جستجوی مقالات مرتبط با کلیدواژه "non-alcoholic fatty liver" در نشریات گروه "تربیت بدنی"

The study of lipid formation and degradation in response to dietary and exercise stimuli may provide a better perspective for preventing and treating nonalcoholic fatty liver disease. Therefore, this study aims to investigate the effects of diet, exercise, and hypoxia on the molecular mechanisms related to lipid metabolism.

A total of twenty-four male Wistar rats aged approximately five weeks with an average weight of 165.9±9.94 grams were randomly divided into four groups including normal diet (ND), high-fat diet (HFD), high-fat diet+exercise in normoxia (HFD+NE), and high-fat diet+exercise in hypoxia (HFD+HE). The maximal aerobic velocity (MAV) was determined under normoxic conditions (at an altitude of approximately 50 m) and hypoxic-hypobaric conditions (at an altitude of approximately 3000 m). Following this, considering overload, exercise sessions were conducted three times a week for a duration of 12 weeks at intensities ranging from 68 to 80 percent of MAV.  At the end, tissue samples were collected to measure changes in the expression of Srebf1, Chreb and Atgl genes. Gene expression was measured using Real-Time PCR method and data were analyzed using ANOVA and Tukey tests at a significance level of p<0.05.

The results showed that in all groups receiving a HFD, liver fat content and expression of Srebf1 and Chreb, genes were increased; whereas the increase in Srebf1 and Chreb was greater in the HFD+HE group than in the other groups. Moreover, Atgl gene expression was lower in the HFD group than in other groups.

A HFD apparently increases liver fat content by increasing lipogenesis and decreasing lipolysis. Exercise is thought to regulate the increase in liver fat content in rats on HFD by increasing the expression of lipolysis genes. Training probably plays a lesser role than diet in altering lipogenic genes expression than nutrition. Hypoxic training had no additional effect on reducing liver fat content.

Introduction and  Oxidative stress and subsequent oxidative damage is one of the main factors in the development of non-alcoholic fatty liver disease (NAFLD). The aim of present study was to investigate comparison the effect of High Intensity Interval Training (HIIT) with and without Portulaca Oleracea Extract on Serum Level of Malondialdehyde (MDA) and Total Antioxidant Capacity (TAC) in Rats with (NAFLD). Twenty five male Wistar rats were randomly divided into five groups: healthy control, fatty liver control, Portulaca Oleracea, HIIT and HIIT+ Portulaca Oleracea. To induce NAFLD, the rats were fed a high-fat diet for 12 weeks. Portulaca Oleracea supplement at 400 mg/kg was given to the experimental groups. HIIT was performed for 8 weeks, 5 sessions per week with 7 repetitions of 1 minute at 90% maximum speed accompanied by active rest intervals including 2 minutes of running at 20% mmaximum speed. To analyze the data, one-way analysis of variance and Tukey's post hoc test were used at the significance level of p<0.05. Serum Level of MDA in fatty liver control was higher than healthy control group (P=0.034). Level of this index in Portulaca Oleracea Extract and HIIT+ Portulaca Oleracea groups were significantly lower than fatty liver control group (P values 0.021 and 0.049 respectively). But No significant difference was observed in the serum level of MDA in the HIIT group compared to the fatty liver control group (P=0.08). Serum level of TAC were significantly higher in Portulaca Oleracea Extract than healthy control and fatty liver control groups (P values 0.044 and 0.001 respectively). Level of this index in HIIT+ Portulaca Oleracea Extract group was significantly higher than fatty liver control group (P=0.003).Discussion and It seems that long term HIIT and Consumption of Portulaca Oleracea extract by reducing lipid peroxidation and improving antioxidant factors in NAFLD subjects, can play an important role in controlling the progress of this disease.

 

Non-alcoholic fatty liver disease, characterized by the deposition of fat in liver cells, can cause fibrosis, cirrhosis, and liver cell damage if not controlled. The aim of this study was to determine the effects of 8 weeks endurance training on fatty liver and lipid profile indices, insulin resistance and body composition in diabetic women with NAFLD.

in this study, 30 diabetic women (age 53±7, height 158±4, and weight 75±9) with non-alcoholic fatty liver participated. Subjects were randomly divided into two groups of control (n=15) and exercise (n=15). The training group program was performed by running in each session for 30-45 minutes and 60-70% of the heart rate reserve and three sessions per week for eight weeks. Liver enzymes, lipid profile, blood sugar, insulin, insulin resistance index, Percent body fat and VO2max were evaluated before and after the training protocol. ANOVA test with repeated measures was used to determine the differences. With confidence interval of P<0.05.

Results of analysis of variance with repeated measures in lipid profile variables (TG, TC, HDL and LDL), liver enzymes (ALT and AST), insulin, insulin resistance, maximum oxygen consumption, WHR, weight and Body mass index showed that the interactive effect of time × group was significant in these variables  (P<0.05). The results of Bonferroni post hoc test reported a significant decrease in fat profile variables in the exercise group compared to the control group except for HDL in the exercise group, which did not show a significant change and in the control group (P <0.05). Also, the comparison between groups showed that there was a significant difference between control and exercise groups in fasting blood sugar factors, ALT, AST, TG, HDL, LDL, insulin, insulin resistance, maximum oxygen consumption, WHR, weight and Percent body fat (P<0.05).Discussion and

These results suggest that moderate intensity aerobic exercise can play an important role in the improvement of these patients by compensating for the destructive effects of type 2 diabetes and non-alcoholic fatty liver. In addition, aerobic exercise can prevent the progression of NAFLD.

The aim of presenet study was survey the Effect of Portulaca Oleracea Supplementation with High Intensity Interval Training (HIIT) on Serum Levels of Liver Enzyme in Rats with Non Alcoholic Fatty Liver (NAFLD).

For this purpose, 25 male Wistar rats randomly divided into 5 groups: healthy control (n = 5), fatty liver control (n = 5), supplement. (N = 5), HIIT (n = 5) and HIIT+ supplement (n = 5). To induce NAFLD, rats were fed a high-fat diet for 12 weeks. Portulaca oleracea supplement at a dose of 400 mg/kg was given to the respective groups. The HIIT training protocol was performed for 8 weeks, 5 sessions per week with 90% of maximum speed. Plasma ALT, AST and ALP levels were measured by photometric methods. For data analysis, one-way ANOVA and post hoc Tukey tests were performed at a significance level of P˂0.05.

AST levels in HIIT training grouP (P=0.007) and supplement+HIIT (P=0.005) was significantly lower than the control grouP. However, despite the decrease in plasma AST levels in the supplement grouP compared to the fatty liver control grouP, this difference was not statistically significant (P=0.052). ALT level in the supplement grouP (P=0.038), HIIT (P=0.047) and HIIT+supplement (P=0.021) was significantly lower than the fatty liver control grouP. There was no significant difference between serum ALP levels of study groups after 8 weeks of HIIT training and portulaca oleracea supplementation (P=0.657).

Base on these results probably Portulaca Oleracea Supplementation with HIIT can be used as a complementary and non-pharmacological therapy in people with NAFLD.

  Inactivity and incorrect eating habits are the most important factors in the prevalence of non-alcoholic fatty liver disease. Therefore, due to the importance of preventing metabolic diseases, the aim of this study was to evaluate the effect of high intensity interval training (HIIT) on serum levels of selenoprotein P, glycemic and body composition indices in women with non-alcoholic fatty liver disease.

 The present study was a quasi-experimental study in which women with non-alcoholic fatty liver disease, 25 of whom were randomly divided into two exercise (13) and control (12) group. The HIIT protocol was performed for 8 weeks and four sessions per week for 60 minutes each session. Blood samples were taken in pre and post-test to measure serum levels of selenoprotein P and other variables. Statistical analysis of data was performed by using paired and independent t-test by spss21 software at significant level of p <0.05.

  The results was showed that after eight weeks of HIIT in the training group compared to the control group, the amounts of selenoprotein , insulin resistance index, body fat percentage, BMI, WHR and body weight  decreased significantly.

  It seems that HIITcan be suggested as a suitable strategy to improve the levels of selenoprotein P, insulin resistance and body composition indices in non-alcoholic fatty liver disease.

Liver hepatokines are one of the contributing factors in non-alcoholic fatty liver disease. One of the most effective treatments for this condition is exercise. Therefore, the aim of this study was to investigate the response of some liver hepatokines to a period of high intensity interval training in women with fatty liver.

twenty Five women with non-alcoholic fatty liverwere randomly divided into two groups: exercise or control. The high intensity interval training protocol was performed for 8 weeks and four sessions per week for 60 minutes each session. Blood samples were taken from the arm vein to 5 cc pre- and post-test conditions. Plasma levels of Leukocyte-derived chemotaxin 2 (LECT2), angiopoietin-dependent growth factor (AGF), sex hormone-binding globulin (SHBG), and insulin were measured. Independent paired T-test was used to determine the intra-group changes of pre-test with post-test of dependent variables, and independent t-test was used to determine the significant difference between the groups.

The present study showed that after eight weeks of intense interval training LECT2 and AGF in the training group compared to the control had a significant decrease and SHBG significantly increased (p <0.05). Also, insulin resistance, body fat percentage, body mass index and waist to pelvic hip ratio have been significantly reduced in the exercise group compared to the control group (p <0.05).

High intensity interval training in women seems to be a non-pharmacological solution to improve insulin resistance and improve fatty liver-related hepatokines.

Aging and postmenopausal hormonal changes cause changes in the function of certain physiological systems of the body, and expose women to the risk of non-alcoholic fatty liver disease (NAFLD) in a unique manner. The present study was conducted to investigate the effect of aerobic-resistance exercise on serum concentration of retinol-bonded protein 4 (RBP4), abdominal obesity, and metabolic markers in postmenopausal women with non-alcoholic fatty liver.

Twenty-four 50-68 year-old sedentary postmenopausal women with fatty liver were randomly divided into exercise and control groups. Aerobic (at intensity of 50% to 75% of maximum heart rate) and resistance (at intensity of 50% to 75% of a maximum repetition) exercises were carried out over three sessions per week for ten weeks. The following indices were measured: liver fat by ultrasound, RBP4 by ELISA method, insulin resistance index (HOMA-IR), anthropometric indices, lipid profile, and liver enzymes. The data were analyzed using ANCOVA, paired t, Wilcoxon, Pearson and Spearman tests.

Aerobic-resistance exercise significantly reduced RBP4 level, insulin resistance index, fasting blood glucose, Anthropometric characteristics, aspartate aminotransferase (AST), triglyceride (TG), LDL, and fatty liver in the exercise group compared to those in the control group (p < 0.05). Moreover, RBP4 had significant relationships with fatty liver, triglyceride, abdominal obesity, and body weight (p < 0.05). No significant change was observed in alanine aminotransferase (ALT), fasting insulin, and HDL (P>0.05).

Aerobic-resistance exercise can reduce RBP4 level and insulin resistance, and improve NAFLD in postmenopausal women by reducing abdominal obesity and lipid profile.

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease that in case of lack of control can cause fibrosis, cirrhosis, and also damage the cells. Lifestyle changes and increasing of physical activity are the basis of managing this disease. The present study aimed to study the effect of aerobic-pilates exercise training on the serum levels of liver enzymes and the sonography of patients with non-alcoholic fatty liver disease. 

In this quasi-experimental study, 20 men with non-alcoholic fatty liver disease were selected by targeted sampling and randomly divided into experimental and control groups. The training period was 6 weeks, during this period the experimental group performed aerobic and pilates exercises, 60 to 90 minutes/4 days a week with 60 to 90 and 40 to 70 percent of maximal heart rate, respectively.  Blood samples and sonography were collected 24 hours before and 48 hours after the end of the intervention, to determine the activity of liver enzymes and also the degree of fatty liver respectivley. For statistical analysis the dependent and  independent t-test and Wilcoxon or Man Whitney U were used. All statistical calculations were performed with SPSS software version 21 and a significant level was set as p≤0.05. 

The serum levels of Alanin aminotransferase (ALT) and Aspartate aminotransferase (AST) enzymes significantly decreased (p=0.02, p=0.001, respectively) in the experimental group. Moreover, the disease severity also showed a significant decrease as compared with the control group (p=0.003). 

Performing a combination of aerobic-pilates exercise for 6 weeks and repeating 4 sessions per week has a significant effect on improving fatty liver disease and can be used as a non-pharmacological method.

Non-alcoholic fatty liver disease, characterized by the deposition of fat in liver cells, can cause fibrosis, cirrhosis, and liver cell damage if not controlled. The aim of this study was to determine the effects of 8 weeks endurance training on fatty liver and lipid profile indices, insulin resistance and body composition in diabetic women with NAFLD.

in this study, 30 diabetic women (age 53±7, height 158±4, and weight 75±9) with non-alcoholic fatty liver participated. Subjects were randomly divided into two groups of control (n=15) and exercise (n=15). The training group program was performed by running in each session for 30-45 minutes and 60-70% of the heart rate reserve and three sessions per week for eight weeks. Liver enzymes, lipid profile, blood sugar, insulin, insulin resistance index, Percent body fat and VO2max were evaluated before and after the training protocol. ANOVA test with repeated measures was used to determine the differences. With confidence interval of P<0.05.

Results of analysis of variance with repeated measures in lipid profile variables (TG, TC, HDL and LDL), liver enzymes (ALT and AST), insulin, insulin resistance, maximum oxygen consumption, WHR, weight and Body mass index showed that the interactive effect of time × group was significant in these variables  (P<0.05). The results of Bonferroni post hoc test reported a significant decrease in fat profile variables in the exercise group compared to the control group except for HDL in the exercise group, which did not show a significant change and in the control group (P <0.05). Also, the comparison between groups showed that there was a significant difference between control and exercise groups in fasting blood sugar factors, ALT, AST, TG, HDL, LDL, insulin, insulin resistance, maximum oxygen consumption, WHR, weight and Percent body fat (P<0.05).

These results suggest that moderate intensity aerobic exercise can play an important role in the improvement of these patients by compensating for the destructive effects of type 2 diabetes and non-alcoholic fatty liver. In addition, aerobic exercise can prevent the progression of NAFLD.