جستجوی مقالات مرتبط با کلیدواژه "هموگلوبین" در نشریات گروه "پزشکی"

Acute kidney diseases impose a significant burden on long-term hospitalizations. The aim of this study was to determine the effect of 8 weeks of swimming exercise and zinc supplementation on renal function markers following unilateral ureteral obstruction in rats.

In this experimental study, 32 nephrectomized rats aged 8-10 weeks and weighing 190-220 grams were randomly divided into 4 groups: 1) nephrectomy control (Nef), 2) swimming training (ST), 3) zinc supplementation (Z), and 4) swimming training + zinc supplementation (ST+Z). Additionally, 8 healthy rats were included as a normal control group to assess the effects of unilateral ureteral obstruction. The ST and ST+Z groups swam for 8 weeks, 3 sessions per week, for 20-45 minutes each session in a special animal pool. The Z and ST+Z groups also received 30 mg/kg zinc sulfate daily by gavage. Serum creatinine, hemoglobin, sodium, potassium, and phosphorus levels were measured.

Sodium and creatinine levels were significantly lower in the Z, ST, and ST+Z groups compared to the Nef group (P≤0.05). Potassium levels were significantly lower in the Z group compared to the Nef group (P=0.018). Phosphorus levels were significantly lower in the ST+Z group compared to the Nef group (P=0.003).

The results of this study showed that exercise and zinc supplementation have interactive effects on improving ion balance and reducing serum creatinine following unilateral ureteral obstruction in animal models. Therefore, it is suggested that the combination of swimming exercise and zinc supplementation be used in conditions of kidney disorders.

Optimizing DNA extraction for the preservation of telomere length – as a biomarker for ageing and vari-ous diseases – is highly important. Long-term stored blood samples are considered essential resources for genetic studies. In this study, different lysis buffers were used along with CTAB extraction buffer to inves-tigate the quality of extracted DNA and the effect of its accompanying inhibitors on quantitative PCR (q-PCR) in telomere studies.

DNA extraction was performed using six RBC lysis buffers and CTAB-based extraction buffer. DNA integrity was evaluated by gel electrophoresis, quantity by absorbance at 260 nm and its purity with expected values of 1.8 and 2-2.2 for the ratios of A260/A280 and A260/A230. The quantitative effect of each buffer in q-PCR and the repeatability of the results were assessed by calculating the reaction efficiency, coefficient of determination (R2), and percentage of coefficient of variation (%CV).

Buffer number 5 (10 mM Tris-HCl, pH 7.6, 50 mM NaCl) yielded the highest amount of DNA extraction (324.93 ng/ml, %CV 11.53). All the extracted DNA samples were pure, as indicated by the acceptable A260/A280 and A260/A230ratios (p>0.05). Gel analysis revealed that the extracted DNA of all the buffers ex-cept one was intact. The DNA molecule extracted with buffer number 1 (155 mM NH4Cl, 10 mM KHCO3, and 5 mM EDTA) showed the best performance in q-PCR for HBG gene (efficiency=0.126, R2=0.97) and telomere (efficiency=0.99, R2=0.99).

The DNA molecule extracted from frozen blood samples by buffer number 1 showed the least q-PCR inhibition for telomere study.

The correlation between hemoglobin and hematocrit with CT number superior sagittal sinus was investigated in this study. This issue can be used in the diagnosis of superior sagittal sinus thrombosis or anemia.

Methods and Materials:

 The participants of this cross-sectional study were 100 patients referred to Beasat Hospital of Hamadan for head CT scan in 2021. The CT number of the superior sagittal sinus was measured from the CT images obtained with a 16 slice CT scanner. Hemoglobin and hematocrit levels were obtained from complete blood count (CBC) test. Data were analyzed using SPSS software and Pearson’s correlation test was used to determine the relationship between CT number and hemoglobin or hematocrit. Independent t-test was used to compare the results.

The average age of the patients was 48.58 ± 20.68 years. The mean CT number of the superior sagittal sinus was 50.78 ± 5.94 HU in sequential mode and it was 50.53 ± 5.66 HU in spiral method (P=0.84). The average hemoglobin of the blood of the patients was 13.66 ± 2.07 g/dl and their hematocrit value was 42.47 ± 4.80%. There was not any significant correlation between the superior sagittal sinus CT number and the hemoglobin level (r=0.04, n=100 and p=0.637); however, there was a significant positive correlation between the superior sagittal sinus CT number and the hematocrit level in the sequential scan mode(r=0.39, n=100 and p<0.01).

It is not possible to obtain the blood hemoglobin level by measuring the CT number of the superior sagittal sinus; however, the hematocrit level can be estimated using the sequential scan mode.

</span></span> Determining the concentration of hydrogen peroxide in liquids and biological samples is very important because of its effects on human health. This study aimed to design a new electrochemical biosensor based on hemoglobin to detect hydrogen peroxide in serum samples.</span></span></span></span></span></span>

</span></span> In this study, a basic science, a biosensor based on modifying the glassy carbon electrode surface with a nanocomposite consisting of cobalt oxide nanoparticles and multi-walled carbon nanotube functionalized with a carboxyl group (MWCNT/Co3</sub>O4</sub>) and hemoglobin stabilized on this nanocomposite was made as a biological recognition element.</span></span></span></span></span></span>

</span></span> In optimal conditions, the biosensor was used to measure different concentrations of hydrogen peroxide. The designed biosensor showed a wide linear response range from 10 μM to 500 μM, a detection limit of 0.512 μM, and high reproducibility and stability.</span></span></span></span></span></span>

</span></span> In this innovative research work, MWCNTs/Co3</sub>O4</sub> nanocomposite was used to make a diagnostic biosensor. The presented biosensor showed an acceptable performance in the measurement of hydrogen peroxide in serum samples and laboratory solutions.</span></span></span></span></span></span></div>
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Many of hip fracture patients need transfusion. We examined the frequency of blood transfusion, the relative factors, and the threshold of hemoglobin in hip fracture patients receiving blood transfusion before and during pelvic surgeries.

This retrospective cross-sectional study was conducted on all patients with proximal femur fractures who underwent hip surgery at Shahid Chamran Hospital in Shiraz in 2020. The frequency of blood transfusion, hemoglobin threshold, and the related factors was investigated.

Out of 218 patients, 65 (29.8%) had received blood out of whom 23 patients (35.4%) had received blood before surgery. The hemoglobin threshold before transfusion was 10.99. The average hemoglobin in patients who received blood was less than the patients who did not receive blood (p< 0.001) 10.55 ± 1.61 versus 12.45 ± 1.61. The average number of units used in patients who received blood was 2.30 ± 0.72 (1 to 4 blood units). The frequency of blood transfusion was related to hemoglobin before surgery, gender, type of anesthesia, type of surgery, history of anemia, duration of surgery, and surgeon. The amount of blood consumption did not depend on the patient age .

The average hemoglobin before transfusion was higher than previous studies. It seems that the blood transfusion threshold was higher than in previous studies. Considering the risks and costs of blood transfusion, it seems that physicians' education and emphasis on the use of restrictive transfusion strategy can lead to reduction of blood consumption, reduction of complications, and better blood management.

Thalassemia patients are associated with a wide range of serious psychological and clinical challenges and, like any other chronic disease, the psychological state of individuals is affected. The aim of this study was to compare the effectiveness of act therapy and cognitive-behavioral therapy on life expectancy and hemoglobin levels in patients with thalassemia major.

The research method was quasi-experimental with pre-test design, post-test with control group. A total of 75 thalassemia major patients referred to Imam Ali Hospital in Karaj who were eligible for the study were identified and randomly assigned to three groups of 25 (two intervention groups and one control group). For the first group, act therapy was performed in 8 sessions and in the second group, cognitive-behavioral therapy was performed in 8 sessions, and the control group received routine care.

Mixed analysis of variance was used to analyze the data. The results showed that the effect of treatment (act) and cognitive-behavioral therapy on increasing life expectancy in patients with thalassemia major (P = 0.001) was statistically significant compared to the control group. Also, the increase in mean life expectancy in act therapy was more than cognitive-behavioral therapy and was statistically significant (P <0.001). But there was no significant difference in hemoglobin level between experimental and control groups.

Considering the effectiveness of treatment (act) and cognitive-behavioral therapy on life expectancy in patients with thalassemia major, the results of this study can be used in real applications.

Zinc sulfate binds to the R group of some amino acids, such as histidine and cysteine, resulting in protein precipitation. In an ELISA and colorimetric experiments, we determined the optimal concentration of zinc sulfate to precipitate hemoglobin, which in turn affects the level and activity of Caspase 3 in red blood cells.

Osmotic stress was induced on red blood cells under hypertonic and hypotonic conditions. An isotonic condition was used as a control without osmotic stress. The cells were incubated at 37oC for 15 min and 24 hrs. Different concentrations of zinc sulfate were set up experimentally, stepwise after the lysis of RBC samples with ultrasound waves and removal of cell membranes by centrifugation. Zinc sulfate was allowed to bind to hemoglobin at different time intervals at room temperature. Afterward, hemoglobin was precipitated at various time intervals through centrifugation. The supernatants were then measured by ELISA and colorimetric methods for Caspase 3 level and activity.

The optimal conditions were found to be 6 mM zinc sulfate, 10 min incubation at room temperature to bind zinc sulfate to hemoglobin, and 30 min centrifugation at 3000 rpm to precipitate hemoglobin.

This study showed that zinc sulfate with a concentration of 6 mM precipitates and removes hemoglobin without affecting the level or activity of Caspase 3.

Preeclampsia is a disorder of pregnancy characterized by high blood pressure. Regarding vascular and red blood cell (RBC) damages in preeclampsia patients, the present study was performed with aim to investigate the relationship between the level of RBC indicators with the incidence and severity of preeclampsia.

This case-control study was conducted within one year (July 2021 to July 2022) on 22 pregnant women with mild preeclampsia, 38 pregnant women with severe preeclampsia, and 38 healthy pregnant women who referred to Amiral Momenin Hospital in Zabol city. Evaluation of the number of red blood cells and the amount of hemoglobin, hematocrit, MCV, MCH, and MCHC was obtained by analyzing 2 ml of blood containing anticoagulant. Data analysis was done using SPSS statistical software (version 26) and independent t-test, chi-square, Pearson, and logistic regression analysis. P<0.05 was considered statistically significant.

Among the basic variables, having a history of preeclampsia (P=0.005), body mass index (P=0.030), systolic blood pressure (P<0.001) and diastolic blood pressure (P<0.001) had significant differences between the three studied groups. Among the RBC indices, MCV was significantly different between the studied groups (P=0.043). Hemoglobin (r= -0.248, P=0.034), MCV (r= -0.335, P=0.004), and MCH (r= -0.315, P=0.007) had a significant correlation with systolic blood pressure. Hemoglobin [OR (95% CI)= 0.545 (0.335, 0.912), P=0.021], hematocrit [OR (95% CI)= 0.789, (0.644, 0.967), P=0.022], and MCV [OR (95% CI)= 0.891 (0.808, 0.983), P=0.022] were related to the severity of preeclampsia.

Considering the significant reduction of MCV index in the preeclampsia group and the correlation of this decrease with the increase of systolic blood pressure and the severity of preeclampsia, it is suggested that this non-invasive index be measured during pregnancy for screening of preeclampsia.

Diabetes is one of the most important health problems in the world. The aim of this study was to evaluate the response of a session of resistance exercise with blood flow restriction (REBFR) to hemodynamic and hematological changes in type 2 diabetic patients.
Fifteen patients with type 2 diabetes performed knee flexion and extension of the resistance exercise with and without BFR in two sessions with intensity of 20% and 80% 1RM, respectively. Hemodynamic and hematological changes were measured at before, immediately and 30 minutes after exercise. Repeated analysis of variance was used to evaluate the effect of the intervention on quantitative factors.
The mean values ​​of systolic and diastolic blood pressure and heart rate values ​​in both training sessions were not significantly different (P <0.05). The results showed that there was no significant difference between WBC, RBC, HCT, Hb, MCH, MCHC, MCV and PV indices between resistance exercise sessions with and without BFR (P <0.05). According to the findings, the amount of RBC and Hb increased significantly immediately after REBFR (P <0.05), which returned to resting levels after 30 minutes of recovery.
Low-intensity REBFR due to no significant change in hemodynamic, hematological and platelet parameters can be an effective and low-cost mechanism in preventing cardiovascular disease in patients with type 2 diabetes and as a Non-pharmacological treatment system and alternative to high-intensity resistance exercise to prevent muscle atrophy, especially in clinical populations, especially diabetics.

Cesarean section surgery is one of the most common surgeries in the world. 3-5 percent of all blood transfusions are associated with obstetrics cesarean section surgery has a higher risk than vaginal delivery. Potential blood transfusion-associated risks have caused health providers to assess blood transfusion use more precisely which resulted in a decreased tendency for blood product prescription. Packed red blood cell transfusion-related during cesarean section surgeries have decreased to 1.1 to 1.6 percent in some medical centers while have remained 5.2 to 6.8 percent in some others. Blood product transfusion is life-saving per se but is associated with some complications. Complications include disturbance of body temperature control acute lung injury, delayed hemolytic reactions, none hemolytic reactions, and infectious which can cause mild or serious complications. In many centers all over the world, blood transfusions have been instructed but some researches show they are not followed.

in 2019, aimed at packed red blood cell transfusion condition we instructed a descriptive-analytic study on 303 patients who have gone cesarean section surgery in years 207-2018 at Shahid Motahari teaching hospital in Ormia University of Medical Sciences in Iran. The results of the study showed the prevalence of anemic patients (Hb <10.5 gram per deciliter) at admission for surgery was 23.4%. 46.6% of patients who received PRBC had Hb≥10 at discharge from the hospital. 41.8% of patients had Hb≥ 10 gr/dl during hospitalization.

According to our research, a significant percentage of patients had over-transfusions. Lack of in-hospital transfusion guidelines and triggers and targets for patients’ hemoglobin correction needs serious attention to be instructed as soon as possible.

Ventilator-associated pneumonia (VAP) is an important complication in intensive care unit (ICU) patients with endotracheal intubation. Finding potential early indicators of this condition can aid in reducing the disease burden. We aimed to investigate the relationship between VAP occurrence and serum levels of C-reactive protein (CRP), procalcitonin (PCT), and hemoglobin (Hgb) during ICU hospitalization of brain trauma patients.

This descriptive-analytical study was carried out on brain trauma patients (99 male, 39 female), referring to the 5th Azar hospital in Gorgan, Iran, in the course of 2017. The patients were hospitalized in ICU with endotracheal intubation and mechanical ventilation. The diagnosis of VAP was confirmed by a 12-score rating based on chest radiographs, body temperature, white blood cell count, and sputum culture. After admission, serum CRP, PCT, and Hgb were documented daily for 6 days.

According to the diagnostic criteria, VAP was confirmed in 41 patients (30%). Serum CRP and PCT levels on the 6th-day post-admission were significantly associated with VAP diagnosis, while Hgb levels did not differ significantly between VAP and non-VAP patients. Serum levels of CRP, PCT, and Hgb on the 6th day were not associated with age or sex.

Our results indicate that serum CRP and PCT levels are associated with the occurrence of VAP in ICU patients receiving mechanical ventilation. Therefore, these biomarkers could be utilized to warn physicians about the possibility of VAP, thereby reducing mortality rate and hospitalization length.

Periodontal inflammation, which is one of the most common infectious diseases, can be caused by poor oral hygiene and microbial plaque, and the resulting inflammatory products can also lead to systemic effects on the peripheral blood system. The present study aimed to investigate the relationship of periodontal indices with hematocrit and hemoglobin in patientsMaterials & This cross-sectional observational study was performed on those referring to Mashhad University of Medical Sciences Cohort Center with a complete file. Firstly, patients' periodontal indices, including the Community Periodontal Index of Treatment Needs (CPITN) and Löe-Silness gingival index (GI), were extracted from the existing record files. These individuals were assigned to three groups according to the CPITN variable. Individuals with CPITN zero were considered a healthy group, individuals with CPITN 1 and 2 as a gingivitis group, and individuals with a CPITN of 3 or 4 as a periodontitis group. Blood indices (hemoglobin, hematocrit) were also extracted from patients' records. Thereafter, the relationship of hematocrit and hemoglobin with their periodontal indices was investigated using statistical tests. In this study, the records of 242 participants, including 158 females and 84 males, were examined, out of whom 87 cases were healthy, 89 had gingivitis, and 68 had periodontits. In males and females, there were no significant differences between mean hemoglobin; however, the mean hematocrit of men in the healthy group was significantly higher than that in the gingivitis group. The mean of hematocrit were 2.4± 45.7 and 2.7±43.3 in the healthy and gingivitis groups, respectively. Nonetheless, in females, GI displayed no association with hematocrit or hemoglobin in either group. There was no significant difference between blood indices and periodontal disease in this study. In men, there was no significant difference in mean hemoglobin; nonetheless, the mean hematocrit was significantly higher in the healthy group than that in the gingivitis group. However, in females, there was no significant difference between mean hematocrit and hemoglobin. No correlation was detected between GI and hematocrit or hemoglobin in either group. Predictive regression analysis illustrated that for each unit increase in GI, the average hematocrit would be 0.37 units lower; however, no significant relationship was found between GI and hemoglobin.

Regular exercise is considered as a physiological stimulus for the release of hematopoietic stem cells from the bone marrow. The aim of this study is to determine the effect of one week of aerobic training on the production of CD34+ hematopoietic cells and the amount of white blood cells and hemoglobin after autologous transplantation in leukemia patients.

In this semi-experimental study, 39 patients who were candidate for autologous stem cell transplantation referred to Taleghani Hospital were randomly divided into two experimental and control groups. The experimental group exercised on the treadmill with an intensity of 40-60% of the reserve heart rate for one week. But the control group did not receive any intervention. The blood sample was taken from each patient immediately after training and at the time of hospitalization and discharge.

The number of CD34+ cells increased after training in both groups (P >0.0001), But there was no significant difference between the two groups. The amount of white blood cells did not increase significantly in two groups. The amount of hemoglobin decreased significantly in both groups (P >0.05). However, at the time of discharge, there was no significant difference between the two groups in the amount of white blood cells and hemoglobin.

Although the combination of G-CSF treatment and aerobic exercise does not facilitate faster recovery of blood cells, it does not delay recovery and does not pose a risk to patients who underwent autologous peripheral blood stem cell transplantation.

Mortality is one of the common consequences of non-trauma patients (NTP) admitted to the intensive care unit. In this study, hemoglobin concentration and its relationship with clinical outcome in NTP was investigated

This cross-sectional study was performed on the records of 400 non-trauma patients admitted to the General Intensive Care Unit of Besat Hospital in Hamadan during 2020-2022 in terms of hemoglobin concentration and its relationship with clinical outcome. Study data were analyzed using SPSS software version 23 and Student t-tests, one-way analysis of variance, and Pearson correlation coefficient.

In this Cross-sectional study, cancer (18.8%), drug poisoning (14.8%), poisoning (14.5%), and DKA (8.8%) were the most common causes of non-trauma hospitalization. The incidence of in-hospital death was 18.8%. Sepsis, pulmonary embolism, myocardial infarction, meningitis and DIC with 46.7%, 22.7%, 18.7%, 6.7% and 5.3% were the most common causes of death, respectively. There was a significant relationship between hemoglobin concentration with age, sex and duration of hospitalization (p<0.05). A significant relationship was observed between lower hemoglobin concentration before and during hospitalization with increased mortality (p<0.001).

In the present study, the hemoglobin of non-trauma patients decreased during hospitalization compared to pre-hospitalization period and this decrease in hemoglobin level was associated with increased mortality of non-trauma patients in the hospital.

Postpartum hemorrhage is the most leading cause of maternal mortality worldwide; prevention of it can be effective in reducing mortality and complications. Studies have shown the contractile and anti-inflammatory properties of Urtica dioica and its effect on reducing menstrual bleeding, so the present study was performed aimed to determine the effect of Urtica dioica drops on postpartum hemorrhage.

This triple-blind randomized clinical trial study was conducted in 2019 on 100 women referred to Kamali Hospital in Karaj (Iran) for vaginal delivery in two groups of intervention and control. The intervention group received 10 drops of Urtica dioica and the control group received 10 placebo drops after delivery. Bleeding was measured using PBLAC chart up to 24 hours after delivery. Hemoglobin and hematocrit levels were measured at arrival and 6 hours postpartum. Data were analyzed using SPSS software (version 20) and independent t-test, Mann-Whitney, Fisher, Chi-square and repeated measures ANOVA. P<0.05 was considered statistically significant.

There was no statistically significant difference between the two groups in terms of demographic and obstetric variables (p>0.05). The mean of bleeding in the first 24 hours after delivery was 55.94±11.55 ml for the intervention group and 71.48±12.45 ml for the control group, which was significantly different (p=0.001). Also, the mean decrease of hemoglobin (p = 0.006) and hematocrit (p = 0.001) level was significantly lower in the Urtica dioica group than the control group.

Urtica dioica drop have a significant effect on reducing bleeding and reducing hemoglobin and hematocrit after childbirth and is helpful in reducing postpartum hemorrhage.

Iron deficiency anemia reduces the activity of thyroperoxidase and thus inhibits the production of thyroid hormone. Therefore, this study was performed with aim to determine the relationship between complete blood count parameters with the level of thyroid stimulating hormone in pregnant women.

This descriptive-analytical cross-sectional study was performed in 2018 on 130 pregnant women who had referred to community health centers covered by Gonabad University of Medical Sciences for first prenatal care. Data were collected at maternal referral, using a checklist containing demographic information of maternity (maternal age, education, occupation, gestational age, etc.) and first trimester pregnancy test results. Data were analyzed by SPSS software (version 16) and Kolmogorov-Smirnov, Spearman correlation and Pearson correlation tests. P<0.05 was considered statistically significant.

Mean TSH of women was 1.95± 1.24 mlu/l and mean total Hb was 12.81±1.08 g/dl and mean total MCHC was 23.89±1.34 g/dl. In multivariate model, none of the variables had a significant statistical relationship with TSH and only the MCHC variable had a significant relationship with TSH (P = 0.041).

The MCHC variable had a significant relationship with TSH, but the other blood parameters had no significant relationship with TSH level. It is recommended that further studies be performed in the future to determine the relationship between these two variables.

Anemia is common in both age groups of 9-24 months and adolescence. Considering the fact that anemia in children is associated with various complications such as stunted growth, activity intolerance, behavioral changes, inattention, irritability and changes in the immune response, the aim of this study was to compare the frequency of anemia in infants with normal birth weight and LBW at 12 months of age.

This was an analytical study using the historical cohort method with a parallel design from February 2017 to July 2016. The study population was all the infants referred to health centers of Yazd at the age of 12 months for vaccination, who were monitored. 100 infants were selected and divided into two groups of 50 with normal birth weight (more than 2500 g) and the birth weight less than 2500 g by simple random sampling, and CBC and ferritin tests were run for them. In this study, the hemoglobin less than 11 was considered anemia, and finally, the data were analyzed by SPSS software.

The results showed that the two groups of the LBW and the normal weight were not different in terms of sex, but the type of feeding was different, and infants of LBW group used more powdered milk. 22% of LBW infants and 38% of normal weight infants were anemic.

According to the results of the study, it seems that the rate of anemia is due to the use of powdered milk,  iron supplements with higher doses for LBW infants early on, and better and constant care compared to infants with normal weight. However, more comprehensive studies with larger sample sizes can be effective in explaining these anemia-related factors in LBW infants.

Cardiovascular Disease (CVD) is the leading cause of death in developing countries. Inflammation significantly contributes to the process of atherosclerosis. Therefore, evaluating White Blood Cells (WBC) and platelet counts as markers of inflammatory as well as hematocrit as a marker of blood viscosity may predict coronary events. The present study aimed to evaluate the relationship between hematological indices and the incidence of cardiovascular events.

This study was based on the results of the Isfahan Cohort Study (ICS) which was a long-term, population-based study of 6504 adults over the age of 35 years with no history of CVD who were followed up for any incidence of CVD from 2001 to 2015. Basic levels of hematological indices were measured by entering the study.

About 49.5% of the population were male. The mean age of the population and individuals with CVD were about 51 and 57.6 years, respectively. Significant relationships were observed between systolic and diastolic blood pressures, fasting blood glucose, triglyceride, cholesterol, Low-Density Lipoprotein (LDL) levels, and waist circumference with the incidence of cardiovascular events (P<0.001 for all). Hematocrit, hemoglobin, RBC, and WBC measures were significantly associated with the incidence of cardiovascular events (P=0.002 for all). There was no significant relationship between platelet levels and the incidence of cardiovascular events.

Hematological indices including WBC and RBC counts as well as hemoglobin and hematocrit levels can predict the incidence of cardiovascular events.

According to the relevant studies, among the reported TMPRSS6 polymorphisms associated with iron deficiency anemia, rs855791 has the highest association with hemoglobin level and disease severity. The aim of this study was to investigate the relationship between rs855791and iron deficiency anemia in Sanandaj.

In this case-control study conducted in the Spring of 2016, the frequency of rs855791 polymorphism in TMPRSS6 gene was evaluated in 40 patients with iron deficiency anemia and 80 healthy randomly selected individuals without age and sex restrictions by PCR-RFLP method. Then, the relationship between rs855791  and the level of hemoglobin, ferritin, and MCV in sick and healthy individuals was investigated by SPSS V19 statistical software.

The frequencies of CC, CT, and TT among 40 patients were 15, 37.5, and 47.5 and they were 33.75, 42.5, and 23.75% among 80 healthy controls, respectively. Therefore, there was a significant relationship between TT genotype and disease (p= 0.010). Also, a significant relationship was observed between the frequency of CC and the absence of disease [OR= 0.34, p= 0.035]. The higher frequency of CT in the control group than the indicates a lower risk of people with CT genotype. The results also show a significant relationship between low Hb, MCV, and Ferritin with the genotype so that people with TT genotype had lower Hb, MCV, and ferritin than people with CC and TC genotypes.

TMPRSS6 rs855791 polymorphism was shown to be effective in subject patients with iron deficiency anemia in Sanandaj city.