keyvan hejazi

Osteocalcin (OC) carboxylation functions as a hormone in glucose metabolism, enhancing insulin secretion, sensitivity, and energy consumption.

This study aimed to examine the effect of eight weeks of moderate-intensity interval training on uncarboxylated OC levels and insulin resistance markers in obese women.

This semi-experimental study included 20 obese women aged 35 to 45, who were randomly divided into two groups: An experimental group (10 participants) and a control group (10 participants). The moderate-intensity interval training program lasted eight weeks, with three sessions per week, each lasting 20 to 40 minutes, at an intensity of 50% to 75% of maximum heart rate. A one-way repeated measures analysis of variance was used to assess intra-group and inter-group changes.

The moderate-intensity interval training program resulted in significant reductions in weight, Body Mass Index (BMI), waist-to-hip ratio, insulin levels, and the Insulin Resistance Index. Additionally, uncarboxylated OC levels and maximal oxygen consumption significantly increased by the end of the study period. Time interaction changes within the group were statistically significant for waist-to-hip ratio, glucose, insulin, insulin resistance, and maximal oxygen consumption.

Moderate-intensity interval training increased uncarboxylated OC levels and decreased the Insulin Resistance Index in obese women. These findings suggest that moderate-intensity interval training can be recommended as a preventive or therapeutic strategy for managing obesity and potential metabolic diseases associated with obesity.

Acute aerobic and anaerobic exercise can cause a state of oxidative stress characterized by an increase in oxidized molecules in a variety of tissues and body fluids. The amount of oxidation depends on the mode of exercise, intensity, and duration, and is specifically related to the degree of oxidant production. This research investigates the effect of eight weeks of plyoball and resistance band training on glutathione peroxidase, malondialdehyde, and performance indicators of female handball players.

In this semi-experimental study, 30 female handball players aged between 10 and 16 were randomly divided into the following three groups: 1) Handball training (n=10), 2) Handball+resistance band (n=10), and 3) Handball+plyoball training group (n=10). The plyoball and resistance band training program consisted of eight weeks (two sessions per week) and each session lasted 45 to 60 min. The one-way analysis of variance repeated measures were used for within and between group changes, respectively.

Eight weeks of plyoball and resistance band training caused a significant increase in glutathione peroxidase levels and decreased salivary malondialdehyde levels in handball players. The accuracy and strength of the handball shot increased significantly at the end of the eight-week intervention period.

According to the results, the greatest increase in the levels of glutathione peroxidase was in the group of handball exercises with a resistance band and the greatest decrease in the levels of malondialdehyde was in the group of handball exercises alone. The highest amount of improvement in the accuracy and strength of the handball shot was achieved in the group of handball training with the resistance band. Therefore, the performance of handball exercises with resistance bands can be recommended to improve the levels of oxidative stress, accuracy use, and shot strength in handball players compared to other training groups.

Diabetes can be a life-threatening condition, and maintaining blood sugar levels, proper nutrition, and regular physical activity are crucial for controlling diabetes and preventing its complications. The present study aimed to investigate the effect of twelve weeks of resistance band training on the levels of spexin and insulin resistance indices in women with type 2 diabetes.

In this semi-experimental study, 22 women with type 2 diabetes were randomly divided into two groups: resistance band (n=11) and control (n=11). The exercise program consisted of 12 weeks, three sessions per week, and each session lasted for 45 to 60 minutes. One-way ANOVA with repeated measures was used for within- and between-group changes.

The results showed that the interaction changes in serum spexin levels were significant between the experimental and control groups (p=0.012). However, no significant changes were observed in glucose (p=0.229), insulin (p=0.116), and insulin resistance index (p=0.178). Within-group changes in the insulin resistance index were significant (p=0.04). According to the Bonferroni post-hoc test, there was no significant difference in serum spexin level between pre-test and the eighth week (p=0.141) and between pre-test and the twelfth week (p=0.429).

Resistance band training, compared to the control group, significantly increased spexin and led to a considerable improvement in fasting glucose concentration, insulin, and insulin resistance index. Therefore, it is suggested that resistance band training can be implemented as a suitable alternative to home-based resistance training for individuals with type 2 diabetes.

The thyroid, impacted by lifestyle factors like diet and physical activity, is crucial for overall health. Selenium, an essential antioxidant supplement, plays a key role in thyroid gland function. This study aimed to explore the combined effects of an eight-week moderate-intensity interval training (MIIT) regimen and selenium supplementation on thyroid hormone levels, lipid profile, and overall quality of life (QOL) in women with hypothyroidism.

In this quasi-experimental study, 46 women diagnosed with hypothyroidism were randomly assigned to one of four groups: placebo, supplement-only, exercise plus supplement, and exercise plus placebo. Selenium supplementation dosage was set at 200 micrograms per day. MIIT program spanned eight weeks, with three sessions weekly lasting 20-30 minutes each, maintaining an intensity of 60-80% of the maximum heart rate. Pre- and post-intervention assessments included anthropometric measurements [weight, body mass index (BMI), waist-to-hip ratio (WHR), and body fat percentage], QOL evaluations, thyroid hormone levels, lipid profile analysis, and C-reactive protein (CRP).

Significant interactions over time were observed within the groups, particularly in CRP levels, lipid profile parameters (excluding total cholesterol), thyroid hormone levels, QOL metrics, and some anthropometric indices (excluding WHR) (p=0.001).

The combination of MIIT and selenium supplementation demonstrated favorable outcomes, including reduced lipid profile levels, increased thyroid hormone levels, and enhanced QOL. This integrated approach shows promise in effectively enhancing thyroid function in women managing hypothyroidism.

Inactivity and passive lifestyle have led to an increase in mortality and the incidence of chronic diseases such as hypertension, type 2 diabetes and obesity. The aim of this study was to investigate the effects of eight weeks of rhythmic exercises with music on IGFBP-3, insulin resistance index and quality of life in women with different body mass indices. 

In this quasi-experimental study, 33 sedentary women were randomly divided into three groups: exercise + normal )body mass index [BMI] 20 to 24.9 kg/m²) (n= 11), exercise + overweight (BMI 25 to 29.9 kg/m²) (n=11), and exercise + obese (BMI 30 to 34.9 kg/m²) (n=11). The rhythmic exercise program consisted of 8 weeks, three sessions per week and each session was performed for 45 to 60 minutes with an intensity equal to 60 to 70% HRmax. The paired t-test and one-way ANOVA with repeated measures were used to compare changes within and between groups. 

The results showed that the time interaction in the groups in terms of IGFBP-3, insulin, glucose, insulin resistance and quality of life was not statistically significant. The results of the comparison of within-group means showed that in the normal body mass index group, the overweight and obese groups, IGFBP-3 levels, quality of life have significantly increased. In the overweight and obese body mass index groups, serum insulin levels, glucose, and insulin resistance index significantly decreased. 

Rhythmic exercise increased IGFBP-3 concentration and decreased fasting glucose, fasting insulin, insulin resistance index in all three groups.

Liver enzymes are associated with obesity and various components of metabolic syndrome. The manifestation of this syndrome is accompanied by a high risk of diabetes and atherosclerotic cardiovascular disease. The aim of this research was to investigate the effects of eight weeks of intense and moderate rhythmic exercise on some liver enzymes and functional performance in obese women.

In this semi-experimental study, 30 obese women aged 35 to 45 years who were sedentary were selected using convenience sampling and then randomly allocated into three groups: moderate-intensity rhythmic exercise (n=9), intense rhythmic exercise (n=10), and control (11 participants). One-way ANOVA and paired t-test were used for intra- and intergroup comparisons.

The concentrations of aspartate aminotransferase, gamma-glutamyl transferase, and triglycerides decreased significantly in the intense exercise group and the moderate exercise group. Alanine aminotransferase levels only showed a significant decrease in the intense exercise group (P=0.05). Fat accumulation index was significantly reduced only in the moderate exercise group (P=0.009). Maximum oxygen consumption and flexibility increased significantly in the intense and moderate exercise groups (P=0.001), but agility decreased significantly in both exercise groups at the end of the training period (P=0.001).

Rhythmic exercises with different intensities training can be an effective method to improve liver enzymes and functional indicators in obese women.

Physical inactivity leads to insulin resistance and diabetes. Insulin resistance is a hallmark feature of type 2 diabetes. The purpose of this study was to investigate the effect of eight weeks of Pilates or Traband training on serum glucose levels, markers of insulin resistance, neuropathic pain and some functional indices of women with type 2 diabetes. In this semi-experimental study, 34 women with type 2 diabetes were randomly divided into three groups: Pilates training (n=12), Traband training (n=11) and control (n=11). The exercise program consisted of eight weeks, three sessions per week, and each session lasted 45-60 minutes. To investigate the changes in the pain index, repeated measurement and Bonferroni's post hoc test were used. The paired sample t-test method and analysis of covariance (ANCOVA) were used to compare within and between groups, respectively. Findings showed that fasting glucose concentration, insulin, and insulin resistance index significantly decreases only in the Traband training group; However, there was no significant change in the Pilates and control groups. The pain index during the time series was significant (p = 0.01). In both Pilates and Traband groups, there was a significant increase in the variables of muscle endurance, flexibility and maximal oxygen consumption (p = 0.01). Exercise training in accordance with the Traband model causes statistically and clinically more significant changes in fasting glucose concentration, insulin, insulin resistance index than Pilates intervention. Therefore, it is possible to use Traband exercise to improve type 2 diabetic patients and prevent the harmful effects of diabetes for women with type 2 diabetes.

Oxidative stress can harm cells, proteins, and DNA and play a role in the aging process. The present study was conducted to determine the impacts of six weeks of Pilates exercises and Lycium barbarum supplement on oxidative stress indices of saliva and body composition of inactive elderly females.

This field trial was carried out on 49 inactive elderly females. The subjects were selected in a purposeful manner and were randomly assigned to 4 groups, including control, supplement, exercise, and exercise plus supplement. The exercise program protocol was implemented for six weeks, three 45-60 minute sessions per week with an intensity of 50-70% maximum heart rate. The Lycium barbarum supplement group used 14 g of supplement daily. Oxidative stress indices of saliva and body composition were compared. The individuals’ physical activity level was determined using the Kaiser Physical Activity Survey (KPAS) and the samples’ health status was specified using the Physical Activity Readiness Questionnaire (PAR-Q).

The amount of malondialdehyde had a statistically significant reduction in the exercise plus supplement group compared to the control group, the exercise group, and the supplement group (P<0.05). The amount of malondialdehyde was not statistically significant in the exercise group and the supplement group compared to the control group. The amount of salivary catalase was not statistically significant in the exercise group plus supplement group compared to the control group, the exercise group, and the supplement group. The amount of salivary catalase had a statistically significant increase in the exercise group compared to the control group and the supplement group (P<0.05). The amount of glutathione peroxidase had no statistically significant difference in the exercise plus supplement group compared to the control group but had a statistically significant increase compared to the supplement group (P<0.05). The amount of glutathione peroxidase had a statistically significant increase in the exercise group than in the supplement group (P<0.05).

Regular exercise with moderate intensity and Lycium barbarum supplement resulted in improved antioxidant function and body composition in inactive elderly females.

The study of physical and health-related fitness and body composition indicators in workers is very important to prevent performance degradation. Therefore, this study aims to investigate such indicators among the employees of Izogam Shargh Company.

In this descriptive-analytical study, 150 workers from 150 stations in Mashhad city were selected by stratified random sampling and divided into three age groupsnamely. 25-34, 35-44 and 45-54 years. Two -way analysis of covariance (ANCOVA) and Bonferroni post-hoc test were performed to compare the variables in the three age groups.

Significant differences were found in body composition indicators, i.e., weight between the age groups 25-34 years with 35- 44 years (P=0.008) and 35-44 years with 45- 54 years (P=0.001), body mass index between the age groups 25-34 years with 45-54 years (P=0.001) and 35-44 years with 45-54 years (P=0.001), body fat percentage between the age groups 25-34 years with 45- 54 years (P = 0.006), maximum oxygen consumption between the age groups 25-34 years with 35-44 years (P=0.001), 25-34 years with 45-54 years (P=0.001), and 35-44 years with 45-54 years (P=0.001). In addition, significant differences were found in all physical and health-related fitness indicators, i.e., agility, explosive strength, flexibility, abdominal muscle endurance, and shoulder girdle muscle endurance, between the age groups 25-34 years with 35-44 years (P=0.001), 25-34 years with 45-54 years (P=0.001), and 35-44 years with 45-54 years (P=0.001).

The results of this study show that the level of  physical fitness of employees decreases with age. Therefore, it is suggested that the managers of companies create the necessary conditions and incentives for employees to engage in regular physical activity.

Paraquat toxicity can damage organisms through mechanisms that are not yet fully understood. Evidence shows that regular exercise and appropriate antioxidant supplements can help reduce the complications caused by paraquat toxicity. This study aimed to evaluate the effect of aerobic exercise training, along with piperine supplement, on the liver levels of tumor necrosis factor-alpha (TNF-a) and interleukin-10 (IL-10) in Wistar rats induced with paraquat.

In this experimental study, 40 adult Wistar rats were randomly placed into 5 groups of 8, including 1) sham, 2) negative control-paraquat, 3) paraquat + training, 4) paraquat + training + piperine, and 5) paraquat + piperine. Aerobic training included 7 weeks of walking on a treadmill (5 sessions per week for 30-40 min per session, at a speed of 10-18 m/min). Paraquat was administered to the rats by intraperitoneal injection at a dose of 5 mg/kg of body weight. The piperine supplement was daily gavaged at a dose of 10 mg/kg of body weight. The concentration of TNF-a and IL-10 was measured in the liver tissue.

A significant increase in IL-10 and a decrease in TNF-a concentrations were observed between the paraquat-negative control groups compared to the sham, paraquat + exercise, paraquat + piperine, and paraquat + exercise + piperine groups (P<0.05). There was a significant difference between the mean concentrations of TNF-a in the liver tissue between the two negative control groups - paraquat with paraquat + piperine supplement (P<0.05), paraquat + exercise + piperine (P<0.05), paraquat + exercise (P<0.05), and sham (P<0.05). There was a significant difference in concentrations of IL-10 in the liver tissue between the two negative control groups - paraquat with paraquat + piperine supplement, paraquat + exercise + piperine, paraquat + exercise), and sham (P<0.05).

The concentration of TNF-a and IL-10 in male rats induced with paraquat were significantly decreased and increased, respectively, compared to paraquat + piperine supplement, paraquat + exercise + piperine, paraquat + exercise, and sham groups. Therefore, it seems that performing aerobic exercise, along with piperine supplementation, can be a proper way to reduce the inflammation caused by paraquat.

Chronic exposure to paraquat can lead to lung and liver damage, kidney failure, and Parkinsonian lesions in addition to fibrosis. Paraquat toxicity occurs through excessive production of free radicals which results in oxidative stress and damage. The aim of the current study was to evaluate the effect of a period of aerobic exercises and supplementation with piperine on liver enzymes in rats induced with paraquat. 48 adult rats were divided into six groups: 1) Sham, 2) negative control paraquat 3) paraquat + training, 4) paraquat + training + piperine, 5) paraquat + piperine and 6) positive control paraquat + vitamin E. Aerobic exercise training included: seven weeks of walking on treadmill for 5 sessionsper-week 30-40 min per session at a speed of 10 to 18 m/min. The paraquat poison was prepared at dose of 5 mg/kg of rat body weight and was injected intraperitoneally. Daily gavage of piperine supplement was provided at dose of 10 mg/kg of rat body weight. ANOVA statistical test was used to determine the mean difference between groups. There were significant differences in Alanine Transaminase (ALT) and Aspartate Transaminase (AST) levels between the sham, paraquat+exercise, paraquat+piperine, paraquat+exercise+piperine, and positive control paraquat+vitamin E groups compared to the negative control paraquat-group. Furthermore, significant increase in ALT and AST levels was observed in the negative control group compared to the sham, paraquat+exercise, paraquat+piperine and paraquat+exercise+piperine and positive control paraquat+vitamin E groups (p<0.001). The results showed that in rats belonging to exercise training, only exercise training with piperine and piperine decreased the ALT and AST levels compared to the negative control group. However, more research is needed to support these findings.

Anthropometric indices such as body mass index, Waist Circumference (WC), Waist-to-Hip Ratio (WHR), and Waist-to-Height Ratio (WHtR) are used to identify adolescent obesity and overweight because of their easiness, safety, and accuracy of measurement. This study aimed to evaluate the anthropometric indices in predicting overweight/obesity in male students.

In this descriptive-analytical study, 162 male students of Hakim Sabzevari University, Sabzevar City, Iran, were selected by a simple stratified-random sampling method. The checkerboard and New York test were used to check for musculoskeletal abnormalities. Body composition indices, including height, weight, body mass index, WC, hip circumference, WHR, and WHtR, were measured. The obtained data were analyzed by ANOVA test and Receiver Operating Characteristics (ROC).

Mean values WC, WHR, the WHtR in different groups of body mass index were significantly different. The area under the curve for WC (P=0.001), WHR (P=0.001), and WHtR (P=0.001) had a significant difference, too. 

The present study showed that the area under the curve for WHR has better detective ability for overweight and obesity than other variables such as WC and WHtR.

 Structural postural changes due to aging are common among the elderly due to decreased muscle mass and tissue. We evaluated the effect of 10 weeks of core muscle training on serum levels of follistatin, myostatin, and pain in older women with low back pain.
Methods & Materials: A total of 18 older women with low back pain (aged 60 to 70 y) were randomly assigned into two groups: experimental (n=9) and control (n=9). The training program of core muscles included 55 to 60 min sessions, 3 times per week for 10 weeks. Before and after the training, serum follistatin and myostatin, along with pain intensity and lumbar function, were evaluated. The obtained data were analyzed by paired sample t test and Analysis of Covariance (ANCOVA) to compare intragroup and intergroup differences, respectively.

 Core muscle training led to a significant reduction in the relative pain scale (P=0.001). Follistatin (P=0.001) and myostatin (P=0.001) levels increased and decreased significantly at the end of the training period, respectively. Lumbar function improved in the training group. Changes in means of between groups in relative pain scale, follistatin, myostatin, and lumbar function have a significant difference (P<0.05).

 Core muscle training was associated with a decline in myostatin level, increase in follistatin level, and improving lumbar function. In summary, core muscle training may decrease muscle atrophy related to age.

Irisin myokine whose secretion is induced by exercise is associated with an increase in thermogenesis. However, the effect of aerobic exercise with different intensities on the production and release of irisin in overweight individuals is controversial. This study aimed to investigate the effect of eight weeks of aerobic training with different intensities on PGC-1α, FNDC5, UCP1, and irisin in obese male Wistar rats.

In this experimental study, 24 adult obese male Wistar rats (weight: 250-300 g; body mass index [BMI] >30 g/cm2) divided into three groups, including aerobic training with 28 m/min (moderate intensity [MI]), aerobic training with 34 m/min (high intensity [HI]), and control. All training groups exercised for eight weeks walking on a treadmill (five 60-min sessions per week). The paired sample t test and one-way ANOVA were used to determine the intra- and inter-group differences. Furthermore, Tukey’s post hoc test was used.

The levels of PGC-1α in muscle tissue in aerobic training groups with MI and HI increased (P=0.001 and F=11.81) compared to control group. The levels of irisin (P=0.006 and F=6.10) and UCP1 (P=0.04) were significantly increased in MI group. On the other hand, FNDC5 increased significantly in both MI and HI groups (P=0.001 and F=12.49). While irisin and UCP1 levels increased in HI group compared to the control group, the change was not statistically significant (P>0.05). The levels of irisin, UCP1, and FNDC5 increased more significantly in MI group than in HI group (P<0.05).

Both types of aerobic training (MI and HI) had a beneficial effect on changes in irisin, UCP1, FNDC5, and PGC-1α levels. Accordingly, moderate exercise possibly changes the phenotype of white to brown adipose tissue leading to an increase in thermogenesis, body weight loss, and sensitivity to insulin.

Osteoporosis is the most common disorder of bone and mineral metabolism. This disease is associated with decreased bone density and loss of bone microstructure, leading to increased fragility and risk of bone fractures.

The aim of this study was to evaluate the effect of eight weeks of aerobic interval training on the serum concentrations of alkaline phosphatase, osteocalcin, and parathyroid hormone in middle-aged men.

This was a quasi-experimental study of 24 men, who were divided into two groups of control (n = 12) and aerobic interval training (n = 12). Training performed during eight weeks, three times a week, each session for 45 to 60 minutes. Blood samples were analyzed for the concentrations of calcium, phosphorus, alkaline phosphatase, osteocalcin, and parathyroid hormone before and after completion of the training program. Paired samples t-test and analysis of covariance (ANCOVA) were run to analyze the data (P ≤ 0.05).

Weight and bodymass index decreased significantly, and themaximum oxygen consumption at the end of the training program increased significantly in the experimental group. Eight weeks of aerobic exercise led to a significant increase in the amounts of calcium (P = 0.001), phosphorus (P = 0.001), alkaline phosphatase (P = 0.001), osteocalcin (P = 0.001), and parathyroid hormone (P = 0.001) in the experimental group.

It can be stated that eight weeks of aerobic interval training may be effective in preventing osteoporosis by reducing body composition indices and increasing calcium, phosphorus, alkaline phosphatase, osteocalcin, and serum parathyroid hormone in inactive men.

Fibrinogen is one of the most important inflammation factors and a prediction index in cardio vascular diseases. This study was performed with aim to evaluate the effect of aerobic exercise with constant and variable intensities on body composition and some physiological indicators and coagulation factors in middle aged overweight women.

This semi-experimental and practical study was performed in 2015 on 30 women in three groups: aerobic exercise with constant intensity (n=10), variable intensity (n=10) and control (n=10) in the city of Bojnourd. The aerobic training program included eight weeks of aerobic training, 30 minutes of aerobic training with a constant intensity with 60% of heart rate and variable intensity included 2 minutes of bike pedaling with 50% of maximal heart rate and 1 minute of bike pedaling with 70% of maximal heart rate. The levels of fibrinogen, PT, PTT, platelet count and non-coagulation factor were collected 24 hours before and 48 hours after the training session. Data were analyzed by SPSS software (version 25) and dependent t-test, Analysis of covariance (ANCOVA) and tukey post hoc test for intra-group and inter-group changes, respectively. P<0.05 was considered statistically significant

Weight (constant intensity, P=0.001 and variable intensity, P=0.001), body mass index (constant intensity, P=0.001 and variable intensity, P=0.001), systolic (constant intensity, P=0.03 and variable intensity, P=0.001), and diastolic blood pressure (constant intensity, P=0.001 and variable intensity, P=0.001) decreased significantly in both groups. However, body fat percentage decreased significantly only in the constant intensity group (P=0.001). Prothrombin time (PT) (constant intensity, P=0.004 and variable intensity, P=0.009), thromboplastin time (PTT) (constant intensity, P=0.005 and variable intensity, P=0.01), fibrinogen (constant intensity, P=0.001 and variable intensity, P=0.02), and platelet counts (constant intensity, P=0.02 and variable intensity, P=0.001) significantly decreased in both groups. However, non-coagulation factor significantly increased in both groups (constant intensity, P=0.003 and variable intensity, P=0.001). The amount of flexibility (constant intensity, P=0.003 and variable intensity, P=0.001) and maximal oxygen consumption (constant intensity, P=0.001 and variable intensity, P=0.001) increased significantly in both groups

Eight weeks of aerobic training with two constant and variable intensities by reducing body composition indices, coagulation factors and increasing fitness indices in overweight women can possibly improve cardiovascular health and reduce inflammation.

 One of the most challenging aspects of coronavirus disease 2019 (COVID-19) is that a newly infected individual shows diagnosable symptoms, such as body temperature (Tb) rise, several days after contracting the disease. In the early phase of infection (i.e., incubation period), an undiagnosed and unaware individual can spread the virus to others. The fastest and most efficient route of COVID-19 transmission is the respiratory system. Therefore, developing a model of the respiratory system to predict changes in the lung performance upon COVID-19 infection is useful for early diagnosis and intervention during the incubation period.

 This modeling study aimed to evaluate the respiratory system to present an early intervention for COVID-19 and its transmission.

 A simple model was developed by performing mass and energy balances on the lungs; it was simulated by the Aspen HYSYS chemical process simulator.

 To compensate for the virus-infected lung inefficiency, the O2 concentration increased in the exhaled air at the cost of decreased CO2 concentration. Contrary to previous findings on the reduced stability of coronavirus in hot and humid environments, it was found that very hot and humid environments promote the viral transmission rate because of the direct heat transfer to the body via respiration and condensation of water vapor that may cause infection in the respiratory tract.

 Our model revealed that measurement of O2 or CO2 composition of exhaled gas, using a non-invasive and inexpensive device at home, allows for the early diagnosis of infection and its prevention. This study also aimed to highlight the actual effects of high temperature and high relative humidity (RH) on increasing the virus transmission rates, as opposed to the generally accepted hypothesis of decreased coronavirus stability under these conditions.
 

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is the main regulator in energy metabolism. Training stimulates many processes like mitochondrial biogenesis, glucose metabolism, and fatty acids metabolism. It also increases the capacity of fat oxidation. The purpose of this study was to investigate the effects of eight-week aerobic training of different intensities on PGC-1α, interferon regulatory factor 4 (IRF4), and atherogenic index in obese male Wistar rats. Twenty-four obese male rats induced by a high-fat diet (weight: 250 to 300 gr, BMI >30g/cm2) were divided into three groups: aerobic training of moderate intensity (MI), aerobic training of high intensity (HI), and the control group (C). The MI and HI training groups carried out exercise training by eight weeks of walking on a treadmill for five sessions/week, 60 min per session, and at a speed of 28 m/min and 34 m/min, respectively. The levels of PGC-1a in the MI and HI groups significantly increased compared to the C group (p < 0.05). Moreover, there was no significant differences between IRF4 levels of MI and HI groups (p > 0.05). The serum HDL-C levels increased only in the MI group compared to the C group (p  < 0.05). The LDL-C, TG, TC, and atherogenic index levels reduced more significantly in MI and HI groups than in the C group (p  < 0.05). The results show that eight-week aerobic training of two moderate and high intensities may be the signaling pathways to the activation of the PGC-1a protein (i.e., a key regulator of energy metabolism and mitochondrial biogenesis) in skeletal muscle.

 Wrestling is a fast-paced activity in which resistance training is essential to improve athlete performance. We evaluated the effect of comparison of the effect of eight weeks resistance training with two patterns of pyramidal and inverse pyramidal on bio-motor ability, Anthropometrical and skill profile of freestyle wrestlers.

 In this semi experimental study, 24 male freestyle wrestlers were randomly assigned into two groups [pyramidal (n=12) and inverse pyramidal endurance (n=12)]. The pyramidal and inverse pyramidal resistance training included (8 weeks, 3 times per a week, 60 minutes per session). Bio-motor ability, Anthropometrical and skill profile were measured at baseline and at the end of the study. Paired and independent sample t-test were used to compare within and between-group means and the results were tested at the significant level P<0.05.

 Training lead to changes on weight, body mass index, body fat percent, maximum power into pyramidal and inverse pyramidal groups (P<0.05). Anaerobic power, explosive power, muscular endurance increased significantly in both pyramidal and inverse pyramidal patterns. There were significant differences in the between-group mean changes in the variables of weight, body mass index and muscular endurance between the two experimental groups (P<0.05).

 Resistance exercises with pyramidal and inverse pyramidal patterns led to significant weight loss, body mass index, body fat percentage, and improvement of skill profile and biometric indicators. Therefore, using both types of training may have a positive effect on wrestlerschr('39') performance indicators.

Addiction not only causes social and behavioral disorders but also affects various aspects of physical health, causing huge financial damages to individuals, families, and societies. Addicts have lower health and physical activity than the general population. The objective of this study was to investigate the effect of six weeks of aerobic training (in the morning and afternoon) on some cardiovascular indices and quality of life in drug addicted women. In this semi-experimental study, we selected 30 addicted women in Bojnourd city in 2016 by convenience and purposeful sampling method and divided them into experimental (n=15) and control (n=15) groups. The training protocol comprised six weeks of aerobic training (three sessions per week in the morning and afternoon) with each session lasting 45-60 minutes with an intensity of 50-70% of maximal heart rate reserve. All participants were briefed on all study procedures and potential risks; they signed a written consent form after having read and understood the details of the experiments. We used paired sample t-test and ANCOVA to compare within and between-group variance changes;p Weight (66.93±3.23 vs 65.89±3.13), body mass index (24.23±1.95 vs 23.86±1.97), body fat percentage (18.84±2.00 vs 17.96±2.03), fibrinogen (345.80±36.46 vs 338.06±38.74), and serum C-reactive protein (167.40±7.66 vs 159.80±13.96) decreased significantly at the end of the six-week aerobic training period (p <0.05). There were significant differences between the experimental and control groups regarding the mean changes of weight (P=0.001), body mass index (P=0.001), body fat percentage (P=0.005), maximal oxygen consumption (P=0.01), physical restraint (P=0.001), general health (P=0.001), vital force (P=0.004), social activity (P=0.001), physical performance (P=0.001), emotional performance (P=0.001), and life satisfaction (P=0.001). Six weeks of aerobic training in the morning and afternoon is likely to improve cardiovascular health and reduce the risk of atherosclerosis in female drug addicts.

The 3000-meter run is one of the most popular and enduring materials among endurance and semi-endurance races and because of the special conditions of this field, which can use aerobic and anaerobic energy production systems at the same time. We evaluated the effect of eight weeks resistance and endurance training on physiological, functional factors and elite runnerchr('39')s record.

In this semi experimental study, 24 male runners were randomly assigned into two groups [resistance (n=11) and endurance (n=11)]. The resistance and endurance training included (8 weeks, 3 times per a week, 55-60 minutes per session). Physiological and functional factors were measured at baseline and at the end of the study. Repeated measures analysis of variance was used to compare within-group and between-group means and the results were tested at the significant level p<0.05.

Training lead to changes on heart rate, blood pressure, muscle strength, muscular endurance, balance and a record of 3000 meters were significant in both resistance and endurance training groups (P<0.05). There were significant differences in the between-group mean changes in the variables of heart rate, blood pressure, muscle strength, muscular endurance, balance and a record of 3000 meters between the resistance and endurance groups (P<0.05).

Resistance and endurance training were associated with increased muscle strength, muscular endurance, balance, and a significant reduction in the male runnerchr('39')s record. In summary, using both types of exercise may have a positive effect on runnerschr('39') records and performance indicators.

 The lack of physical activity and obesity causes mild chronic inflammation that is associated with increased plasma levels of inflammatory markers. Evidence suggests that physical activity can reduce inflammatory markers.

 The purpose of this study was to determine the effects of eight weeks of aerobic training with two intensities on levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and insulin resistance in obese Wistar rats.

 Twenty-four Wistar male rats (fourteen weeks old and weighing 250 - 300 g, body mass index > 30 g/cm2) were used. After two weeks of familiarity with the laboratory environment, the animals were randomly divided into three groups: (1) high-intensity aerobic exercise (n = 8); (2) moderate-intensity aerobic exercise (n = 8), and control (n = 8). The rats in moderate and high-intensity aerobic exercise groups were performed an increasing training for eight weeks and five days a week and one session per day for 60 minutes running at different speeds on a rodent motor-driven treadmill. Data were analyzed by paired sample t-test and repeated measures (ANOVA) for the inter-group and intra-group comparison of the variance changes.

 Significant differences were found in serum TNF-α levels (P = 0.027 and F = 3.42), IL-6 levels (P = 0.043 and F = 2.99), and insulin resistance index (P = 0.008 and F = 4.69) between the moderate, high-intensity aerobic exercises, and control groups. The levels of TNF-α concentration was significantly different between moderate-intensity and control group (P = 0.01) and between the high-intensity and control groups (P = 0.01). The insulin resistance index in MI (P = 0.01) and HI (P = 0.01) groups significantly decreased compared to the control group.

 The results of the present study show that both types of moderate-intensity and high-intensity aerobic exercise lead to the reduction of TNF-α, interleukin-6, and insulin resistance index compared to the control group. Further studies are needed to shed light on the effects of different types of exercise on such indices, especially the use of long-term training sessions.

Several studies have been done on the effects of fasting on human health indicating the beneficial effects of fasting on weight control, lipid metabolism, and lowering blood pressure in healthy people. The present study aimed at investigating the effects of Ramadan fasting on apolipoproteins A and B (Apo A and Apo B) and the atherogenic index of the fasting and non-fasting students.

This quasi-experimental study was conducted on 29 men aged 20-25 years. The samples were divided into the fasting (n=15) and non-fasting (n=14) groups. Serum levels of apolipoproteins A and B, biochemical-hematological factors, and atherogenic index were measured three days before the fasting month and after Ramadan. The inter-group and intra-group comparison was performed using student’s t-test, and one-way Analysis of Variance (ANOVA) was used to assess the differences between the groups. 

In the fasting group, a significant reduction was observed in Apo B, triglyceride, total cholesterol, low-density lipoprotein, low-density lipoprotein to high-density, and triglycerides to high-density lipoprotein cholesterol ratio. However, the Apo A (P=0.001) and high-density lipoprotein (P=0.004) significantly increased after the intervention. The Atherogenic index, white blood cells, red blood cells, hemoglobin, hematocrit, and platelet count significantly decreased in the fasting group (P≤0.05).

According to the results, fasting during Ramadan could improve the biochemical and hematological factors. Therefore, it is recommended to use some biochemical and hematological indices to compare the effects of fasting to improve in of students these parameters.

Renal failure is strongly associated with serum osmolarity and changes in electrolytes and some blood metabolites. Because fasting is often associated with Ramadan, especially during the warm months of the year, there is a concern that renal function may be affected.

This study aimed to observe the effect of one month of fasting on electrolytes, serum osmolarity and body composition in fasting and non-fasting students.

Twenty-nine healthy males (age 21.20 ± 1.69 years and body mass index 25.03 ± 2.11 kg/m2) were divided into two groups: fasting (n = 15) and non-fasting (n = 14). All measurements such as electrolytes index, serum osmolarity and body composition were collected before and after the fasting month. Data were analyzed with repeated measure ANOVA to compare within and between groups. The significance level was set at P < 0.05.

Within-group variations were changed BMI, WHR, hip circumference, and waist circumference. Fasting glucose levels were significantly decreased at the end of the fasting period (P < 0.05). Fasting urea, creatinine, uric acid, sodium, potassium, osmolarity increased significantly in the fasting group but no significant change was observed in serum albumin levels.

According to this result, fasting during Ramadan leads to an increase in osmolarity and serum electrolytes and a decrease in body composition. However, the use of healthy eating principles during Ramadan can help minimize these changes.

Visfatin and resistin are adipokines involved in metabolic regulation and physiological processes.

This study aimed to investigate the effects of eight weeks of aerobic training with different intensities on serum levels of resistin and visfatin in obese male rats.

24 adult obese rats (weight: 250 to 300 gr, BMI > 30 g/cm2) divided into three groups: aerobic training with 28 m/min (moderate intensity), aerobic training with 34 m/min (high intensity) and, control group. All training groups did exercise training for 8 weeks (5 sessions/per-week for 60 minutes per session). 48 hours after the training period, the level of serum visfatin and resistin levels was measured.

Unlike the levels of resistin concentration (P = 0.001) in different groups, there was no significant difference between visfatin levels in all three groups. Resistin concentration was not significantly changed in the moderate-intensity group compared to the control group, (185.10 ± 12.85 vs. 202.76 ± 17.39) (P = 0.05). There was a significant difference between the high intensity and control groups (P = 0.001). There was no significant difference in visfatin concentration in MI and HI groups compared to the control group (P > 0.05).

There is a significant difference in the levels of resistin concentration in different groups. There was no significant difference between visfatin levels in all three groups. Therefore, it seems that aerobic training with high intensity has a better effect on the prevention of obesity and cardiovascular disease.