اینترلوکین 6

Systemic lupus erythematosus is a common autoimmune disease whose pathogenesis is not fully understood. However, the available evidence suggests that overstimulation of the immune system leads to a reaction against self-antigens and the initiation of inflammatory responses. The end result is an imbalance between inflammatory and anti-inflammatory cytokines, leading to widespread inflammation in the body of lupus patients. One of the most important pro-inflammatory cytokines is interleukin-17, which not only plays a role in the response to extracellular pathogens, but also appears to be involved in the pathogenesis of autoimmune diseases. Levels of this cytokine are higher in lupus patients than in healthy people, as confirmed by the meta-analysis results. While using interleukin-17 blocking antibodies to treat lupus has produced conflicting results. For example, studies have reported successful results in a mouse model and even in a patient with refractory lupus nephritis complicated by psoriasis vulgaris. However, another article stated that this cytokine is not involved in lupus disease and that its inhibition does not improve autoantibody levels or glomerulonephritis in mice. Based on the available data, it appears that the use of interleukin-17 blockers in the treatment of lupus requires further investigation and research.

Alzheimer's disease represents the most prevalent form of dementia, characterized by a gradual decline in memory function. This study aimed to examine the impact of 12 weeks of resistance training combined with sumac supplementation on various inflammatory and apoptotic markers in the serum of male rats exhibiting Alzheimer's disease.

In this experimental study, 35 rats were randomly divided into five groups: control, Alzheimer's, Alzheimer's + sumac supplement, Alzheimer's + resistance training, and Alzheimer's + resistance training + sumac supplement. To induce Alzheimer's, 8 mg/kg of trimethyltin chloride was administered to the rats along with 200μl of normal saline. Sumac was added to the food of the subjects at a rate of 10% and was freely available to them. Resistance training was performed for 12 weeks, five times a week, in the form of climbing a ladder with weights attached to their tails, one meter long, with 26 steps and an angle of 85 degrees. Then, the rats were sacrificed and blood samples were taken. IL-18 and Cas3 were examined using the ELISA method. IL-18 and Cas3 were examined using ELISA. The data results were analyzed using one-way ANOVA with Tukey's post hoc test at a significance level (p<0.0001) using SPSS software version 16.

The findings indicated that a period of resistance training along with sumac supplementation significantly reduced the levels of interleukin 18 and caspase 3 (p<0.0001). However, sumac supplementation alone, as well as resistance training alone, significantly reduced the expression of caspase 3 protein (p<0.0001), but had no significant effect on the levels of interleukin 18 (p<0.05).

Our findings showed that resistance training combined with sumac supplementation can improve the levels of inflammatory and apoptotic indices.

Background and purpose

Aging is a complex process characterized by multiple cellular and molecular disorders, gradually leading to a decline in physiological and cognitive functions. In this context, the prevalence of obesity, a key factor that exacerbates these issues, is increasing. This study aimed to examine the impact of a combined exercise intervention on interleukin-10 levels, vascular endothelial growth factor (VEGF), the neutrophil-to-lymphocyte ratio, cognitive performance, and gait performance in obese elderly men.

This randomized clinical trial (IRCT20200509047372N1) included 40 obese elderly men (mean age: 61.90± 2.84 years; BMI: 31.01 ± 1.53 kg/m²), who were randomly assigned to either an intervention group (n= 20) or a control group (n= 20). The intervention group participated in a combined exercise regimen for 16 weeks, with three sessions per week, each lasting 90 minutes. Plasma levels of interleukin-10, VEGF, and the neutrophil-to-lymphocyte ratio, as well as cognitive and gait performance, were measured 48 hours before and after the intervention. Data normality was assessed using the Shapiro-Wilk test, and statistical analysis was performed using paired t-tests and ANCOVA at a significance level of 0.05, with SPSS version 26.

The findings indicated that the combined exercise intervention significantly improved cognitive and gait performance in the experimental group (P= 0.001). Additionally, interleukin-10 and VEGF levels increased significantly in the experimental group (P=0.001). However, no significant differences were observed in BMI or weight between the two groups (P> 0.05). Similarly, no significant changes were found in the neutrophil-to-lymphocyte ratio in either group (P > 0.05).

These findings suggest that combined exercise may enhance cognitive and gait performance while increasing interleukin-10 and VEGF levels in obese elderly men. However, this exercise intensity did not significantly affect the neutrophil-to-lymphocyte ratio.

(Clinical Trials Registry Number: IRCT20200509047372N1)

The relationship between heart diseases and oxidative stress has been determined. The aim of this research was to determine the effect of aerobic training along with melatonin on the expression of interleukin-6 (IL-6) gene in the heart tissue of diabetic male rats.

In this experimental research, 64 eight-week-old male Wistar rats (weight range: 204 ± 11.3 grams) were randomly were placed into eight groups: diabetes control, diabetes+melatonin, diabetes+exercise,diabetes+melatonin+exercise.Healthy+melatonin,healthy+exercise,healthy+melatonin+exercise and healthy controls. Diabetes was induced by injecting streptozotocin 50 mg/kg of rat weight. Then, the exercise groups performed six weeks of continuous aerobic training on the treadmill. Also, melatonin was injected at a dose of 10 mg/kg of weight daily for 6 weeks. The level of IL-6 gene expression in heart tissue was measured by real time technique. One-way analysis of variance and Tukey's post hoc test were used for statistical analysis and the significance level (P ≥ 0.05) was considered.

The results showed that the induction of diabetes caused a significant increase in IL-6 in the diabetic groups compared to the healthy groups (P<0.05). Also, there was a significant decrease in IL-6 gene expression in the diabetes+melatonin+exercise group compared to the control diabetes group (P<0.05).

Based on the results of aerobic exercise along with melatonin supplementation can reduce inflammation in the heart tissue of diabetic rats by reducing IL-6 and thus prevent diabetic cardiomyopathy.

Chronic obstructive pulmonary disease (COPD) is a respiratory disease in which inflammation plays a significant role in its progression. Exercise and nutritional strategies are effective in improving inflammation; therefore, the aim of this study was to determine the effect of a combined exercise program and N-acetylcysteine supplementation on inflammatory markers in patients with COPD.

In this semi-experimental study, 80 male patients with COPD were randomly divided into 4 groups (20 subjects each): combined exercise, combined exercise with supplementation, supplementation, and placebo. The exercises were performed for 12 weeks, 6 sessions per week, for 60 minutes. 1800 mg of N-acetylcysteine supplement was administered daily along with 3 main meals. The levels of interleukin-6, interleukin-8, and C-reactive protein were measured in the blood at pre- and post-test.

After 12 weeks of intervention, the mean values of interleukin-6, interleukin-8, and CRP decreased significantly by 12.9%, 20.3%, and 5%, respectively, in the exercise + supplement group (P=0.001). Interleukin-6 (P=0.001), interleukin-8 (P=0.001), and CRP (P=0.04) levels were significantly lower in the exercise + supplement group compared to the placebo group. Moreover, interleukin-6 (P=0.001) and interleukin-8 (P=0.001) levels were significantly lower in the exercise group compared to the placebo group.

It seems that combined exercise and N-acetylcysteine supplementation have a positive effect on interleukin-6, interleukin-8, and CRP markers in patients with COPD.

Demyelinating lesions, widespread tissue damage, and neuronal connectivity impairments in white matter are associated with reduced cognitive decline in multiple sclerosis (MS) patients. These findings are particularly prominent in the corpus callosum of the brain. Interleukin-10 (IL-10) is an anti-inflammatory cytokine secreted by regulatory T cells (Tregs) with anti-inflammatory properties and can inhibit the production of pro-inflammatory cytokines produced by macrophages and T cells. IL-6 is a multifunctional cytokine involved in the immune system of autoimmune diseases. The IL-6 gene consists of 5 exons, 4 introns, and a proximal promoter region located on the 7p21 chromosomal locus in humans. This study aimed to determine the effects of IL-10 (-1082/-819) and IL-6 (-174) gene polymorphisms on corpus callosum changes in women with MS.

This case-control study was conducted on 40 women with MS aged 20-40 years referring to Golestan and Kowsar Magnetic Resonance Imaging (MRI) centers in Gorgan and 20 women without MS, autoimmune or inflammatory diseases over 40 years during 2015. Ten mL of blood was taken from the subjects for genotyping. Additionally, DNA extraction was performed using the phenol-chloroform method, and DNA genotyping was performed using the sequence specific primer-polymerase chain reaction (SSP-PCR) method. Brain MRI images of the subjects were employed to measure the corpus callosum and to investigate the relationship with the investigated polymorphisms.

After performing the tests and obtaining different IL-6, IL-10 (-819), and IL-10 (-1082) genotypes, no significant statistical correlation was observed between IL genotypes in the case and control groups. Additionally, no significant correlation was observed between the different IL-6, IL-10 (-819), and IL-10 (-1082) genotypes and changes in the size of different parts of the corpus callosum, including rostrum width, splenium width, body width, the ratio of body length to anteroposterior length, and the ratio of body length to maximum height between the case and control groups. Reductions in the variables of rostrum width, splenium width, body width, the ratio of body width to anteroposterior length, and the ratio of body width to maximum height were significant in both case and control groups (P<0.05). Only the reduction in splenium width was significantly associated with the occurrence of MS (P<0.009, odds ratio [OR]=2.35, 95% confidence interval [CI]=4.51-1.22).

There was no relationship between the morphometric changes of reduced corpus callosum and the changes in IL-6, IL-10 (-819), and IL-10 (-1082) genotypes in patients with MS.

Resistance exercises with high loads of HLRT cause physiological changes in body systems, including the immune system. On the other hand, little research has been done on the effect of high-intensity bodybuilding exercises on women's immune systems. The present study investigated the effect of resistance activity in a single bout with two different intensities and recovery on TNF-α and interleukin-6 gene expression, hs-CRP, and systemic immune-inflammatory marker SII on female bodybuilders.

In this semi-experimental study, 12 healthy female athletes (aged 30 ± 5) volunteered. The samples performed weekly resistance training at 70% and 85% of 1RM in two recovery times of one and two minutes. Thirty-six hours after training, sampling was done following a ten-hour fasting period. The samples were centrifuged at 3000 rpm and kept at -20 ℃. Ultimately, all levels of TNF-α and interleukin-6, hs-CRP, and systemic immune-inflammatory markers SII were checked in the medical laboratory. A consent form was obtained from the participants.

The results of resistance training using the HLRT method compared to moderate-intensity resistance training showed an increase in training intensity of up to 85% 1RM and a one-minute recovery. There was a significant decrease in the level of interleukin-6, TNF-α (P < 0.001), and hs-CRP (P < 0.025) and a significant increase in the level of SII systemic immune-inflammatory markers (P < 0.001).

It seems that increasing the intensity of resistance training - with increasing load - HLRT does not hurt the immune system, and it reduces pro-inflammatory factors interleukin-6, TNF-α and hs-CRP, as well as increases SII in female bodybuilders.

Vascular dementia (VaD) is a cognitive impairment that affects the expression of triggering receptor expressed on myeloid cells 2 (TREM2) and interleukin 33 (IL-33). The present study aimed to investigate the preventive effect of endurance and cognitive-motor dual-task training on the TREM2 and IL-33 expression in rats with VaD.

Forty middle-aged male Wistar rats were randomly assigned to four groups: healthy control, dementia, endurance training + dementia, and dual cognitive-motor task + dementia. The rats in the endurance training group underwent running exercises, while the cognitive-motor dual-task group participated in the Morris water maze for 8 weeks. Following the interventions and the creation of a vascular dementia model through a 30-minute common carotid artery occlusion, blood samples were collected. IL-33 serum levels were measured using the ELISA method, and TREM2 expression was assessed by Western blotting after extracting the hippocampus.

The results show that both training methods significantly affected the levels of TREM2 and IL-33. TREM2 levels were significantly higher in both exercise groups compared to the control group and significantly lower compared to the dementia group. Furthermore, IL-33 levels were significantly higher in both exercise groups compared to the control group, with a significant difference observed between the control and dementia groups.

Endurance and cognitive-motor dual-task training appear to help maintain appropriate concentrations of TREM2, potentially preventing cognitive and functional decline associated with vVaD. However, no significant difference in IL-33 levels was found between the exercise and dementia groups, highlighting the need for further research on the type, intensity, and impact of exercise on this variable.

Regenerative treatments in endodontics are biological treatments to manage immature teeth, remove inflamed and necrotic tissue, and create a suitable environment for tissue repair. In these treatments, substances with reparative properties of dental pulp and dentin are placed on the pulpal tissue. Interleukin-6 is one of the cytokines secreted in response to various immune activities of the body and studies have demonstrated its vital role in mineralization induction and hard tissue formation. Recently, calcium silicate-based materials have been widely implemented in dentistry due to their great biocompatibility and hard tissue formation induction. Considering the role of IL-6 in the regulation of stem cells, the purpose of this study is to compare the effect of CEM cement, Biodentine, TheraCal LC, and MTA on the level of IL-6 secretion by dental pulp stem cells.

In this laboratory study, 4 types of cement were used as the main groups, and 1 control group contained culture medium without cement. Discs were prepared under sterile conditions in six-well plates with a diameter of 35 mm and a height of 2 mm and they were given time to set for 48 hours. Human pulp stem cells were obtained from Iran's Center for Biological Resources and cultured in a culture medium containing DMEM with 15% FBS and 1% penicillin-streptomycin (10,000 units/ml) as antibiotics. Pulp stem cells at passages 3-5 were used for experiments. Discs of each cement were prepared under sterile conditions and according to the manufacturer's instructions. To prepare the extract of each cement, the DMEM cell culture medium was placed near these discs for 24 hours. Then, human dental pulp stem cells (hDPSCs) were cultured in the vicinity of the disc extract for 72 hours. After that, this extract was collected and the level of IL-6 secretion in it was measured by the ELISA method. The experiments were repeated 3 times. Then the obtained data were entered into SPSS 16 software and analyzed using analysis of variance and the Kruskal-Wallis test.

The results showed that the highest level of IL-6 secretion by cells was in the presence of TheraCal LC, Biodentine, and CEM, respectively; But there was no significant difference between the groups. The average level of IL-6 secretion in the presence of MTA was lower than in other groups and this difference was significant (P<0.01).

The results of the present study showed a lower level of IL-6 cytokine secretion by pulpal stem cells in the presence of MTA compared to TheraCal, CEM, and Biodentine types of cement. Considering the role that IL-6 can have in osteogenic and odontogenic activities, the results of this study can be useful in establishing information in the field of introducing the most suitable cements for clinical procedures.

Parkinson's disease is associated with a dysfunction in the inflammatory system. This study aims to evaluate the effects of eight weeks of aerobic training combined with garlic supplementation on the expression of interferon gamma (IFN-γ) and interleukin 4 (IL-4) genes in the brain tissue of reserpine-induced parkinsonian rats.

In this experimental study, 32 reserpine-induced parkinsonian rats (administered an intraperitoneal injection of 2 mg/kg reserpine) were divided into four groups: 1) reserpine, 2) aerobic training (AT) for eight weeks, 3) garlic supplementation (G), and 4) AT + G. Additionally, eight healthy rats were included in a healthy control group. The aerobic training regimen consisted of five sessions per week for eight weeks, with each session lasting between 15 and 48 minutes at a speed of 10 to 24 m/min. Rats received 500 mg/kg/day of aqueous garlic extract via gavage. The gene expression levels of IFN-γ and IL-4 in the brain tissue were measured using the RT-PCR method. Motor balance was assessed using a rotarod device.

IFN-γ gene expression was significantly lower in the G, AT, and AT + G groups compared to the reserpine group (P < 0.001). Furthermore, IL-4 levels and motor balance scores were significantly higher in these groups than in the reserpine group (P < 0.001). Notably, the combined effect of eight weeks of aerobic exercise (AT) with garlic supplementation (G) on reducing IFN-γ gene expression levels and enhancing motor balance was significantly more favorable than that of garlic supplementation alone (P ≥ 0.05).

Both aerobic exercise and garlic supplementation seem to exert beneficial effects on the inflammatory and anti-inflammatory systems in the brain tissue, as well as on motor balance in neurological diseases. These findings suggest that integrating aerobic training with garlic supplementation may enhance therapeutic approaches for managing Parkinson's disease.

Physical activity has a dual effect on inflammation and the results of studies are very contradictory. The aim of this study was the interactive effect of six weeks of TRX training and oral intake of mango tree leaf extract on interleukin-12 and anterometric indices of overweight and inactive obese male students.

In a semi-experimental research, 48 overweight and inactive obese students with an age range of 20-25 years were purposefully selected and divided into 4 groups of 12: control, extract, exercise and exercise+extract. For six weeks (three sessions per week), they did TRX exercises and took 500 mg capsules containing mango leaf extract twice a day lunch and dinner. Blood sampling was done 24 hours before and 48 hours after the last training session. Interleukin-12 serum level was measured by ELISA method using human kit. Data were analyzed with dependent t-test and one-way analysis of variance and significance level less than 0.05 in SPSS-25 software (P<0.05).

A significant difference was observed in the levels of interleukin-12 in the exercise, exercise+extract and extract groups compared to the pre-test (p=0.001). The pre- and post-test differences between the groups using one-way analysis of variance on weight, fat percentage, body mass index and interleukin-12 levels showed a significant difference between the research groups (p < 0.05 between groups).

Six weeks of TRX training and consumption of mango leaf extract may be effective in reducing weight, fat percentage, body mass index and interleukin-12 serum levels. On the other hand, one of the ways to control inflammation is to do TRX exercises with mango leaf extract.

 Chronic obstructive pulmonary disease (COPD) is one of the respiratory diseases in which inflammation plays a key role in its development. Exercise training has acritical role in improving chronic inflammation. Nonetheless, the effects of various exercise training on inflammatory markers in these patients are not clear. Therefore, the present study aimed to assess the impact of exercise on the inflammatory markers, including IL-6, TNF-α, and c-reactive protein in patients with COPD.

A systematic search was conducted on PubMed, Web of Science, SID, Magiran, and Google scholar databases for articles published until July 2023. A meta-analysis was performed for the impact of exercise on inflammatory markers in COPD patients. Effect size (SMD) and 95% confidence interval were calculated using random effect model. Moreover, I2 test was employed to determine heterogeneity, while Funnel plot test and Egger test were used to check publication bias.

The results of the data analysis of 11 studies on 578 patients with COPD demonstrated that exercise led to a non-significant decrease in circulating CRP values [SMD=-0.413 (-0.100 to 0.175), P=0.16], IL-6 [SMD=-0.164 (-0.69 to 0.36], P=0.54], TNF-α [SMD=-0.358 (-1.44 to 0.72), P=0.51) in COPD patients. Furthermore, the results of the subgroup analysis pointed out that aerobic training [SMD=-0.55, P=0.1] compared to resistance training [SMD=-0.09, P=0.7] led to a decrease in CRP in patients with COPD. Nonetheless, this difference was not significant.

The findings of the present meta-analysis illustrated that aerobic exercise is probably an effective exercise intervention to reduce CRP in patients with COPD.

Irritable bowel syndrome (IBS) is a prevalent functional disorder of the gastrointestinal tract that affects approximately 11% of people worldwide. The exact mechanisms underlying IBS remain unclear, but evidence suggests that low-grade inflammation is involved in its pathophysiology. Interleukin-6 (IL-6) is a key cytokine that mediates inflammatory responses in the intestinal mucosa and has been linked to the development of IBS. Our study aimed to provide an overview of the current knowledge on the role of IL-6 in IBS.

The present study was conducted based on a search on the PubMed database, where only 26 articles investigated the role of IL-6 in irritable bowel syndrome were found.

Our review revealed that patients with IBS had higher levels of IL-6 in their serum/plasma. Furthermore, increased expression of IL-6 mediated by cholinergic signalling was associated with increased abdominal pain/discomfort and bloating. More recently, an interaction between IL-6 and corticotrophin-releasing factor was shown to provide more insight into the mechanisms underlying IBS symptoms during stressful periods, which are experienced by almost two-thirds of patients with IBS. Elevated levels of IL-6 were also correlated with increased fatigue and intestinal inflammation. Targeting IL-6 expression or IL-6 signalling pathway using probiotics, vitamin D3 or a replacement diet may offer a novel therapeutic strategy to improve IBS symptoms, abdominal pain, bloating and fatigue after consumption of ancient wheat products.

Further studies are needed to elucidate the causal relationship between IL-6 and IBS, as well as the molecular pathways and cellular targets of IL-6 in the gut.

Interval exercises with high intensity and consumption of plant extracts probably have beneficial effects on inflammatory indicators. The aim of this study was to investigate the effect of eight weeks of High-Intensity Interval Training (HIIT) and the consumption of Loquat leaf extract on the serum levels of TNF-α and interleukin-18 in obese men with non-alcoholic fatty liver disease.

In this semi-experimental study, forty men with non-alcoholic fatty liver disease with body mass index (33.92 ± 1.82) with informed written consent were randomly selected and assigned into four groups: control, training, Extract, Extract + training (Each group of 10 people). Exercises were performed for eight weeks and three sessions per week for 60 minutes with intensity between 80-95% of the reserve heart rate. Two capsules of 250 mg of Loquat leaf extract were also prescribed daily. Paired t-test and analysis of covariance were used.

A significant decrease in the levels of TNF-α (15.3%) and interleukin 18 (14.9%) was observed in the training + extract group (P<0.05). A significant difference was observed in the levels of TNF-α (P=0.001) and interlock 18 (P=0.001) between the groups, and these changes were more significant in the Extract + training group than in the training and extract groups.

It is concluded that performing intense intermittent training along with Loquat leaf extract will be able to improve TNF-α and interleukin 18 indices related to fatty liver in people with non-alcoholic fatty liver disease. However, confirmation of this hypothesis requires more research.

The COVID-19 pandemic, caused by the coronavirus, has emerged as one of the most pressing healthcare challenges of this century. The role of laboratory data in diagnosing severe forms of COVID-19 remains inconclusive. This research aimed to find ways to quickly prevent COVID-19. This research involved 43 COVID-19 patients monitored from March 2022 to May 2022 at the Mehregan Private Center in Khuzestan Province. Hematological and biochemical tests of the patients were performed. Measurements of D-dimer and Interleukin-6 were performed using the Biotek ELX 800TS analyzer, while fibrinogen levels were determined through the Clauss coagulation method. Data analysis was carried out using SPSS version 22 and GraphPad Prism version 9. There is a significant difference in the levels of interleukin 6, D-Dimer, and fibrinogen, which was equal to 0.0001 (P<0.05). Threshold level and area under the receptor operating characteristic curve (ROC) interleukin-6 was 20.06 pg/ml and 0.837, D-dimer 952.5 ng/ml and 0.929, and fibrinogen was 206.5 mg/dL and 0.768, respectively. The specificity and sensitivity of predicting the severity of COVID-19 interleukin 6 were 67.44% and 100%, D-dimer 60.47% and 97.67%, and fibrinogen 53.49 % and 95.35%, respectively. Interleukin-6 and D-dimer had the highest specificity and sensitivity for early prediction of the severity of COVID-19, but for fibrinogen, this level was not as obvious as the other two factors. D-dimer and interleukin-6 had more pronounced effects on the             severity of this disease, while fibrinogen had a lower impact.

Aging is generally associated with a progressive decrease in physical activity, which can affect the quality of life and lead to negative structural and functional changes in different body tissues and reduce their efficiency.High levels of interleukin-10 and interleukin-15 cytokines are related to longevity. The aim of this study is the effect of 12 weeks of resistance training on the serum levels of interleukin-10 and interleukin-15 in middle-aged women.Subjects and

40 middle-aged women (40-59 years old) were selected and randomly divided into2 equal experimental and control groups. The experimental group performed a resistance training program with a training load of 65% to 80%1RM for 12 weeks.Finally,48 hours after the last exercise, the levels of interleukin-10 and interleukin-15 were measured by ELISA method. The Kolmogorov Smirnov test was used to compare the data, and the independent t-test was used for the effectiveness of the exercise at a significance level of P<0.05.

The findings showed that there is no difference in weight and BMI between the experimental and control groups before the start of the research (P<0.05). But after training, it was statistically significant (P< 0.05).Also, a significant increase was observed in the levels of interleukin-10 and interleukin-15 after training(P=0.001).

It seems that the increased regulation of anti-inflammatory cytokines can have a positive effect on the improvement of physiological conditions caused by resistance training in middle-aged women. Therefore, it is recommended to use strength training to improve the levels of cytokines to increase the strength and performance of muscle mass.

Cytokines play an important role in my disease and are considered an important target for therapeutic interventions. the purpose of this research is to investigate the effect of a period of resistance training on the serum level of 17 and interferon beta in young women with MS. Was.

The present study was conducted in a semi-experimental way with a pre-test and post-test design. 30 women with MS with age range of 30-35 years were randomly selected in two exercise and control groups. Resistance exercises were performed for 8 weeks and three sessions a week, each session lasting 60 minutes with an intensity of 60-70% of the maximum heart rate. Blood samples were taken before and after the training protocol with 12 hours of fasting and the levels of interleukin 17 and beta interferon were measured by ELISA method. Data were analyzed using SPSS version 22 software and covariance test.

The results showed that after 8 hours of resistance training intervention, the amount of interleukin 17 in the training group decreased significantly and the amount of beta interferon showed a significant increase compared to the control group

Since moderate intensity resistance training decreased interleukin 17 and increased beta interferon in patients with MS, it seems that exercise intervention can be used to treat and prevent the progression of MS along with used drug treatments.