جستجوی مقالات مرتبط با کلیدواژه "interleukin 6" در نشریات گروه "تربیت بدنی"

The purpose of this research was to investigate the effect of 8 and 12 weeks of high intensity interval training (HIIT) on the serum level of C-reactive protein (CRP), interleukin-6 (IL-6), homocysteine (HCY) and lipid profile of active middle-aged men.For this purpose, 30 active middle-aged men, were randomly divided into two groups: HIIT training and control group. HIIT Training subjects do HIT training 3 session per week for 12 weeks with 90% of maximum heart rate. The Serum levels of CRP, IL-6, HCY, HDL, LDL, TC and TG were measured 12 hours before the first session of training protocol, and 48 hours after 8th and 12th weeks of HIIT. Results show that HIIT had a significant effect on LDL, TC and TG Indices in active middle-aged men in both 8 and 12 weeks (P˂0/05). On the other hand, HIIT did not have a significant effect on CRP (P=0/848), IL-6 (P=0/080) and HCY (P=0/247) indices in 8 weeks, but it did have a significant effect on CRP (P=0/003), IL-6 (P=0/019) and HCY (P=0/012) indices in 12 weeks. HIIT appears to produce favorable changes on lipid profile of middle-aged men over a period of 8 weeks, But it does not have the ability to improve their inflammatory indicators and create favorable changes in inflammatory indices, it is necessary to perform HIIT for more than 8 weeks and a period of 12 weeks will bring about favorable changes and It is likely to have an effective role in preventing middle-aged heart diseases.

Multiple sclerosis is the most common autoimmune inflammatory demyelinating disease of the central nervous system that affects the myelinated axons of the central nervous system and causes neurological deterioration. The prevalence of this disease in women is reported to be 3 times that of men. In recent years, more people with the disease have sought alternative drug therapies to manage symptoms, including mind-body therapies such as yoga, meditation, breathing, and relaxation techniques. The present study was conducted with the aim of investigating the effect of eight weeks of yoga training on the serum levels of tumor necrosis factor alpha, interleukin 6, interleukin 10 and body composition in women with multiple sclerosis.

In this semi-experimental study, 20 women with multiple sclerosis who were referred to the medical centers of Semnan city (mean±SD; age, 36.75±6.10 years; body mass index, 26.88±6.02 kg/m2; and with EDSS index >3.5) were selected and randomly divided into two groups of yoga training (n=10) and control (n=10). The experimental group performed yoga training for eight weeks, three sessions per week (24 sessions) in an indoor hall with a temperature of 25-26°C. The training protocol started with performing two sets of 10 seconds for 15 movements and to observe the overload principle every two weeks, 5 seconds were added for each training movement and one movement was added to the training protocol, where at the final week number of movements reached 18 movements and 15 seconds. During this period, the control group had no regular physical activity and had normal daily activities. In order to determine and control the training pressure, the Borg’s rate of perceived exertion (RPE) scale was used. Statistical analysis of the data was performed by using the repeated measures of ANOVA, independent t-test and dependent t-test at a significance level of p≤0.05.

The results of this study showed a significant decrease in the serum levels of tumor necrosis factor alpha, interleukin 6 and interleukin 10 in the experimental group compared to the control group after eight weeks of training (p=0.001). However, no significant difference was observed in the body composition of women with multiple sclerosis compared to the control group after eight weeks of yoga (p>0.05).

Finally, the results of this research showed that eight weeks of yoga training by reducing inflammatory cytokines and adjusting the serum index of tumor necrosis factor alpha and interleukin 6, can be used as a complementary treatment along with drug treatments for patients with multiple sclerosis.

Cardiovascular diseases are the most important cause of death among women. Hormonal changes around and after menopause can affect inflammatory factors such as interleukins and tumor necrosis factor alpha (TNF-α) as well as vascular function. The aim of this research was to determine the effect of a session of aerobic exercise with moderate intensity on interleukins 6 and 8, TNF-α, as well as vascular function (flow mediated dilation) in premenopausal and postmenopausal women.

In this semi-experimental study, 30 inactive women without any cardiovascular disease participated in the study voluntarily, which were allocated into two equal groups (n=15) of premenopausal women (age, 47.7±1.3 years) and postmenopausal women (age, 56.8±1.5 years). Participants in both groups performed a session of moderate intensity aerobic exercise included 30 min of running on a treadmill at 60-70% of heart rate reserve. Participants' blood samples were collected 30 min before and 30 min after the exercise and were analyzed to measure inflammatory factors (interleukin 6, interleukin 8 and TNF-α). Vascular function was evaluated by measuring flow mediated dilation at 15 min before and 15 min after aerobic exercise. Data were analyzed by using SPSS software and covariance test (P>0.05).

In response to a session of moderate intensity aerobic exercise, no significant difference was seen in interleukin 6 and 8 between two groups of premenopausal and postmenopausal women (P=0.432, P=0.097), but TNF-α decreased significantly in premenopausal whereas it it did not change in postmenopausal women (P=0.003). In addition, vascular dilation after a session of moderate intensity aerobic exercise was significantly (P=0.001) different between premenopausal and postmenopausal women , where, flow mediated dilation increased in premenopausal compared to postmenopausal women.

Based on the increased FMD and decreased TNF-α in premenopausal women, in general our findings show that following acute exercise factors associated with endothelial responsiveness are improved in premenopausal women while responses are decreased in postmenopausal womenHowever, lack of differences in interleukins 6 and 8 between premenopausal and postmenopausal women might indicate increased inflammation in premenopausal women, which is a reason for the onset or increases in disorders of endothelial function during menopause.

Increased inflammation caused by obesity is related to vascular health. The present study was conducted with the aim of investigating the effect of aerobic training and caloric restriction on some indicators of vascular inflammation and interleukin 1 in obese male rats.

Twenty-four male rats were randomly divided into four groups: control, exercise, calorie restriction, and exercise + calorie restriction. The aerobic training program was maintained for eight weeks, and the intensity was 24-33 meters per minute with a slope of 15%, and the duration of the training was from 10 minutes on the first day of training to 60 minutes per day, increasing in the fifth week of training and until the end of the program with the same conditions. Restricted groups received 50% of the amount of food consumed by other groups. The concentration of I-selectin, ICAM and interleukin-1 was measured by ELISA method. One-way analysis of variance and Tukey's post hoc test were used at a significance level of 0.05.

The findings showed that aerobic training, calorie restriction and aerobic training with calorie restriction led to a significant decrease in e-selectin (P=0.001), decrease in ICAM (P=0.002) and interleukin-1 (P=0.001).

Eight weeks of aerobic training without and with calorie restriction leads to improvement of some vascular inflammation factors.

The aim of this study was to evaluate the effect of HMB-FA supplementation on inflammatory parameters during a two-race microcycle in Soccer players.

A total of 24 Soccer players (mean age: 23±30 years) were randomly divided into two groups supplement (n = 12) and placebo (n = 12). Subjects in the supplement group and the placebo group participated in a weekly microcycle with two races per week. Subjects in the supplement-training group consumed three grams of HMB-FA daily during a weekly soccer cycle. Serum levels of inflammatory markers of interleukin-1 beta, interleukin-6 and reactive protein-C in seven stages (before supplementation, before the first race, after the first race, 24 hours after the first race, before the second race, after from the second race, 24 hours after the second race) were evaluated. For data analysis, repeated measures test and paired t-test and SPSS software version 25 were used. Significance level was considered α = 0.05.

The results of the present study showed that training and two Soccer matches increased all inflammatory indices (for all, P≤0.05).

Consumption of HMB-FA supplement reduces inflammatory factors during a two-match Soccer microcycle, which shows the ability of this supplement to control the inflammatory status of Soccer players in inflammatory conditions caused by two matches per week.

Introduction and Inflammatory markers play an important role in the pathogenesis of diabetes. However, the effect of exercise and Mulberry leaf extract on diabetics is not well known. The purpose of this study was to investigate the effect of eight weeks of aerobic-resistance exercises along with the consumption of Mulberry leaf extract on the serum levels of TNF-α and interleukin 18 in elderly patients with type 2 diabetes. In this clinical study, 40 elderly men (mean age: 67.07±1.50) with type 2 diabetes were randomly divided into five control groups (8 people), placebo (8 people), and Mulberry leaf extract (8 people). Combined training (8 people) and Mulberry leaf extract + combined training (8 people) were included. The exercises were done for eight weeks and three sessions per week for 90 minutes. 3000 mg of Mulberry leaf extract per day was prescribed along with three main meals. Before the intervention and 48 hours after the last training session, serum levels of TNF-α and interleukin 18 were measured through blood samples. The SPSS software and the analysis of covariance statistical test, followed by the Benferroni post hoc test at a significance level of 0.05, were used to analyze the data. A significant decrease in TNF-α and interleukin 18 levels was observed in the exercise, extract and exercise+extract groups (P<0.05). The results between the groups showed a significant difference in TNF-α (P=0.001) and interleukin 18 (P=0.001), which is greater in the extract + exercise group than the exercise and extract groups.Discussion and It seems that 8 weeks of combined exercise combined with the consumption of Mulberry leaf extract reduces the inflammatory cytokines TNF-α and interleukin-18 in elderly men with type 2 diabetes.

Introduction and Brain trauma is one of the most common causes of damage to the central nervous system that can cause death and long-term disabilities. The purpose of this research is to investigate the effect of a swimming training course on the amount of memory and interleukin-6 in the hippocampus and prefrontal cortex of rats with brain trauma. The current research is experimental and developmental. 40 NMRI male mice were randomly divided into 2 equal groups (trained mice and non-trained mice). Mice in the training group underwent swimming training from the age of 28 days to the age of 80 days for 8 weeks (5 days per week). After completing the exercise protocol, each group was divided into 2 equal groups by a simple random method, rats without training (control, trauma) and training rats (swimming training, swimming training trauma). At the end of the eighth week, trauma induction was performed on the right temporal region in the trauma swimming training group and trauma by weight drop method. 14 days after trauma induction, the rats were tested for new object recognition memory. Statistical analysis was done through one-way analysis of variance with Tukey's post hoc test at a significance level of P≥ 0.05 and using SPSS-26 software. The results of the research showed that 8 weeks of swimming exercise significantly increases the amount of memory in rats suffering from brain trauma (P=0.001). Also, 8 weeks of swimming exercise causes a significant decrease in the amount of interleukin-6 in the prefrontal cortex of rats with brain trauma (P=0.003), but this decrease was not significant in the hippocampus (P=0.076).Discussion and The results of the present study showed that swimming exercises before brain trauma can reduce inflammation and memory disorders caused by brain trauma through mechanisms such as reducing the level of pro-inflammatory cytokines such as interleukin-6.

The purpose of this study was to investigate the effect of Interval resistance training with different intensities on the levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and neuroglin-4 (NRG-4) in obese men.

In this semi- experimental research, 44 obese men aged 20-30 years old in Tabriz city were selected and divided into 4 control groups, low intensity Interval resistance training with low intensity, medium intensity and high intensity. In the continuation, the subjects of the resistance training group performed their training program for 12 weeks, three sessions a week with 3 different intensities (40% 1RM with 20 repetitions, 60% 1RM with 12 repetitions and 80% 1RM with 20 repetitions) and 48 hours before the first training session and 48 hours after the last resistance training session, the subjects' personal characteristics and serum levels of IL-6, TNF-α and NRG-4 were measured by ELISA.

The research findings showed that 12 weeks Interval resistance training decreased serum levels of IL-6 in group with high intensity (P=0.01) and increased serum levels of NRG-4 in exercise groups with different intensities(P=0.001) in obese men, but it had no significant effect on TNF-α levels (P=0.05). The dcrease in IL-6 and increase in neuroglin-4 levels in the high intensity Interval resistance training group (P=0.02) was the most compared to other groups (P=0.02 and P=0.001; respectively).

It seems that Interval resistance training with different intensities can improve inflammatory indices and neuroglin-4 in obese people, and this improvement was more prominent in high-intensity resistance training.

Atherosclerosis is a chronic disease whose first stages can begin in childhood. Obesity is one of the major risk factors for atherosclerosis, which is becoming an epidemic. The increase in prevalence of obesity has focused more attention on the relationship between obesity and atherosclerosis, and although the relationship between obesity and atherosclerosis has been widely reported, its potential mechanisms still need to be further elucidated. Salusins are a new class of bioactive peptides that play an important role as endogenous regulators of atherosclerosis process. Obesity is associated with a chronic inflammatory response characterized by abnormal adipokine production and activation of some pro-inflammatory signaling pathways. Past studies have shown that inflammatory process has a cause and effect relationship with obesity and cardiovascular diseases, including atherosclerosis. Also, arterial endothelial disorder is an early disorder in process of atherosclerosis, and presence of this disorder in obese children has been widely reported. The most important potential factor that will lead to obesity, inflammatory conditions and endothelial dysfunction is immobility. On the other hand, physical activity has wide health benefits and is considered as an important factor in primary and secondary prevention of cardiovascular diseases. Therefore, the current research seeks to investigate the role of physical activity in improving endogenous regulators of atherosclerosis in obese and sedentary children.

The purpose of the present study is to compare resting levels of Interleukin-6, Tumor Necrosis Factor-Alpha, and some portions in the immune system of athletes and non-athletes with spinal cord injury. Convenience sampling was used in this study and accordingly 10 non-athletes and 10 athletes from different fields were chosen. For testing the immune system, the number of white blood cells (lymphocytes, monocytes, and neutrophils), and for testing inflammatory indexes, resting levels of Interleukin-6 and Tumor Necrosis Factor-Alpha in the blood serum sample were measured. For measurement of blood parameters, ELSA method and the special kit were used. Descriptive statistics was used for data explanation/description and inferential statistics was used to explore the research results. Independent t-test was applied for the comparison between the research variables related to two athletic and non-athletic groups. The results revealed that there is no significant difference between athletes and non-athletes in Interleukin-6 (p=0.859), Tumor Necrosis Factor-Alpha (p=0.539), and the number of white blood cells (p=0.942). It seems that exercising is not considered as a threat for the immune system of those who have spinal cord injury although more research is needed to explore the effect of sport on the immune system of such patients.

Diabetes leads to defects in BDNF function and disturbances in CRP and IL-6 serum levels. The purpose of the study was to determine the effect of eight weeks of simultaneous endurance-resistance exercise on BDNF, CRP, and IL-6 serum levels in type1 diabetic male Wistar rats.

In this experimental study, 30 adults male Wistar rats (250-300 grams and aged six weeks) were randomly divided into three groups including two diabetic groups, diabetic exercise (n=10), diabetic control (n=10) and a non-diabetic group, healthy control (n=10). At the end of the eight-week-old, an amount of 55 mg/kg of body weight of streptozocin (STZ) was injected intraperitoneally, to make diabetic. The diabetic exercise group performed the eight weeks of combined exercises; 5 times per week (endurance exercise with 75% Vo2max on the treadmill and strength training including 15 times climbing the ladder). To measure the serum levels of BDNF, CRP, and IL-6, blood samples were taken. One-way ANOVA and post-hoc Bonferroni test were used to compare between-group and intra-group changes of BDNF, CRP, and IL-6. The significance level was P<0.05.

After eight weeks of endurance-resistance training, BDNF level significantly increased in the diabetic exercise group compared to the diabetic group (P=0.009). Whereas, it significantly decreased in the diabetic control group compared to the healthy control (P=0.0001). CRP levels significantly decreased in the diabetic exercise group compared to the diabetic group (P=0.008). However, it significantly increased the diabetic control group compared to the healthy control (P=0.0001). There was no significant change in IL-6 level (P=0.057).

It is recommended that diabetic people perform eight weeks of simultaneous endurance-resistance exercises to increase BDNF levels and reduce inflammation.

Glucose absorption improves in the human body by IL-15 and related metabolic disorders in patients with metabolic syndrome (MS) may be affected by aerobic exercise. The aim of this study was to investigate the effect of an aerobic exercise session on interleukin-15 levels and metabolic risk factors.

In this study 20 men with MS were selected voluntarily and randomly divided into two control (n=10) and aerobic exercise (n=10) groups. The exercise program included 12weeks of aerobic exercise with 3 sessions per week and each session consisted of 45 minutes of exercise with an intensity of 60-70% of the maximal heart rate. Blood samples were taken from the subjects before and after the intervention of the exercise program to measure blood variables including IL-15, HDL, LDL, TG, TC, and blood glucose. The data were analyzed by independent and dependent sample t-tests at a significance level of 0.05.

There is a significant difference between the two groups in all variables. In the exercise group, in the post-test compared to the pre-test, the values of IL-15, HDL, and VO2peak significantly increased (P<0.05).  The values of BW, BMI, WC, MBP, TC, TG, LDL, FBS, and insulin resistance index had a significant decrease (P<0.05).

12 weeks of moderate- intensity aerobic exercise program can be suggested as a non-drug method to control metabolic risk factors in patients with metabolic syndrome.

physical activity can play a supportive role in breast cancer improvement by regulating and modulating cytokines. Interleukin 10 is an anti-inflammatory cytokine that plays an important role in preventing the growth and metastasis of breast cancer, and interleukin 4 is an inflammatory cytokine that causes the growth and development of cancer cells. The present study was conducted with the aim of investigating the effect of 12 weeks of Pilates exercises on the serum levels of interleukin 4 and interleukin 10 in women with breast cancer.

The present study was conducted in a semi-experimental manner with two experimental and control groups on 30 women with breast cancer. The experimental group was given Pilates exercises for 12 weeks and 3 sessions each week for 60 minutes, while the control group did not participate in any physical activity. Blood samples were taken 48 hours before and after exercise intervention to measure interleukin 4 and 10 variables.

Based on the results of the correlated t test, the serum level of interleukin 10 in the experimental group increased significantly compared to the control group (P=0.001), and the amount of interleukin 4 in the experimental group showed a significant decrease compared to the control group(P=0.001).

Performing Pilates exercises with the benefit of anti-inflammatory cytokines and reducing inflammatory cytokines improves the health status of women with breast cancer. Therefore, doing exercises can help patients as a therapeutic factor. 

The inflammatory factors can be considered as one of the important factors involved in metabolic disorders and diabetes. The identifying of the best type of exercise training has been considered as an important method for reducing inflammation. The purpose of this study was to compare the effects of six weeks aerobic, resistance and concurrent exercise trainings on plasma levels of IL-10/TNF-α ratio and insulin resistance index in diabetic male Wistar rats.

The research was performed as an experimental research method. Statistical population were consisted of male Wistar rats with a weight range of 130 to 150 gr. Forty male Wistar rats were randomly divided into five groups (n=8) including resistance training (intensity about 60% one repetition maximum), aerobic training (intensity of 50-60% VO2max), concurrent training, diabetic control and inactive healthy control groups. All groups performed their relevant exercises for six weeks/three times in each week. Forty eight hours after of last training session, blood samples were taken directly from the heart and blood data were collected. Inflammatory factors and insulin resistance were measured by ELISA and HOMA-IR methods respectively. The one-way analysis of variance and LSD post hoc statistical methods were applied at a significant level of p≤0.05.

Levels of IL-10/TNF-α ratio in diabetic control (p=0.001), aerobic training (p=0.02), resistance training (p=0.003) and concurrent training (p=0.003) groups significantly decreased compared to healthy control. On the other hand, in training groups compared to diabetic control, no significant change was observed (p>0.05). Moreover, insulin resistance index in aerobic, resistance and concurrent training groups (p=0.002, p=0.03 and p=0.01 respectively) significantly decreased compared to the diabetic control. No significant differences were observed between the training groups.

Performing of resistance, aerobic and concurrent exercises for six weeks improves type II diabetes; but it probably does not have enough potential to improve the body’s inflammatory conditions.

Considering the worldwide obesity and its adverse effects on health, physical and mental condition of obese people and also the response of cytokines secretion in response to muscle contractions and their effect on reducing the percentage of fat and obesity, in this study the effect of two types of high intensity interval training on plasma interleukin-6 and irisin concentrations was observed in young overweight womenThis research is a quasi-experimental and laboratory study in which two types of high intensity interval training protocols were performed for 30 weeks on 30 available targeted samples (in 3 random groups, HIIT1, HIIT2 and control).Findings showed that the use of two types of high intensity interval training protocols of 4- phase and 8-phase on interleukin-6 levels in the post-test had significant changes compared to the pre-test (P<0.05) and reduced it, but in comparison between the two types of HIIT training No interleukin-6 levels were observed. Also, intense 4-phase and 8-phase high intensity interval training had significant effects on plasma irisin concentration in the post-test compared to the pre-test (P<0.05) and a significant increase was observed, but there was a difference between the two types of HIIT training. No significant levels were reported in irisin levels.In general, it can be said that according to the results obtained from the two protocols of intense intermittent exercise, 4-phase and 8-phase, had a positive and significant effect on plasma levels of interleukin-6 and irisin in overweight women and can play an effective role in weight loss in these people.