±6.90, tail DNA (%) was 4.56±1.55 in contrast to 16.00±4.55, and tail moment (µm) was 0.28±0.11 against 2.33±0.83 (p < 0.001).  The results showed that Z.multiflora Boiss aqueous and ethanolic extracts were significantly able to scavenge DPPH radicals through a possible radical scavenging activity mechanism.

As a result, the ethanolic extract had a better effect than the aqueous extract of Z. multiflora Boiss in preventing oxidative DNA damage to human lymphocytes.

Various studies have demonstrated that different rest Intervals has a significant effect on hormonal, metabolic and cardiovascular responses. This factors can lead to different muscle damage responses.

20 untrained subjects (25.4 ± 0.068 years, height 1.74 ± 0.97 cm and weight 30.8 ± 8.48 kg) in three sessions of eccentric resistance exercise with 24 hours rest between each session Participated in this study. Subjects were divided into 2 groups of 10 subjects who performed 50 eccentric contractions with number of 5 sets, 10 repetitions, and the interset rest interval 1 and 3 minutes with 85% of one repetition maximum (1RM). Alpha necrosis tumor factor, were measured immediately before , immediately after each session and 24 hours after the last training session. Variance analysis with repeated measurment and Bonferroni post- hoc test were used to statistical analysis of data.

Alpha necrosis tumor factor in the immediately after each training session and 24 hours after the last training session in 2 groups significantly increased (P <0.05), but no significant difference in All dependent variable was found in 2 groups at different time points.

The repetition of eccentric exercise for three consecutive days causes muscle damage that can be a factor influencing the immune system and causing inflammatory responses in untrained individuals independent of manipulating the interset rest intervals.

The aim of this study was to determine the effect of twelve weeks of manual therapy on pain and range of motion in women with chronic non-specific back pain.

In this clinical trial study, 50 women between 25 and 65 years old with chronic non-specialized low back pain were randomly selected and divided into two experimental groups of manual therapy with mean age (28.15 ±7.00), weight ( 60.00±8.11), height (165.18 ±7.60) and a control group with mean age (40 ± 15.00), weight (60±9.00), height (160±8.00) were divided. The control group was given only low back pain training program and the experimental group received manual treatment for 12 weeks and 1 session per week. The variableswere measured in two stages of pre-test and post-test. In order to analyze the differences within the group, paired t-test and one-way analysis of variance were used to examine the differences between the groups.

The results showed that training intervention was effective in improving pain and range of motion, a statistically significant difference was observed between the experimental and control groups (p <0.05).

In general, the results of the present study showed that pain and range of motion in women with chronic low back pain after 12 weeks of training consisting of twelve sessions of treatment during 12 weeks and once a week improves for manual therapy.

The educational status of students during their studies in universities is very important. Being aware of the shortcomings and factors related to the educational status and recognizing in a timely manner, it is possible to provide solutions to prevent students᾽ academic failure. Therefore, this research was conducted to study the relationship between educational status and related factors in paramedical students of Gonabad University of Medical Sciences.

This descriptive -analytical study has been done between 2018 and 2020. The study population included students of the paramedical faculty of Gonabad University of Medical Sciences who had spent at least one semester at Gonabad University of Medical Sciences and were selected by census method. Data collection tool was a questionnaire consisting of two parts: demographic information and Pham and Taylor questionnaires that were used to assess the educational status. Data were analyzed through descriptive statistics (Frequency , mean and standard deviation), Pearson and Spearman- Brown correlation coefficient test, independent t- test and one- way analysis of variance by SPSS.

Of the 330 students who were participated in this research, (43.6%) were male and (56.4%) were female. The results showed that (45.8%) had favorable educational status, (53.6%) had average and (0.6%) had unfavorable educational status. There was a statistically significant relationship between academic achievement with marriage (p = 0.006) and field of study (p <0.001). there was a significant relationship between the father’s job and academic achievement (p = 0.008). The results showed that the academic achievement scores of students with average economic status were lower and the grade point average of the whole class who had unfavorable economic status was also lower. In other words, there was a significant relationship between grade point average and economic status (p = 0.026).

According to the findings of the present study, the majority of the students had moderate academic status and some factors related to it were marital status, field of study and parent occupation. In order to promoting academic achievement and preventing students’ academic failure, programs such as student counseling, identifying and helping students at risk, empowering professors to help students and improving their academic motivation can be done.also Providing training workshops and using lesson planning is suggested.

Moderate to severe exercise trainings may damage most of the body’s tissues, but the use of antioxidant supplements can modulate the exercise-induces oxidative stress. The purpose of the present study was to investigate serum changes of glutathione peroxidase (GPX) and superoxide dismutase (SOD) in sedentary females consumed coenzyme Q10 following a moderate or severe acute resistance training.

The present research was a semi-experimental study. Twenty seven female students were randomly divided into three groups including two resistance training groups and one control group. Two intervention groups performed one session of resistance training with moderate intensity (70% 1RM) and severe intensity (85% 1RM) at the beginning and end of two weeks of the research protocol. During these two weeks, they orally consumed 30 g/day coenzyme Q10 supplement. Blood sample was taken immediately after the acute training and supplementation. GPX and SOD activity were measured by enzymatic colorimetric method. The results were extracted using repeated measure ANOVA and LSD tests at the p<0.05 significant level.

Moderate and severe acute resistance training did not cause a significant changes in serum enzyme GPX (p=0.06, p=0.19 respectively) and SOD (p=0.42 and p=0.61 respectively) activity, but after two weeks of coenzyme Q10 supplementation it was associated with increases in the activity of SOD (p=0.01, p=0.006) and GPX (p=0.01). Comparing the effect of the two types of training, intensive resistance training resulted in a further decrease in GPX index (p=0.002).

The use of short-term coenzyme Q10 supplementation improves antioxidant status of sedentary individuals and can alleviate the anxiety of practitioners to avoid the damaging effects of oxidative stress after intense acute resistance training (above 85% 1RM) and can be included with other supplements as a nutritional strategy.

Hepatitis B infection is one of the common diseases and the most prevalent communicable virus transferred by blood to the healthcare personnel. Active immunity, through vaccination, is the most effective way to prevent hepatitis B infection. The current study aimed to determine the protective antibody titer against HBs antigen in Gonabad University of Medical Sciences students, Gonabad City, Iran, 2018.

The present cross-sectional study was conducted on 416 students of Gonabad University of Medical Sciences. The HBsAb level was determined in blood samples by an Enzyme-Linked Immunosorbent Assay (ELISA) kit made in Iran. Data were analyzed using descriptive statistics like frequency distribution tables and inferential statistics as independent 2-sample t-test and Chi-square test to determine the relationship between variables. The significance level was considered P<0.05.

HBsAb level of 217 cases (51.8%) was below 10 IU/mL, 96 (61.3%) had an HBsAb level between 10 and 100 IU/mL, and in 106 (36.5%) cases, HBsAb level was above 100 IU/mL. There was no statistically significant difference between the means of HBsAb in terms of gender, age, and body mass index (P<0.05).

In general, more than 50% of the study participants had mild immunity against hepatitis B viruses. Therefore, in these people, it is recommended to check the antibody titer periodically to ensure immunity against hepatitis B.

This study was performed to investigate the effect of cholestasis on memory and the role of sex difference in this effect.

This experimental study performed at Gonabad University of Medical Sciences, male rats were divided into 4 groups of 8 (sham and 3 cholestatic groups) to investigate the effect of cholestasis (7, 14 and 21 days) on lateral memory. To evaluate the effect of sex difference on the memory of cholestatic mice, rats were divided into 6 groups of 8 (male and female sham, male and female gonadectomy, male and female cholestatic-gonadectomy). In the gonadectomy groups, the testicles and ovaries were surgically removed, in the cholestatic groups, the bile duct was closed, and in the sham groups, only surgical stress was received. A shuttle box was used to evaluate the passive avoidance memory. Data were evaluated by PRISM software and ANOVA test.

In the study of memory in male cholestatic groups during days 7, 14 and 21, after cholestasis, the mean latency of dark room entry in all three groups were significantly reduced (P <0.05) compared to the sham group. Also, in the male gonadectomy group, the mean delay time in entering the dark room compared to the sham group showed a significant decrease (P < 0.05). In male and female cholestatic-gonadectomy groups, this time was significantly reduced compared to male and female sham groups as well as male and female clastatic (P < 0.05, P < 0.001).

Based on these findings, it can be concluded that due to the sex difference in the effect of cholestasis on memory and learning, sex hormones may have some protective effect on memory impairment due to cholestasis.

Fibroblast growth factor 21 (FGF21) increases lipolysis and fatty acid oxidation. The effect of different volumes of resistance training on FGF21 is not well defined. Therefore, the aim of this study was to compare the effects of high and low volume of resistance trainings on serum level of FGF-21, body composition and mobility in sedentary obese older women.

Thirty sedentary obese elderly women (age 64.57±4.50 years, body mass index 32.34±2.69 kg/m2, and body fat percent 40.93±2.11) who were resident in Mashhad participated in this quasi-experimental study. The subjects were randomly assigned into three equal groups of control, low volume resistance training (LVRT), and high volume resistance training (HVRT). The subjects performed LVRT (one-set) and HVRT (three-set) protocols twice weekly for 12 weeks. Anthropometric and biochemical evaluations were carried out one week before the first session and 48 hours after the last session. In addition, 30-second chair stand, arm curl, two minutes step and eight foot up-and-go tests were evaluated. Dependent t-test and analysis of covariance were used to examine the intra- and inter-group differences, respectively.

Following training, the body fat percentage was significantly lower in HVRT group than LVRT group (P=0.001). In contrast, the results in 30-second chair stand (P=0.001) and arm curl (P=0.001) were significantly higher in HVRT group than LVRT group. However, there were no significant differences between two groups of HVRT and LVRT in weight (P=0.999), body mass index (P=0.999), FGF21 (P=0.999), two minutes step (P=0.072), and eight foot up-and-go (P=0.231) at the end of the protocols.

These results demonstrate that three-set resistance training resulted in greater improvements in body composition and mobility than single-set resistance training in obese elderly women.

Cytokines and growth factors plays an important role in increasing the capacity of stem cell proliferation and migration, and recently, attention has also been paid to the role of Physical activity in this regard. The aim of this study was to determine the effect of two types of acute interval and continuous aerobic exercises on serum hematopoietic stem cell CD34 and chemokine SDF-1 in overweight women.

Thirty female overweight students volunteered to participate in the study and then were randomly divided into three equal groups (two experimental and one control group). Experimental groups performed an acute interval (2 minutes 50% and 1 minutes 80% VO2max) and a continuous (60% VO2max) aerobic exercise for 60 minutes on treadmill. The CD34 and SDF-1 indices were measured by ELISA method and the results were extracted using one-way covariance analysis, and LSD post hoc test on statistical significance as p

The acute interval and continuous aerobic exercise increased significantly the stem cells CD34 (p=0.005 & p=0.002, respectively) and the chemokine SDF-1 (p=0.0001) and there is no differences between the effect of two types of exercise on these variables (p>0.05).

The increase in these two indicators following interval and continuous aerobic exercises indicates that not only the implementation of these activities does not have a negative effect on the immune system of the participants, but also could be indication of the activation of the physiological regenerative mechanisms following exercise- induced inflammation.

Morphine as an opioid compound has different and sometimes conflicting effects on memory and learning process. Bile duct ligation causes cholestasis, which disrupts liver function. It is known that opioid systems are involved in cholestasis. The aim of this study was to investigate the possible effect of morphine on the memory of cholestatic rats.

In this experimental study, the cholestatic model in male Wistar rats (weighing 200-250 g) was induced by bile duct ligation (BDL). The animals were injected with morphine (4 and 6 mg/kg, ip), naloxone (0.6 and 0.8 mg/kg, ip), and morphine and naloxone in different groups. Passive avoidance memory was evaluated on day 7 after BDL by shuttle box test.  Data were analyzed by PRISM software and ANOVA.

Naloxone (0.6 and 0.8 mg/kg), 30 min before the test, did not show significant changes in the memory of the cholestatic rats compared to the BDL group, whereas, morphine (4 and 6 mg/kg) showed significant increase in step-through latency (P<0.05). Also, naloxone (0.6 mg/kg, ip) 15 minutes before injection of morphine (6 mg/kg( showed a significant increase in acquired memory on day 7 after BDL (P<0.0001).

According to findings, morphine had a protective effect on memory impairment induced by cholestasis.

Physical activity is usually accompanied by free radicals’ production and oxidative stress. Moreover, to prevent adverse effects, coaches and athletes have to use proper supplementation. Therefore, the present study aimed to investigate the effect of short-term coenzyme Q10 supplementation on malondialdehyde and serum catalase enzyme activity following moderate and severe acute resistance training in inactive female students. 

 In total, 27 female students were randomly divided into three groups; the groups were homogeneous and equal (two groups of resistance training and one control group). The experimental groups were subjected to moderate-intensity acute (70% 1RM) acute and severe acute activity (85% 1RM) and supplemented with coenzyme Q10 (30 mg /d). CAT and MDA were measured in ELISA using a human kit.

 Moderate and severe acute resistance activities did not alter MDA and catalytic activity (P>0.05); however, after 2 weeks of coenzyme Q10 supplementation, those resulted in a significant decrease in MDA (0.006 and 0.01, respectively) and CAT (0.04 and 0.007, respectively). There were no significant differences between the effects of two exercises (P>0.05). 

Short-term (two weeks) supplementation of coenzyme Q10 and severe acute resistance activity could reduce two important oxidative stress indexes (MDA and CAT).

Hydrogen peroxide (H2O2) increases the vascular endothelial growth factor (VEGF), while these two factores are affected by exercise and vitamin E. The aim of the present study was to investigate the effect of vitamin E succinate supplementation along with continuous and interval exercise trainings on VEGF and H2O2 in rat brain.

Fifty-six Albino Wistar rats (12 years old, 250 to 300 gr) were randomly divided into 7 groups: control (C), vehicle (V), supplements (S), continuous training (CT), continuous training + supplement (CT+S), interval training (IT), interval training + supplementation (IT+S). Rat brain was dissected after 6 weeks of continuous (80% VO2max) and interval exercise training (95 to 100% VO2max) along with vitamin E supplementation (60 mg/kg body weight/day). The content of VEGF and H2O2 were measured using sandwich ELISA and colorimetric assay, respectively.Data were analysed using one-way analysis of variance followed by Bonferroni post-hoc comparison at p.

Brain H2O2 (p=0.01 and p=0.001, respectively) level and VEGF (p=0.007 and p=0.001, respectively) increased significantly in both of CT and IT groups compare to C group; while the IT resulted in a greater increase in H2O2 and VEGF than those of CT (p=0.02 for both of H2O2 and VEGF). However, vitamin E supplementation had no significant effect on H2O2 (p=0.59, p=0.99 and p=0.51, respectively) and brain VEGF (p=0.99, p=0.99 and p=0.67, respectively) in S, CT + S and IT + S groups. Furthermore, the results showed a positive correlation between BDNF and H2O2 (r=0.73, p=0.001).

Performing of exercise training with maximal sprint can result in greater increase in some factors involved in angiogenesis than continuous training; however vitamin E succinate supplementation has not effect on these angiogenic gains.

Reactive oxygen species (ROS) result in serious damage oxidation of proteins, lipids and genomic structures. Studies have shown that production of ROS increases during intensive exercise training. The aim of present study was to investigate the effect of two type sprint and endurance exercise trainings on 8-oxoguanine DNA glycosylase (OGG1) and hydroxy-2'-deoxyguanosine (8-OHdG) levels in the brain and liver of Wistar rats. 24 adult Albino Wistar rats were randomly divided into sedentary control, sprint exercise training, and endurance exercise training groups. Rats in sprint and endurance exercise training groups ran on treadmill for 6 weeks, 6 days per week, at 80 to 100 percent of maximal oxygen consumption. OGG1 and 8-OHdG levels were measured using sandwich ELISA assay. Data analyzed using one way ANOVA at P≤0.05 level. Results showed that both of sprint and endurance exercise trainings result in significant increase in OGG1 levels in brain and liver. Sprint exercise training resulted in greater increase in brain OGG1 than endurance exercise training. However, sprint and endurance exercise training had no significant effect on 8-OHdG levels in brain and liver tissues. OGG1 content correlated negatively with 8-OHdG levels. Collectively, sprint and endurance exercise trainings prevents from genomic structure through an increase in OGG1 contents.

The antioxidant supplements to reduce the damaging effects of free radicals after extreme sports is crucial; Thus, the effect of Jujube fruit consumption on serum levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) young men after an intensive anaerobic exercise is studied. The present study was a control quasi-experimental research with two-group including exercise with and without jujube fruit juice. 20 young males were randomly assigned into two homogeneous groups including exercise and user jujube fruit (0.4 mg/kg for 3 weeks) and exercise group. Both groups participated in 30-second Wingate test. Blood samples were collected at three stages including the base, after jujube fruit consumption and after the exercise protocol. Results in SPSS software (version 15) with independent t-tests, analysis of variance with repeated measurements and Post-Hoc Bonferroni, at a significant level, p≤0.05 was extracted. The baseline IL-6 was significantly lower than before and after the Wingate test (p<0.05) and in the training group, IL-6 was significantly higher after the Wingate test than the baseline (p=0.01). The TNF-α post- Wingate test was significantly higher than the baseline and before the test (p<0.05). In the training group, the TNF-α was not statistically significant (p=0.06) in three phases. Moreover, there were no significant differences between the IL-6 and TNF-α changes in the post and or pre-test with the baseline in both experimental or control groups (p>0.05). Jujube fruits do not have the potential to control the IL-6 and TNF-α as inflammatory markers following of the intensive anaerobic workouts

Hypertension is one of most common clinical disorder and there is a positive relationship among prevalence risk of cardiovascular diseases, overweight, and hypertension. This research aimed to investigate the effects of ginger supplement and high intensity interval training (HIIT) on blood pressure, VO2max, and body fat percentage in overweight women.
In this randomized placebo-controlled quasi-experimental study, according to research team facilities, 24 healthy overweight women (age range, 20-30 years), were divided into 3 groups of ginger (n=8), training舩 (n=8), and trainingꙖ鱹 (n=8) and performed 10 weeks of HIIT (40m-maximal shuttle run) and daily consumed 3 g of ginger or placebo tablets. To test the hypothesis of the research, paired t-test, one-way ANOVA, and Tukey post-hoc tests, were used at the significance level of p After 10 weeks, significant decrease was observed in systolic blood pressure in ginger뚶ꊞ⧠ (p=0.001) and ginger (p=0.001) groups, and a decrease was observed in diastolic blood pressure in ginger (p=0.01) group. Also, body fat percentage significantly decreased in ginger뚶ꊞ⧠ (p=0.01) compared to the ginger group, and VO2max significantly increased in training舩 (p=0.000) and trainingꙖ鱹 (p=0.000) groups compared to the ginger group.
Based on the findings of this study, HIIT and ginger consumption can be a good strategy to improve systolic and diastolic blood pressures in women. Also, this kind of trainings is an effective approach in improving cardiorespiratory function and body composition in the population of overweight women.

Studies have reported conflicting results regarding the acute effects of exercise on inflammatory, oxidative stress and muscle damage parameters. Therefore, this study aimed to investigate the effect of acute resistance exercise on serum levels of tumor necrosis factor alpha (TNF-α), as a marker of inflammation, malondialdehyde (MDA), as a marker of oxidative stress, and levels of lactate dehydrogenase (LDH) and creatine kinase (CK), as two markers of muscle damage.
For this purpose, 20 healthy and inactive women (age, 21.55.56 year; BMI, 21.68.26 kg/m2) were randomly divided into acute resistance exercise and control groups. The subjects performed one bout of acute resistance exercise with 85% of one-repetition maximum (1RM) at 8 stations (bench press, leg press, seated rows, overhead press, seated leg press, arm extension, arm curls and calf raises), each exercise were done for 3 sets. Blood samples were taken before and immediately after exercise. TNF-α and MDA levels were measured using ELISA method by commercial kits. Moreover, LDH and CK were measured by photometric method. Paired sample t-test and independent t-tests were used to analyzed dependent variable within and between groups, respectively (p One bout of acute resistance exercise had significant increases (p 0.001) in serum levels of TNF-α and MDA. Also, serum levels of muscle damage parameters, LDH (p=0.03) and CK (p=0.001), showed significantly increases following acute resistance exercise.
One bout of intense resistance exercise is associated with oxidative and muscle damage in inactive women, therefore adoption of training and nutritional approaches are essential when implementing with this kind of exercise.

Intense exercise damages tissues and disturb some cellular processes through oxidative stress and antioxidants can modulate intense exercise-induced oxidative stress. The aim of the present study was to examine the effect of Ziziphus jujube supplements on the glutathione peroxidase (GPX) and superoxide dismutase (SOD) activity in serum after a single session of resistance training. In this semi-experimental study, 24 young non-athletes females were purposefully selected and were randomly divided into two groups; Ziziphus jujube consumption+intensive resistance exercise and intensive resistance exercise. The first group received 0.4g/kg of body weight of Ziziphus jujube daily for 3 weeks, but another group prohibited from Ziziphus jujube consumption. Both groups carried out a session of intensive resistance exercise consisting of 5 movements at 90% of one maximum repetition. Blood samples were measured in three phases; baseline, after 3 weeks of the Ziziphus jujube consumption, and after the resistance exercise session. In order to valuation the enzymes activity the enzymatic method was used. Data were analyzed by the repeated measures ANOVA and LSD tests in SPSS 22 software. The Ziziphus jujube supplement significantly increased GPX activity (p=0.001) but it had no significant (p=0.19) influence on SOD activity. In addition, intensive resistance training significantly decreased the SOD (p=0.03) and GPX (p=0.02) activity immediately after exercise. Using Ziziphus jujube supplements improves the antioxidant enzyme activity of GPX, but this improvement is not likely enough to inhibit the depression of the antioxidant status after performing resistance exercise